{"id":"https://openalex.org/W7225252114","doi":"https://doi.org/10.3329/cmoshmcj.v25i2.93823","title":"Molecular Detection of Carbapenem Resistant Genes among Gram Negative Bacteria Isolated from Neonatal Sepsis Cases in a Tertiary Care Hospital of Bangladesh","display_name":"Molecular Detection of Carbapenem Resistant Genes among Gram Negative Bacteria Isolated from Neonatal Sepsis Cases in a Tertiary Care Hospital of Bangladesh","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7225252114","doi":"https://doi.org/10.3329/cmoshmcj.v25i2.93823"},"language":"en","primary_location":{"id":"doi:10.3329/cmoshmcj.v25i2.93823","doi":"https://doi.org/10.3329/cmoshmcj.v25i2.93823","is_oa":true,"landing_page_url":"https://doi.org/10.3329/cmoshmcj.v25i2.93823","pdf_url":"https://www.banglajol.info/index.php/CMOSHMCJ/article/download/93823/60711","source":{"id":"https://openalex.org/S2764821823","display_name":"Chattagram Maa-O-Shishu Hospital Medical College Journal","issn_l":"2305-7890","issn":["2305-7890","2306-4919"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chattagram Maa-O-Shishu Hospital Medical College Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.banglajol.info/index.php/CMOSHMCJ/article/download/93823/60711","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124741655","display_name":"Uhtsa Khisa","orcid":"https://orcid.org/0009-0006-7427-1120","observed_orcids":["https://orcid.org/0009-0006-7427-1120"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uhtsa Khisa","raw_affiliation_strings":["Lecturer Department of Microbiology Rangamati Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lecturer Department of Microbiology Rangamati Medical College","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112984087","display_name":"Nazia Haque","orcid":"https://orcid.org/0000-0001-9308-7675","observed_orcids":["https://orcid.org/0000-0001-9308-7675"]},"institutions":[{"id":"https://openalex.org/I75447333","display_name":"Mymensingh Medical College Hospital","ror":"https://ror.org/000kb2a90","country_code":"BD","type":"healthcare","lineage":["https://openalex.org/I75447333"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Nazia Haque","raw_affiliation_strings":["Department of Microbiology Mymensingh Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology Mymensingh Medical College","institution_ids":["https://openalex.org/I75447333"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160653326","display_name":"Rahima Begum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rahima Begum","raw_affiliation_strings":["Department of Microbiology Parkview Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology Parkview Medical College","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160715044","display_name":"Jobyda Khanam Chaity","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75447333","display_name":"Mymensingh Medical College Hospital","ror":"https://ror.org/000kb2a90","country_code":"BD","type":"healthcare","lineage":["https://openalex.org/I75447333"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Jobyda Khanam Chaity","raw_affiliation_strings":["Department of Microbiology Mymensingh Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology Mymensingh Medical College","institution_ids":["https://openalex.org/I75447333"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5118672122","display_name":"Kallins Chakma","orcid":"https://orcid.org/0009-0006-9444-5597","observed_orcids":["https://orcid.org/0009-0006-9444-5597"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kallins Chakma","raw_affiliation_strings":["Rangamati General Hospital Rangamati, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rangamati General Hospital Rangamati, Bangladesh","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.79717642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"2","first_page":"3","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbapenem-resistance","display_name":"carbapenem resistance","score":0.9729999899864197},{"id":"https://openalex.org/keywords/carbapenemase-genes","display_name":"carbapenemase genes","score":0.9810000061988831},{"id":"https://openalex.org/keywords/neonatal-sepsis","display_name":"neonatal