{"id":"https://openalex.org/W7225239936","doi":"https://doi.org/10.1111/acel.70798","title":"The Vicious Cycle of Sleep Disruption and Inflammaging: Mechanisms, Consequences, and Therapeutic Opportunities","display_name":"The Vicious Cycle of Sleep Disruption and Inflammaging: Mechanisms, Consequences, and Therapeutic Opportunities","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225239936","doi":"https://doi.org/10.1111/acel.70798","pmid":"https://pubmed.ncbi.nlm.nih.gov/42982749","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13736552"},"language":"en","primary_location":{"id":"doi:10.1111/acel.70798","doi":"https://doi.org/10.1111/acel.70798","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.70798","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.70798","source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.70798","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160722704","display_name":"Fu\u2010Ying Zhao","orcid":"https://orcid.org/0009-0006-8695-5845","observed_orcids":["https://orcid.org/0009-0006-8695-5845"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fu\u2010Ying Zhao","raw_affiliation_strings":["Department of Biochemistry &amp; Molecular Biology China Medical University  Shenyang Liaoning Province China"],"raw_orcid":"https://orcid.org/0009-0006-8695-5845","affiliations":[{"raw_affiliation_string":"Department of Biochemistry &amp; Molecular Biology China Medical University  Shenyang Liaoning Province China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087812098","display_name":"Jia\u2010Mei Wang","orcid":"https://orcid.org/0000-0001-6558-3372","observed_orcids":["https://orcid.org/0000-0001-6558-3372"]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia\u2010Mei Wang","raw_affiliation_strings":["Department of Laboratory Medicine The First Hospital of China Medical University  Shenyang Liaoning Province China"],"raw_orcid":"https://orcid.org/0000-0001-6558-3372","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine The First Hospital of China Medical University  Shenyang Liaoning Province China","institution_ids":["https://openalex.org/I4210140515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160571252","display_name":"Shi\u2010Yang Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shi\u2010Yang Lu","raw_affiliation_strings":["Department of Biochemistry &amp; Molecular Biology China Medical University  Shenyang Liaoning Province China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry &amp; Molecular Biology China Medical University  Shenyang Liaoning Province China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040566972","display_name":"\u90dd\u4eae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Hao","raw_affiliation_strings":["Department of Biochemistry &amp; Molecular Biology China Medical University  Shenyang Liaoning Province China","Department of Chemistry, School of Forensic Medicine China Medical University  Shenyang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry &amp; Molecular Biology China Medical University  Shenyang Liaoning Province China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Department of Chemistry, School of Forensic Medicine China Medical University  Shenyang China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160647969","display_name":"Hai\u2010Yan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hai\u2010Yan Zhang","raw_affiliation_strings":["Department of Geriatrics The First Affiliated Hospital of China Medical University  Shenyang Liaoning Province China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics The First Affiliated Hospital of China Medical University  Shenyang Liaoning Province China","institution_ids":["https://openalex.org/I4210140515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103259596","display_name":"Hua\u2010Qin Wang","orcid":"https://orcid.org/0000-0003-2266-6674","observed_orcids":["https://orcid.org/0000-0003-2266-6674"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hua\u2010Qin Wang","raw_affiliation_strings":["Department of Biochemistry &amp; Molecular Biology China Medical University  Shenyang Liaoning Province China"],"raw_orcid":"https://orcid.org/0000-0003-2266-6674","affiliations":[{"raw_affiliation_string":"Department of Biochemistry &amp; Molecular Biology China Medical University  Shenyang Liaoning Province China","institution_ids":["https://openalex.org/I91656880"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103259596","https://openalex.org/A5160647969"],"corresponding_institution_ids":["https://openalex.org/I4210140515","https://openalex.org/I91656880"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62727273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sleep-disruption","display_name":"sleep disruption","score":0.8820000290870667},{"id":"https://openalex.org/keywords/inflammaging","display_name":"inflammaging","score":0.9919999837875366},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.6359999775886536},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7129999995231628},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tlr4-signaling","display_name":"TLR4 signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9959999918937683},{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.9340000152587891},{"id":"https://openalex.org/keywords/t-cell-senescence","display_name":"T cell