{"id":"https://openalex.org/W7225201554","doi":"https://doi.org/10.1021/acssuschemeng.6c08222","title":"Transition-Metal- and Light-Free C\u2013H (Trideutero)methylation of Quinoxalones Using (Deuterated) DMSO","display_name":"Transition-Metal- and Light-Free C\u2013H (Trideutero)methylation of Quinoxalones Using (Deuterated) DMSO","publication_year":2026,"publication_date":"2026-11-03","ids":{"openalex":"https://openalex.org/W7225201554","doi":"https://doi.org/10.1021/acssuschemeng.6c08222"},"language":"en","primary_location":{"id":"doi:10.1021/acssuschemeng.6c08222","doi":"https://doi.org/10.1021/acssuschemeng.6c08222","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acssuschemeng.6c08222","pdf_url":null,"source":{"id":"https://openalex.org/S2502047864","display_name":"ACS Sustainable Chemistry & Engineering","issn_l":"2168-0485","issn":["2168-0485"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Sustainable Chemistry & Engineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029174279","display_name":"Sangita Dattatray Shinde","orcid":"https://orcid.org/0000-0002-1715-7376","observed_orcids":["https://orcid.org/0000-0002-1715-7376"]},"institutions":[{"id":"https://openalex.org/I4210102411","display_name":"National Institute of Pharmaceutical Education and Research - Ahmedabad","ror":"https://ror.org/01dphnv87","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210102411"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sangita Dattatray Shinde","raw_affiliation_strings":["National Institute of Pharmaceutical Education and Research (NIPER) \u2013 Ahmedabad , , Palaj, , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Pharmaceutical Education and Research (NIPER) \u2013 Ahmedabad , , Palaj, , ,","institution_ids":["https://openalex.org/I4210102411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153692685","display_name":"Anusri Debnath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102411","display_name":"National Institute of Pharmaceutical Education and Research - Ahmedabad","ror":"https://ror.org/01dphnv87","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210102411"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anusri Debnath","raw_affiliation_strings":["National Institute of Pharmaceutical Education and Research (NIPER) \u2013 Ahmedabad , , Palaj, , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Pharmaceutical Education and Research (NIPER) \u2013 Ahmedabad , , Palaj, , ,","institution_ids":["https://openalex.org/I4210102411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160519520","display_name":"Babu Guguloth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102411","display_name":"National Institute of Pharmaceutical Education and Research - Ahmedabad","ror":"https://ror.org/01dphnv87","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210102411"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Babu Guguloth","raw_affiliation_strings":["National Institute of Pharmaceutical Education and Research (NIPER) \u2013 Ahmedabad , , Palaj, , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Pharmaceutical Education and Research (NIPER) \u2013 Ahmedabad , , Palaj, , ,","institution_ids":["https://openalex.org/I4210102411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160420925","display_name":"Mayuri Vijay Magar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102411","display_name":"National Institute of Pharmaceutical Education and Research - Ahmedabad","ror":"https://ror.org/01dphnv87","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210102411"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mayuri Vijay Magar","raw_affiliation_strings":["National Institute of Pharmaceutical Education and Research (NIPER) \u2013 Ahmedabad , , Palaj, , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Pharmaceutical Education and Research (NIPER) \u2013 Ahmedabad , , Palaj, , ,","institution_ids":["https://openalex.org/I4210102411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069910183","display_name":"Dinesh Kumar","orcid":"https://orcid.org/0000-0003-2680-881X","observed_orcids":["https://orcid.org/0000-0003-2680-881X"]},"institutions":[{"id":"https://openalex.org/I4210102411","display_name":"National Institute of Pharmaceutical Education and Research - Ahmedabad","ror":"https://ror.org/01dphnv87","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210102411"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Dinesh Kumar","raw_affiliation_strings":["National Institute of Pharmaceutical Education and Research (NIPER) \u2013 Ahmedabad , , Palaj, , ,"],"raw_orcid":"https://orcid.org/0000-0003-2680-881X","affiliations":[{"raw_affiliation_string":"National Institute of Pharmaceutical Education and Research (NIPER) \u2013 Ahmedabad , , Palaj, , ,","institution_ids":["https://openalex.org/I4210102411"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069910183"],"corresponding_institution_ids":["https://openalex.org/I4210102411"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73067869,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10354","display_name":"Catalytic C\u2013H Functionalization Methods","score":0.7211999893188477,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10354","display_name":"Catalytic C\u2013H Functionalization Methods","score":0.7211999893188477,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.09489999711513519,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.02419999986886978,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-h-methylation","display_name":"C\u2013H