sepsis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.8870000243186951},{"id":"https://openalex.org/keywords/oxa-48","display_name":"OXA-48","score":0.9570000171661377},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae-carbapenemase","display_name":"KPC","score":0.8949999809265137},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.9100000262260437},{"id":"https://openalex.org/keywords/neonatal-intensive-care","display_name":"neonatal intensive care","score":0.8169999718666077},{"id":"https://openalex.org/keywords/bangladesh","display_name":"Bangladesh","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C2775953899","wikidata":"https://www.wikidata.org/wiki/Q6993495","display_name":"Neonatal sepsis","level":3,"score":0.6990000009536743},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.631600022315979},{"id":"https://openalex.org/C2776685102","wikidata":"https://www.wikidata.org/wiki/Q410897","display_name":"Carbapenem","level":3,"score":0.6068999767303467},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5641999840736389},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5529999732971191},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.5367000102996826},{"id":"https://openalex.org/C2776051709","wikidata":"https://www.wikidata.org/wiki/Q632006","display_name":"Gram-negative bacteria","level":4,"score":0.5364000201225281},{"id":"https://openalex.org/C2777091541","wikidata":"https://www.wikidata.org/wiki/Q9008292","display_name":"Neonatal intensive care unit","level":2,"score":0.5223000049591064},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.4869000017642975},{"id":"https://openalex.org/C2776040555","wikidata":"https://www.wikidata.org/wiki/Q19903321","display_name":"Antimicrobial stewardship","level":4,"score":0.47519999742507935},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46000000834465027},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.44020000100135803},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4399000108242035},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.43619999289512634},{"id":"https://openalex.org/C2779473907","wikidata":"https://www.wikidata.org/wiki/Q886695","display_name":"Blood culture","level":3,"score":0.42419999837875366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4059000015258789},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.38429999351501465},{"id":"https://openalex.org/C166888038","wikidata":"https://www.wikidata.org/wiki/Q4118322","display_name":"Infection control","level":2,"score":0.3504999876022339},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.3492000102996826},{"id":"https://openalex.org/C64778159","wikidata":"https://www.wikidata.org/wiki/Q271021","display_name":"Cephalosporin","level":3,"score":0.32420000433921814},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3231000006198883},{"id":"https://openalex.org/C2779259085","wikidata":"https://www.wikidata.org/wiki/Q418946","display_name":"Colistin","level":3,"score":0.31779998540878296},{"id":"https://openalex.org/C161369605","wikidata":"https://www.wikidata.org/wiki/Q41803","display_name":"Gram","level":3,"score":0.28189998865127563},{"id":"https://openalex.org/C2779375183","wikidata":"https://www.wikidata.org/wiki/Q421670","display_name":"Meropenem","level":4,"score":0.27810001373291016},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C11636898","wikidata":"https://www.wikidata.org/wiki/Q390585","display_name":"Agar diffusion test","level":4,"score":0.26989999413490295}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3329/cmoshmcj.v25i2.93823","doi":"https://doi.org/10.3329/cmoshmcj.v25i2.93823","is_oa":true,"landing_page_url":"https://doi.org/10.3329/cmoshmcj.v25i2.93823","pdf_url":"https://www.banglajol.info/index.php/CMOSHMCJ/article/download/93823/60711","source":{"id":"https://openalex.org/S2764821823","display_name":"Chattagram Maa-O-Shishu Hospital Medical College Journal","issn_l":"2305-7890","issn":["2305-7890","2306-4919"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chattagram Maa-O-Shishu Hospital Medical College Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3329/cmoshmcj.v25i2.93823","doi":"https://doi.org/10.3329/cmoshmcj.v25i2.93823","is_oa":true,"landing_page_url":"https://doi.org/10.3329/cmoshmcj.v25i2.93823","pdf_url":"https://www.banglajol.info/index.php/CMOSHMCJ/article/download/93823/60711","source":{"id":"https://openalex.org/S2764821823","display_name":"Chattagram Maa-O-Shishu Hospital Medical College Journal","issn_l":"2305-7890","issn":["2305-7890","2306-4919"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chattagram Maa-O-Shishu Hospital Medical College Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225252114.pdf","grobid_xml":"https://content.openalex.org/works/W7225252114.