{"id":"https://openalex.org/W7225249260","doi":"https://doi.org/10.1021/acs.jchemed.5c01260","title":"Application of Bioinformatics Tools and Cell Biotechnology in Case Studies of Precision Medicine: A Comprehensive Experimental Practice for Upper-Division Undergraduates","display_name":"Application of Bioinformatics Tools and Cell Biotechnology in Case Studies of Precision Medicine: A Comprehensive Experimental Practice for Upper-Division Undergraduates","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7225249260","doi":"https://doi.org/10.1021/acs.jchemed.5c01260"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jchemed.5c01260","doi":"https://doi.org/10.1021/acs.jchemed.5c01260","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jchemed.5c01260","pdf_url":null,"source":{"id":"https://openalex.org/S105208853","display_name":"Journal of Chemical Education","issn_l":"0021-9584","issn":["0021-9584","1938-1328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","erih-plus","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Education","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071401771","display_name":"Jin Yan Huang","orcid":"https://orcid.org/0000-0002-0698-1693","observed_orcids":["https://orcid.org/0000-0002-0698-1693"]},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jin Huang","raw_affiliation_strings":["East China University of Science and Technology , , ,"],"raw_orcid":"https://orcid.org/0000-0002-0698-1693","affiliations":[{"raw_affiliation_string":"East China University of Science and Technology , , ,","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100624915","display_name":"Yuhui Zhang","orcid":"https://orcid.org/0000-0002-5158-0645","observed_orcids":["https://orcid.org/0000-0002-5158-0645","https://orcid.org/0009-0001-7600-5882"]},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Zhang","raw_affiliation_strings":["East China University of Science and Technology , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China University of Science and Technology , , ,","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160614191","display_name":"Zhaomin Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaomin Xu","raw_affiliation_strings":["East China University of Science and Technology , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China University of Science and Technology , , ,","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100653633","display_name":"Zhongyu Xu","orcid":"https://orcid.org/0000-0001-5861-9840","observed_orcids":["https://orcid.org/0000-0001-5861-9840"]},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongyu Xu","raw_affiliation_strings":["East China University of Science and Technology , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China University of Science and Technology , , ,","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160586746","display_name":"Zhongying Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongying Sun","raw_affiliation_strings":["East China University of Science and Technology , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China University of Science and Technology , , ,","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043671209","display_name":"Ying Huang","orcid":"https://orcid.org/0000-0002-1470-0804","observed_orcids":["https://orcid.org/0000-0002-1470-0804"]},"institutions":[{"id":"https://openalex.org/I4210113659","display_name":"Guangdong Institute for Drug Control","ror":"https://ror.org/0264gw370","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210113659"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Huang","raw_affiliation_strings":["Guangdong Institute for Drug Control , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Institute for Drug Control , ,","institution_ids":["https://openalex.org/I4210113659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043671209","https://openalex.org/A5071401771"],"corresponding_institution_ids":["https://openalex.org/I143593769","https://openalex.org/I4210113659"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73366565,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12327","display_name":"Various Chemistry Research Topics","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/3304","display_name":"Education"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10254","display_name":"Innovations in Medical Education","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3304","display_name":"Education"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.9860000014305115},{"id":"https://openalex.org/keywords/bioinformatics-education","display_name":"bioinformatics education","score":0.8939999938011169},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cbioportal","display_name":"cBioPortal","score":0.7459999918937683},{"id":"https://openalex.org/keywords/pymol","display_name":"PyMOL","score":0.8309999704360962},{"id":"https://openalex.org/keywords/protein-conformational-change","display_name":"protein conformational change","score":0.8360000252723694},{"id":"https://openalex.org/keywords/drug-target-interactions","display_name":"drug-target interactions","score":0.949999988079071},{"id":"https://openalex.org/keywords/cell-culture","display_name":"cell culture","score":0.5490000247955322},{"id":"https://openalex.org/keywords/mts-assay","display_name":"MTS assay","score":0.9629999995231628},{"id":"https://openalex.org/keywords/drug-response","display_name":"drug response","score":0.7260000109672546},{"id":"https://openalex.org/keywords/pharmacy-education","display_name":"pharmacy education","score":0.777999997138977},{"id":"https://openalex.org/keywords/targeted-drug-development","display_name":"targeted drug development","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C104863432","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmacy","level":2,"score":0.5400000214576721},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4269999861717224},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.40560001134872437},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.38100001215934753},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3716999888420105},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.3677999973297119},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.36239999532699585},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35830000042915344},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.3458000123500824},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.3384999930858612},{"id":"https://openalex.org/C163293594","wikidata":"https://www.wikidata.org/wiki/Q7834541","display_name":"Translational