{"id":"https://openalex.org/W7225230648","doi":"https://doi.org/10.1093/ijfood/vvag238","title":"High-Dose Inulin Ameliorates Renal Function and Lipid Disorders but Does Not Optimize Gut Microecology in C57BL/6J Mice with Chronic Kidney Disease","display_name":"High-Dose Inulin Ameliorates Renal Function and Lipid Disorders but Does Not Optimize Gut Microecology in C57BL/6J Mice with Chronic Kidney Disease","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7225230648","doi":"https://doi.org/10.1093/ijfood/vvag238"},"language":"en","primary_location":{"id":"doi:10.1093/ijfood/vvag238","doi":"https://doi.org/10.1093/ijfood/vvag238","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ijfood/vvag238","pdf_url":null,"source":{"id":"https://openalex.org/S106548112","display_name":"International Journal of Food Science & Technology","issn_l":"0950-5423","issn":["0950-5423","1365-2621"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Food Science and Technology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/ijfood/vvag238","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104727261","display_name":"Chunhai Shao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210146205","display_name":"Obstetrics and Gynecology Hospital of Fudan University","ror":"https://ror.org/04rhdtb47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146205"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunhai Shao","raw_affiliation_strings":["Department of Epidemiology, School of Public Health, Fudan University , Shanghai 200032 ,","Department of Nutrition, Huashan Hospital, Fudan University , Shanghai 200040 ,","Department of Nutrition, Shanghai Fifth People\u2019s Hospital Fudan University , Shanghai 200240 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, Fudan University , Shanghai 200032 ,","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of Nutrition, Huashan Hospital, Fudan University , Shanghai 200040 ,","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]},{"raw_affiliation_string":"Department of Nutrition, Shanghai Fifth People\u2019s Hospital Fudan University , Shanghai 200240 ,","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210146205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072925021","display_name":"\u6768\u91d1\u5c71","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinshan Yang","raw_affiliation_strings":["Department of Epidemiology, School of Public Health, Fudan University , Shanghai 200032 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, Fudan University , Shanghai 200032 ,","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160601151","display_name":"Lingli Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingli Hu","raw_affiliation_strings":["Department of Nutrition, Huashan Hospital, Fudan University , Shanghai 200040 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Huashan Hospital, Fudan University , Shanghai 200040 ,","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114079264","display_name":"Yuhuan Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210146205","display_name":"Obstetrics and Gynecology Hospital of Fudan University","ror":"https://ror.org/04rhdtb47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146205"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhuan Wei","raw_affiliation_strings":["Department of Nutrition, Shanghai Fifth People\u2019s Hospital Fudan University , Shanghai 200240 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Shanghai Fifth People\u2019s Hospital Fudan University , Shanghai 200240 ,","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210146205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160688833","display_name":"Changfei Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changfei Shi","raw_affiliation_strings":["Department of Epidemiology, School of Public Health, Fudan University , Shanghai 200032 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, Fudan University , Shanghai 200032 ,","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100699718","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0003-4896-0142","observed_orcids":["https://orcid.org/0000-0003-4896-0142"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Department of Nutrition, Huashan Hospital, Fudan University , Shanghai 200040 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Huashan Hospital, Fudan University , Shanghai 200040 ,","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100654594","display_name":"Weibing Wang","orcid":"https://orcid.org/0000-0002-4497-5251","observed_orcids":["https://orcid.org/0000-0002-4497-5251"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weibing Wang","raw_affiliation_strings":["Department of Epidemiology, School of Public Health, Fudan University , Shanghai 200032 ,"],"raw_orcid":"https://orcid.org/0000-0002-4497-5251","affiliations":[{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, Fudan University , Shanghai 200032 ,","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160578527","display_name":"Yuan Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210146205","display_name":"Obstetrics and Gynecology Hospital of Fudan University","ror":"https://ror.org/04rhdtb47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146205"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuan Cui","raw_affiliation_strings":["Department of Nutrition, Shanghai Fifth People\u2019s Hospital Fudan University , Shanghai 200240 