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4399291406","https://openalex.org/W4389849763","https://openalex.org/W3166489630","https://openalex.org/W7214579351","https://openalex.org/W4249721733","https://openalex.org/W3209296360","https://openalex.org/W2954537918","https://openalex.org/W7168837116","https://openalex.org/W4393343550","https://openalex.org/W4395005747"],"abstract_inverted_index":{"Background:":[0],"Carbapenem-resistant":[1],"Gram":[2,95,164,205],"negative":[3,44,96,165,206],"bacteria":[4,45],"have":[5],"emerged":[6],"as":[7],"a":[8],"major":[9],"cause":[10],"of":[11,25,56,169,183,202,217,240],"neonatal":[12,48,221],"sepsis,":[13],"posing":[14],"serious":[15],"challenges":[16],"to":[17,52,79,121,151,176,236],"effective":[18],"antimicrobial":[19,218],"therapy":[20],"in":[21,195,224],"resource-limited":[22],"settings.":[23],"Detection":[24],"underlying":[26],"carbapenemase":[27,58,127,153,203],"genes":[28,60,154],"is":[29],"essential":[30],"for":[31,126],"understanding":[32],"resistance":[33,175,219],"mechanisms":[34],"and":[35,51,65,142,158,229],"guiding":[36],"infection":[37],"control":[38],"policies.":[39],"To":[40],"identify":[41],"carbapenem-resistant":[42,140],"gram":[43],"isolated":[46],"from":[47,139],"sepsis":[49,77,222],"cases":[50],"detect":[53,152],"the":[54,80,181,238],"presence":[55],"common":[57],"encoding":[59],"by":[61,90,100,109,190],"conventional":[62],"PCR.":[63],"Materials":[64],"methods:":[66],"This":[67],"cross-sectional":[68],"study":[69],"was":[70,107,137,193],"conducted":[71],"among":[72,186,220],"neonates":[73],"with":[74],"clinically":[75],"suspected":[76],"admitted":[78],"Neonatal":[81],"Intensive":[82],"Care":[83],"Unit":[84],"(NICU).":[85],"Blood":[86],"samples":[87],"were":[88,98,123,148,167],"cultured":[89],"BACT/ALERT":[91],"3D":[92],"automated":[93],"system.":[94],"isolates":[97,141,166,188],"identified":[99],"standard":[101],"microbiological":[102],"techniques.":[103],"Antimicrobial":[104],"susceptibility":[105,120],"testing":[106],"performed":[108],"Kirby-Bauer":[110],"disk":[111],"diffusion":[112],"method":[113],"following":[114],"CLSI":[115],"guidelines.":[116],"Isolates":[117],"showing":[118],"reduced":[119],"carbapenems":[122],"screened":[124],"phenotypically":[125],"production":[128],"using":[129],"Modified":[130],"Carbapenem":[131],"Inactivation":[132],"Method":[133],"(mCIM).":[134],"Genomic":[135],"DNA":[136],"extracted":[138],"polymerase":[143],"chain":[144],"reaction":[145],"(PCR)":[146],"assays":[147],"carried":[149],"out":[150],"including":[155],"NDM,":[156],"KPC":[157,192],"OXA-48.":[159],"Results:":[160],"A":[161],"total":[162],"48":[163],"recovered,":[168],"which":[170],"34":[171],"(70.83%)":[172],"exhibited":[173],"phenotypic":[174],"carbapenems.":[177],"Molecular":[178],"analysis":[179],"revealed":[180],"predominance":[182],"NDM":[184,211],"(20.59%)genes":[185],"resistant":[187,242],"followed":[189],"OXA48(14.70%).No":[191],"detected":[194],"any":[196],"isolates.":[197],"Conclusion:":[198],"The":[199],"high":[200],"prevalence":[201],"producing":[204],"bacteria,":[207],"particularly":[208],"those":[209],"harboring":[210],"gene":[212],"underscores":[213],"an":[214],"alarming":[215],"trend":[216],"pathogens":[223],"Bangladesh.":[225],"Continuous":[226],"molecular":[227],"surveillance":[228],"strict":[230],"antibiotic":[231],"stewardship":[232],"are":[233],"urgently":[234],"needed":[235],"contain":[237],"spread":[239],"multi-drug":[241],"organisms.":[243],"Chatt":[244],"Maa":[245],"Shi":[246],"Hosp":[247],"Med":[248],"Coll":[249],"J;":[250],"Vol.25":[251],"(2);":[252],"July":[253],"2026;":[254],"Page":[255],"3-9":[256]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-05T00:00:00"}