{"id":"https://openalex.org/W7225253260","doi":"https://doi.org/10.1186/s13023-026-04690-y","title":"Overlooked brain injury manifesting as diplopia in Wilson disease","display_name":"Overlooked brain injury manifesting as diplopia in Wilson disease","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7225253260","doi":"https://doi.org/10.1186/s13023-026-04690-y"},"language":"en","primary_location":{"id":"doi:10.1186/s13023-026-04690-y","doi":"https://doi.org/10.1186/s13023-026-04690-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13023-026-04690-y","pdf_url":null,"source":{"id":"https://openalex.org/S71291065","display_name":"Orphanet Journal of Rare Diseases","issn_l":"1750-1172","issn":["1750-1172"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orphanet Journal of Rare Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13023-026-04690-y","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112539162","display_name":"Shu-Pei Jia","orcid":"https://orcid.org/0009-0002-0851-1975","observed_orcids":["https://orcid.org/0009-0002-0851-1975"]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu-Pei Jia","raw_affiliation_strings":["Encephalopathy Department, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, China","Key Laboratory of Xin\u2019An Medicine, Ministry of Education, Hefei, China"],"raw_orcid":"https://orcid.org/0009-0002-0851-1975","affiliations":[{"raw_affiliation_string":"Encephalopathy Department, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, China","institution_ids":["https://openalex.org/I253932293"]},{"raw_affiliation_string":"Key Laboratory of Xin\u2019An Medicine, Ministry of Education, Hefei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160622176","display_name":"Wen-Ming Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wen-Ming Yang","raw_affiliation_strings":["Encephalopathy Department, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, China","Key Laboratory of Xin\u2019An Medicine, Ministry of Education, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Encephalopathy Department, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, China","institution_ids":["https://openalex.org/I253932293"]},{"raw_affiliation_string":"Key Laboratory of Xin\u2019An Medicine, Ministry of Education, Hefei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160646683","display_name":"Mei-Xia Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mei-Xia Wang","raw_affiliation_strings":["Encephalopathy Department, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, China","Key Laboratory of Xin\u2019An Medicine, Ministry of Education, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Encephalopathy Department, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, China","institution_ids":["https://openalex.org/I253932293"]},{"raw_affiliation_string":"Key Laboratory of Xin\u2019An Medicine, Ministry of Education, Hefei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160691554","display_name":"Hai-lin Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai-lin Jiang","raw_affiliation_strings":["Encephalopathy Department, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, China","Key Laboratory of Xin\u2019An Medicine, Ministry of Education, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Encephalopathy Department, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, China","institution_ids":["https://openalex.org/I253932293"]},{"raw_affiliation_string":"Key Laboratory of Xin\u2019An Medicine, Ministry of Education, Hefei, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089688495","display_name":"Zhuang Tao","orcid":"https://orcid.org/0000-0003-1032-1011","observed_orcids":["https://orcid.org/0000-0003-1032-1011"]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuang Tao","raw_affiliation_strings":["Encephalopathy Department, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, China","Key Laboratory of Xin\u2019An Medicine, Ministry of Education, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Encephalopathy Department, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, China","institution_ids":["https://openalex.org/I253932293"]},{"raw_affiliation_string":"Key Laboratory of Xin\u2019An Medicine, Ministry of Education, Hefei, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5160622176"],"corresponding_institution_ids":["https://openalex.org/I253932293"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.80481,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.6577000021934509,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.6577000021934509,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.2930000126361847,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wilson-s-disease","display_name":"Wilson's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diplopia","display_name":"diplopia","score":0.996999979019165},{"id":"https://openalex.org/keywords/brain-injury","display_name":"brain injury","score":0.8069999814033508},{"id":"https://openalex.org/keywords/neurological-symptoms","display_name":"neurological