{"id":"https://openalex.org/W7225252823","doi":"https://doi.org/10.64898/2026.11.03.764009","title":"Developing synthetic auxin-based trans-kingdom signaling","display_name":"Developing synthetic auxin-based trans-kingdom signaling","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7225252823","doi":"https://doi.org/10.64898/2026.11.03.764009"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.03.764009","doi":"https://doi.org/10.64898/2026.11.03.764009","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.03.764009","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/04/2026.11.03.764009.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/04/2026.11.03.764009.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023557774","display_name":"Madison Furnish","orcid":"https://orcid.org/0000-0002-8483-5579","observed_orcids":["https://orcid.org/0000-0002-8483-5579"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madison Furnish","raw_affiliation_strings":["Colorado State University;"],"raw_orcid":"https://orcid.org/0000-0002-8483-5579","affiliations":[{"raw_affiliation_string":"Colorado State University;","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089887473","display_name":"Emmanuel J. Kokarakis","orcid":"https://orcid.org/0009-0006-5167-172X","observed_orcids":["https://orcid.org/0009-0006-5167-172X"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emmanuel J Kokarakis","raw_affiliation_strings":["Michigan State University"],"raw_orcid":"https://orcid.org/0009-0006-5167-172X","affiliations":[{"raw_affiliation_string":"Michigan State University","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160706324","display_name":"Dahlia Kopycienski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dahlia Kopycienski","raw_affiliation_strings":["Colorado State University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colorado State University;","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160702696","display_name":"Bjorn Thune-Larsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bjorn Thune-Larsen","raw_affiliation_strings":["Colorado State University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colorado State University;","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007719112","display_name":"Daniel C. Ducat","orcid":"https://orcid.org/0000-0002-1520-0588","observed_orcids":["https://orcid.org/0000-0002-1520-0588"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel C Ducat","raw_affiliation_strings":["Michigan State University"],"raw_orcid":"https://orcid.org/0000-0002-1520-0588","affiliations":[{"raw_affiliation_string":"Michigan State University","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059896867","display_name":"Arjun Khakhar","orcid":"https://orcid.org/0000-0002-4676-6533","observed_orcids":["https://orcid.org/0000-0002-4676-6533"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arjun Khakhar","raw_affiliation_strings":["Colorado State University;"],"raw_orcid":"https://orcid.org/0000-0002-4676-6533","affiliations":[{"raw_affiliation_string":"Colorado State University;","institution_ids":["https://openalex.org/I92446798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059896867"],"corresponding_institution_ids":["https://openalex.org/I92446798"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.6406000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.6406000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.08919999748468399,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.04690000042319298,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"synthetic biology","score":0.6589999794960022},{"id":"https://openalex.org/keywords/auxin","display_name":"auxin","score":0.8040000200271606},{"id":"https://openalex.org/keywords/indole-3-acetic-acid","display_name":"indole-3-acetic acid","score":0.9760000109672546},{"id":"https://openalex.org/keywords/auxin-biosynthesis","display_name":"auxin biosynthesis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/synechococcus-elongatus","display_name":"Anacystis nidulans","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cyanobacteria","display_name":"cyanobacteria","score":0.8619999885559082},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.906000018119812},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.9800000190734863},{"id":"https://openalex.org/keywords/interkingdom-communication","display_name":"interkingdom communication","score":0.6000000238418579},{"id":"https://openalex.org/keywords/dynamic-range","display_name":"dynamic range","score":0.6679999828338623},{"id":"https://openalex.org/keywords/root-microbe-interactions","display_name":"root-microbe interactions","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.718500018119812},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.6193000078201294},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5929999947547913},{"id":"https://openalex.org/C207778908","wikidata":"https://www.wikidata.org/wiki/Q190022","display_name":"Auxin","level":3,"score":0.5667999982833862},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5436000227928162},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4593000113964081},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.4499000012874603},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42800000309944153},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42340001463890076},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3950999975204468},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3790999948978424},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.3601999878883362},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3553999960422516},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.34049999713897705},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.32710000872612},{"id":"https://openalex.org/C2778177256","wikidata":"https://www.wikidata.org/wiki/Q192949","display_name":"Plant