{"id":"https://openalex.org/W7225251076","doi":"https://doi.org/10.1021/acsinfecdis.6c00901","title":"GB-79, Leelamine Isonitrile, Defines a New Antifungal Scaffold Active against Drug-Resistant Candida Species","display_name":"GB-79, Leelamine Isonitrile, Defines a New Antifungal Scaffold Active against Drug-Resistant Candida Species","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225251076","doi":"https://doi.org/10.1021/acsinfecdis.6c00901"},"language":"en","primary_location":{"id":"doi:10.1021/acsinfecdis.6c00901","doi":"https://doi.org/10.1021/acsinfecdis.6c00901","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.6c00901","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acsinfecdis.6c00901","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160676787","display_name":"Jae-Yeon Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jae-Yeon Choi","raw_affiliation_strings":["Curatix, LLC , , ,","Yale University School of Medicine , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Curatix, LLC , , ,","institution_ids":[]},{"raw_affiliation_string":"Yale University School of Medicine , , , ,","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074259457","display_name":"Griffin L. Barnes","orcid":"https://orcid.org/0000-0002-5731-4380","observed_orcids":["https://orcid.org/0000-0002-5731-4380"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Griffin L. Barnes","raw_affiliation_strings":["University of California , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California , , , ,","institution_ids":["https://openalex.org/I2803209242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160712222","display_name":"Zehao Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zehao Li","raw_affiliation_strings":["University of California , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California , , , ,","institution_ids":["https://openalex.org/I2803209242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032942104","display_name":"Karine G. Le Roch","orcid":"https://orcid.org/0000-0002-4862-9292","observed_orcids":["https://orcid.org/0000-0002-4862-9292","https://orcid.org/0000-0003-3608-2418"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karine G. Le Roch","raw_affiliation_strings":["University of California , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California , , , ,","institution_ids":["https://openalex.org/I2803209242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021859707","display_name":"Christopher D. Vanderwal","orcid":"https://orcid.org/0000-0001-7218-4521","observed_orcids":["https://orcid.org/0000-0001-7218-4521"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher D. Vanderwal","raw_affiliation_strings":["University of California , , , ,"],"raw_orcid":"https://orcid.org/0000-0001-7218-4521","affiliations":[{"raw_affiliation_string":"University of California , , , ,","institution_ids":["https://openalex.org/I2803209242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008481640","display_name":"Choukri Ben Mamoun","orcid":"https://orcid.org/0000-0001-5028-1400","observed_orcids":["https://orcid.org/0000-0001-5028-1400"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Choukri Ben Mamoun","raw_affiliation_strings":["Yale University School of Medicine , , , ,"],"raw_orcid":"https://orcid.org/0000-0001-5028-1400","affiliations":[{"raw_affiliation_string":"Yale University School of Medicine , , , ,","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.8644189,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11900","display_name":"Fungal Plant Pathogen Control","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.7114999890327454},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.6995999813079834},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4918999969959259},{"id":"https://openalex.org/C2909919671","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal drugs","level":3,"score":0.4837999939918518},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47049999237060547},{"id":"https://openalex.org/C2780161414","wikidata":"https://www.wikidata.org/wiki/Q29887808","display_name":"Invasive candidiasis","level":4,"score":0.4449000060558319},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4138999879360199},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.39089998602867126},{"id":"https://openalex.org/C2909938017","wikidata":"https://www.wikidata.org/wiki/Q2712836","display_name":"Candida infections","level":3,"score":0.38260000944137573},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.37549999356269836},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.3677999973297119},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.36469998955726624},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.35920000076293945},{"id":"https://openalex.org/C2991737395","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal drug","level":3,"score":0.3506999909877777},{"id":"https://openalex.org/C6555983","wikidata":"https://www.wikidata.org/wiki/Q7181398","display_name":"Phenotypic