{"id":"https://openalex.org/W7225201763","doi":"https://doi.org/10.3389/fragi.2026.1984937","title":"Transcription\u2013replication conflicts at telomeres: the emerging role of telomeric repeat-containing RNA (TERRA) R-loops in genome instability and cancer","display_name":"Transcription\u2013replication conflicts at telomeres: the emerging role of telomeric repeat-containing RNA (TERRA) R-loops in genome instability and cancer","publication_year":2026,"publication_date":"2026-11-03","ids":{"openalex":"https://openalex.org/W7225201763","doi":"https://doi.org/10.3389/fragi.2026.1984937"},"language":"en","primary_location":{"id":"doi:10.3389/fragi.2026.1984937","doi":"https://doi.org/10.3389/fragi.2026.1984937","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fragi.2026.1984937","pdf_url":"https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2026.1984937/pdf","source":{"id":"https://openalex.org/S4210191507","display_name":"Frontiers in Aging","issn_l":"2673-6217","issn":["2673-6217"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2026.1984937/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094743733","display_name":"Sibin Nambidi","orcid":"https://orcid.org/0009-0003-0866-6843","observed_orcids":["https://orcid.org/0009-0003-0866-6843"]},"institutions":[{"id":"https://openalex.org/I220840466","display_name":"Chettinad Academy of Research and Education","ror":"https://ror.org/0394w2w14","country_code":"IN","type":"education","lineage":["https://openalex.org/I220840466"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sibin Nambidi","raw_affiliation_strings":["Medical Biotechnology Lab, Faculty of Allied and Healthcare Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Biotechnology Lab, Faculty of Allied and Healthcare Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE)","institution_ids":["https://openalex.org/I220840466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119531090","display_name":"Neeharika Sara Sennie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I220840466","display_name":"Chettinad Academy of Research and Education","ror":"https://ror.org/0394w2w14","country_code":"IN","type":"education","lineage":["https://openalex.org/I220840466"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Neeharika Sara Sennie","raw_affiliation_strings":["Medical Biotechnology Lab, Faculty of Allied and Healthcare Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Biotechnology Lab, Faculty of Allied and Healthcare Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE)","institution_ids":["https://openalex.org/I220840466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107608912","display_name":"Sneha Pallatt","orcid":"https://orcid.org/0009-0008-5649-1597","observed_orcids":["https://orcid.org/0009-0008-5649-1597"]},"institutions":[{"id":"https://openalex.org/I220840466","display_name":"Chettinad Academy of Research and Education","ror":"https://ror.org/0394w2w14","country_code":"IN","type":"education","lineage":["https://openalex.org/I220840466"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sneha Pallatt","raw_affiliation_strings":["Medical Biotechnology Lab, Faculty of Allied and Healthcare Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Biotechnology Lab, Faculty of Allied and Healthcare Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE)","institution_ids":["https://openalex.org/I220840466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024625640","display_name":"Antara Banerjee","orcid":"https://orcid.org/0000-0002-5519-6878","observed_orcids":["https://orcid.org/0000-0002-5519-6878"]},"institutions":[{"id":"https://openalex.org/I220840466","display_name":"Chettinad Academy of Research and Education","ror":"https://ror.org/0394w2w14","country_code":"IN","type":"education","lineage":["https://openalex.org/I220840466"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Antara Banerjee","raw_affiliation_strings":["Medical Biotechnology Lab, Faculty of Allied and Healthcare Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Biotechnology Lab, Faculty of Allied and Healthcare Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE)","institution_ids":["https://openalex.org/I220840466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042040126","display_name":"Marco Scarpa","orcid":"https://orcid.org/0000-0002-0217-6523","observed_orcids":["https://orcid.org/0000-0002-0217-6523"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Scarpa","raw_affiliation_strings":["Department of Surgical, Oncological and Gastroenterological Sciences (DISCOG), University of Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical, Oncological and Gastroenterological Sciences (DISCOG), University of Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031399876","display_name":"Surajit Pathak","orcid":"https://orcid.org/0000-0002-7306-1272","observed_orcids":["https://orcid.org/0000-0002-7306-1272"]},"institutions":[{"id":"https://openalex.org/I220840466","display_name":"Chettinad Academy of Research and Education","ror":"https://ror.org/0394w2w14","country_code":"IN","type":"education","lineage":["https://openalex.org/I220840466"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Surajit Pathak","raw_affiliation_strings":["Medical Biotechnology Lab, Faculty of Allied and