{"id":"https://openalex.org/W7225251798","doi":"https://doi.org/10.1002/jat.70494","title":"Chronic Arsenic Exposure Induces Hepatocyte Proliferation in Rats via the Gut\u2010Liver Axis: Interventions With Fecal Microbiota Transplantation and/or Arsenic Withdrawal","display_name":"Chronic Arsenic Exposure Induces Hepatocyte Proliferation in Rats via the Gut\u2010Liver Axis: Interventions With Fecal Microbiota Transplantation and/or Arsenic Withdrawal","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7225251798","doi":"https://doi.org/10.1002/jat.70494","pmid":"https://pubmed.ncbi.nlm.nih.gov/42982582"},"language":"en","primary_location":{"id":"doi:10.1002/jat.70494","doi":"https://doi.org/10.1002/jat.70494","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jat.70494","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jat.70494","source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jat.70494","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160633237","display_name":"Kanglin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kanglin Wang","raw_affiliation_strings":["Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China","institution_ids":["https://openalex.org/I17721919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160643570","display_name":"Yan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Liu","raw_affiliation_strings":["Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China","institution_ids":["https://openalex.org/I17721919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103010704","display_name":"Longmei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longmei Wang","raw_affiliation_strings":["Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China","institution_ids":["https://openalex.org/I17721919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041060334","display_name":"Yifan Xu","orcid":"https://orcid.org/0000-0003-2617-4220","observed_orcids":["https://orcid.org/0000-0003-2617-4220"]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifan Xu","raw_affiliation_strings":["Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China","institution_ids":["https://openalex.org/I17721919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160598319","display_name":"Zhengzheng Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengzheng Gu","raw_affiliation_strings":["Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China","institution_ids":["https://openalex.org/I17721919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160610626","display_name":"Ruiqin Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruiqin Sun","raw_affiliation_strings":["Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China","institution_ids":["https://openalex.org/I17721919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160591502","display_name":"Cailing Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cailing Wei","raw_affiliation_strings":["Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University  Taiyuan Shanxi China","Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China","MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical university  Taiyuan Shanxi China","Shanxi Key Laboratory of Environmental Health Impairment and Prevention Shanxi Medical University  Taiyuan Shanxi China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University  Taiyuan Shanxi China","institution_ids":["https://openalex.org/I17721919"]},{"raw_affiliation_string":"Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China","institution_ids":["https://openalex.org/I17721919"]},{"raw_affiliation_string":"MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical university  Taiyuan Shanxi China","institution_ids":["https://openalex.org/I17721919"]},{"raw_affiliation_string":"Shanxi Key Laboratory of Environmental Health Impairment and Prevention Shanxi Medical University  Taiyuan Shanxi China","institution_ids":["https://openalex.org/I17721919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160687612","display_name":"Qian Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Zhao","raw_affiliation_strings":["Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University  Taiyuan Shanxi China","Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China","MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical university  Taiyuan Shanxi China","Shanxi Key Laboratory of Environmental Health Impairment and Prevention Shanxi Medical University  Taiyuan Shanxi China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University  Taiyuan Shanxi China","institution_ids":["https://openalex.org/I17721919"]},{"raw_affiliation_string":"Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China","institution_ids":["https://openalex.org/I17721919"]},{"raw_affiliation_string":"MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical university  Taiyuan Shanxi China","institution_ids":["https://openalex.org/I17721919"]},{"raw_affiliation_string":"Shanxi Key Laboratory of Environmental Health Impairment and Prevention Shanxi Medical University  Taiyuan Shanxi