screening","level":4,"score":0.3425999879837036},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.32739999890327454},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.320499986410141},{"id":"https://openalex.org/C2780908437","wikidata":"https://www.wikidata.org/wiki/Q464067","display_name":"Mycosis","level":2,"score":0.31779998540878296},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3068000078201294},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.28060001134872437},{"id":"https://openalex.org/C2780670043","wikidata":"https://www.wikidata.org/wiki/Q139137","display_name":"Candida glabrata","level":3,"score":0.26510000228881836},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2574999928474426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25200000405311584}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acsinfecdis.6c00901","doi":"https://doi.org/10.1021/acsinfecdis.6c00901","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.6c00901","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1021/acsinfecdis.6c00901","doi":"https://doi.org/10.1021/acsinfecdis.6c00901","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.6c00901","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1687425191","https://openalex.org/W1832443905","https://openalex.org/W1968917541","https://openalex.org/W1990797169","https://openalex.org/W1999788391","https://openalex.org/W2008201798","https://openalex.org/W2054469882","https://openalex.org/W2074073932","https://openalex.org/W2099951777","https://openalex.org/W2107794472","https://openalex.org/W2108675611","https://openalex.org/W2136677555","https://openalex.org/W2140948740","https://openalex.org/W2141563676","https://openalex.org/W2163052215","https://openalex.org/W2169357831","https://openalex.org/W2216117396","https://openalex.org/W2231020609","https://openalex.org/W2332055181","https://openalex.org/W2470291098","https://openalex.org/W2529676164","https://openalex.org/W2533342042","https://openalex.org/W2588098478","https://openalex.org/W2600957803","https://openalex.org/W2612278270","https://openalex.org/W2615277755","https://openalex.org/W2741597852","https://openalex.org/W2750959598","https://openalex.org/W2751530162","https://openalex.org/W2752772336","https://openalex.org/W2765742851","https://openalex.org/W2767031614","https://openalex.org/W2777281989","https://openalex.org/W2790728643","https://openalex.org/W3022998148","https://openalex.org/W3100984105","https://openalex.org/W3176825707","https://openalex.org/W4242318543","https://openalex.org/W4386282971","https://openalex.org/W4388017158","https://openalex.org/W4390919957","https://openalex.org/W4394819989","https://openalex.org/W4400904300","https://openalex.org/W4402891827","https://openalex.org/W4405654771"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"The":[1,40],"global":[2],"rise":[3],"in":[4,25,46,99,136],"invasive":[5],"fungal":[6,38,134],"infections":[7],"and":[8,76,127,149,174],"antifungal":[9,17,44,91,147,179],"resistance":[10],"highlights":[11],"an":[12],"urgent":[13],"need":[14],"for":[15,157,170],"new":[16,159],"scaffolds.":[18],"Using":[19],"a":[20,34,145,167],"focused":[21],"phenotypic":[22,154],"screening":[23,155],"approach":[24],"yeast,":[26],"we":[27],"identified":[28],"the":[29,59,151],"leelamine":[30],"isonitrile":[31],"GB-79":[32,64,95,131,143,165],"as":[33,81,144],"potent":[35,43],"inhibitor":[36],"of":[37,71,153,177],"growth.":[39],"compound":[41],"displayed":[42],"activity":[45,67],"vitro":[47],"across":[48],"genetically":[49],"diverse":[50],"strains,":[51],"with":[52,86,111,162],"lower":[53],"IC50":[54],"values":[55],"than":[56],"fluconazole":[57],"under":[58],"experimental":[60],"conditions":[61],"tested.":[62],"Importantly,":[63],"showed":[65],"strong":[66],"against":[68],"clinical":[69],"isolates":[70],"Candida":[72,74,82],"albicans,":[73],"parapsilosis,":[75],"Nakaseomyces":[77],"glabratus":[78],"(formerly":[79],"known":[80],"glabrata),":[83],"including":[84],"strains":[85],"reduced":[87,132],"susceptibility":[88],"to":[89,108],"existing":[90],"agents.":[92],"In":[93],"vivo,":[94],"was":[96],"well":[97],"tolerated":[98],"mice":[100],"following":[101],"single-dose":[102],"oral":[103,129],"administration":[104],"at":[105],"doses":[106],"up":[107],"100":[109],"mg/kg,":[110],"no":[112],"mortality":[113],"or":[114],"marked":[115],"body-weight":[116],"changes.":[117],"Despite":[118],"high":[119],"systemic":[120],"clearance,":[121],"low":[122],"exposure":[123],"after":[124],"intravenous":[125],"dosing,":[126],"poor":[128],"bioavailability,":[130],"renal":[133],"burden":[135],"C.":[137],"albicans-infected":[138],"animals.":[139],"These":[140],"findings":[141],"establish":[142],"promising":[146,168],"scaffold":[148],"demonstrate":[150],"value":[152],"strategies":[156],"uncovering":[158],"chemical":[160],"entities":[161],"translational":[163],"potential.":[164],"provides":[166],"foundation":[169],"medicinal":[171],"chemistry":[172],"optimization":[173],"further":[175],"development":[176],"next-generation":[178],"therapeutics.":[180]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-05T00:00:00"}