senescence","score":0.9760000109672546},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":0.9929999709129333},{"id":"https://openalex.org/keywords/epigenetic-aging","display_name":"epigenetic aging","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.9610000252723694},{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/senotherapeutics","display_name":"senotherapeutics","score":0.9259999990463257},{"id":"https://openalex.org/keywords/healthy-longevity","display_name":"healthy longevity","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.7515000104904175},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.6503000259399414},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5975000262260437},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5871999859809875},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5552999973297119},{"id":"https://openalex.org/C2780937657","wikidata":"https://www.wikidata.org/wiki/Q5141192","display_name":"Sleep restriction","level":4,"score":0.48750001192092896},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.47209998965263367},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4564000070095062},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.45410001277923584},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.3822000026702881},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3774000108242035},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.3749000132083893},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.36629998683929443},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.3637999892234802},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3497999906539917},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.33469998836517334},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.3294999897480011},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.31700000166893005},{"id":"https://openalex.org/C2778329153","wikidata":"https://www.wikidata.org/wiki/Q1364801","display_name":"Sleep deprivation","level":3,"score":0.30979999899864197},{"id":"https://openalex.org/C39282277","wikidata":"https://www.wikidata.org/wiki/Q5499626","display_name":"Free-running sleep","level":5,"score":0.30230000615119934},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29820001125335693},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.29589998722076416},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.2831000089645386},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.2671999931335449},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.2660999894142151},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.2549999952316284},{"id":"https://openalex.org/C2910720111","wikidata":"https://www.wikidata.org/wiki/Q1364801","display_name":"Sleep loss","level":4,"score":0.2515000104904175}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012893","descriptor_name":"Sleep Wake Disorders","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/acel.70798","doi":"https://doi.org/10.1111/acel.70798","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.70798","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.70798","source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13736552","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13736552/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13736552/pdf/ACEL-25-e70798.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"Text"},{"id":"pmid:42982749","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42982749","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/acel.70798","doi":"https://doi.org/10.1111/acel.70798","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.70798","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.70798","source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4832337192","display_name":null,"funder_award_id":"2024-MSLH-542","funder_id":"https://openalex.org/F4320323086","funder_display_name":"Natural Science Foundation of Liaoning Province"},{"id":"https://openalex.org/G7467011509","display_name":null,"funder_award_id":"2025-BS-0627","funder_id":"https://openalex.org/F4320326183","funder_display_name":"Doctoral Start-up Foundation of Liaoning Province"}],"funders":[{"id":"https://openalex.org/F4320323086","display_name":"Natural Science Foundation of Liaoning Province","ror":null},{"id":"https://openalex.org/F4320326183","display_name":"Doctoral Start-up Foundation of Liaoning Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225239936.pdf","grobid_xml":"https://content.openalex.org/works/W7225239936.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W290180496","https://openalex.org/W1004153210","https://openalex.org/W1279301897","https://openalex.org/W1937224863","https://openalex.org/W1973601624","https://openalex.org/W1979504051","https://openalex.org/W2020278153","https://openalex.org/W2022222693","https://openalex.org/W2052211155","https://openalex.org/W2062286859","https://openalex.org/W2067031028","https://openalex.org/W2086702258","https://openalex.org/W2128411449","https://openalex.org/W2134939550","https://openalex.org/W2135777766","https://openalex.org/W2140324542","https://openalex.org/W2146866147","https://openalex.org/W2157611470","https://openalex.org/W2163162795","https://openalex.org/W2201607793","https://openalex.org/W2316232712","https://openalex.org/W2329427490","https://openalex.org/W2336656712","https://openalex.org/W2477372147