{"id":"https://openalex.org/W7225225340","doi":"https://doi.org/10.1002/masy.70509","title":"Characterization of Serum Biomacromolecular Response: Immunoglobulin and Cytokine Polymer Profiles in Cutaneous Leishmaniasis Patients","display_name":"Characterization of Serum Biomacromolecular Response: Immunoglobulin and Cytokine Polymer Profiles in Cutaneous Leishmaniasis Patients","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7225225340","doi":"https://doi.org/10.1002/masy.70509"},"language":"en","primary_location":{"id":"doi:10.1002/masy.70509","doi":"https://doi.org/10.1002/masy.70509","is_oa":false,"landing_page_url":"https://doi.org/10.1002/masy.70509","pdf_url":null,"source":{"id":"https://openalex.org/S7773033","display_name":"Macromolecular Symposia","issn_l":"1022-1360","issn":["1022-1360","1521-3900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecular Symposia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5134181820","display_name":"Jinan Mahmood Saad","orcid":"https://orcid.org/0009-0006-3067-9861","observed_orcids":["https://orcid.org/0009-0006-3067-9861"]},"institutions":[{"id":"https://openalex.org/I72539421","display_name":"University of Tikrit","ror":"https://ror.org/01zfzax10","country_code":"IQ","type":"education","lineage":["https://openalex.org/I72539421"]}],"countries":["IQ"],"is_corresponding":true,"raw_author_name":"Jinan Mahmood Saad","raw_affiliation_strings":["Department of Biology Education College for Women University of Tikrit  Tikrit Iraq"],"raw_orcid":"https://orcid.org/0009-0006-3067-9861","affiliations":[{"raw_affiliation_string":"Department of Biology Education College for Women University of Tikrit  Tikrit Iraq","institution_ids":["https://openalex.org/I72539421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038608859","display_name":"Intisar Ghanim Abdulwahhab","orcid":"https://orcid.org/0000-0002-1599-9078","observed_orcids":["https://orcid.org/0000-0002-1599-9078"]},"institutions":[{"id":"https://openalex.org/I72539421","display_name":"University of Tikrit","ror":"https://ror.org/01zfzax10","country_code":"IQ","type":"education","lineage":["https://openalex.org/I72539421"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Intisar Ghanim Abdulwahhab","raw_affiliation_strings":["Department of Biology Education College for Women University of Tikrit  Tikrit Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology Education College for Women University of Tikrit  Tikrit Iraq","institution_ids":["https://openalex.org/I72539421"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103954265","display_name":"Muthana Badeea Farhan","orcid":"https://orcid.org/0000-0002-4693-455X","observed_orcids":["https://orcid.org/0000-0002-4693-455X"]},"institutions":[{"id":"https://openalex.org/I27768575","display_name":"University of Anbar","ror":"https://ror.org/055a6gk50","country_code":"IQ","type":"education","lineage":["https://openalex.org/I27768575"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Muthana Badeea Farhan","raw_affiliation_strings":["College of Basic Education \u2013 Haditha University of Anbar  Ramadi Iraq","Upper Euphrates Center For Sustainable Development Research University of Anbar  Ramadi Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Education \u2013 Haditha University of Anbar  Ramadi Iraq","institution_ids":["https://openalex.org/I27768575"]},{"raw_affiliation_string":"Upper Euphrates Center For Sustainable Development Research University of Anbar  Ramadi Iraq","institution_ids":["https://openalex.org/I27768575"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5134181820"],"corresponding_institution_ids":["https://openalex.org/I72539421"],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.88340202,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cutaneous-leishmaniasis","display_name":"cutaneous leishmaniasis","score":1.0},{"id":"https://openalex.org/keywords/immunoglobulins","display_name":"immunoglobulins","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7919999957084656},{"id":"https://openalex.org/keywords/iga","display_name":"IgA","score":0.7580000162124634},{"id":"https://openalex.org/keywords/igm","display_name":"IgM","score":0.9980000257492065},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":1.0},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9639999866485596},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":1.0},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":1.0},{"id":"https://openalex.org/keywords/host-immune-response","display_name":"host immune response","score":0.9139999747276306},{"id":"https://openalex.org/keywords/host-pathogen-interface","display_name":"host-pathogen interface","score":0.7409999966621399},{"id":"https://openalex.org/keywords/macromolecular-interactions","display_name":"macromolecular