methylation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dimethyl-sulfoxide","display_name":"dimethyl sulfoxide","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cesium-carbonate","display_name":"cesium carbonate","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cascade-reactions","display_name":"cascade reactions","score":0.6499999761581421},{"id":"https://openalex.org/keywords/green-chemistry","display_name":"green chemistry","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.7696999907493591},{"id":"https://openalex.org/C2777814067","wikidata":"https://www.wikidata.org/wiki/Q1752317","display_name":"Tandem","level":2,"score":0.7225000262260437},{"id":"https://openalex.org/C2778452553","wikidata":"https://www.wikidata.org/wiki/Q407927","display_name":"Dimethyl sulfoxide","level":2,"score":0.7055000066757202},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6811000108718872},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.667900025844574},{"id":"https://openalex.org/C2778448320","wikidata":"https://www.wikidata.org/wiki/Q408395","display_name":"Sulfoxide","level":2,"score":0.5898000001907349},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5472999811172485},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.45329999923706055},{"id":"https://openalex.org/C2991944050","wikidata":"https://www.wikidata.org/wiki/Q36534","display_name":"Reaction conditions","level":3,"score":0.3912999927997589},{"id":"https://openalex.org/C124681953","wikidata":"https://www.wikidata.org/wiki/Q339062","display_name":"Decomposition","level":2,"score":0.31679999828338623},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.28299999237060547},{"id":"https://openalex.org/C58548122","wikidata":"https://www.wikidata.org/wiki/Q838390","display_name":"Cascade reaction","level":3,"score":0.26910001039505005},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.2554999887943268}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acssuschemeng.6c08222","doi":"https://doi.org/10.1021/acssuschemeng.6c08222","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acssuschemeng.6c08222","pdf_url":null,"source":{"id":"https://openalex.org/S2502047864","display_name":"ACS Sustainable Chemistry & Engineering","issn_l":"2168-0485","issn":["2168-0485"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Sustainable Chemistry & Engineering","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1985782619","https://openalex.org/W1987037160","https://openalex.org/W1994318136","https://openalex.org/W2045869022","https://openalex.org/W2057856741","https://openalex.org/W2071328592","https://openalex.org/W2098951988","https://openalex.org/W2170687270","https://openalex.org/W2321381449","https://openalex.org/W2333982792","https://openalex.org/W2522316057","https://openalex.org/W2767579003","https://openalex.org/W2782048540","https://openalex.org/W2783462791","https://openalex.org/W2800189970","https://openalex.org/W2901628001","https://openalex.org/W2909275830","https://openalex.org/W2938459114","https://openalex.org/W2956540645","https://openalex.org/W2964149079","https://openalex.org/W2974890858","https://openalex.org/W2978748556","https://openalex.org/W3012193510","https://openalex.org/W3048732375","https://openalex.org/W3085271405","https://openalex.org/W3134425407","https://openalex.org/W3165282671","https://openalex.org/W3210963342","https://openalex.org/W4200132094","https://openalex.org/W4206552485","https://openalex.org/W4206767245","https://openalex.org/W4220907440","https://openalex.org/W4282934091","https://openalex.org/W4289519809","https://openalex.org/W4379380007","https://openalex.org/W4386597725","https://openalex.org/W4391777913","https://openalex.org/W4392672412","https://openalex.org/W4396512383","https://openalex.org/W4398206513","https://openalex.org/W4399488845","https://openalex.org/W4403130327","https://openalex.org/W4403600678","https://openalex.org/W4409017030","https://openalex.org/W7117303976","https://openalex.org/W7165683171"],"related_works":["https://openalex.org/W4293390651","https://openalex.org/W4413928327","https://openalex.org/W7140281859","https://openalex.org/W7167691370","https://openalex.org/W4411227852","https://openalex.org/W4312106457","https://openalex.org/W2887304743","https://openalex.org/W2908413369","https://openalex.org/W3092162398","https://openalex.org/W2999056907"],"abstract_inverted_index":{"Abstract":[0],"A":[1],"practical":[2],"and":[3,25,34,52,72],"environmentally":[4],"benign":[5],"protocol":[6],"for":[7,40],"the":[8,22,26,38],"C\u2013H":[9,74],"methylation":[10,43],"of":[11],"quinoxalin-2(1H)-ones":[12],"has":[13],"been":[14],"developed":[15],"using":[16,58],"dimethyl":[17],"sulfoxide":[18],"(DMSO)":[19],"as":[20],"both":[21],"methyl":[23],"source":[24],"reaction":[27],"medium.":[28],"Facilitated":[29],"by":[30],"Cs2CO3,":[31],"this":[32],"transition-metal-":[33],"light-free":[35],"approach":[36],"bypasses":[37],"need":[39],"specialized,":[41],"toxic":[42],"reagents":[44],"or":[45],"radical":[46],"initiators.":[47],"The":[48],"method":[49],"is":[50],"scalable":[51],"can":[53,66],"be":[54,67],"extended":[55],"to":[56,69],"C3-trideuteromethylation":[57,71],"DMSO-d6.":[59],"Notably,":[60],"under":[61],"these":[62],"conditions,":[63],"N-benzyl":[64],"quinoxalinones":[65],"programmed":[68],"tandem":[70],"benzylic":[73],"deuteration.":[75]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-04T00:00:00"}