{"id":"https://openalex.org/W7225205992","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.1153","title":"1153 Melanocyte PD-L1 and type I interferons (IFN-Is) promote metastasis and immune suppression in UVB-associated melanoma","display_name":"1153 Melanocyte PD-L1 and type I interferons (IFN-Is) promote metastasis and immune suppression in UVB-associated melanoma","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225205992","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.1153"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2026-sitc2026.1153","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.1153","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.1153","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A1317.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/14/Suppl_2/A1317.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160435344","display_name":"Nathaniel G Spicer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel G Spicer","raw_affiliation_strings":["Dartmouth College, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth College, Lebanon, NH, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079368617","display_name":"Carlos O Ontiveros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos O Ontiveros","raw_affiliation_strings":["UT Health San Antonio, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT Health San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087871331","display_name":"Clare E Murray","orcid":"https://orcid.org/0000-0003-2595-4436","observed_orcids":["https://orcid.org/0000-0003-2595-4436"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clare E Murray","raw_affiliation_strings":["UT Health San Antonio, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT Health San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112876541","display_name":"Haiyan Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haiyan Bai","raw_affiliation_strings":["Dartmouth Hitchcock Hospital, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth Hitchcock Hospital, Lebanon, NH, USA","institution_ids":["https://openalex.org/I1289422878"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082545896","display_name":"Lucas A. Salas","orcid":"https://orcid.org/0000-0002-2279-4097","observed_orcids":["https://orcid.org/0000-0002-2279-4097"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4390039367","display_name":"Dartmouth Cancer Center","ror":"https://ror.org/044b05b34","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039367"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucas A Salas","raw_affiliation_strings":["Dartmouth Cancer Center, Lebanon, NH, USA","Dartmouth College, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth Cancer Center, Lebanon, NH, USA","institution_ids":["https://openalex.org/I4390039367"]},{"raw_affiliation_string":"Dartmouth College, Lebanon, NH, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159364807","display_name":"Matthew Lindley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039367","display_name":"Dartmouth Cancer Center","ror":"https://ror.org/044b05b34","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039367"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Lindley","raw_affiliation_strings":["Dartmouth Cancer Center, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth Cancer Center, Lebanon, NH, USA","institution_ids":["https://openalex.org/I4390039367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079542108","display_name":"Irene Georgakoudi","orcid":"https://orcid.org/0000-0002-0049-6697","observed_orcids":["https://orcid.org/0000-0002-0049-6697"]},"institutions":[{"id":"https://openalex.org/I4390039367","display_name":"Dartmouth Cancer Center","ror":"https://ror.org/044b05b34","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039367"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene Georgakoudi","raw_affiliation_strings":["Dartmouth Cancer Center, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth Cancer Center, Lebanon, NH, USA","institution_ids":["https://openalex.org/I4390039367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082998103","display_name":"Sladjana Skopelja\u2010Gardner","orcid":"https://orcid.org/0000-0001-6350-9582","observed_orcids":["https://orcid.org/0000-0001-6350-9582"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sladjana Skopelja-Gardner","raw_affiliation_strings":["Dartmouth College, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth College, Lebanon, NH, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074770263","display_name":"Tyler Jay