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Shanghai Fifth People\u2019s Hospital Fudan University , Shanghai 200240 ,","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210146205"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5160578527"],"corresponding_institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210146205"],"apc_list":{"value":2000,"currency":"GBP","value_usd":2638},"apc_paid":{"value":2000,"currency":"GBP","value_usd":2638},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85014346,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.7714999914169312,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.7714999914169312,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.20309999585151672,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2779742124","wikidata":"https://www.wikidata.org/wiki/Q201552","display_name":"Inulin","level":2,"score":0.9082000255584717},{"id":"https://openalex.org/C120667501","wikidata":"https://www.wikidata.org/wiki/Q6839493","display_name":"Microecology","level":2,"score":0.8137999773025513},{"id":"https://openalex.org/C2775980262","wikidata":"https://www.wikidata.org/wiki/Q218870","display_name":"Prebiotic","level":2,"score":0.70660001039505},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.5945000052452087},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5916000008583069},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5701000094413757},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5651000142097473},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5601999759674072},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5529999732971191},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4733999967575073},{"id":"https://openalex.org/C2777390665","wikidata":"https://www.wikidata.org/wiki/Q5571239","display_name":"Glomerulosclerosis","level":4,"score":0.4198000133037567},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.32899999618530273},{"id":"https://openalex.org/C2992125399","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Lipid accumulation","level":2,"score":0.31859999895095825},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.31189998984336853},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.30790001153945923},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.30640000104904175},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C3018683220","wikidata":"https://www.wikidata.org/wiki/Q736715","display_name":"Chronic renal disease","level":3,"score":0.2712000012397766},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.27090001106262207},{"id":"https://openalex.org/C3018485028","wikidata":"https://www.wikidata.org/wiki/Q178623","display_name":"Renal stone","level":3,"score":0.26330000162124634},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.2621999979019165}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ijfood/vvag238","doi":"https://doi.org/10.1093/ijfood/vvag238","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ijfood/vvag238","pdf_url":null,"source":{"id":"https://openalex.org/S106548112","display_name":"International Journal of Food Science & Technology","issn_l":"0950-5423","issn":["0950-5423","1365-2621"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Food Science and Technology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/ijfood/vvag238","doi":"https://doi.org/10.1093/ijfood/vvag238","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ijfood/vvag238","pdf_url":null,"source":{"id":"https://openalex.org/S106548112","display_name":"International Journal of Food Science & Technology","issn_l":"0950-5423","issn":["0950-5423","1365-2621"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Food Science and Technology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Based":[1],"on":[2],"our":[3],"clinical":[4],"trial":[5],"benefits":[6],"of":[7,20,42,93],"soluble":[8],"dietary":[9],"fibre":[10],"in":[11,25,115,126],"chronic":[12],"kidney":[13],"disease":[14],"(CKD),":[15],"we":[16],"investigated":[17],"the":[18,69,88,101],"effects":[19,92],"20%":[21],"high-dose":[22,94],"inulin":[23,65,95,106],"(INU)":[24],"adenine-induced":[26],"CKD":[27],"mice.":[28],"As":[29],"expected,":[30],"INU":[31],"alleviated":[32],"renal":[33,40,55,108],"injury,":[34],"reduced":[35],"serum":[36,51,61],"creatinine,":[37],"and":[38,45,59,81,90,109],"downregulated":[39],"expression":[41],"inflammatory,":[43],"fibrotic":[44],"STING-related":[46],"molecules.":[47],"It":[48],"also":[49],"improved":[50],"lipid":[52,56,110],"profiles,":[53],"upregulated":[54],"metabolism":[57],"genes,":[58],"remodelled":[60],"lipidomic":[62],"composition.":[63],"Notably,":[64],"failed":[66],"to":[67],"elevate":[68],"main":[70],"short-chain":[71],"fatty":[72],"acids":[73],"(SCFAs)":[74],"levels":[75],"or":[76],"beneficially":[77],"reshape":[78],"gut":[79,102,117],"microbiota,":[80],"even":[82],"enriched":[83],"potential":[84],"opportunistic":[85],"pathogens.":[86],"Therefore,":[87],"renoprotective":[89],"lipid-regulating":[91],"are":[96],"not":[97],"primarily":[98],"mediated":[99],"by":[100],"microbiota-SCFAs":[103],"axis.":[104],"High-dose":[105],"ameliorates":[107],"damage":[111],"but":[112],"shows":[113],"limitations":[114],"optimizing":[116],"microecology,":[118],"providing":[119],"experimental":[120],"evidence":[121],"for":[122],"rational":[123],"prebiotic":[124],"application":[125],"CKD.":[127]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-05T00:00:00"}
