{"id":"https://openalex.org/W7225252600","doi":"https://doi.org/10.1038/s12276-026-01877-y","title":"IDH2 links mitochondrial \u03b1-ketoglutarate to epigenetic thermogenic activation in brown adipose tissue","display_name":"IDH2 links mitochondrial \u03b1-ketoglutarate to epigenetic thermogenic activation in brown adipose tissue","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7225252600","doi":"https://doi.org/10.1038/s12276-026-01877-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/42982892"},"language":"en","primary_location":{"id":"doi:10.1038/s12276-026-01877-y","doi":"https://doi.org/10.1038/s12276-026-01877-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s12276-026-01877-y","pdf_url":null,"source":{"id":"https://openalex.org/S57588113","display_name":"Experimental & Molecular Medicine","issn_l":"1226-3613","issn":["1226-3613","2092-6413"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-1","kci-registered","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental &amp; Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s12276-026-01877-y","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5138368949","display_name":"Soo-Young Park","orcid":"https://orcid.org/0000-0002-5409-6664","observed_orcids":["https://orcid.org/0000-0002-5409-6664"]},"institutions":[{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soo-Young Park","raw_affiliation_strings":["Department of Physiology, Keimyung University School of Medicine, Daegu, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Keimyung University School of Medicine, Daegu, Republic of Korea","institution_ids":["https://openalex.org/I52010207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160716814","display_name":"Min-Hee Seo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min-Hee Seo","raw_affiliation_strings":["Department of Physiology, Keimyung University School of Medicine, Daegu, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Keimyung University School of Medicine, Daegu, Republic of Korea","institution_ids":["https://openalex.org/I52010207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048006373","display_name":"Sulagna Mukherjee","orcid":"https://orcid.org/0000-0001-6595-4137","observed_orcids":["https://orcid.org/0000-0001-6595-4137"]},"institutions":[{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sulagna Mukherjee","raw_affiliation_strings":["Department of Physiology, Keimyung University School of Medicine, Daegu, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Keimyung University School of Medicine, Daegu, Republic of Korea","institution_ids":["https://openalex.org/I52010207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059454424","display_name":"Yong Hyun Jeon","orcid":"https://orcid.org/0000-0003-3161-7698","observed_orcids":["https://orcid.org/0000-0003-3161-7698"]},"institutions":[{"id":"https://openalex.org/I4210162961","display_name":"Daegu-Gyeongbuk Medical Innovation Foundation","ror":"https://ror.org/05cc1v231","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210162961"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong Hyun Jeon","raw_affiliation_strings":["Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea","institution_ids":["https://openalex.org/I4210162961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160591576","display_name":"Dae-Kyu Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dae-Kyu Song","raw_affiliation_strings":["Department of Physiology, Keimyung University School of Medicine, Daegu, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Keimyung University School of Medicine, Daegu, Republic of Korea","institution_ids":["https://openalex.org/I52010207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135121799","display_name":"Oh Byung-chul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byung-Chul Oh","raw_affiliation_strings":["Lee Gil Ya Cancer and Diabetes Institute, Department of Physiology, Gachon University School of Medicine, Younsoo-gu, Incheon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lee Gil Ya Cancer and Diabetes Institute, Department of Physiology, Gachon University School of Medicine, Younsoo-gu, Incheon, Republic of Korea","institution_ids":["https://openalex.org/I12832649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160620427","display_name":"Juro Sakai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Juro Sakai","raw_affiliation_strings":["Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077274238","display_name":"Timothy F. Osborne","orcid":"https://orcid.org/0000-0002-5150-4300","observed_orcids":["https://orcid.org/0000-0002-5150-4300"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy F. Osborne","raw_affiliation_strings":["Institute for Fundamental Biomedical Research, Department of Medicine and Biological Chemistry, Johns Hopkins University School of Medicine, St Petersburg, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Fundamental Biomedical Research, Department of Medicine and Biological Chemistry, Johns Hopkins University School of Medicine, St Petersburg, FL, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112687204","display_name":"Hye Ra Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye Ra Jung","raw_affiliation_strings":["Department of Pathology, Keimyung University School