{"id":"https://openalex.org/W7225251120","doi":"https://doi.org/10.21203/rs.3.rs-11131474/v1","title":"Age changes what a risk-factor count tells the referring physician: recorded cardiometabolic burden and obstructive coronary artery disease on CT angiography in a single-centre cross-sectional study","display_name":"Age changes what a risk-factor count tells the referring physician: recorded cardiometabolic burden and obstructive coronary artery disease on CT angiography in a single-centre cross-sectional study","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7225251120","doi":"https://doi.org/10.21203/rs.3.rs-11131474/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11131474/v1","doi":"https://doi.org/10.21203/rs.3.rs-11131474/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11131474/v1","pdf_url":"https://www.researchsquare.com/article/rs-11131474/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11131474/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157453320","display_name":"Xiaohua Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122818","display_name":"The Affiliated Taizhou People's Hospital of Nanjing Medical University","ror":"https://ror.org/02fvevm64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122818"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohua Sun","raw_affiliation_strings":["Taizhou People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taizhou People\u2019s Hospital","institution_ids":["https://openalex.org/I4210122818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160684417","display_name":"Huimin Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122818","display_name":"The Affiliated Taizhou People's Hospital of Nanjing Medical University","ror":"https://ror.org/02fvevm64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122818"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huimin Gu","raw_affiliation_strings":["Taizhou People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taizhou People\u2019s Hospital","institution_ids":["https://openalex.org/I4210122818"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5122715870","display_name":"Dongrui Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122818","display_name":"The Affiliated Taizhou People's Hospital of Nanjing Medical University","ror":"https://ror.org/02fvevm64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122818"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongrui Liu","raw_affiliation_strings":["Taizhou People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taizhou People\u2019s Hospital","institution_ids":["https://openalex.org/I4210122818"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210122818"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14212","display_name":"Health Promotion and Cardiovascular Prevention","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obstructive-coronary-artery-disease","display_name":"obstructive coronary artery disease","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cardiometabolic-risk-factors","display_name":"cardiometabolic risk factors","score":0.9810000061988831},{"id":"https://openalex.org/keywords/age-differences","display_name":"age differences","score":0.628000020980835},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8999999761581421},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.9259999990463257},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.8270000219345093},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6759999990463257},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9380000233650208},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":1.0},{"id":"https://openalex.org/keywords/coronary-ct-angiography","display_name":"coronary CT angiography","score":0.7689999938011169},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.5860000252723694},{"id":"https://openalex.org/keywords/general-practitioner-referral","display_name":"general practitioner referral","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9460999965667725},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.7724999785423279},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.739300012588501},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5878000259399414},{"id":"https://openalex.org/C3019004856","wikidata":"https://www.wikidata.org/wiki/Q42297149","display_name":"Coronary angiography","level":3,"score":0.5479999780654907},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5397999882698059},{"id":"https://openalex.org/C143095724","wikidata":"https://www.wikidata.org/wiki/Q515895","display_name":"Odds","level":3,"score":0.5392000079154968},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5016000270843506},{"id":"https://openalex.org/C534262118","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Medical diagnosis","level":2,"score":0.5016000270843506},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.48489999771118164},{"id":"https://openalex.org/C2780643987","wikidata":"https://www.wikidata.org/wiki/Q468414","display_name":"Angiography","level":2,"score":0.439300000667572},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41280001401901245},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.38839998841285706},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.37119999527931213},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.36730000376701355},{"id":"https://openalex.org/C2781347138","wikidata":"https://www.wikidata.org/wiki/Q1024492","display_name":"Computed tomography