Healthcare Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Biotechnology Lab, Faculty of Allied and Healthcare Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE)","institution_ids":["https://openalex.org/I220840466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060350709","display_name":"Asim K. Duttaroy","orcid":"https://orcid.org/0000-0003-1619-3778","observed_orcids":["https://orcid.org/0000-0003-1619-3778"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Asim K. Duttaroy","raw_affiliation_strings":["Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo","institution_ids":["https://openalex.org/I184942183"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5031399876","https://openalex.org/A5060350709"],"corresponding_institution_ids":["https://openalex.org/I184942183","https://openalex.org/I220840466"],"apc_list":{"value":2550,"currency":"CHF","value_usd":3077},"apc_paid":{"value":2550,"currency":"CHF","value_usd":3077},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85363831,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomeres","display_name":"telomeres","score":0.796999990940094},{"id":"https://openalex.org/keywords/terra","display_name":"Terra","score":0.8429999947547913},{"id":"https://openalex.org/keywords/rna-dna-hybrids","display_name":"RNA-DNA hybrids","score":0.871999979019165},{"id":"https://openalex.org/keywords/r-loops","display_name":"R-loops","score":0.9819999933242798},{"id":"https://openalex.org/keywords/transcription-replication-conflict","display_name":"transcription-replication conflict","score":0.9879999756813049},{"id":"https://openalex.org/keywords/replication-stress","display_name":"replication stress","score":0.7689999938011169},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.8100000023841858},{"id":"https://openalex.org/keywords/break-induced-replication","display_name":"break-induced replication","score":0.968999981880188},{"id":"https://openalex.org/keywords/telomere-dysfunction","display_name":"telomere dysfunction","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8820000290870667},{"id":"https://openalex.org/keywords/alternative-lengthening-of-telomeres","display_name":"alternative lengthening of telomeres","score":0.9900000095367432},{"id":"https://openalex.org/keywords/telomere-recombination","display_name":"telomere recombination","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.9334999918937683},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7383999824523926},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.7281000018119812},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5968000292778015},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5849000215530396},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5026000142097473},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.47870001196861267},{"id":"https://openalex.org/C60449816","wikidata":"https://www.wikidata.org/wiki/Q5113903","display_name":"Chromosomal fragile site","level":4,"score":0.46869999170303345},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.43320000171661377},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.43160000443458557},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.43140000104904175},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.3718999922275543},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3614000082015991},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.34880000352859497},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.335999995470047},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.29980000853538513},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2946999967098236},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.29350000619888306},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.2816999852657318},{"id":"https://openalex.org/C78604142","wikidata":"https://www.wikidata.org/wiki/Q1640582","display_name":"Fight-or-flight response","level":3,"score":0.2809000015258789},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.26840001344680786},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2676999866962433},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.2623000144958496},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2567000091075897},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.25130000710487366}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fragi.2026.1984937","doi":"https://doi.org/10.3389/fragi.2026.1984937","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fragi.2026.1984937","pdf_url":"https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2026.1984937/pdf","source":{"id":"https://openalex.org/S4210191507","display_name":"Frontiers in Aging","issn_l":"2673-6217","issn":["2673-6217"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fragi.2026.1984937","doi":"https://doi.org/10.3389/fragi.2026.1984937","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fragi.2026.1984937","pdf_url":"https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2026.1984937/pdf","source":{"id":"https://openalex.org/S4210191507","display_name":"Frontiers in Aging","issn_l":"2673-6217","issn":["2673-6217"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327266","display_name":"Chettinad Academy of Research and Education","ror":"https://ror.org/0394w2w14"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225201763.pdf","grobid_xml":"https://content.openalex.org/works/W7225201763.