hormone","level":3,"score":0.29910001158714294},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.2976999878883362},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.29109999537467957},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28940001130104065},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.2849000096321106},{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.27000001072883606}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.03.764009","doi":"https://doi.org/10.64898/2026.11.03.764009","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.03.764009","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/04/2026.11.03.764009.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.03.764009","doi":"https://doi.org/10.64898/2026.11.03.764009","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.03.764009","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/04/2026.11.03.764009.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225252823.pdf","grobid_xml":"https://content.openalex.org/works/W7225252823.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W116253160","https://openalex.org/W1987198662","https://openalex.org/W2000516534","https://openalex.org/W2011301426","https://openalex.org/W2079042867","https://openalex.org/W2099540110","https://openalex.org/W2110854495","https://openalex.org/W2160243998","https://openalex.org/W2288379730","https://openalex.org/W2590991425","https://openalex.org/W2593395106","https://openalex.org/W2606736166","https://openalex.org/W2785014466","https://openalex.org/W2889484641","https://openalex.org/W2911187837","https://openalex.org/W2950236183","https://openalex.org/W3080506686","https://openalex.org/W3081550394","https://openalex.org/W3128261063","https://openalex.org/W3177628571","https://openalex.org/W4225714453","https://openalex.org/W4312210860","https://openalex.org/W4322624842","https://openalex.org/W4392985440","https://openalex.org/W4401941721","https://openalex.org/W4405841929"],"related_works":["https://openalex.org/W2288379730","https://openalex.org/W7153197154","https://openalex.org/W4402356080","https://openalex.org/W4213003952","https://openalex.org/W2950325309","https://openalex.org/W2052036460","https://openalex.org/W4387448524","https://openalex.org/W2785218065","https://openalex.org/W4408345400","https://openalex.org/W2171310281"],"abstract_inverted_index":{"Synthetic":[0],"trans-kingdom":[1,29,77,89,226],"signaling":[2,30,90,153,227],"systems":[3,31,154],"with":[4,131,187],"tunable":[5,150,224],"transduction":[6,47],"properties":[7],"provide":[8],"a":[9,38,72,88,114,223],"unique":[10],"avenue":[11],"to":[12,62,75,146],"explore":[13],"how":[14,107,125],"communication":[15],"between":[16],"organisms":[17],"coordinate":[18],"behaviors":[19],"without":[20],"the":[21,84,94,118,182,188,191,196,211,219],"confounding":[22],"complexity":[23],"of":[24,190],"natural":[25],"systems.":[26],"However,":[27],"existing":[28],"suffer":[32],"from":[33,210],"either":[34,51],"toxic":[35],"signal":[36,44,127],"molecules,":[37],"need":[39],"for":[40,43,87,222],"rare":[41],"precursors":[42],"generation,":[45],"or":[46,53],"machinery":[48],"which":[49],"is":[50],"species-specific":[52],"cannot":[54],"be":[55,63,111,129,144,231],"easily":[56],"tuned.":[57],"This":[58],"limits":[59],"their":[60,69],"capacity":[61],"broadly":[64,232],"applied":[65,233],"across":[66,155,234],"kingdoms":[67],"and":[68,124,134],"utility":[70],"as":[71],"model":[73,115,192],"system":[74,91,228],"study":[76],"interactions.":[78],"In":[79],"this":[80,126],"work":[81],"we":[82,178],"elucidate":[83],"design":[85,220],"principles":[86,221],"based":[92],"on":[93],"plant":[95],"phytohormone,":[96],"Indole":[97],"3-Acetic":[98],"Acid":[99],"(auxin),":[100],"that":[101,160,180,229],"overcomes":[102],"these":[103,141],"challenges.":[104],"We":[105,138,158],"demonstrate":[106,159,218],"auxin":[108,164,197],"biosynthesis":[109],"can":[110,128,143,166,200,230],"engineered":[112],"into":[113],"sender":[116],"organism,":[117],"cyanobacteria":[119],"Synechococcus":[120],"elongatus":[121,162,184],"PCC":[122],"7942,":[123],"tuned":[130],"low":[132],"leak":[133],"high":[135],"dynamic":[136],"range.":[137],"also":[139],"show":[140,179],"signals":[142,165],"connected":[145],"gene":[147,168,202],"expression":[148,169,203],"using":[149],"synthetic":[151,206],"auxin-responsive":[152,205],"multiple":[156],"kingdoms.":[157],"S.":[161,183],"generated":[163],"tune":[167],"in":[170],"co-cultured":[171],"Saccharomyces":[172],"cerevisiae":[173],"via":[174,204],"auxin-induced":[175],"degradation.":[176],"Additionally,":[177],"when":[181],"are":[185],"associated":[186],"roots":[189],"plant,":[193],"Arabidopsis":[194],"thaliana,":[195],"they":[198],"generate":[199],"control":[201],"transcription":[207],"factors":[208],"expressed":[209],"plants":[212],"genome.":[213],"Taken":[214],"together,":[215],"our":[216],"results":[217],"auxin-based":[225],"species.":[235]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-05T00:00:00"}