angiography","level":3,"score":0.33709999918937683},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.32330000400543213},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.29670000076293945},{"id":"https://openalex.org/C3018348675","wikidata":"https://www.wikidata.org/wiki/Q4797557","display_name":"Arterial disease","level":3,"score":0.29170000553131104},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.27410000562667847},{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.26930001378059387},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.25519999861717224}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11131474/v1","doi":"https://doi.org/10.21203/rs.3.rs-11131474/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11131474/v1","pdf_url":"https://www.researchsquare.com/article/rs-11131474/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11131474/v1","doi":"https://doi.org/10.21203/rs.3.rs-11131474/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11131474/v1","pdf_url":"https://www.researchsquare.com/article/rs-11131474/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225251120.pdf","grobid_xml":"https://content.openalex.org/works/W7225251120.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W140064290","https://openalex.org/W1932640386","https://openalex.org/W2059796825","https://openalex.org/W2512716582","https://openalex.org/W2626834961","https://openalex.org/W2966815933","https://openalex.org/W2973091513","https://openalex.org/W2988196295","https://openalex.org/W3113095026","https://openalex.org/W3172701583","https://openalex.org/W3201595862","https://openalex.org/W3210672698","https://openalex.org/W4284896820","https://openalex.org/W4293475661","https://openalex.org/W4385549426","https://openalex.org/W4385838585","https://openalex.org/W4387439311","https://openalex.org/W4394019198","https://openalex.org/W4396623081","https://openalex.org/W4396733463","https://openalex.org/W4402064302","https://openalex.org/W4403700540","https://openalex.org/W4407265291","https://openalex.org/W4410523397","https://openalex.org/W4411171520","https://openalex.org/W4414341072","https://openalex.org/W4416537356","https://openalex.org/W7130597175"],"related_works":["https://openalex.org/W3172701583","https://openalex.org/W4306251075","https://openalex.org/W4411096348","https://openalex.org/W3085844810","https://openalex.org/W2056953368","https://openalex.org/W2116713642","https://openalex.org/W1975915392","https://openalex.org/W3213113168","https://openalex.org/W3204288582","https://openalex.org/W7166451063"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"General":[2],"practitioners":[3],"considering":[4],"coronary":[5,90],"computed":[6],"tomography":[7],"angiography":[8],"(CCTA)":[9],"usually":[10],"have":[11],"only":[12],"admission":[13],"diagnoses":[14,80],"and":[15,35,38,56,75,81,107,176,190,203,241],"recent":[16],"laboratory":[17,82,109],"results.":[18],"Whether":[19],"the":[20,30,53,69,161,167],"number":[21,70],"of":[22,48,59,71,141,199],"cardiometabolic":[23],"risk":[24,134,186],"factors":[25,187],"in":[26,124,129,231,237],"those":[27],"records":[28],"means":[29],"same":[31],"at":[32,178],"every":[33],"age,":[34],"whether":[36],"HbA1c":[37,198,240],"eGFR":[39,206,242],"add":[40],"discrimination,":[41],"is":[42],"untested.":[43],"Methods":[44],"Single-centre":[45],"cross-sectional":[46],"study":[47],"adult":[49],"CCTA":[50,248],"examinations":[51],"from":[52,79,96,151],"general":[54],"practice":[55],"cardiology":[57],"pathways":[58],"a":[60,99,217],"tertiary":[61],"hospital,":[62],"2021":[63],"to":[64,146,155],"2025.":[65],"The":[66,212],"exposure":[67],"was":[68,94,122,171,188],"hypertension,":[72],"diabetes,":[73],"dyslipidaemia":[74],"renal":[76],"impairment":[77],"recorded":[78,185,213],"results":[83],"within":[84],"30":[85],"days":[86],"before":[87,247],"CCTA.":[88],"Obstructive":[89,120],"artery":[91],"disease":[92],"(CAD)":[93],"read":[95,251],"reports":[97],"by":[98,252],"validated":[100],"text":[101],"rule.":[102],"After":[103],"excluding":[104],"prior":[105],"revascularisation":[106],"incomplete":[108],"data,":[110],"5,225":[111],"patients":[112,126,233],"were":[113,195],"analysed":[114],"with":[115,153,157,220,225],"patient-clustered":[116],"logistic":[117],"regression.":[118],"Results":[119],"CAD":[121,183,222],"reported":[123],"1,018":[125],"(19.5%),":[127],"similarly":[128],"both":[130],"pathways.":[131],"Each":[132],"additional":[133],"factor":[135],"carried":[136],"an":[137],"adjusted":[138,148],"odds":[139,169,193],"ratio":[140,170],"1.70":[142],"(95%":[143],"CI":[144],"1.57":[145],"1.84);":[147],"prevalence":[149],"rose":[150],"9.2%":[152],"none":[154],"43.9%":[156],"four.":[158],"Age":[159],"modified":[160],"association":[162],"(interaction":[163],"P":[164],"<":[165],"0.001):":[166],"per-factor":[168],"2.20":[172],"under":[173],"55":[174],"years":[175],"1.46":[177],"75":[179],"or":[180,201],"older;":[181],"obstructive":[182,221],"without":[184],"0.4%":[189],"21.2%.":[191],"Adjusted":[192],"ratios":[194],"4.41":[196],"for":[197,205],"8.0%":[200],"higher":[202],"1.64":[204],"below":[207],"60":[208],"mL/min/1.73":[209],"m\u00b2.":[210],"Conclusions":[211],"risk-factor":[214,245],"count":[215],"shows":[216],"dose-response":[218],"relationship":[219],"that":[223],"weakens":[224],"age.":[226,253],"A":[227],"clean":[228],"record":[229],"reassures":[230],"younger":[232],"but":[234],"much":[235],"less":[236],"older":[238],"ones.":[239],"refine":[243],"risk;":[244],"review":[246],"should":[249],"be":[250]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-05T00:00:00"}