{"id":"https://openalex.org/W7225238973","doi":"https://doi.org/10.1007/s44178-026-00309-1","title":"Advances in cryoablation in tumor immunotherapy","display_name":"Advances in cryoablation in tumor immunotherapy","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7225238973","doi":"https://doi.org/10.1007/s44178-026-00309-1"},"language":"en","primary_location":{"id":"doi:10.1007/s44178-026-00309-1","doi":"https://doi.org/10.1007/s44178-026-00309-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s44178-026-00309-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s44178-026-00309-1.pdf","source":{"id":"https://openalex.org/S4387279979","display_name":"Holistic Integrative Oncology","issn_l":"2731-4529","issn":["2731-4529"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Holistic Integrative Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://link.springer.com/content/pdf/10.1007/s44178-026-00309-1.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160582352","display_name":"Xiaoqun Yang","orcid":"https://orcid.org/0009-0008-0783-1743","observed_orcids":["https://orcid.org/0009-0008-0783-1743"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoqun Yang","raw_affiliation_strings":["Department of Clinical Medicine, Hebei Medical University, Tangshan, Hebei, China"],"raw_orcid":"https://orcid.org/0009-0008-0783-1743","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Hebei Medical University, Tangshan, Hebei, China","institution_ids":["https://openalex.org/I111381250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5160582352"],"corresponding_institution_ids":["https://openalex.org/I111381250"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.83636133,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.04820000007748604,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryoablation","display_name":"cryoablation","score":1.0},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.9269999861717224},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tumor-antigens","display_name":"tumor antigens","score":0.8379999995231628},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.8159999847412109},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.7799999713897705},{"id":"https://openalex.org/keywords/kidney-cancer","display_name":"kidney cancer","score":0.9309999942779541},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C2777628079","wikidata":"https://www.wikidata.org/wiki/Q202448","display_name":"Cryoablation","level":3,"score":0.9793000221252441},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7337999939918518},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5410000085830688},{"id":"https://openalex.org/C3020187634","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Tumor ablation","level":3,"score":0.5040000081062317},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.45179998874664307},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4424999952316284},{"id":"https://openalex.org/C2778014663","wikidata":"https://www.wikidata.org/wiki/Q17149193","display_name":"Microwave ablation","level":3,"score":0.42820000648498535},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.37619999051094055},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3743000030517578},{"id":"https://openalex.org/C2780106285","wikidata":"https://www.wikidata.org/wiki/Q2705075","display_name":"Cryosurgery","level":2,"score":0.3621000051498413},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3587999939918518},{"id":"https://openalex.org/C2992520072","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation oncology","level":3,"score":0.3488999903202057},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3327000141143799},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.31060001254081726},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.30720001459121704},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.2939000129699707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2870999872684479},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.25949999690055847}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s44178-026-00309-1","doi":"https://doi.org/10.1007/s44178-026-00309-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s44178-026-00309-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s44178-026-00309-1.pdf","source":{"id":"https://openalex.org/S4387279979","display_name":"Holistic Integrative Oncology","issn_l":"2731-4529","issn":["2731-4529"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Holistic Integrative Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s44178-026-00309-1","doi":"https://doi.org/10.1007/s44178-026-00309-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s44178-026-00309-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s44178-026-00309-1.pdf","source":{"id":"https://openalex.org/S4387279979","display_name":"Holistic Integrative Oncology","issn_l":"2731-4529","issn":["2731-4529"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Holistic Integrative Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225238973.pdf","grobid_xml":"https://content.openalex.org/works/W7225238973.