{"id":"https://openalex.org/W7225237909","doi":"https://doi.org/10.5281/zenodo.23940015","title":"HERBAL CREAM FORMULATION: A REVIEW OF THERAPEUTIC POTENTIAL","display_name":"HERBAL CREAM FORMULATION: A REVIEW OF THERAPEUTIC POTENTIAL","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7225237909","doi":"https://doi.org/10.5281/zenodo.23940015"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.23940015","doi":"https://doi.org/10.5281/zenodo.23940015","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23940015","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.23940015","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160591945","display_name":"Jitesh Deshmukh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jitesh Deshmukh","raw_affiliation_strings":["Final Year B. Pharmacy Student, Department of Pharmacy, Genba Sopanrao Moze College of Pharmacy, Wagholi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Final Year B. Pharmacy Student, Department of Pharmacy, Genba Sopanrao Moze College of Pharmacy, Wagholi, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160666351","display_name":"Rutuja Gophane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rutuja Gophane","raw_affiliation_strings":["Department of Pharmaceutics, Genba Sopanrao Moze College of Pharmacy, Wagholi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Genba Sopanrao Moze College of Pharmacy, Wagholi, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160657192","display_name":"Sachin Gadade","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sachin Gadade","raw_affiliation_strings":["Department of Pharmacology, Genba Sopanrao Moze College of Pharmacy, Wagholi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Genba Sopanrao Moze College of Pharmacy, Wagholi, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160616850","display_name":"Dipak Jaradkar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dipak Jaradkar","raw_affiliation_strings":["Final Year B. Pharmacy Student, Department of Pharmacy, Genba Sopanrao Moze College of Pharmacy, Wagholi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Final Year B. Pharmacy Student, Department of Pharmacy, Genba Sopanrao Moze College of Pharmacy, Wagholi, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144091924","display_name":"Pritam Ghadge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pritam Ghadge","raw_affiliation_strings":["Department of Pharmaceutics, Genba Sopanrao Moze College of Pharmacy, Wagholi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Genba Sopanrao Moze College of Pharmacy, Wagholi, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020287767","display_name":"Tushar Shelke","orcid":"https://orcid.org/0009-0006-3168-243X","observed_orcids":["https://orcid.org/0009-0006-3168-243X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dr. Tushar Shelke","raw_affiliation_strings":["Department of Pharmacology, Genba Sopanrao Moze College of Pharmacy, Wagholi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Genba Sopanrao Moze College of Pharmacy, Wagholi, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.92105058,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.7836999893188477,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.7836999893188477,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.09149999916553497,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.047600001096725464,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyherbal-cream","display_name":"polyherbal cream","score":0.8769999742507935},{"id":"https://openalex.org/keywords/topical-herbal-formulation","display_name":"topical herbal formulation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/neem","display_name":"Azadirachta indica","score":0.9769999980926514},{"id":"https://openalex.org/keywords/ocimum-sanctum","display_name":"Ocimum sanctum","score":1.0},{"id":"https://openalex.org/keywords/aloe-vera","display_name":"Aloe vera","score":1.0},{"id":"https://openalex.org/keywords/turmeric","display_name":"turmeric","score":0.9829999804496765},{"id":"https://openalex.org/keywords/curcuminoids","display_name":"curcuminoids","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cream-formulation","display_name":"cream formulation","score":0.5199999809265137},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.8299999833106995},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8040000200271606},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9160000085830688},{"id":"https://openalex.org/keywords/extract-standardization","display_name":"extract standardization","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C2779404486","wikidata":"https://www.wikidata.org/wiki/Q80079","display_name":"Aloe vera","level":2,"score":0.9142000079154968},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.7674000263214111},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.4830999970436096},{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.47119998931884766},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.429500013589859},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.42010000348091125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3720000088214874},{"id":"https://openalex.org/C2781087243","wikidata":"https://www.wikidata.org/wiki/Q229987","display_name":"Methylparaben","level":3,"score":0.3449999988079071},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3411000072956085},{"id":"https://openalex.org/C2779429693","wikidata":"https://www.wikidata.org/wiki/Q274959","display_name":"Distilled water","level":2,"score":0.3149999976158142},{"id":"https://openalex.org/C2777230291","wikidata":"https://www.wikidata.org/wiki/Q33551","display_name":"Curcuma","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C2779824472","wikidata":"https://www.wikidata.org/wiki/Q207123","display_name":"Herb","level":3,"score":0.3059999942779541},{"id":"https://openalex.org/C2993907526","wikidata":"https://www.wikidata.org/wiki/Q1259977","display_name":"Aqueous