Curiel","orcid":"https://orcid.org/0000-0001-6962-9411","observed_orcids":["https://orcid.org/0000-0001-6962-9411"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4390039367","display_name":"Dartmouth Cancer Center","ror":"https://ror.org/044b05b34","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039367"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler J Curiel","raw_affiliation_strings":["Dartmouth Cancer Center, Lebanon, NH, USA","Dartmouth College, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth Cancer Center, Lebanon, NH, USA","institution_ids":["https://openalex.org/I4390039367"]},{"raw_affiliation_string":"Dartmouth College, Lebanon, NH, USA","institution_ids":["https://openalex.org/I107672454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A1317","last_page":"A1317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7319999933242798},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.8939999938011169},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.9490000009536743},{"id":"https://openalex.org/keywords/uv-b-radiation","display_name":"UV-B radiation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/melanocyte-origin","display_name":"melanocyte origin","score":0.5400000214576721},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/immunosuppressive-tumor-microenvironment","display_name":"immunosuppressive tumor microenvironment","score":0.8640000224113464},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitor-resistance","display_name":"immune checkpoint inhibitor resistance","score":0.8360000252723694},{"id":"https://openalex.org/keywords/nras-mutant-melanoma","display_name":"NRAS-mutant melanoma","score":0.8100000023841858},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7279999852180481},{"id":"https://openalex.org/keywords/melanoma-of-unknown-primary","display_name":"unknown primary melanoma","score":0.3230000138282776}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.843999981880188},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7401999831199646},{"id":"https://openalex.org/C2779769559","wikidata":"https://www.wikidata.org/wiki/Q247101","display_name":"Melanocyte","level":3,"score":0.6685000061988831},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6438000202178955},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6334999799728394},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6327999830245972},{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.47679999470710754},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4075999855995178},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.32739999890327454},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.3122999966144562}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jitc-2026-sitc2026.1153","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.1153","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.1153","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A1317.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2026-sitc2026.1153","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.1153","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.1153","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A1317.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2368926932","display_name":null,"funder_award_id":"5P30CA023108","funder_id":"https://openalex.org/F4320319768","funder_display_name":"Dartmouth Cancer Center"}],"funders":[{"id":"https://openalex.org/F4320319768","display_name":"Dartmouth Cancer Center","ror":"https://ror.org/044b05b34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225205992.pdf","grobid_xml":"https://content.openalex.org/works/W7225205992.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416449315","https://openalex.org/W2030106234","https://openalex.org/W7225197503","https://openalex.org/W2513583837","https://openalex.org/W2914563055","https://openalex.org/W2147598914","https://openalex.org/W4404534386","https://openalex.org/W4401888873","https://openalex.org/W4214742507","https://openalex.org/W7214217118"],"abstract_inverted_index":{"Background":[0],"Melanoma":[1],"is":[2,36,81,438],"a":[3],"highly":[4,390],"metastatic":[5,391],"form":[6],"of":[7,68,212,241,262,276,289,317,353,366,385],"skin":[8],"cancer":[9],"primarily":[10],"caused":[11],"by":[12,180,416],"ultraviolet":[13],"B":[14],"(UVB)":[15],"radiation.":[16],"UVB":[17,152,165,222,239,269,341,354],"exposure":[18,153,223,240,270,342],"induces":[19],"local":[20],"and":[21,41,43,53,56,74,79,116,127,133,139,146,164,172,186,193,226,230,256,306,337,368,375,377,392,399,423,437],"systemic":[22],"IFN-I":[23,51,72,125