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1552804793","https://openalex.org/W1885611760","https://openalex.org/W1973269120","https://openalex.org/W1989764849","https://openalex.org/W1990730061","https://openalex.org/W1995954071","https://openalex.org/W1999289656","https://openalex.org/W2017410663","https://openalex.org/W2018592534","https://openalex.org/W2029096357","https://openalex.org/W2029399624","https://openalex.org/W2030694165","https://openalex.org/W2042669918","https://openalex.org/W2059114662","https://openalex.org/W2061394445","https://openalex.org/W2064665989","https://openalex.org/W2066671159","https://openalex.org/W2075955132","https://openalex.org/W2079591537","https://openalex.org/W2080808765","https://openalex.org/W2081904018","https://openalex.org/W2088604038","https://openalex.org/W2098793684","https://openalex.org/W2101859149","https://openalex.org/W2114611853","https://openalex.org/W2116220875","https://openalex.org/W2119769028","https://openalex.org/W2132729014","https://openalex.org/W2140542743","https://openalex.org/W2142308283","https://openalex.org/W2158500407","https://openalex.org/W2164976776","https://openalex.org/W2176221773","https://openalex.org/W2266683146","https://openalex.org/W2288738065","https://openalex.org/W2327408918","https://openalex.org/W2411910056","https://openalex.org/W2463547628","https://openalex.org/W2513122557","https://openalex.org/W2578528809","https://openalex.org/W2590810956","https://openalex.org/W2594249286","https://openalex.org/W2612745836","https://openalex.org/W2615189646","https://openalex.org/W2615210350","https://openalex.org/W2734116565","https://openalex.org/W2743247719","https://openalex.org/W2768416443","https://openalex.org/W2784073741","https://openalex.org/W2792588868","https://openalex.org/W2887577080","https://openalex.org/W2891904864","https://openalex.org/W2913071545","https://openalex.org/W2913794490","https://openalex.org/W2914968449","https://openalex.org/W2937784059","https://openalex.org/W2945219971","https://openalex.org/W2945565966","https://openalex.org/W2947880146","https://openalex.org/W2948062678","https://openalex.org/W2955788529","https://openalex.org/W2967868675","https://openalex.org/W2971459028","https://openalex.org/W2976986038","https://openalex.org/W3005302859","https://openalex.org/W3032564094","https://openalex.org/W3094101678","https://openalex.org/W3119610754","https://openalex.org/W3127051356","https://openalex.org/W3156470888","https://openalex.org/W3182670728","https://openalex.org/W4206772417","https://openalex.org/W4253483740","https://openalex.org/W4317939691","https://openalex.org/W4387966854","https://openalex.org/W4401918614"],"related_works":["https://openalex.org/W2976986038","https://openalex.org/W4220998994","https://openalex.org/W4254387906","https://openalex.org/W4317939691","https://openalex.org/W2123342256","https://openalex.org/W4391618485","https://openalex.org/W3012746037","https://openalex.org/W4394063532","https://openalex.org/W2995058199","https://openalex.org/W2795274735"],"abstract_inverted_index":{"Abstract":[0],"Cryoablation":[1,35,106,120],"has":[2],"become":[3],"an":[4],"effective,":[5],"non-invasive":[6],"way":[7],"to":[8,67,129,135],"treat":[9],"tumors":[10],"because":[11,47],"it":[12,48],"is":[13,19,36],"precise":[14],"and":[15,32,64,69,110,132],"not":[16,75],"painful.":[17],"It":[18],"currently":[20],"more":[21,57],"commonly":[22],"used":[23],"for":[24,85],"solid":[25],"cancers":[26],"such":[27],"as":[28],"liver,":[29],"kidney,":[30],"lung,":[31],"breast":[33],"cancer.":[34,137],"different":[37,123],"from":[38],"other":[39],"kinds":[40],"of":[41,125],"radiation":[42],"treatment":[43],"or":[44],"microwave":[45],"ablation":[46],"makes":[49],"the":[50,78,90,101,116],"tumor":[51,80],"antigens":[52],"come":[53],"out":[54],"in":[55,119],"a":[56],"natural":[58],"way.":[59],"This":[60],"activates":[61],"T":[62],"cells":[63],"primes":[65],"them":[66],"recognize":[68],"attack":[70],"cancer":[71],"cells.":[72],"Thus,":[73],"cryoablation":[74],"only":[76],"eradicates":[77],"local":[79],"but":[81],"also":[82,113],"creates":[83],"opportunities":[84],"combination":[86],"strategies":[87],"that":[88],"harness":[89],"body\u2019s":[91],"own":[92],"immune":[93],"system.":[94],"In":[95],"this":[96],"paper,":[97],"we":[98,111],"will":[99,112],"study":[100],"molecular":[102],"mechanism":[103],"through":[104],"which":[105],"produces":[107],"anti-tumor":[108],"immunity,":[109],"talk":[114],"about":[115],"latest":[117],"developments":[118],"combined":[121],"with":[122],"types":[124],"immunotherapy.":[126],"We":[127],"want":[128],"find":[130],"new":[131],"better":[133],"ways":[134],"cure":[136]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-05T00:00:00"}