{"id":"https://openalex.org/W7225205162","doi":"https://doi.org/10.25258/ijddt.16.86s.145","title":"Association of Intraoperative Hemodynamic Instability and Myocardial Injury Biomarkers With Major Adverse Cardiovascular Events After Cardiac Surgery: A Prospective Cohort Study","display_name":"Association of Intraoperative Hemodynamic Instability and Myocardial Injury Biomarkers With Major Adverse Cardiovascular Events After Cardiac Surgery: A Prospective Cohort Study","publication_year":2026,"publication_date":"2026-11-03","ids":{"openalex":"https://openalex.org/W7225205162","doi":"https://doi.org/10.25258/ijddt.16.86s.145"},"language":"en","primary_location":{"id":"doi:10.25258/ijddt.16.86s.145","doi":"https://doi.org/10.25258/ijddt.16.86s.145","is_oa":true,"landing_page_url":"https://doi.org/10.25258/ijddt.16.86s.145","pdf_url":"https://doi.org/10.25258/ijddt.16.86s.145","source":{"id":"https://openalex.org/S4210211336","display_name":"International Journal of Drug Delivery Technology","issn_l":"0975-4415","issn":["0975-4415"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Drug Delivery Technology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.25258/ijddt.16.86s.145","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5151740771","display_name":"Muhammad Yasir Khan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muhammad Yasir Khan","raw_affiliation_strings":["Associate Professor, Department of Cardiac Surgery, Sardar Fateh Muhammad Khan Buzdar Institute of Cardiology, Dera Ghazi Khan, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor, Department of Cardiac Surgery, Sardar Fateh Muhammad Khan Buzdar Institute of Cardiology, Dera Ghazi Khan, Pakistan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085556034","display_name":"Danish Naveed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137562272","display_name":"Ayub Medical College","ror":"https://ror.org/03aypnd11","country_code":"PK","type":"education","lineage":["https://openalex.org/I137562272"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Danish Naveed","raw_affiliation_strings":["Assistant Professor, Department of Cardiovascular Surgery, Ayub Medical College, Abbottabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, Department of Cardiovascular Surgery, Ayub Medical College, Abbottabad, Pakistan","institution_ids":["https://openalex.org/I137562272"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076167181","display_name":"Noreen Atzaz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Noreen Atzaz","raw_affiliation_strings":["Assistant Professor, Department of Chemical Pathology, Rawal Institute of Health Sciences, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, Department of Chemical Pathology, Rawal Institute of Health Sciences, Pakistan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.89085494,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"86s","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.3589000105857849,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.3589000105857849,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.3118000030517578,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11930","display_name":"Cardiac, Anesthesia and Surgical Outcomes","score":0.30959999561309814,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-adverse-cardiovascular-events","display_name":"major adverse cardiovascular events","score":0.847000002861023},{"id":"https://openalex.org/keywords/cardiac-surgery","display_name":"cardiac surgery","score":0.9470000267028809},{"id":"https://openalex.org/keywords/intraoperative-hemodynamic-instability","display_name":"intraoperative hemodynamic instability","score":0.984000027179718},{"id":"https://openalex.org/keywords/intraoperative-hypotension","display_name":"intraoperative hypotension","score":0.9319999814033508},{"id":"https://openalex.org/keywords/myocardial-injury-markers","display_name":"myocardial injury biomarkers","score":0.9449999928474426},{"id":"https://openalex.org/keywords/high-sensitivity-cardiac-troponin","display_name":"high-sensitivity troponin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/creatine-kinase-mb","display_name":"creatine kinase-MB","score":0.9980000257492065},{"id":"https://openalex.org/keywords/postoperative-cardiovascular-complications","display_name":"postoperative cardiovascular complications","score":0.8889999985694885},{"id":"https://openalex.org/keywords/risk-prediction","display_name":"risk prediction","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2780739214","wikidata":"https://www.wikidata.org/wiki/Q6723023","display_name":"Mace","level":4,"score":0.945900022983551},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9143000245094299},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.7591000199317932},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.6978999972343445},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.623199999332428},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.6035000085830688},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5859000086784363},{"id":"https://openalex.org/C2778789114","wikidata":"https://www.wikidata.org/wiki/Q235007","display_name":"Cardiac surgery","level":2,"score":0.5568000078201294},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.5151000022888184},{"id":"https://openalex.org/C144469398","wikidata":"https://www.wikidata.org/wiki/Q24785650","display_name":"Troponin T","level":3,"score":0.4569000005722046},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4334999918937683},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4302000105381012},{"id":"https://openalex.org/C115725540","wikidata":"https://www.wikidata.org/wiki/Q7846263","display_name":"Troponin