{"id":"https://openalex.org/W7225235754","doi":"https://doi.org/10.3389/ti.2026.17469","title":"Recurrence of immunoglobulin A nephropathy after kidney transplantation: a therapeutic gap in the era of targeted therapies","display_name":"Recurrence of immunoglobulin A nephropathy after kidney transplantation: a therapeutic gap in the era of targeted therapies","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7225235754","doi":"https://doi.org/10.3389/ti.2026.17469"},"language":"en","primary_location":{"id":"doi:10.3389/ti.2026.17469","doi":"https://doi.org/10.3389/ti.2026.17469","is_oa":true,"landing_page_url":"https://doi.org/10.3389/ti.2026.17469","pdf_url":"https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2026.17469/pdf","source":{"id":"https://openalex.org/S121647140","display_name":"Transplant International","issn_l":"0934-0874","issn":["0934-0874","1432-2277"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplant International","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2026.17469/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003011692","display_name":"Luis Sanchez-Russo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luis Sanchez-Russo","raw_affiliation_strings":["Glomerular Disease Institute, Central Florida Kidney Specialists"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glomerular Disease Institute, Central Florida Kidney Specialists","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027928026","display_name":"George Vasquez\u2010Rios","orcid":"https://orcid.org/0000-0001-8651-3605","observed_orcids":["https://orcid.org/0000-0001-8651-3605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Vasquez-Rios","raw_affiliation_strings":["Glomerular and Genetic Diseases Center, Renal Medicine Associates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glomerular and Genetic Diseases Center, Renal Medicine Associates","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083826351","display_name":"Leonardo V. Riella","orcid":"https://orcid.org/0000-0002-7636-3196","observed_orcids":["https://orcid.org/0000-0002-7636-3196","https://orcid.org/0000-0001-7876-2783"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonardo V. Riella","raw_affiliation_strings":["Department of Medicine, Massachusetts General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005075162","display_name":"Paolo Cravedi","orcid":"https://orcid.org/0000-0001-7837-0923","observed_orcids":["https://orcid.org/0000-0001-7837-0923"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paolo Cravedi","raw_affiliation_strings":["Department of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2700,"currency":"EUR","value_usd":3051},"apc_paid":{"value":2700,"currency":"EUR","value_usd":3051},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.86466531,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.12710000574588776,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.954800009727478},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.8669000267982483},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.5820000171661377},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.5184000134468079},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5058000087738037},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.45899999141693115},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.4577000141143799},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.4544000029563904},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4453999996185303},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.40959998965263367},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4065999984741211},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.40450000762939453},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4027000069618225},{"id":"https://openalex.org/C2777991916","wikidata":"https://www.wikidata.org/wiki/Q421617","display_name":"Eculizumab","level":4,"score":0.3937999904155731},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3790000081062317},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.33660000562667847},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.319599986076355},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.31679999828338623},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3125},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.287200003862381},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.28139999508857727},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.28119999170303345},{"id":"https://openalex.org/C2779458710","wikidata":"https://www.wikidata.org/wiki/Q1088059","display_name":"Chronic allograft nephropathy","level":4,"score":0.2745000123977661},{"id":"https://openalex.org/C168444539","wikidata":"https://www.wikidata.org/wiki/Q105196","display_name":"Organ transplantation","level":3,"score":0.272599995136261},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26499998569488525},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.258899986743927},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.25870001316070557},{"id":"https://openalex.org/C2775965419","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter trial","level":4,"score":0.25529998540878296},{"id":"https://openalex.org/C2775946357","wikidata":"https://www.wikidata.org/wiki/Q1713037","display_name":"Membranous nephropathy","level":4,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/ti.2026.17469","doi":"https://doi.org/10.3389/ti.2026.17469","is_oa":true,"landing_page_url":"https://doi.org/10.3389/ti.2026.17469","pdf_url":"https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2026.17469/pdf","source":{"id":"https://openalex.org/S121647140","display_name":"Transplant International","issn_l":"0934-0874","issn":["0934-0874","1432-2277"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplant International","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/ti.2026.17469","doi":"https://doi.org/10.3389/ti.2026.17469","is_oa":true,"landing_page_url":"https://doi.org/10.3389/ti.2026.17469","pdf_url":"https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2026.17469/pdf","source":{"id":"https://openalex.org/S121647140","display_name":"Transplant International","issn_l":"0934-0874","issn":["0934-0874","1432-2277"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplant International","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225235754.pdf","grobid_xml":"https://content.openalex.org/works/W7225235754.