symptoms","score":0.953000009059906},{"id":"https://openalex.org/keywords/copper-metabolism-disorder","display_name":"copper metabolism disorder","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C2780581723","wikidata":"https://www.wikidata.org/wiki/Q775940","display_name":"Diplopia","level":2,"score":0.9526000022888184},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7044000029563904},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.6035000085830688},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5859000086784363},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.4627000093460083},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.44690001010894775},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.4309000074863434},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4262000024318695},{"id":"https://openalex.org/C2780317758","wikidata":"https://www.wikidata.org/wiki/Q3339235","display_name":"Neurological disorder","level":3,"score":0.40630000829696655},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3734000027179718},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.37130001187324524},{"id":"https://openalex.org/C2908845642","wikidata":"https://www.wikidata.org/wiki/Q760256","display_name":"Ocular Motility Disorders","level":3,"score":0.3488999903202057},{"id":"https://openalex.org/C3018987647","wikidata":"https://www.wikidata.org/wiki/Q3221083","display_name":"Motor symptoms","level":4,"score":0.34220001101493835},{"id":"https://openalex.org/C2777639682","wikidata":"https://www.wikidata.org/wiki/Q225957","display_name":"Dysarthria","level":2,"score":0.3319999873638153},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.3303000032901764},{"id":"https://openalex.org/C2778261627","wikidata":"https://www.wikidata.org/wiki/Q2608695","display_name":"Movement disorders","level":3,"score":0.32280001044273376},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3172999918460846},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.28940001130104065},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.27399998903274536},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.27230000495910645},{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.2718000113964081},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.26829999685287476},{"id":"https://openalex.org/C2775880387","wikidata":"https://www.wikidata.org/wiki/Q1036662","display_name":"Hypokinesia","level":2,"score":0.26589998602867126},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.26570001244544983},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.2556000053882599}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s13023-026-04690-y","doi":"https://doi.org/10.1186/s13023-026-04690-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13023-026-04690-y","pdf_url":null,"source":{"id":"https://openalex.org/S71291065","display_name":"Orphanet Journal of Rare Diseases","issn_l":"1750-1172","issn":["1750-1172"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orphanet Journal of Rare Diseases","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s13023-026-04690-y","doi":"https://doi.org/10.1186/s13023-026-04690-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13023-026-04690-y","pdf_url":null,"source":{"id":"https://openalex.org/S71291065","display_name":"Orphanet Journal of Rare Diseases","issn_l":"1750-1172","issn":["1750-1172"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orphanet Journal of Rare Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4284885299","https://openalex.org/W2162043637","https://openalex.org/W4391260585","https://openalex.org/W7166350910","https://openalex.org/W2010100418","https://openalex.org/W2422097419","https://openalex.org/W2907562114","https://openalex.org/W3206538101","https://openalex.org/W4282823775","https://openalex.org/W1971956614"],"abstract_inverted_index":{"Abstract":[0],"Current":[1],"understanding":[2],"of":[3,59,88],"neurological":[4,57,89],"impairment":[5],"in":[6,48,91],"Wilson":[7],"disease":[8],"(WD)":[9],"both":[10],"nationally":[11],"and":[12,26,69],"internationally,":[13],"has":[14],"largely":[15],"focused":[16],"on":[17,84],"manifestations":[18],"such":[19],"as":[20,64],"psychiatric":[21],"disturbances,":[22],"motor":[23],"dysfunction,":[24],"dysarthria,":[25],"cognitive":[27],"decline.":[28],"In":[29],"this":[30],"study,":[31],"five":[32],"patients":[33],"with":[34,37],"WD":[35,60],"presenting":[36],"diplopia":[38,63],"were":[39],"identified,":[40],"whereas":[41],"no":[42],"comparable":[43],"cases":[44],"have":[45],"been":[46],"reported":[47],"the":[49,55],"published":[50],"literature.":[51],"This":[52],"observation":[53],"expands":[54],"recognized":[56],"spectrum":[58],"by":[61],"highlighting":[62],"a":[65,81],"potential":[66],"clinical":[67],"manifestation":[68],"encourages":[70],"further":[71],"investigation":[72],"into":[73],"its":[74],"underlying":[75],"mechanisms.":[76],"These":[77],"results":[78],"may":[79],"offer":[80],"novel":[82],"perspective":[83],"previously":[85],"unrecognized":[86],"pathways":[87],"injury":[90],"WD.":[92]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-05T00:00:00"}