,140,201,218,299],"signaling,":[24],"which":[25,92,388],"has":[26],"context-dependent":[27],"roles":[28,365],"in":[29,39,91,118,282,314,343,371],"anti-tumor":[30,147],"immunity.":[31,339],"The":[32],"immune":[33,278,355],"checkpoint":[34,279],"PD-L1":[35,48,61,156],"frequently":[37],"upregulated":[38],"melanoma,":[40,291],"we":[42,292],"others":[44],"have":[45,378],"shown":[46],"tumor-intrinsic":[47],"signals":[49,126,219],"modulate":[50],"responses":[52],"promote":[54,302],"metastasis":[55,80,117,145,171,229,336,376],"treatment":[57,274,384],"resistance.":[58],"However,":[59],"how":[60],"on":[62,142,158,335,357],"melanocytes":[63,159],"(melPD-L1),":[64],"the":[65,232,260,273,318,383,440],"melanoma":[66,77,88,114,144,169,248,265,320,347,373],"cells":[67,185,192],"origin,":[69],"regulates":[70],"UVB-induced":[71,213,297,369],"signaling":[73,202,300],"subsequently":[75],"affects":[76],"development":[78,115,374],"unreported.Methods":[82],"We":[83,120],"developed":[84],"inducible,":[85],"UVB-accelerable":[86],"Nras-mutant":[87],"mouse":[89,287,435],"models":[90,288],"spontaneous":[93],"melanomas":[94],"arise":[95],"from":[96],"PD-L1-replete":[97],"(CTRL":[98],"TNQ61R)":[99,103],"or":[100,206],"PD-L1-deficient":[101],"(melPD-L1KO":[102],"melanocytes,":[104],"along":[105],"with":[106],"derivative":[107],"mT/mG":[108,309],"reporter":[109,311],"TNQ61R":[110,310],"mice":[111,245,312],"to":[112,123,136,204,221,247,301,322],"track":[113],"situ.":[119],"used":[121],"\u03b1IFNAR":[122],"block":[124],"performed":[128],"flow":[129],"cytometry,":[130],"confocal":[131],"microscopy,":[132],"RNA":[134],"sequencing":[135],"investigate":[137],"melPD-L1":[138,210,295,324,367],"effects":[141,334,356],"UVB-accelerated":[143,328],"immunity.Results":[148],"Clinically":[149],"relevant":[150],"acute":[151],"induced":[154],"sustained":[155,351],"upregulation":[157,325],"during":[160,326],"early":[161,327],"melanomagenesis.":[162],"MelPD-L1":[163],"cooperatively":[166],"promoted":[167],"autochthonous":[168,264],"lung":[170,228,257],"an":[173],"immunosuppressive":[174,233],"primary":[175,253],"tumor":[176,249,254],"microenvironment":[177],"(TME),":[178],"characterized":[179],"increased":[181,252],"suppressive":[182],"regulatory":[183],"T":[184,191],"decreased":[187],"cytotoxic":[188],"CD8":[189],"+":[190],"NK":[194],"cells.":[195],"UVB-exposed":[196],"melPD-L1-replete":[197],"tumors":[198],"had":[199],"elevated":[200],"compared":[203],"UVB-na\u00efve":[205],"melPD-L1KO":[207],"tumors,":[208],"indicating":[209],"amplification":[211],"chronic":[214,298],"IFN-Is.":[215],"Strikingly,":[216],"blocking":[217],"prior":[220,246,268],"reduced":[224],"UVB-":[225],"melPD-L1-dependent":[227,333],"reversed":[231],"TME.":[234],"In":[235],"complementary":[236],"transplant":[237],"experiments,":[238],"wild-type":[242],"(WT)":[243],"adult":[244],"challenge":[250],"significantly":[251],"growth":[255],"metastasis,":[258],"phenocopying":[259],"findings":[261],"our":[263,285],"models.":[266],"Further,":[267],"completely":[271],"abolished":[272],"efficacy":[275],"\u03b1PD-1/\u03b1CTLA-4":[277],"blockade":[280],"(ICB)":[281],"melanoma.Conclusions":[283],"Using":[284],"novel":[286,364],"UVB-associated":[290],"demonstrate":[293],"that":[294],"amplifies":[296],"long-term":[303],"TME":[304,321],"immunosuppression":[305],"distant":[307],"metastasis.":[308],"enabled":[313],"situ":[315],"monitoring":[316],"developing":[319],"show":[323],"melanomagenesis,":[329],"potentially":[330],"mediating":[331],"downstream":[332],"anti-melanoma":[338],"Prior":[340],"WT":[344],"adults":[345],"abrogated":[346],"ICB":[348,358],"response,":[349],"showing":[350],"consequences":[352],"efficacy.":[359],"Overall,":[360],"these":[361],"data":[362],"establish":[363],"IFN-Is":[370],"driving":[372],"important":[379],"clinical":[380],"implications":[381],"for":[382,434],"NRAS-mutant":[386],"melanomas,":[387],"are":[389,414],"UVB-associated.Acknowledgements":[393],"NCI":[394,417],"(R01CA292467,":[395],"R01CA202965),":[396],"Gmelich":[397],"chair,":[398],"Guyre":[400],"funds":[401],"supported":[402,406,415],"TJC.":[403],"NIH":[404,424],"T32AI007363":[405],"NS.":[407],"Shared":[408],"resources":[409],"at":[410],"Dartmouth":[411],"Cancer":[412,418],"Center":[413,419],"Support":[420],"Grant":[421],"5P30CA023108":[422],"1S10OD021616.Ethics":[425],"Approval":[426],"This":[427],"study":[428],"obtained":[429],"all":[430],"necessary":[431],"ethics":[432],"approvals":[433],"experiments":[436],"under":[439],"approved":[441],"IACUC":[442],"protocol":[443],"#":[444],"2285.":[445]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-04T00:00:00"}