extract","level":2,"score":0.2987000048160553},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.2955000102519989},{"id":"https://openalex.org/C2779717098","wikidata":"https://www.wikidata.org/wiki/Q131207","display_name":"Cosmetics","level":2,"score":0.29339998960494995},{"id":"https://openalex.org/C2778993495","wikidata":"https://www.wikidata.org/wiki/Q157830","display_name":"Glycyrrhiza","level":3,"score":0.2752000093460083},{"id":"https://openalex.org/C2779969877","wikidata":"https://www.wikidata.org/wiki/Q861699","display_name":"Phytotherapy","level":3,"score":0.2678000032901764},{"id":"https://openalex.org/C2991677592","wikidata":"https://www.wikidata.org/wiki/Q132325","display_name":"Ayurvedic medicine","level":2,"score":0.2632000148296356},{"id":"https://openalex.org/C3020322424","wikidata":"https://www.wikidata.org/wiki/Q1259977","display_name":"Herbal extracts","level":2,"score":0.25589999556541443},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.25450000166893005},{"id":"https://openalex.org/C2780751074","wikidata":"https://www.wikidata.org/wiki/Q7189797","display_name":"Phytomedicine","level":2,"score":0.2531000077724457},{"id":"https://openalex.org/C2781035296","wikidata":"https://www.wikidata.org/wiki/Q21698","display_name":"Azadirachta","level":2,"score":0.2524000108242035}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.23940015","doi":"https://doi.org/10.5281/zenodo.23940015","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23940015","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.23940016","doi":"https://doi.org/10.5281/zenodo.23940016","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23940016","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5281/zenodo.23940015","doi":"https://doi.org/10.5281/zenodo.23940015","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23940015","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6949773811","https://openalex.org/W4319346390","https://openalex.org/W7218244025","https://openalex.org/W4408961322","https://openalex.org/W7162528160","https://openalex.org/W3145044817","https://openalex.org/W7217832828","https://openalex.org/W7155916748","https://openalex.org/W7160201743","https://openalex.org/W2928756999"],"abstract_inverted_index":{"The":[0,30,119],"growing":[1],"interest":[2],"in":[3,14,208,216],"plant-based":[4],"topical":[5,74,270],"preparations":[6],"has":[7,63,106],"encouraged":[8],"the":[9,34,124,134,146,152,200,204,209,217,234,261,275],"development":[10],"of":[11,38,59,112,126,145,168,203,233,240,267],"polyherbal":[12,40],"formulations":[13],"which":[15],"botanicals":[16,154],"with":[17,82],"different":[18],"phytochemical":[19],"profiles":[20],"are":[21],"incorporated":[22],"into":[23,186],"a":[24,39,127,187],"single":[25],"pharmaceutical":[26],"or":[27],"cosmetic":[28],"system.":[29],"present":[31],"review":[32],"examines":[33],"formulation":[35,173,219,283],"and":[36,54,77,85,98,116,143,157,165,181,196,257,285],"evaluation":[37,232],"cream":[41,189,211],"prepared":[42],"from":[43],"Neem":[44,76],"(Azadirachta":[45],"indica),":[46],"Tulsi":[47,78],"(Ocimum":[48],"sanctum),":[49],"Aloe":[50,89,169,179],"vera":[51,90,170,180],"(Aloe":[52],"vera),":[53],"Turmeric":[55,182],"(Curcuma":[56],"longa).":[57],"Each":[58],"these":[60,222],"medicinal":[61],"plants":[62],"been":[64,80],"investigated":[65,93],"for":[66,94,151,277],"biological":[67],"properties":[68],"that":[69,123],"may":[70,237],"be":[71,225],"relevant":[72],"to":[73],"use.":[75],"have":[79],"associated":[81],"antimicrobial,":[83],"antioxidant":[84],"anti-inflammatory":[86,115],"effects,":[87],"whereas":[88],"is":[91,130],"widely":[92],"its":[95,103,113],"moisturizing,":[96],"soothing":[97],"skin-supportive":[99],"characteristics.":[100],"Turmeric,":[101],"particularly":[102],"curcuminoid":[104],"fraction,":[105],"received":[107],"considerable":[108],"research":[109],"attention":[110],"because":[111],"antioxidant,":[114],"antimicrobial":[117],"potential.":[118],"literature":[120,263],"further":[121,265],"indicates":[122],"nature":[125],"plant":[128,137],"extract":[129,280],"strongly":[131],"influenced":[132],"by":[133],"extraction":[135,141,164],"solvent,":[136],"material,":[138],"processing":[139],"conditions,":[140],"duration":[142],"concentration":[144],"resulting":[147],"extract.":[148],"Reported":[149],"methods":[150],"selected":[153],"include":[155,238],"aqueous":[156],"alcoholic":[158],"extraction,":[159,162,279],"maceration,":[160],"Soxhlet":[161],"methanolic":[163],"mechanical":[166],"recovery":[167],"gel.":[171],"A":[172],"study":[174],"specifically":[175],"involving":[176],"Neem,":[177],"Tulsi,":[178],"describes":[183],"their":[184],"incorporation":[185],"semisolid":[188],"containing":[190],"liquid":[191],"paraffin,":[192],"beeswax,":[193],"borax,":[194],"methylparaben":[195],"distilled":[197],"water.":[198],"However,":[199],"individual":[201],"quantities":[202],"four":[205],"herbal":[206],"extracts":[207],"final":[210],"were":[212],"not":[213],"clearly":[214],"stated":[215],"available":[218,262],"report;":[220],"therefore,":[221],"amounts":[223],"should":[224],"established":[226],"experimentally":[227],"rather":[228],"than":[229],"inferred.":[230],"Appropriate":[231],"finished":[235],"product":[236],"assessment":[239],"appearance,":[241],"colour,":[242],"odour,":[243],"homogeneity,":[244],"pH,":[245],"viscosity,":[246],"spreadability,":[247],"emulsion":[248],"type,":[249],"after-feel,":[250],"washability,":[251],"centrifugation":[252],"behaviour,":[253],"spectrophotometric":[254],"characteristics,":[255],"stability":[256],"microbial":[258],"quality.":[259],"Overall,":[260],"supports":[264],"investigation":[266],"this":[268],"four-herb":[269],"system,":[271],"while":[272],"also":[273],"emphasizing":[274],"need":[276],"controlled":[278],"standardization,":[281],"reproducible":[282],"procedures":[284],"systematic":[286],"quality":[287],"evaluation.":[288]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-05T00:00:00"}