China","institution_ids":["https://openalex.org/I17721919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160688777","display_name":"Ben Li","orcid":"https://orcid.org/0000-0002-3996-9586","observed_orcids":["https://orcid.org/0000-0002-3996-9586"]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ben Li","raw_affiliation_strings":["Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University  Taiyuan Shanxi China","Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China","MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical university  Taiyuan Shanxi China","Shanxi Key Laboratory of Environmental Health Impairment and Prevention Shanxi Medical University  Taiyuan Shanxi China"],"raw_orcid":"https://orcid.org/0000-0002-3996-9586","affiliations":[{"raw_affiliation_string":"Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University  Taiyuan Shanxi China","institution_ids":["https://openalex.org/I17721919"]},{"raw_affiliation_string":"Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China","institution_ids":["https://openalex.org/I17721919"]},{"raw_affiliation_string":"MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical university  Taiyuan Shanxi China","institution_ids":["https://openalex.org/I17721919"]},{"raw_affiliation_string":"Shanxi Key Laboratory of Environmental Health Impairment and Prevention Shanxi Medical University  Taiyuan Shanxi China","institution_ids":["https://openalex.org/I17721919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017785808","display_name":"Xiaoyan Yan","orcid":"https://orcid.org/0000-0003-0809-3670","observed_orcids":["https://orcid.org/0000-0003-0809-3670","https://orcid.org/0009-0003-8560-3432","https://orcid.org/0009-0006-6233-9562"]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyan Yan","raw_affiliation_strings":["Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University  Taiyuan Shanxi China","Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China","MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical university  Taiyuan Shanxi China","Shanxi Key Laboratory of Environmental Health Impairment and Prevention Shanxi Medical University  Taiyuan Shanxi China"],"raw_orcid":"https://orcid.org/0000-0003-0809-3670","affiliations":[{"raw_affiliation_string":"Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University  Taiyuan Shanxi China","institution_ids":["https://openalex.org/I17721919"]},{"raw_affiliation_string":"Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China","institution_ids":["https://openalex.org/I17721919"]},{"raw_affiliation_string":"MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical university  Taiyuan Shanxi China","institution_ids":["https://openalex.org/I17721919"]},{"raw_affiliation_string":"Shanxi Key Laboratory of Environmental Health Impairment and Prevention Shanxi Medical University  Taiyuan Shanxi China","institution_ids":["https://openalex.org/I17721919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002441340","display_name":"Yulan Qiu","orcid":"https://orcid.org/0000-0001-6334-9662","observed_orcids":["https://orcid.org/0000-0001-6334-9662","https://orcid.org/0000-0002-3961-956X"]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yulan Qiu","raw_affiliation_strings":["Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University  Taiyuan Shanxi China","Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China","MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical university  Taiyuan Shanxi China","Shanxi Key Laboratory of Environmental Health Impairment and Prevention Shanxi Medical University  Taiyuan Shanxi China"],"raw_orcid":"https://orcid.org/0000-0001-6334-9662","affiliations":[{"raw_affiliation_string":"Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University  Taiyuan Shanxi China","institution_ids":["https://openalex.org/I17721919"]},{"raw_affiliation_string":"Department of Toxicology, School of Public Health Shanxi Medical University  Jinzhong Shanxi China","institution_ids":["https://openalex.org/I17721919"]},{"raw_affiliation_string":"MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical university  Taiyuan Shanxi China","institution_ids":["https://openalex.org/I17721919"]},{"raw_affiliation_string":"Shanxi Key Laboratory of Environmental Health Impairment and Prevention Shanxi Medical University  Taiyuan Shanxi China","institution_ids":["https://openalex.org/I17721919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002441340"],"corresponding_institution_ids":["https://openalex.org/I17721919"],"apc_list":{"value":3940,"currency":"USD","value_usd":3940},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72975207,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10710","display_name":"Arsenic contamination and mitigation","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10710","display_name":"Arsenic contamination and mitigation","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-arsenic-exposure","display_name":"chronic arsenic exposure","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sodium-arsenite","display_name":"sodium