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W1557728494","https://openalex.org/W1836973230","https://openalex.org/W1984373702","https://openalex.org/W1998204932","https://openalex.org/W1999626396","https://openalex.org/W2001323937","https://openalex.org/W2007433513","https://openalex.org/W2013770032","https://openalex.org/W2014324433","https://openalex.org/W2021881561","https://openalex.org/W2035132012","https://openalex.org/W2040206306","https://openalex.org/W2040860750","https://openalex.org/W2050293032","https://openalex.org/W2059971436","https://openalex.org/W2060955969","https://openalex.org/W2065529250","https://openalex.org/W2103694115","https://openalex.org/W2105006322","https://openalex.org/W2107332686","https://openalex.org/W2110761051","https://openalex.org/W2117692326","https://openalex.org/W2124577886","https://openalex.org/W2128956771","https://openalex.org/W2142453523","https://openalex.org/W2150953804","https://openalex.org/W2152613205","https://openalex.org/W2154968223","https://openalex.org/W2161232591","https://openalex.org/W2187574279","https://openalex.org/W2258427811","https://openalex.org/W2321647501","https://openalex.org/W2394983080","https://openalex.org/W2514514743","https://openalex.org/W2557435811","https://openalex.org/W2577194681","https://openalex.org/W2595332769","https://openalex.org/W2623921962","https://openalex.org/W2625903386","https://openalex.org/W2733026364","https://openalex.org/W2743251723","https://openalex.org/W2793604187","https://openalex.org/W2797725119","https://openalex.org/W2798187866","https://openalex.org/W2800422008","https://openalex.org/W2800706415","https://openalex.org/W2892224724","https://openalex.org/W2913346540","https://openalex.org/W2922166925","https://openalex.org/W2948327089","https://openalex.org/W2987058388","https://openalex.org/W2995962979","https://openalex.org/W3021844846","https://openalex.org/W3033161347","https://openalex.org/W3092346193","https://openalex.org/W3093002718","https://openalex.org/W3093230859","https://openalex.org/W3108385506","https://openalex.org/W3110151758","https://openalex.org/W3134355526","https://openalex.org/W3135169426","https://openalex.org/W3151668984","https://openalex.org/W3195966954","https://openalex.org/W3216241483","https://openalex.org/W4220908212","https://openalex.org/W4224043339","https://openalex.org/W4225316996","https://openalex.org/W4248393660","https://openalex.org/W4250543592","https://openalex.org/W4296793936","https://openalex.org/W4306852054","https://openalex.org/W4353084594","https://openalex.org/W4360862296","https://openalex.org/W4362668689","https://openalex.org/W4365142061","https://openalex.org/W4385649227","https://openalex.org/W4387164465","https://openalex.org/W4387167010","https://openalex.org/W4387638488","https://openalex.org/W4387643990","https://openalex.org/W4392517141","https://openalex.org/W4392812377","https://openalex.org/W4394688535","https://openalex.org/W4400696416","https://openalex.org/W4404639230","https://openalex.org/W4408507897","https://openalex.org/W4410747673","https://openalex.org/W4411161738","https://openalex.org/W4412068609","https://openalex.org/W4412100393","https://openalex.org/W4412174394","https://openalex.org/W4413138910","https://openalex.org/W7117923374","https://openalex.org/W7118594128"],"related_works":["https://openalex.org/W4392517141","https://openalex.org/W4362668689","https://openalex.org/W3195966954","https://openalex.org/W1997919779","https://openalex.org/W4412068609","https://openalex.org/W4402945939","https://openalex.org/W3166992506","https://openalex.org/W6967241423","https://openalex.org/W7213563415","https://openalex.org/W4319869459"],"abstract_inverted_index":{"Telomeres":[0],"are":[1,6],"complex":[2],"chromosomal":[3],"components":[4],"that":[5,53],"crucial":[7],"for":[8],"genome":[9,57],"integrity":[10],"but":[11,32],"frequently":[12],"experience":[13],"replication":[14,64,72],"stress":[15],"due":[16],"to":[17,47,63,91,107],"their":[18],"repetitive,":[19],"G-rich":[20],"nature":[21],"and":[22,74,81],"active":[23],"transcription.":[24],"TERRA":[25],"is":[26,33],"a":[27,35,61],"mediator":[28],"of":[29,38,71,101],"telomere":[30,82,110],"homeostasis":[31],"also":[34],"causative":[36],"factor":[37],"RNA-DNA":[39],"hybrid":[40],"(R-loop)":[41],"formation,":[42],"which":[43],"can":[44,58],"give":[45],"rise":[46],"transcription-replication":[48],"conflicts":[49],"(TRCs).":[50],"Telomeric":[51],"R-loops":[52],"persist":[54],"in":[55,76,89],"the":[56],"act":[59],"as":[60],"barrier":[62],"fork":[65],"movement,":[66],"cause":[67],"reversal":[68],"or":[69],"collapse":[70],"forks,":[73],"result":[75],"fragile":[77],"telomeres,":[78],"break-induced":[79],"replication,":[80],"dysfunction.":[83],"Although":[84],"normal":[85],"cells":[86],"undergo":[87],"senescence":[88],"response":[90],"this":[92],"stress,":[93],"cancer":[94],"cells,":[95],"especially":[96],"those":[97],"with":[98],"alternative":[99],"lengthening":[100],"telomeres":[102],"(ALT),":[103],"exploit":[104],"telomeric":[105],"TRCs":[106],"facilitate":[108],"recombination-mediated":[109],"elongation.":[111]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-04T00:00:00"}