I","level":3,"score":0.3871999979019165},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.35910001397132874},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.34880000352859497},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.3382999897003174},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3246999979019165},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.32260000705718994},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.3116999864578247},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3050999939441681},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.301800012588501},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.2939000129699707},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.2833999991416931},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2782000005245209},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.2538999915122986}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.25258/ijddt.16.86s.145","doi":"https://doi.org/10.25258/ijddt.16.86s.145","is_oa":true,"landing_page_url":"https://doi.org/10.25258/ijddt.16.86s.145","pdf_url":"https://doi.org/10.25258/ijddt.16.86s.145","source":{"id":"https://openalex.org/S4210211336","display_name":"International Journal of Drug Delivery Technology","issn_l":"0975-4415","issn":["0975-4415"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Drug Delivery Technology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.25258/ijddt.16.86s.145","doi":"https://doi.org/10.25258/ijddt.16.86s.145","is_oa":true,"landing_page_url":"https://doi.org/10.25258/ijddt.16.86s.145","pdf_url":"https://doi.org/10.25258/ijddt.16.86s.145","source":{"id":"https://openalex.org/S4210211336","display_name":"International Journal of Drug Delivery Technology","issn_l":"0975-4415","issn":["0975-4415"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Drug Delivery Technology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225205162.pdf","grobid_xml":"https://content.openalex.org/works/W7225205162.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W2142823558","https://openalex.org/W2541386048","https://openalex.org/W2809427753","https://openalex.org/W2978771132","https://openalex.org/W2990505687","https://openalex.org/W3023453722","https://openalex.org/W3043031904","https://openalex.org/W3104808192","https://openalex.org/W3134134745","https://openalex.org/W3142863379","https://openalex.org/W4238277289","https://openalex.org/W4309436974","https://openalex.org/W4386898182","https://openalex.org/W4387218540","https://openalex.org/W4387965852","https://openalex.org/W4403284141","https://openalex.org/W4403307286","https://openalex.org/W4407586054"],"related_works":["https://openalex.org/W4296629351","https://openalex.org/W3209591429","https://openalex.org/W7220897222","https://openalex.org/W3046018801","https://openalex.org/W2785763335","https://openalex.org/W7094065248","https://openalex.org/W159462626","https://openalex.org/W2113200241","https://openalex.org/W4412570080","https://openalex.org/W2125918815"],"abstract_inverted_index":{"Background:":[0],"Major":[1],"adverse":[2],"cardiovascular":[3,23,183,206],"events":[4],"(MACE)":[5],"remain":[6],"important":[7],"complications":[8],"following":[9],"cardiac":[10,35,48,79],"surgery.":[11],"Intraoperative":[12,74],"hemodynamic":[13,75],"instability":[14],"and":[15,62,81,142,154,209,214],"myocardial":[16,186],"injury":[17,187],"biomarkers":[18,188],"may":[19,180],"contribute":[20],"to":[21,28,71,203],"postoperative":[22,77,182,215],"risk.":[24],"This":[25,39],"study":[26,43],"aimed":[27],"evaluate":[29],"their":[30],"association":[31],"with":[32,163],"MACE":[33,90,104,119,134],"among":[34,116],"surgical":[36],"patients.":[37],"Methods:":[38],"prospective":[40,195],"observational":[41],"cohort":[42],"included":[44],"120":[45],"patients":[46,108,117],"undergoing":[47],"surgery":[49],"at":[50],"Sardar":[51],"Fateh":[52],"Muhammad":[53],"Khan":[54],"Buzdar":[55],"Institute":[56],"of":[57],"Cardiology,":[58],"Dera":[59],"Ghazi":[60],"Khan,":[61],"Ayub":[63],"Medical":[64],"College,":[65],"Abbottabad,":[66],"Pakistan,":[67],"from":[68],"January":[69,72],"2025":[70],"2026.":[73],"parameters,":[76],"high-sensitivity":[78],"troponin,":[80],"creatine":[82],"kinase-MB":[83],"were":[84,87,112,159],"evaluated.":[85],"Patients":[86],"monitored":[88],"for":[89],"during":[91],"30-day":[92],"followup.":[93],"Multivariable":[94],"logistic":[95],"regression":[96],"assessed":[97],"associated":[98,162],"factors.":[99],"Results:":[100],"In":[101],"the":[102,133],"dataset,":[103],"occurred":[105],"in":[106,132],"32":[107],"(26.7%).":[109],"Hypotensive":[110],"episodes":[111,179],"significantly":[113],"more":[114],"frequent":[115],"experiencing":[118],"(2.9":[120],"\u00b1":[121,125],"1.7":[122],"versus":[123],"2.2":[124],"1.6;":[126],"p=0.044).":[127],"Hypotension":[128,149],"duration":[129,150],"was":[130],"greater":[131],"group,":[135],"although":[136],"statistically":[137],"insignificant":[138],"(p=0.073).":[139],"Postoperative":[140],"troponin":[141,155],"CK-MB":[143],"concentrations":[144],"showed":[145],"no":[146],"significant":[147],"differences.":[148],"(aOR":[151,156],"1.32;":[152],"p=0.118)":[153],"0.95;":[157],"p=0.685)":[158],"not":[160],"independently":[161],"MACE.":[164],"The":[165],"combined":[166],"predictive":[167,192],"model":[168],"demonstrated":[169,189],"limited":[170,190],"discrimination":[171],"(AUC=0.620).":[172],"Conclusion:":[173],"findings":[174],"suggest":[175],"that":[176],"intraoperative":[177],"hypotensive":[178],"accompany":[181],"complications,":[184],"whereas":[185],"independent":[191],"value.":[193],"Larger":[194],"investigations":[196],"using":[197],"observed":[198],"clinical":[199],"data":[200],"are":[201],"necessary":[202],"establish":[204],"reliable":[205],"risk":[207],"predictors":[208],"improve":[210],"perioperative":[211],"patient":[212],"assessment":[213],"monitoring":[216],"strategies.":[217]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-04T00:00:00"}