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W1519093179","https://openalex.org/W1551595687","https://openalex.org/W1952087827","https://openalex.org/W2014173345","https://openalex.org/W2015918955","https://openalex.org/W2040706558","https://openalex.org/W2046698013","https://openalex.org/W2061425666","https://openalex.org/W2064214572","https://openalex.org/W2100040074","https://openalex.org/W2121260651","https://openalex.org/W2126623226","https://openalex.org/W2168214962","https://openalex.org/W2230340795","https://openalex.org/W2336804053","https://openalex.org/W2491857047","https://openalex.org/W2622306756","https://openalex.org/W2755834104","https://openalex.org/W2784057818","https://openalex.org/W2884338836","https://openalex.org/W2891025965","https://openalex.org/W2899174359","https://openalex.org/W2902603153","https://openalex.org/W2911011964","https://openalex.org/W2934520107","https://openalex.org/W2941711645","https://openalex.org/W2949689705","https://openalex.org/W3054659704","https://openalex.org/W3092339924","https://openalex.org/W3101888437","https://openalex.org/W3170820416","https://openalex.org/W3191113475","https://openalex.org/W3201987355","https://openalex.org/W4229459588","https://openalex.org/W4250806340","https://openalex.org/W4280506915","https://openalex.org/W4293055992","https://openalex.org/W4307428122","https://openalex.org/W4319733209","https://openalex.org/W4353040056","https://openalex.org/W4360823173","https://openalex.org/W4365457345","https://openalex.org/W4366409454","https://openalex.org/W4376286414","https://openalex.org/W4377093548","https://openalex.org/W4385803938","https://openalex.org/W4388304602","https://openalex.org/W4389093267","https://openalex.org/W4391444142","https://openalex.org/W4391654942","https://openalex.org/W4403799026","https://openalex.org/W4404290105","https://openalex.org/W4408410634","https://openalex.org/W4409644254","https://openalex.org/W4410019290","https://openalex.org/W4412476278","https://openalex.org/W4412865732","https://openalex.org/W4412865919","https://openalex.org/W4412866029","https://openalex.org/W4413452521","https://openalex.org/W4414081401","https://openalex.org/W4414160218","https://openalex.org/W4414335273","https://openalex.org/W4415053667","https://openalex.org/W4415426344","https://openalex.org/W4415899604","https://openalex.org/W4415992137","https://openalex.org/W4416041942","https://openalex.org/W4416422790","https://openalex.org/W4416876992","https://openalex.org/W4417516181","https://openalex.org/W7140679942","https://openalex.org/W7140799249","https://openalex.org/W7142857322","https://openalex.org/W7147236703","https://openalex.org/W7159969680","https://openalex.org/W7163523184"],"related_works":[],"abstract_inverted_index":{"Immunoglobulin":[0],"A":[1],"nephropathy":[2],"(IgAN)":[3],"frequently":[4],"recurs":[5],"after":[6,59,176],"kidney":[7,77],"transplantation":[8,177],"and":[9,22,45,65,72,105,140,149,173,191],"remains":[10],"an":[11],"underrecognized":[12],"cause":[13],"of":[14,138],"allograft":[15],"loss.":[16],"Although":[17],"targeted-release":[18],"budesonide,":[19],"B-cell":[20,139],"modulators,":[21],"complement":[23],"inhibitors":[24],"have":[25],"transformed":[26],"native":[27],"IgAN":[28,131],"treatment,":[29],"transplant":[30,196],"recipients":[31],"were":[32],"excluded":[33],"from":[34,52,125],"trials,":[35],"leaving":[36],"management":[37],"based":[38],"largely":[39],"on":[40,62],"case":[41],"reports,":[42],"small":[43],"series,":[44],"registry":[46],"data.":[47],"Reported":[48],"recurrence":[49],"rates":[50],"range":[51],"10%":[53],"to":[54,75,127,161,165],"30%":[55],"at":[56],"10\u201315":[57],"years":[58],"transplant,":[60],"depending":[61],"biopsy":[63],"practices":[64],"diagnostic":[66],"criteria.":[67],"Younger":[68],"age,":[69],"preemptive":[70],"transplantation,":[71],"rapid":[73],"progression":[74],"end-stage":[76],"disease":[78],"are":[79],"the":[80,145],"most":[81],"consistent":[82],"risk":[83],"factors.":[84],"Two":[85],"large":[86],"registries":[87],"suggested":[88],"that":[89],"maintenance":[90],"corticosteroids":[91],"reduce":[92],"recurrence,":[93],"but":[94,180],"this":[95],"association":[96],"was":[97,108],"not":[98,109],"confirmed":[99],"in":[100,195],"propensity-matched":[101],"or":[102],"multicenter":[103],"studies,":[104],"induction":[106],"immunosuppression":[107,160],"adequately":[110],"accounted":[111],"for.":[112],"Recurrence":[113],"significantly":[114],"worsens":[115],"graft":[116,122],"survival,":[117],"with":[118,170],"hazard":[119],"ratios":[120],"for":[121],"loss":[123],"ranging":[124],"2":[126],"nearly":[128],"4.":[129],"Mechanistically,":[130],"is":[132,178],"increasingly":[133],"viewed":[134],"as":[135],"a":[136,150],"disorder":[137],"plasma-cell":[141],"biology":[142],"driven":[143],"by":[144],"B-cell-activating":[146],"factor":[147],"(BAFF)":[148],"proliferation-inducing":[151],"ligand":[152],"(APRIL)":[153],"axis,":[154],"which":[155],"may":[156],"explain":[157],"why":[158],"T-cell-focused":[159],"prevent":[162,166],"rejection":[163],"fails":[164],"recurrence.":[167],"Early":[168],"experience":[169],"B-cell-,":[171],"plasma-cell-,":[172],"complement-targeted":[174],"therapies":[175],"encouraging":[179],"limited.":[181],"Progress":[182],"will":[183],"require":[184],"harmonized":[185],"registries,":[186],"validated":[187],"biomarkers,":[188],"industry":[189],"collaboration,":[190],"dedicated":[192],"randomized":[193],"trials":[194],"recipients.":[197]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-05T00:00:00"}
