{"id":"https://openalex.org/W7225223422","doi":"https://doi.org/10.3389/fneur.2026.1962864","title":"Association between early platelet aggregation function and 30-day mortality in patients with cerebral hemorrhage: a retrospective neurocritical care cohort study","display_name":"Association between early platelet aggregation function and 30-day mortality in patients with cerebral hemorrhage: a retrospective neurocritical care cohort study","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7225223422","doi":"https://doi.org/10.3389/fneur.2026.1962864"},"language":"en","primary_location":{"id":"doi:10.3389/fneur.2026.1962864","doi":"https://doi.org/10.3389/fneur.2026.1962864","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1962864","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1962864/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1962864/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160658593","display_name":"Fei Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Yin","raw_affiliation_strings":["Department of Emergency, Suzhou Ninth People's Hospital, Suzhou Ninth Hospital Affiliated to Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, Suzhou Ninth People's Hospital, Suzhou Ninth Hospital Affiliated to Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058338837","display_name":"\u9c81\u6587\u8389","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenli Lu","raw_affiliation_strings":["Department of Rehabilitation, Suzhou Ninth People's Hospital, Suzhou Ninth Hospital Affiliated to Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation, Suzhou Ninth People's Hospital, Suzhou Ninth Hospital Affiliated to Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138967782","display_name":"Rongqing Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongqing Hu","raw_affiliation_strings":["Department of Rehabilitation, Suzhou Ninth People's Hospital, Suzhou Ninth Hospital Affiliated to Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation, Suzhou Ninth People's Hospital, Suzhou Ninth Hospital Affiliated to Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160586141","display_name":"Chengzhi Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengzhi Xu","raw_affiliation_strings":["Department of Emergency, Suzhou Ninth People's Hospital, Suzhou Ninth Hospital Affiliated to Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, Suzhou Ninth People's Hospital, Suzhou Ninth Hospital Affiliated to Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011755895","display_name":"\u77f3\u5f3a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qiang Shi","raw_affiliation_strings":["Department of Emergency, Suzhou Ninth People's Hospital, Suzhou Ninth Hospital Affiliated to Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, Suzhou Ninth People's Hospital, Suzhou Ninth Hospital Affiliated to Soochow University","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011755895"],"corresponding_institution_ids":["https://openalex.org/I3923682"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.8490173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8970999717712402},{"id":"https://openalex.org/C165455791","wikidata":"https://www.wikidata.org/wiki/Q7002299","display_name":"Neurointensive care","level":2,"score":0.7688000202178955},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6636999845504761},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5975000262260437},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5131000280380249},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.5052000284194946},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.46970000863075256},{"id":"https://openalex.org/C2777094939","wikidata":"https://www.wikidata.org/wiki/Q1368943","display_name":"Intracerebral hemorrhage","level":3,"score":0.4426000118255615},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.438400000333786},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4097999930381775},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3691999912261963},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.3034000098705292},{"id":"https://openalex.org/C2777736543","wikidata":"https://www.wikidata.org/wiki/Q693442","display_name":"Subarachnoid hemorrhage","level":2,"score":0.29980000853538513},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.29679998755455017},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.2816999852657318},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.26989999413490295},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.2687000036239624},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.2563999891281128},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.25}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fneur.2026.1962864","doi":"https://doi.org/10.3389/fneur.2026.1962864","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1962864","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1962864/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fneur.2026.1962864","doi":"https://doi.org/10.3389/fneur.2026.1962864","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1962864","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1962864/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225223422.pdf","grobid_xml":"https://content.openalex.org/works/W7225223422.