arsenite","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hepatocyte-proliferation","display_name":"hepatocyte proliferation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/gut-liver-axis","display_name":"gut-liver axis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8820000290870667},{"id":"https://openalex.org/keywords/butyrate","display_name":"butyrate","score":0.8830000162124634},{"id":"https://openalex.org/keywords/lachnospiraceae","display_name":"Lachnospiraceae","score":0.8790000081062317},{"id":"https://openalex.org/keywords/blautia","display_name":"Blautia","score":0.996999979019165},{"id":"https://openalex.org/keywords/mir-22","display_name":"miR-22","score":0.9739999771118164},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/gsk3b","display_name":"GSK3B","score":0.8330000042915344},{"id":"https://openalex.org/keywords/ctnnb1","display_name":"CTNNB1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.7770000100135803},{"id":"https://openalex.org/keywords/groundwater-arsenic-contamination","display_name":"groundwater arsenic contamination","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C502230775","wikidata":"https://www.wikidata.org/wiki/Q871","display_name":"Arsenic","level":2,"score":0.7997000217437744},{"id":"https://openalex.org/C2778497195","wikidata":"https://www.wikidata.org/wiki/Q730249","display_name":"Arsenic poisoning","level":3,"score":0.6452999711036682},{"id":"https://openalex.org/C172507514","wikidata":"https://www.wikidata.org/wiki/Q730249","display_name":"Arsenic toxicity","level":3,"score":0.6254000067710876},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5995000004768372},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.5501000285148621},{"id":"https://openalex.org/C2779704485","wikidata":"https://www.wikidata.org/wiki/Q3825240","display_name":"Lachnospiraceae","level":5,"score":0.42989999055862427},{"id":"https://openalex.org/C2776979534","wikidata":"https://www.wikidata.org/wiki/Q193213","display_name":"Butyrate","level":3,"score":0.42910000681877136},{"id":"https://openalex.org/C2776305511","wikidata":"https://www.wikidata.org/wiki/Q10859825","display_name":"Arsenite","level":3,"score":0.42239999771118164},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4083000123500824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3725999891757965},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.3630000054836273},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.3610999882221222},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.3402999937534332},{"id":"https://openalex.org/C149971331","wikidata":"https://www.wikidata.org/wiki/Q1444355","display_name":"Hepatotoxin","level":3,"score":0.33799999952316284},{"id":"https://openalex.org/C132165134","wikidata":"https://www.wikidata.org/wiki/Q4796457","display_name":"Arsenic contamination of groundwater","level":3,"score":0.3287999927997589},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3222000002861023},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.31450000405311584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3127000033855438},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3037000000476837},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2930999994277954},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.2906999886035919},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.27649998664855957},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C2779495234","wikidata":"https://www.wikidata.org/wiki/Q419586","display_name":"Sodium arsenite","level":3,"score":0.26339998841285706},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.2599000036716461}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/jat.70494","doi":"https://doi.org/10.1002/jat.70494","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jat.70494","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jat.70494","source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},{"id":"pmid:42982582","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42982582","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied toxicology : JAT","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jat.70494","doi":"https://doi.org/10.1002/jat.70494","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jat.70494","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jat.70494","source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225251798.pdf","grobid_xml":"https://content.openalex.org/works/W7225251798.