bioinformatics","level":5,"score":0.33640000224113464},{"id":"https://openalex.org/C68762167","wikidata":"https://www.wikidata.org/wiki/Q910164","display_name":"Cheminformatics","level":2,"score":0.3294000029563904},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.319599986076355},{"id":"https://openalex.org/C55587333","wikidata":"https://www.wikidata.org/wiki/Q1133029","display_name":"Engineering ethics","level":1,"score":0.3116999864578247},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.3107999861240387},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.31040000915527344},{"id":"https://openalex.org/C165064840","wikidata":"https://www.wikidata.org/wiki/Q1321061","display_name":"Matching (statistics)","level":2,"score":0.30790001153945923},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.304500013589859},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.304500013589859},{"id":"https://openalex.org/C509550671","wikidata":"https://www.wikidata.org/wiki/Q126945","display_name":"Medical education","level":1,"score":0.2921000123023987},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2777000069618225},{"id":"https://openalex.org/C3018419874","wikidata":"https://www.wikidata.org/wiki/Q843601","display_name":"Health science","level":2,"score":0.27160000801086426},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2685999870300293},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.2671000063419342},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2660999894142151}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.jchemed.5c01260","doi":"https://doi.org/10.1021/acs.jchemed.5c01260","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jchemed.5c01260","pdf_url":null,"source":{"id":"https://openalex.org/S105208853","display_name":"Journal of Chemical Education","issn_l":"0021-9584","issn":["0021-9584","1938-1328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","erih-plus","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Education","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.766700029373169},{"display_name":"Quality education","id":"https://metadata.un.org/sdg/4","score":0.6164000034332275}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321657","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W168242038","https://openalex.org/W1963689377","https://openalex.org/W1978302990","https://openalex.org/W2020270838","https://openalex.org/W2149441684","https://openalex.org/W2274550965","https://openalex.org/W2463634719","https://openalex.org/W2559820285","https://openalex.org/W2585792050","https://openalex.org/W2586159641","https://openalex.org/W2594225603","https://openalex.org/W2748942291","https://openalex.org/W2773309042","https://openalex.org/W2887722755","https://openalex.org/W2964025523","https://openalex.org/W2982321167","https://openalex.org/W2988865675","https://openalex.org/W2998581726","https://openalex.org/W3014115276","https://openalex.org/W3040830058","https://openalex.org/W3082774315","https://openalex.org/W3110795050","https://openalex.org/W3132427319","https://openalex.org/W3138506360","https://openalex.org/W3194616240","https://openalex.org/W3214173072","https://openalex.org/W4206804220","https://openalex.org/W4319337483","https://openalex.org/W4377028909","https://openalex.org/W4386851267","https://openalex.org/W4391616278","https://openalex.org/W4399781527","https://openalex.org/W4401443317"],"related_works":["https://openalex.org/W7125804502","https://openalex.org/W2791116795","https://openalex.org/W2129421709","https://openalex.org/W7113317249","https://openalex.org/W4317840179","https://openalex.org/W1969601053","https://openalex.org/W2766445261","https://openalex.org/W1976593132","https://openalex.org/W4200521170","https://openalex.org/W1986695394"],"abstract_inverted_index":{"Abstract":[0],"Precision":[1],"medicine":[2],"(PM)":[3],"tailors":[4],"healthcare":[5],"to":[6,12,77,84],"individual":[7],"genetic":[8,112],"and":[9,33,46,60,81,98,123,134,143,161,176,202,204,210,221],"molecular":[10],"signatures":[11],"achieve":[13],"more-effective":[14],"treatments,":[15],"while":[16],"also":[17],"guiding":[18],"targeted":[19],"drug":[20,132,179],"development.":[21],"Advances":[22],"in":[23,39,54,62,88,127,150,192],"bioinformatics":[24,79,145],"have":[25,34],"greatly":[26],"accelerated":[27],"the":[28,40,55,182,193],"discovery":[29],"of":[30,42,107,147,157,169,178,200],"novel":[31],"therapeutics":[32],"played":[35],"a":[36,69,104],"pivotal":[37],"role":[38],"progress":[41],"PM.":[43,89,108],"For":[44],"biochemistry":[45,72],"pharmacy":[47,194],"undergraduates":[48],"preparing":[49],"for":[50],"careers":[51],"or":[52],"research":[53],"life":[56],"sciences,":[57],"acquiring":[58],"knowledge":[59],"skills":[61],"PM":[63],"is":[64],"essential.":[65],"Herein,":[66],"we":[67],"designed":[68],"four-week":[70],"comprehensive":[71,105],"course":[73,91,186],"that":[74],"enables":[75],"students":[76,102],"apply":[78],"tools":[80],"cell":[82,167],"biotechnology":[83],"practical":[85],"case":[86],"studies":[87],"The":[90,137,185],"combines":[92],"chemical":[93,118],"principles":[94],"with":[95,103,120,154,173],"biological":[96],"phenomena":[97],"clinical":[99],"applications,":[100],"providing":[101],"understanding":[106],"It":[109,215],"demonstrates":[110],"how":[111],"variations":[113],"reshape":[114],"protein":[115,158],"conformation,":[116],"alter":[117],"interactions":[119],"small":[121],"molecules,":[122],"influence":[124],"regulatory":[125],"mechanisms":[126],"living":[128],"systems,":[129],"ultimately":[130],"informing":[131],"development":[133],"therapeutic":[135],"strategies.":[136],"learning":[138,228],"activities":[139],"include":[140],"literature":[141],"review":[142],"presentation,":[144],"analysis":[146],"KRAS":[148],"mutations":[149],"lung":[151,170],"cancer":[152,171],"cells":[153,172],"cBioPortal,":[155],"visualization":[156],"conformational":[159],"changes":[160],"drug-target":[162],"interaction":[163],"patterns":[164],"using":[165],"PyMOL,":[166],"culture":[168],"different":[174],"genotypes,":[175],"assessment":[177],"responses":[180],"through":[181,225],"MTS":[183],"assay.":[184],"has":[187,205],"been":[188],"implemented":[189],"three":[190],"times":[191],"major":[195],"at":[196],"East":[197],"China":[198],"University":[199],"Science":[201],"Technology":[203],"received":[206],"high":[207],"overall":[208],"satisfaction":[209],"positive":[211],"feedback":[212],"from":[213],"students.":[214],"significantly":[216],"enhances":[217],"students\u2019":[218],"scientific":[219],"competencies":[220],"fosters":[222],"greater":[223],"engagement":[224],"hands-on,":[226],"data-driven":[227],"experiences.":[229]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-05T00:00:00"}