","https://openalex.org/W2507645382","https://openalex.org/W2508221593","https://openalex.org/W2518176941","https://openalex.org/W2529770578","https://openalex.org/W2559706866","https://openalex.org/W2761045600","https://openalex.org/W2783435569","https://openalex.org/W2883285706","https://openalex.org/W2884346709","https://openalex.org/W2887914699","https://openalex.org/W2892134688","https://openalex.org/W2896536878","https://openalex.org/W2906721882","https://openalex.org/W2911601413","https://openalex.org/W2921055816","https://openalex.org/W2922219401","https://openalex.org/W2945464151","https://openalex.org/W2971756150","https://openalex.org/W2974643180","https://openalex.org/W2990131872","https://openalex.org/W3003554067","https://openalex.org/W3011967159","https://openalex.org/W3015537206","https://openalex.org/W3087914788","https://openalex.org/W3091133567","https://openalex.org/W3094274839","https://openalex.org/W3126328166","https://openalex.org/W3126914431","https://openalex.org/W3148507305","https://openalex.org/W3160568159","https://openalex.org/W3194691378","https://openalex.org/W3216907602","https://openalex.org/W4213187853","https://openalex.org/W4224004032","https://openalex.org/W4237811408","https://openalex.org/W4296569448","https://openalex.org/W4306253233","https://openalex.org/W4310554357","https://openalex.org/W4360985414","https://openalex.org/W4367396651","https://openalex.org/W4389306271","https://openalex.org/W4390134792","https://openalex.org/W4390635980","https://openalex.org/W4390771353","https://openalex.org/W4392138449","https://openalex.org/W4392647698","https://openalex.org/W4395686065","https://openalex.org/W4396732521","https://openalex.org/W4398202245","https://openalex.org/W4399787967","https://openalex.org/W4401036778","https://openalex.org/W4402484621","https://openalex.org/W4403157507","https://openalex.org/W4405155982","https://openalex.org/W4405457981","https://openalex.org/W4406047187","https://openalex.org/W4406772673","https://openalex.org/W4406985452","https://openalex.org/W4407063709","https://openalex.org/W4407108704","https://openalex.org/W4410074901","https://openalex.org/W4411029192","https://openalex.org/W4411729412","https://openalex.org/W4412564910","https://openalex.org/W4412774061","https://openalex.org/W4414160596","https://openalex.org/W4414707865","https://openalex.org/W4414780297","https://openalex.org/W4416076460","https://openalex.org/W4416975843","https://openalex.org/W7124605851","https://openalex.org/W7125306922","https://openalex.org/W7132834402","https://openalex.org/W7147096905"],"related_works":["https://openalex.org/W2507645382","https://openalex.org/W4405940021","https://openalex.org/W7166493848","https://openalex.org/W7133333317","https://openalex.org/W7144347728","https://openalex.org/W2887914699","https://openalex.org/W4405939532","https://openalex.org/W4414377954","https://openalex.org/W4406864065","https://openalex.org/W3011967159"],"abstract_inverted_index":{"Aging":[0],"is":[1,155],"characterized":[2],"by":[3],"two":[4],"interdependent":[5],"hallmarks:":[6],"a":[7,16,39,157,174],"chronic":[8],"low-grade":[9],"inflammatory":[10,114],"state":[11],"known":[12],"as":[13,97],"inflammaging,":[14],"and":[15,21,51,59,80,91,102,119,142,167],"progressive":[17],"deterioration":[18],"of":[19,67,93,164],"sleep":[20,50,106,110,130,153],"circadian":[22,52,125,139],"rhythms.":[23],"Emerging":[24],"evidence":[25],"indicates":[26],"that":[27,152,169],"these":[28],"are":[29,35],"not":[30,156],"merely":[31],"parallel":[32],"processes":[33],"but":[34,160],"mechanistically":[36],"intertwined":[37],"in":[38],"self-perpetuating":[40],"cycle.":[41],"This":[42],"review":[43],"synthesizes":[44],"current":[45],"knowledge":[46],"on":[47,72],"how":[48],"age-related":[49],"disturbances":[53],"exacerbate":[54],"inflammaging":[55,123],"through":[56],"distinct":[57],"molecular":[58],"cellular":[60,83],"pathways.":[61],"We":[62,150],"examine":[63],"the":[64,68,98,134],"nocturnal":[65],"dysregulation":[66],"immune":[69,74,87],"system,":[70],"focusing":[71],"innate":[73],"hyperactivation":[75],"(e.g.,":[76],"via":[77],"NLRP3":[78],"inflammasome":[79],"TLR4":[81],"signaling),":[82],"senescence":[84],"(SASP),":[85],"adaptive":[86],"decline":[88],"(T-cell":[89],"aging),":[90],"disruption":[92,154],"systemic":[94],"pathways":[95],"such":[96],"gut-brain":[99],"axis.":[100],"Clinical":[101],"epidemiological":[103],"data":[104],"link":[105],"disorders,":[107],"particularly":[108],"obstructive":[109],"apnea,":[111],"to":[112],"elevated":[113],"markers,":[115],"accelerated":[116],"epigenetic":[117],"aging,":[118,166],"cognitive":[120],"decline.":[121],"Conversely,":[122],"impairs":[124],"regulatory":[126],"structures,":[127],"further":[128],"degrading":[129],"quality.":[131],"Interventions":[132],"targeting":[133,170],"sleep-immune":[135],"axis,":[136],"including":[137],"melatonin,":[138],"reinforcement,":[140],"senotherapeutics,":[141],"lifestyle":[143],"modifications,":[144],"hold":[145],"promise":[146],"for":[147,177],"mitigating":[148],"inflammaging.":[149],"conclude":[151],"passive":[158],"symptom":[159],"an":[161],"active":[162],"driver":[163],"immunological":[165],"propose":[168],"this":[171],"axis":[172],"represents":[173],"viable":[175],"strategy":[176],"promoting":[178],"healthy":[179],"longevity.":[180]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-05T00:00:00"}