interactions","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C204389451","wikidata":"https://www.wikidata.org/wiki/Q178593","display_name":"Macromolecule","level":2,"score":0.8726000189781189},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5773000121116638},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.546999990940094},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5449000000953674},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.5123999714851379},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4986000061035156},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4332999885082245},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32019999623298645},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31060001254081726},{"id":"https://openalex.org/C2778474638","wikidata":"https://www.wikidata.org/wiki/Q575241","display_name":"Immune complex","level":3,"score":0.30649998784065247},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.2912999987602234},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.290800005197525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2890999913215637},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.27790001034736633},{"id":"https://openalex.org/C2779102806","wikidata":"https://www.wikidata.org/wiki/Q79453","display_name":"Immunoglobulin A","level":4,"score":0.2590000033378601},{"id":"https://openalex.org/C2778702967","wikidata":"https://www.wikidata.org/wiki/Q2590966","display_name":"Cutaneous leishmaniasis","level":3,"score":0.25459998846054077}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/masy.70509","doi":"https://doi.org/10.1002/masy.70509","is_oa":false,"landing_page_url":"https://doi.org/10.1002/masy.70509","pdf_url":null,"source":{"id":"https://openalex.org/S7773033","display_name":"Macromolecular Symposia","issn_l":"1022-1360","issn":["1022-1360","1521-3900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecular Symposia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1845629018","https://openalex.org/W3132820286","https://openalex.org/W3172203780","https://openalex.org/W4220883505","https://openalex.org/W4379377320","https://openalex.org/W4388010907","https://openalex.org/W4396524604","https://openalex.org/W4400647703","https://openalex.org/W4400689687","https://openalex.org/W4402170518","https://openalex.org/W4403542106","https://openalex.org/W4409735196","https://openalex.org/W4412010000"],"related_works":["https://openalex.org/W2150596924","https://openalex.org/W2893303984","https://openalex.org/W4236428209","https://openalex.org/W4225259124","https://openalex.org/W4388839042","https://openalex.org/W2066732010","https://openalex.org/W3093550233","https://openalex.org/W2578867309","https://openalex.org/W2070340582","https://openalex.org/W2991336360"],"abstract_inverted_index":{"ABSTRACT":[0],"This":[1],"study":[2],"focuses":[3],"on":[4],"the":[5,15,23,40,67,79,87,95,98,121,137,147,151,155,161],"quantitative":[6],"analysis":[7,116],"of":[8,12,43,69,97,125,130,150],"two":[9,127],"key":[10],"classes":[11,129],"these":[13,44,126],"macromolecules:":[14],"Immunoglobulin":[16],"(Ig)":[17],"polymers":[18,73],"(IgA,":[19,74],"IgM,":[20,75],"IgG)":[21,77],"and":[22,76,91,103,123,134,154],"Interleukin":[24],"(IL)":[25],"signaling":[26,99],"oligomers":[27,100],"(IL\u20104,":[28],"IL\u201012,":[29,102],"IL\u201017)":[30],"in":[31,48,66,78,86,136,164],"CL":[32,50,80,138],"patients":[33,51],"undergoing":[34],"Pentostam":[35],"treatment.":[36],"The":[37,60],"investigation":[38],"involved":[39],"structural":[41],"characterization":[42],"serum":[45,131],"macromolecular":[46,89,148],"profiles":[47],"60":[49],"compared":[52],"to":[53,108,119],"30":[54],"healthy":[55],"controls":[56],"from":[57],"Ramadi":[58],"City.":[59],"results":[61],"demonstrate":[62],"a":[63,83,113],"marked":[64],"increase":[65],"concentration":[68],"all":[70],"three":[71],"Ig":[72],"cohort,":[81],"suggesting":[82],"significant":[84],"shift":[85],"host's":[88],"synthesis":[90],"circulation":[92],"dynamics.":[93],"Concurrently,":[94],"levels":[96],"IL\u20104,":[101],"IL\u201017":[104],"were":[105],"also":[106],"found":[107],"be":[109],"significantly":[110],"elevated.":[111],"Furthermore,":[112],"Pearson":[114],"correlation":[115],"was":[117],"performed":[118],"investigate":[120],"inter\u2010relationship":[122],"co\u2010regulation":[124],"distinct":[128],"macromolecules":[132],"(cytokines":[133],"immunoglobulins)":[135],"patient":[139],"group.":[140],"These":[141],"findings":[142],"provide":[143],"critical":[144],"insight":[145],"into":[146],"architecture":[149],"host\u2010pathogen":[152],"interface":[153],"complex":[156],"polymer\u2010polymer":[157],"interactions":[158],"that":[159],"govern":[160],"immune":[162],"response":[163],"leishmaniasis.":[165]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-05T00:00:00"}