of Medicine, Daegu, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Keimyung University School of Medicine, Daegu, Republic of Korea","institution_ids":["https://openalex.org/I52010207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107834849","display_name":"Chang Hwa Jung","orcid":"https://orcid.org/0000-0002-1076-750X","observed_orcids":["https://orcid.org/0000-0002-1076-750X"]},"institutions":[{"id":"https://openalex.org/I4210114577","display_name":"Korea Food Research Institute","ror":"https://ror.org/028jp5z02","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210114577","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chang Hwa Jung","raw_affiliation_strings":["Aging and Metabolism Research Group, Korea Food Research Institute, Jeollabuk-do, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-1076-750X","affiliations":[{"raw_affiliation_string":"Aging and Metabolism Research Group, Korea Food Research Institute, Jeollabuk-do, Republic of Korea","institution_ids":["https://openalex.org/I4210114577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100331189","display_name":"Jaeho Lee","orcid":"https://orcid.org/0000-0001-7946-0699","observed_orcids":["https://orcid.org/0000-0001-7946-0699"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae-Ho Lee","raw_affiliation_strings":["Department of Physiology, College of Medicine and Institute of Medical Science, Gyeongsang National University, Jinju, Republic of Korea. jholee86@gnu.ac.kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Medicine and Institute of Medical Science, Gyeongsang National University, Jinju, Republic of Korea. jholee86@gnu.ac.kr","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010636507","display_name":"Seung\u2010Soon Im","orcid":"https://orcid.org/0000-0002-2743-2108","observed_orcids":["https://orcid.org/0000-0002-2743-2108"]},"institutions":[{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung-Soon Im","raw_affiliation_strings":["Department of Physiology, Keimyung University School of Medicine, Daegu, Republic of Korea. ssim73@kmu.ac.kr"],"raw_orcid":"https://orcid.org/0000-0002-2743-2108","affiliations":[{"raw_affiliation_string":"Department of Physiology, Keimyung University School of Medicine, Daegu, Republic of Korea. ssim73@kmu.ac.kr","institution_ids":["https://openalex.org/I52010207"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4490,"currency":"USD","value_usd":4490},"apc_paid":{"value":4490,"currency":"USD","value_usd":4490},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84343899,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idh2","display_name":"IDH2","score":0.9779999852180481},{"id":"https://openalex.org/keywords/alpha-ketoglutarate","display_name":"alpha-ketoglutarate","score":0.9629999995231628},{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.9750000238418579},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"thermogenesis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tet2","display_name":"TET2","score":0.7670000195503235},{"id":"https://openalex.org/keywords/5-hydroxymethylcytosine","display_name":"5-hydroxymethylcytosine","score":0.9089999794960022},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6460000276565552},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.7369999885559082},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cold-exposure","display_name":"cold exposure","score":0.7210000157356262},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.6140000224113464},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.5879999995231628},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C151279926","wikidata":"https://www.wikidata.org/wiki/Q965695","display_name":"Thermogenesis","level":3,"score":0.8812999725341797},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.8349999785423279},{"id":"https://openalex.org/C2776059313","wikidata":"https://www.wikidata.org/wiki/Q21116031","display_name":"IDH2","level":5,"score":0.761900007724762},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6169999837875366},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5436000227928162},{"id":"https://openalex.org/C2777150147","wikidata":"https://www.wikidata.org/wiki/Q261968","display_name":"Isocitrate dehydrogenase","level":3,"score":0.5397999882698059},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.519599974155426},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5083000063896179},{"id":"https://openalex.org/C12304452","wikidata":"https://www.wikidata.org/wiki/Q21118081","display_name":"PPARGC1A","level":5,"score":0.4794999957084656},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.3950999975204468},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.38100001215934753},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.3522000014781952},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3375000059604645},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.33180001378059387},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.3237000107765198},{"id":"https://openalex.org/C138488276","wikidata":"https://www.wikidata.org/wiki/Q18037158","display_name":"SIRT3","level":5,"score":0.31200000643730164},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3059000074863434},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.27140000462532043},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26460000872612},{"id":"https://openalex.org/C143128242","wikidata":"https://www.wikidata.org/wiki/Q18045527","display_name":"PRDM16","level":4,"score":0.26330000162124634},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.2558000087738037},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.25450000166893005}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s12276-026-01877-y","doi":"https://doi.org/10.1038/s12276-026-01877-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s12276-026-01877-y","pdf_url":null,"source":{"id":"https://openalex.org/S57588113","display_name":"Experimental & Molecular Medicine","issn_l":"1226-3613","issn":["1226-3613","2092-6413"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-1","kci-registered","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental &amp; Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:42982892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42982892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental & molecular medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s12276-026-01877-y","doi":"https://doi.org/10.1038/s12276-026-01877-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s12276-026-01877-y","pdf_url":null,"source":{"id":"https://openalex.org/S57588113","display_name":"Experimental & Molecular Medicine","issn_l":"1226-3613","issn":["1226-3613","2092-6413"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-1","kci-registered","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental &amp; Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1820550290","https://openalex.org/W1981463058","https://openalex.org/W2027753197","https://openalex.org/W2040328785","https://openalex.org/W2046217047","https://openalex.org/W2073804127","https://openalex.org/W2104827888","https://openalex.org/W2132358997","https://openalex.org/W2134757118","https://openalex.org/W2135753172","https://openalex.org/W2146558971","https://openalex.org/W2146625096","https://openalex.org/W2147017751","https://openalex.org/W2165958384","https://openalex.org/W2170414800","https://openalex.org/W2179438025","https://openalex.org/W2310964761","https://openalex.org/W2513724444","https://openalex.org/W2519117803","https://openalex.org/W2739758870","https://openalex.org/W2808196629","https://openalex.org/W2929306280","https://openalex.org/W3003569820","https://openalex.org/W3047486076","https://openalex.org/W3094666465","https://openalex.org/W3197178742","https://openalex.org/W3198714876","https://openalex.org/W4283313066","https://openalex.org/W4299514580","https://openalex.org/W4375860234","https://openalex.org/W4385230274","https://openalex.org/W4388036501","https://openalex.org/W4390349736","https://openalex.org/W4391178990","https://openalex.org/W4393392627"],"related_works":["https://openalex.org/W3004784256","https://openalex.org/W3022046669","https://openalex.org/W2201825351","https://openalex.org/W3103538859","https://openalex.org/W4406596402","https://openalex.org/W2330827049","https://openalex.org/W4411291367","https://openalex.org/W2770114672","https://openalex.org/W7214478435","https://openalex.org/W7117875895"],"abstract_inverted_index":{"Brown":[0],"adipose":[1],"tissue":[2],"(BAT)":[3],"regulates":[4],"energy":[5,107],"expenditure,":[6],"influencing":[7],"metabolic":[8],"health.":[9],"This":[10],"study":[11,140],"aimed":[12],"to":[13,80,132,155],"highlight":[14],"the":[15,52,59,86,133,148],"role":[16],"of":[17,55,61,78,94,101],"isocitrate":[18],"dehydrogenase":[19],"2":[20,91],"(IDH2),":[21],"a":[22,72,142],"mitochondrial":[23,153],"enzyme":[24],"essential":[25],"for":[26,75],"alpha-ketoglutarate":[27],"(\u03b1-KG)":[28],"production,":[29],"in":[30,68,82,103,119],"BAT":[31,48,105,157],"differentiation":[32],"and":[33,37,50,115],"function.":[34],"In":[35],"global":[36],"BAT-specific":[38],"IDH2":[39,69,120],"knockout":[40],"(KO)":[41],"mice,":[42,122],"cold":[43,137],"exposure":[44],"reduced":[45],"thermogenesis,":[46],"induced":[47],"whitening,":[49],"abolished":[51],"cold-dependent":[53],"induction":[54,93,100],"thermogenesis":[56,102],"by":[57],"reducing":[58],"expressions":[60],"key":[62,73],"thermogenic":[63,116,134],"genes.":[64],"Lower":[65],"\u03b1-KG":[66,109,126],"levels":[67],"KO":[70,121],"BAT,":[71],"cofactor":[74],"TET2-mediated":[76],"conversion":[77],"5-methylcytosine":[79],"5-hydroxymethylcytosine":[81],"genomic":[83],"DNA,":[84],"decreased":[85],"nuclear":[87],"factor":[88,90],"erythroid-2-related":[89],"(NRF2)-dependent":[92],"BAT-enriched":[95],"lncRNA":[96],"10":[97],"(lncBATE10).":[98],"Reduced":[99],"IDH2-deficient":[104],"impaired":[106],"balance.":[108],"supplementation":[110],"partially":[111],"restored":[112],"TET2":[113],"function":[114,154],"gene":[117],"expression":[118],"indicating":[123],"that":[124],"IDH2-dependent":[125],"production":[127],"is":[128],"an":[129],"important":[130],"contributor":[131],"response":[135],"during":[136],"exposure.":[138],"Our":[139],"uncovers":[141],"previously":[143],"unrecognized":[144],"novel":[145],"mechanism":[146],"involving":[147],"IDH2-TET2-Nrf2-lncBATE10":[149],"regulatory":[150],"axis,":[151],"linking":[152],"epigenetic":[156],"regulation.":[158]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-05T00:00:00"}