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1716978847","https://openalex.org/W1903888485","https://openalex.org/W1991084052","https://openalex.org/W2010852729","https://openalex.org/W2017146849","https://openalex.org/W2037865217","https://openalex.org/W2047505556","https://openalex.org/W2070164699","https://openalex.org/W2094468745","https://openalex.org/W2111503975","https://openalex.org/W2168912846","https://openalex.org/W2476848306","https://openalex.org/W2502576340","https://openalex.org/W2548980315","https://openalex.org/W2583680906","https://openalex.org/W2592290961","https://openalex.org/W2753370417","https://openalex.org/W2765613654","https://openalex.org/W2772471740","https://openalex.org/W2774935716","https://openalex.org/W2892870770","https://openalex.org/W2907216794","https://openalex.org/W2911082440","https://openalex.org/W2926237638","https://openalex.org/W2955072176","https://openalex.org/W2956601743","https://openalex.org/W2978380263","https://openalex.org/W2990126684","https://openalex.org/W3008196982","https://openalex.org/W3021750856","https://openalex.org/W3023886583","https://openalex.org/W3034726395","https://openalex.org/W3087193805","https://openalex.org/W3089869686","https://openalex.org/W3094300570","https://openalex.org/W3094360637","https://openalex.org/W3114103116","https://openalex.org/W3122147523","https://openalex.org/W3158890392","https://openalex.org/W3190749100","https://openalex.org/W4205632224","https://openalex.org/W4247544731","https://openalex.org/W4285891077","https://openalex.org/W4293001527","https://openalex.org/W4293659399","https://openalex.org/W4294142588","https://openalex.org/W4294761431","https://openalex.org/W4306164505","https://openalex.org/W4310191825","https://openalex.org/W4310677442","https://openalex.org/W4380085985"],"related_works":["https://openalex.org/W4400964699","https://openalex.org/W4399803866","https://openalex.org/W4294838952","https://openalex.org/W4390955691","https://openalex.org/W7225160331","https://openalex.org/W4310191825","https://openalex.org/W7202209863","https://openalex.org/W6887845999","https://openalex.org/W6962905341","https://openalex.org/W4392611680"],"abstract_inverted_index":{"ABSTRACT":[0],"Arsenic":[1],"(As)":[2],"contamination":[3],"in":[4,9,33,152],"groundwater":[5],"has":[6,40],"been":[7,41],"reported":[8],"many":[10],"countries":[11],"and":[12,30,70,97,115,134,149,167,176,204,206,233,254],"is":[13],"a":[14,53,184,215],"major":[15],"risk":[16],"factor":[17],"for":[18,101,281],"liver":[19,34,153],"injury.":[20],"While":[21],"the":[22,37,43,116,169,262],"impact":[23],"of":[24,68,79,118,171,202,209,214,251,256,267,274],"arsenic":[25,55,92,98,139,159,188,191,223,244,275],"exposure":[26,56,140,160,192,245,276],"on":[27],"gut":[28,163,227,252],"microbiota":[29,89,110,228,253,269],"its":[31],"role":[32],"diseases":[35],"through":[36,73,249],"gut\u2010liver":[38],"axis":[39],"documented,":[42],"underlying":[44],"mechanism":[45],"remains":[46],"unclear.":[47],"In":[48],"this":[49],"study,":[50],"we":[51],"established":[52],"chronic":[54,243],"rat":[57],"model":[58],"by":[59,146,199,270],"administering":[60],"sodium":[61],"arsenite":[62],"(NaAsO":[63],"2":[64,102],")":[65],"at":[66],"concentrations":[67],"30":[69],"100":[71],"mg/L":[72],"drinking":[74],"water":[75],"until":[76],"62":[77],"weeks":[78],"age.":[80],"Subsequently,":[81],"high":[82],"As\u2010exposed":[83],"rats":[84],"were":[85,122],"subjected":[86],"to":[87],"fecal":[88,112,180],"transplantation":[90],"(FMT),":[91],"cessation,":[93],"or":[94,272],"combined":[95],"FMT":[96,221,271],"cessation":[99,224,273],"interventions":[100],"months.":[103],"Liver":[104],"pathological":[105],"changes,":[106],"hepatocyte":[107,142,247],"proliferation,":[108,143],"intestinal":[109,268],"composition,":[111,229],"butyrate":[113,181],"levels,":[114],"expression":[117,151,201,208],"butyrate\u2010related":[119],"molecular":[120,236],"markers":[121],"evaluated":[123],"using":[124],"hematoxylin\u2013eosin":[125],"staining,":[126],"immunohistochemistry,":[127],"16S":[128],"rRNA":[129],"gene":[130],"sequencing,":[131],"gas":[132],"chromatography,":[133],"quantitative":[135],"real\u2010time":[136],"PCR.":[137],"Chronic":[138],"increased":[141,200],"as":[144],"evidenced":[145],"elevated":[147],"PCNA":[148],"Ki\u201067":[150],"tissues.":[154],"Microbiota":[155],"analysis":[156],"revealed":[157],"that":[158,242],"significantly":[161,193],"altered":[162],"microbial":[164],"community":[165],"structure":[166],"reduced":[168],"abundance":[170],"butyrate\u2010producing":[172],"bacteria,":[173],"particularly":[174],"Lachnospiraceae":[175],"Blautia":[177],".":[178],"Consistently,":[179],"levels":[182],"showed":[183],"decreasing":[185],"trend":[186],"after":[187],"exposure.":[189],"Furthermore,":[190],"suppressed":[194],"hepatic":[195,284],"miR\u201022":[196,231],"expression,":[197],"accompanied":[198],"Sirt1":[203],"Ctnnb1":[205],"decreased":[207],"Gsk3b":[210],",":[211],"suggesting":[212],"activation":[213],"proliferation\u2010related":[216],"signaling":[217,264],"pathway.":[218,265],"Intervention":[219],"with":[220],"and/or":[222],"partially":[225],"restored":[226],"alleviated":[230],"suppression,":[232],"improved":[234],"arsenic\u2010induced":[235,283],"alterations.":[237],"Collectively,":[238],"these":[239],"findings":[240],"demonstrate":[241],"promotes":[246],"proliferation":[248],"disruption":[250],"reduction":[255],"microbiota\u2010derived":[257],"butyrate,":[258],"which":[259],"may":[260,277],"regulate":[261],"miR\u201022/Sirt1":[263],"Restoration":[266],"provide":[278],"potential":[279],"strategies":[280],"mitigating":[282],"abnormalities.":[285]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-05T00:00:00"}