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1947113872","https://openalex.org/W1976066448","https://openalex.org/W1981194197","https://openalex.org/W2007301755","https://openalex.org/W2012214760","https://openalex.org/W2034400748","https://openalex.org/W2061363260","https://openalex.org/W2074924882","https://openalex.org/W2075638893","https://openalex.org/W2082043630","https://openalex.org/W2106421416","https://openalex.org/W2129207263","https://openalex.org/W2135046866","https://openalex.org/W2136587148","https://openalex.org/W2156665896","https://openalex.org/W2158474808","https://openalex.org/W2328176404","https://openalex.org/W2345125502","https://openalex.org/W2359884680","https://openalex.org/W2560679603","https://openalex.org/W2787493763","https://openalex.org/W2809949684","https://openalex.org/W2890840903","https://openalex.org/W2895676484","https://openalex.org/W2911964244","https://openalex.org/W3042826867","https://openalex.org/W3095089614","https://openalex.org/W4224232395","https://openalex.org/W4231545099","https://openalex.org/W4280566785","https://openalex.org/W4293242440","https://openalex.org/W4327679563"],"related_works":[],"abstract_inverted_index":{"Background":[0],"Cerebral":[1],"hemorrhage":[2,82,86],"has":[3],"a":[4,208,293],"high":[5],"early":[6,105],"mortality":[7,47,118,213,355],"rate,":[8],"and":[9,40,53,67,98,147,153,157,183,242,287,316,338,346,375],"platelet":[10,23,43,202,303,348],"function":[11,25],"may":[12,367],"be":[13],"related":[14],"to":[15,54,88,128,282,306],"patient":[16],"outcomes.":[17],"However,":[18],"the":[19,31,89,158,197,243,263,273,327],"prognostic":[20,61,370],"role":[21],"of":[22,33,211,296],"aggregation":[24,44,102,203,304,349,365],"remains":[26],"unclear.":[27],"Objective":[28],"To":[29],"evaluate":[30],"associations":[32,331],"arachidonic":[34],"acid":[35],"(AA)-,":[36],"adenosine":[37],"diphosphate":[38],"(ADP)-,":[39],"collagen":[41],"(COL)-induced":[42],"with":[45,50,79,207,270,313,352,361],"30-day":[46,212,354],"in":[48,335,359],"patients":[49,78,360],"cerebral":[51,85,362],"hemorrhage,":[52],"determine":[55],"whether":[56],"these":[57],"indicators":[58],"provided":[59],"additional":[60],"information":[62,177],"beyond":[63,178],"conventional":[64],"clinical":[65,289],"variables":[66,161],"disease":[68],"severity":[69],"scores.":[70],"Methods":[71],"This":[72],"retrospective":[73],"observational":[74],"study":[75],"enrolled":[76],"adult":[77],"spontaneous":[80],"intracerebral":[81],"or":[83],"traumatic":[84],"admitted":[87],"neurological":[90],"intensive":[91],"care":[92],"unit":[93],"(NICU)":[94],"between":[95],"September":[96],"2022":[97],"April":[99],"2026.":[100],"Platelet":[101,364],"was":[103,116,126,311,350],"assessed":[104],"after":[106,356],"admission":[107],"using":[108,143],"light":[109],"transmission":[110],"aggregometry":[111],"(LTA).":[112],"The":[113,330],"primary":[114],"outcome":[115],"all-cause":[117],"within":[119,193],"30":[120,194],"days.":[121,195],"Principal":[122],"component":[123],"analysis":[124],"(PCA)":[125],"used":[127],"generate":[129],"an":[130,307],"integrated":[131],"AA":[132,215,244],"+":[133,135,245,247],"ADP":[134,224,246],"COL":[136,233,248],"PCA":[137,249],"score.":[138],"Candidate":[139],"covariates":[140],"were":[141,162,205,332,378],"screened":[142],"least":[144],"absolute":[145],"shrinkage":[146],"selection":[148],"operator":[149],"(LASSO)":[150],"regression,":[151],"Boruta,":[152],"random":[154],"forest":[155],"methods,":[156],"selected":[159],"relevant":[160],"incorporated":[163],"into":[164],"multivariable":[165,357],"logistic":[166],"regression":[167],"models.":[168],"Supportive":[169],"analyses":[170,321],"examined":[171],"discrimination,":[172,269],"calibration,":[173,286],"decision":[174,297],"curve,":[175],"incremental":[176],"APACHE":[179,308],"II,":[180],"overlap-weighted":[181,339],"estimates,":[182],"subgroup":[184],"consistency.":[185],"Results":[186],"Among":[187],"335":[188],"included":[189],"patients,":[190],"78":[191],"died":[192],"In":[196,259,299],"fully":[198,264],"adjusted":[199,265],"models,":[200],"higher":[201,314,353],"values":[204],"associated":[206,312,351],"lower":[209],"risk":[210],"for":[214],"(OR":[216,225,234,251],"0.978,":[217],"95%":[218,227,236,253],"CI":[219,228,237,254],"0.964\u20130.992,":[220],"p":[221,230,239,256],"=":[222],"0.002),":[223],"0.960,":[226,235],"0.942\u20130.978,":[229],"<":[231,240,257],"0.001),":[232,241],"0.943\u20130.977,":[238],"score":[250],"0.613,":[252],"0.494\u20130.759,":[255],"0.001).":[258],"supplementary":[260],"model":[261,310],"assessment,":[262],"models":[266],"demonstrated":[267],"good":[268],"areas":[271],"under":[272],"receiver":[274],"operating":[275],"characteristic":[276],"curves":[277],"(AUCs)":[278],"ranging":[279],"from":[280],"0.839":[281],"0.857,":[283],"acceptable":[284],"bootstrap":[285],"positive":[288],"net":[290],"benefit":[291],"across":[292,326],"wide":[294],"range":[295],"thresholds.":[298],"supportive":[300,369],"analyses,":[301],"adding":[302],"measures":[305],"II-only":[309],"AUCs":[315],"favorable":[317],"NRI/IDI":[318],"results.":[319],"Subgroup":[320],"showed":[322],"generally":[323],"consistent":[324,334],"results":[325],"pre-specified":[328],"subgroups.":[329],"directionally":[333],"extended":[336],"adjustment":[337,358],"sensitivity":[340],"analyses.":[341],"Conclusion":[342],"Reduced":[343],"AA-,":[344],"ADP-,":[345],"COL-induced":[347],"hemorrhage.":[363],"testing":[366],"provide":[368],"information,":[371],"but":[372],"external":[373],"validation":[374],"imaging-based":[376],"confirmation":[377],"needed.":[379]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-05T00:00:00"}