{"id":"https://openalex.org/W7225252736","doi":"https://doi.org/10.5281/zenodo.23956398","title":"The Crypt Cycle as a Source Counter: Crypt Fission is Set by a Cell Division Quota, Not by Crypt Size","display_name":"The Crypt Cycle as a Source Counter: Crypt Fission is Set by a Cell Division Quota, Not by Crypt Size","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7225252736","doi":"https://doi.org/10.5281/zenodo.23956398"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.23956398","doi":"https://doi.org/10.5281/zenodo.23956398","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23956398","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"volume":null,"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.23956398","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064610744","display_name":"Bruce M. Boman","orcid":"https://orcid.org/0000-0002-1335-9149","observed_orcids":["https://orcid.org/0000-0002-1335-9149"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Boman, Bruce M.","raw_affiliation_strings":["University of Delaware"],"raw_orcid":"https://orcid.org/0000-0002-1335-9149","affiliations":[{"raw_affiliation_string":"University of Delaware","institution_ids":["https://openalex.org/I86501945"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064610744"],"corresponding_institution_ids":["https://openalex.org/I86501945"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.22859999537467957,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.22859999537467957,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.1995999962091446,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.1873999983072281,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C66090201","wikidata":"https://www.wikidata.org/wiki/Q15995009","display_name":"Crypt","level":2,"score":0.9681000113487244},{"id":"https://openalex.org/C12294094","wikidata":"https://www.wikidata.org/wiki/Q929080","display_name":"Fission","level":3,"score":0.6880000233650208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4936999976634979},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.4909999966621399},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.3971000015735626},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36079999804496765},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.35199999809265137},{"id":"https://openalex.org/C60798267","wikidata":"https://www.wikidata.org/wiki/Q1226939","display_name":"Division (mathematics)","level":2,"score":0.3149999976158142},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30570000410079956},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2946999967098236},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27799999713897705},{"id":"https://openalex.org/C2780669762","wikidata":"https://www.wikidata.org/wiki/Q4667164","display_name":"Aberrant crypt foci","level":5,"score":0.2727000117301941}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.23956398","doi":"https://doi.org/10.5281/zenodo.23956398","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23956398","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"doi:10.5281/zenodo.23956399","doi":"https://doi.org/10.5281/zenodo.23956399","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23956399","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.5281/zenodo.23956398","doi":"https://doi.org/10.5281/zenodo.23956398","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23956398","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Crypt":[0],"fission":[1,41,80,159,176,274],"replicates":[2],"colonic":[3],"crypts.":[4],"It":[5],"sets":[6],"crypt":[7,34,49,64,124,146],"number":[8],"during":[9],"infancy,":[10],"continues":[11],"slowly":[12],"throughadult":[13],"life,":[14],"and":[15,23,71,86,143,206,258,275,294,313],"is":[16,28,42,76,97,109,164,177,189,251,263,269,281],"elevated":[17],"in":[18,24,93,136],"familial":[19],"adenomatous":[20],"polyposis":[21],"(FAP)":[22],"adenoma,":[25],"where":[26],"it":[27,91,188],"theroute":[29],"by":[30,179,243],"which":[31,118,173,238,250,262],"one":[32,128],"altered":[33],"becomes":[35],"many.":[36],"What":[37],"triggers":[38],"an":[39,98,283],"individual":[40],"unsettled.The":[43],"available":[44],"accounts":[45],"are":[46],"spatial:":[47],"a":[48,67,105,131,192,214,217,225,244,271,301,305],"divides":[50],"once":[51],"its":[52,55,277],"size,":[53],"or":[54],"stem":[56],"cell":[57],"population,":[58],"crossesa":[59],"threshold.":[60],"Each":[61],"asks":[62,144],"the":[63,88,101,119,137,145,156,167,196,199,209,247,286,296],"to":[65,130,147,151,161],"measure":[66],"magnitude":[68],"about":[69],"itself,":[70],"no":[72,309],"apparatus":[73],"for":[74,113],"thatmeasurement":[75],"known.We":[77],"ask":[78],"whether":[79],"requires":[81],"spatial":[82,291],"self-measurement":[83],"at":[84,241],"all,":[85],"test":[87],"alternative":[89],"that":[90,103,175,187,282,289,311],"isscheduled":[92],"division-time.":[94],"The":[95,279],"hypothesis":[96],"ordinal":[99],"quota:":[100],"exemption":[102],"makes":[104,295],"niche":[106],"sitea":[107],"source":[108,120,200],"itself":[110],"finite,":[111],"good":[112],"S":[114],"retained-daughter":[115],"divisions,":[116],"after":[117],"set":[121],"doubles":[122],"andthe":[123],"partitions.":[125],"This":[126],"adds":[127],"rule":[129],"published":[132],"open-loop":[133],"renewal":[134,162,168],"model,":[135],"single":[138],"placethat":[139],"model":[140],"leaves":[141],"unbounded,":[142],"count":[148,201],"rather":[149,181,255,303],"than":[150,256,304],"measure.Four":[152],"results":[153],"follow.":[154],"First,":[155],"ratio":[157],"of":[158,221,273],"rate":[160,163],"fixed":[165],"whenever":[166],"andsource-cycle":[169],"timescales":[170],"scale":[171],"together,":[172],"establishes":[174],"paced":[178],"division":[180,242],"thanby":[182],"elapsed":[183],"time,":[184],"though":[185],"not":[186,276],"counted,":[190],"since":[191],"per-division":[193,218],"hazard":[194],"gives":[195],"same":[197],"constant.Second,":[198],"must":[202,229,318],"cycle":[203],"between":[204],"K":[205],"2K":[207],"across":[208],"quota.":[210],"Third,":[211],"three":[212],"measurementsseparate":[213],"quota":[215],"from":[216,265],"probability,":[219],"two":[220],"them":[222],"without":[223],"imaging":[224],"lesion.":[226],"Fourth,":[227],"anycounter":[228],"survive":[230],"some":[231],"seven":[232],"hundred":[233],"occupant":[234],"replacements":[235],"per":[236],"quota,":[237],"excludes":[239],"factorspartitioned":[240],"saturation":[245],"argument,":[246],"APC/\u03b2-catenin":[248],"loop,":[249],"closed":[252],"feedbackand":[253],"oscillates":[254],"counts,":[257,312],"APC":[259],"promoter":[260],"methylation,":[261],"absent":[264],"normal":[266],"colon.Crypt":[267],"size":[268],"then":[270],"correlate":[272],"cause.":[278],"significance":[280],"ordinalmechanism":[284],"removes":[285],"sensing":[287],"requirement":[288],"every":[290],"account":[292],"incurs,":[293],"elevatedFAP":[297],"index":[298],"legible":[299],"as":[300],"prevalence":[302],"rate.":[306],"We":[307],"identify":[308],"molecule":[310],"give":[314],"thespecification":[315],"any":[316],"candidate":[317],"meet.":[319]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-05T00:00:00"}