{"id":"https://openalex.org/W7225231853","doi":"https://doi.org/10.3390/biology15212001","title":"A Multi-View Heterogeneous Dual-Stream Graph Autoencoder for Predicting circRNA\u2013Disease Associations","display_name":"A Multi-View Heterogeneous Dual-Stream Graph Autoencoder for Predicting circRNA\u2013Disease Associations","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7225231853","doi":"https://doi.org/10.3390/biology15212001"},"language":"en","primary_location":{"id":"doi:10.3390/biology15212001","doi":"https://doi.org/10.3390/biology15212001","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology15212001","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biology15212001","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160579988","display_name":"Yu-Hao Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162994","display_name":"Xijing University","ror":"https://ror.org/05xsjkb63","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162994"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Hao Zhou","raw_affiliation_strings":["School of Electronic Information, Xijing University, Xi\u2019an 710123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electronic Information, Xijing University, Xi\u2019an 710123, China","institution_ids":["https://openalex.org/I4210162994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134298786","display_name":"Changqing Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162994","display_name":"Xijing University","ror":"https://ror.org/05xsjkb63","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162994"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang-Qing Yu","raw_affiliation_strings":["School of Electronic Information, Xijing University, Xi\u2019an 710123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electronic Information, Xijing University, Xi\u2019an 710123, China","institution_ids":["https://openalex.org/I4210162994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130229686","display_name":"Si-Qi Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162994","display_name":"Xijing University","ror":"https://ror.org/05xsjkb63","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162994"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si-Qi Yao","raw_affiliation_strings":["School of Electronic Information, Xijing University, Xi\u2019an 710123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electronic Information, Xijing University, Xi\u2019an 710123, China","institution_ids":["https://openalex.org/I4210162994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160676075","display_name":"Lei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]},{"id":"https://openalex.org/I4210165264","display_name":"Guangxi Academy of Sciences","ror":"https://ror.org/054x1kd82","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210165264"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Wang","raw_affiliation_strings":["Guangxi Key Lab of Human-Machine Interaction and Intelligent Decision, Guangxi Academy of Sciences, Nanning 530007, China","School of Computer Science and Technology, China University of Mining and Technology, Xuzhou 221116, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Lab of Human-Machine Interaction and Intelligent Decision, Guangxi Academy of Sciences, Nanning 530007, China","institution_ids":["https://openalex.org/I4210165264"]},{"raw_affiliation_string":"School of Computer Science and Technology, China University of Mining and Technology, Xuzhou 221116, China","institution_ids":["https://openalex.org/I25757504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019805735","display_name":"Zhu\u2010Hong You","orcid":"https://orcid.org/0000-0003-1266-2696","observed_orcids":["https://orcid.org/0000-0003-1266-2696"]},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhu-Hong You","raw_affiliation_strings":["School of Computer Science, Northwestern Polytechnical University, Xi\u2019an 710129, China"],"raw_orcid":"https://orcid.org/0000-0003-1266-2696","affiliations":[{"raw_affiliation_string":"School of Computer Science, Northwestern Polytechnical University, Xi\u2019an 710129, China","institution_ids":["https://openalex.org/I17145004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5019805735","https://openalex.org/A5160676075"],"corresponding_institution_ids":["https://openalex.org/I17145004","https://openalex.org/I25757504","https://openalex.org/I4210165264"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73237486,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"21","first_page":"2001","last_page":"2001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circular-rna","display_name":"circular RNA","score":0.7739999890327454},{"id":"https://openalex.org/keywords/contrastive-regularization","display_name":"contrastive regularization","score":0.9200000166893005}],"concepts":[{"id":"https://openalex.org/C101738243","wikidata":"https://www.wikidata.org/wiki/Q786435","display_name":"Autoencoder","level":3,"score":0.7696999907493591},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5911999940872192},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5446000099182129},{"id":"https://openalex.org/C118505674","wikidata":"https://www.wikidata.org/wiki/Q42586063","display_name":"Encoder","level":2,"score":0.5303000211715698},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.48980000615119934},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4884999990463257},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.414000004529953},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.4106000065803528},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3982999920845032},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3797999918460846},{"id":"https://openalex.org/C25343380","wikidata":"https://www.wikidata.org/wiki/Q277521","display_name":"Relation (database)","level":2,"score":0.374099999666214},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.35760000348091125},{"id":"https://openalex.org/C125411270","wikidata":"https://www.wikidata.org/wiki/Q18653","display_name":"Encoding (memory)","level":2,"score":0.3249000012874603},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.31220000982284546},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.3052999973297119},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.2847999930381775},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.27489998936653137},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26510000228881836},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.2556000053882599}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/biology15212001","doi":"https://doi.org/10.3390/biology15212001","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology15212001","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/biology15212001","doi":"https://doi.org/10.3390/biology15212001","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology15212001","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W2284415752","https://openalex.org/W2800766678","https://openalex.org/W2807602500","https://openalex.org/W2884943532","https://openalex.org/W2954167484","https://openalex.org/W2974612830","https://openalex.org/W2993587506","https://openalex.org/W3020614442","https://openalex.org/W3082034060","https://openalex.org/W3197071769","https://openalex.org/W3208701685","https://openalex.org/W4200110750","https://openalex.org/W4200310000","https://openalex.org/W4226097900","https://openalex.org/W4281568005","https://openalex.org/W4296580708","https://openalex.org/W4312729251","https://openalex.org/W4313706461","https://openalex.org/W4317739614","https://openalex.org/W4360770766","https://openalex.org/W4382797667","https://openalex.org/W4385267504","https://openalex.org/W4385898810","https://openalex.org/W4387642879","https://openalex.org/W4392558716","https://openalex.org/W4392620875","https://openalex.org/W4400045718","https://openalex.org/W4401082680","https://openalex.org/W4406047213","https://openalex.org/W4406597242","https://openalex.org/W4407763317","https://openalex.org/W4409474031","https://openalex.org/W4410950151","https://openalex.org/W4411448145","https://openalex.org/W4411987748","https://openalex.org/W4414197337","https://openalex.org/W4415027807","https://openalex.org/W7134168993","https://openalex.org/W7204163237","https://openalex.org/W7214347730"],"related_works":["https://openalex.org/W4313527139","https://openalex.org/W4404238200","https://openalex.org/W7162010604","https://openalex.org/W4288902530","https://openalex.org/W4407193507","https://openalex.org/W4294908570","https://openalex.org/W4414152500","https://openalex.org/W4385376532","https://openalex.org/W4283813823","https://openalex.org/W4283772644"],"abstract_inverted_index":{"Circular":[0],"RNAs":[1],"(circRNAs)":[2],"participate":[3],"in":[4,128],"gene":[5],"regulation":[6],"and":[7,48,59,70,99,143],"disease-associated":[8],"processes.":[9],"Computational":[10],"prediction":[11],"of":[12,97,102,112],"circRNA\u2013disease":[13],"associations":[14],"(CDAs)":[15],"can":[16],"help":[17],"prioritize":[18],"candidates":[19,146],"for":[20,33,139,147],"biological":[21],"investigation.":[22],"Here,":[23],"we":[24],"propose":[25],"a":[26],"multi-view":[27,38],"heterogeneous":[28,42,64],"dual-stream":[29,45],"graph":[30,39],"autoencoder":[31],"(MHDA)":[32],"CDA":[34],"prediction.":[35],"MHDA":[36,93,136],"combines":[37,75],"attention":[40,65],"encoding,":[41],"relation":[43],"enhancement,":[44],"association":[46],"reconstruction,":[47],"contrastive":[49],"regularization.":[50],"The":[51,73],"encoder":[52],"learns":[53],"representations":[54,81],"from":[55],"complementary":[56],"similarity":[57],"views":[58],"adaptively":[60],"fuses":[61],"them.":[62],"A":[63],"module":[66],"then":[67],"integrates":[68],"within-type":[69],"cross-type":[71],"relationships.":[72],"decoder":[74],"element-wise":[76],"interactions":[77],"with":[78],"concatenated":[79],"pair":[80],"through":[82],"gated":[83],"fusion":[84],"to":[85],"score":[86],"candidate":[87,122],"associations.":[88],"On":[89],"the":[90,110,113,118,129],"CircR2Disease":[91],"dataset,":[92],"achieves":[94],"an":[95,100],"AUC":[96],"0.9633":[98],"AUPR":[101],"0.9599":[103],"under":[104],"five-fold":[105],"cross-validation.":[106],"Ablation":[107],"analyses":[108],"support":[109],"contributions":[111],"main":[114],"model":[115],"components.":[116],"Of":[117],"top":[119],"25":[120],"ranked":[121],"associations,":[123],"22":[124],"have":[125],"supporting":[126],"evidence":[127],"published":[130],"literature.":[131],"These":[132],"results":[133],"suggest":[134],"that":[135],"is":[137],"useful":[138],"prioritizing":[140],"potential":[141],"CDAs":[142],"provides":[144],"promising":[145],"subsequent":[148],"experimental":[149],"validation.":[150]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-05T00:00:00"}