{"id":"https://openalex.org/W7225201001","doi":"https://doi.org/10.1136/bmjopen-2026-126018","title":"RestoreGut - restoration of the gut microbiome after birth by caesarean section: study protocol for a double-blinded, randomised, placebo-controlled trial","display_name":"RestoreGut - restoration of the gut microbiome after birth by caesarean section: study protocol for a double-blinded, randomised, placebo-controlled trial","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225201001","doi":"https://doi.org/10.1136/bmjopen-2026-126018","pmid":"https://pubmed.ncbi.nlm.nih.gov/42971625","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13735317"},"language":"en","primary_location":{"id":"doi:10.1136/bmjopen-2026-126018","doi":"https://doi.org/10.1136/bmjopen-2026-126018","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2026-126018","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/16/11/e126018.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmjopen.bmj.com/content/bmjopen/16/11/e126018.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031646847","display_name":"Kaare Tran\u00e6s","orcid":"https://orcid.org/0000-0002-2107-8523","observed_orcids":["https://orcid.org/0000-0002-2107-8523"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]},{"id":"https://openalex.org/I4210123840","display_name":"Copenhagen Prospective Studies on Asthma in Childhood","ror":"https://ror.org/034zy7551","country_code":"DK","type":"facility","lineage":["https://openalex.org/I4210123840"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kaare Tran\u00e6s","raw_affiliation_strings":["Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark","Department of Food Science, University of Copenhagen, Frederiksberg C, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-2107-8523","affiliations":[{"raw_affiliation_string":"Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802567020","https://openalex.org/I2802582725","https://openalex.org/I4210123840"]},{"raw_affiliation_string":"Department of Food Science, University of Copenhagen, Frederiksberg C, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160493611","display_name":"Nina Nathan Ols\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Nina Nathan Ols\u00e9n","raw_affiliation_strings":["Department of Gynecology, Fertility and Obstetrics, Juliane Marie Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Fertility and Obstetrics, Juliane Marie Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024358012","display_name":"Morten Helms","orcid":"https://orcid.org/0000-0002-1140-0021","observed_orcids":["https://orcid.org/0000-0002-1140-0021"]},"institutions":[{"id":"https://openalex.org/I2801942218","display_name":"Hvidovre Hospital","ror":"https://ror.org/00edrn755","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801942218","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Morten Helms","raw_affiliation_strings":["Department of Infectious Diseases, Copenhagen University Hospital Hvidovre, Hvidovre, Capital Region of Denmark, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Copenhagen University Hospital Hvidovre, Hvidovre, Capital Region of Denmark, Denmark","institution_ids":["https://openalex.org/I2801942218","https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016909807","display_name":"Torben S\u00f8lbeck Rasmussen","orcid":"https://orcid.org/0000-0002-9907-8953","observed_orcids":["https://orcid.org/0000-0002-9907-8953","https://orcid.org/0000-0003-2717-0475"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Torben S\u00f8lbeck Rasmussen","raw_affiliation_strings":["Department of Food Science, University of Copenhagen, Frederiksberg C, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science, University of Copenhagen, Frederiksberg C, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013015252","display_name":"Julie Nyholm Kyvsgaard","orcid":"https://orcid.org/0000-0002-8089-861X","observed_orcids":["https://orcid.org/0000-0002-8089-861X"]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]},{"id":"https://openalex.org/I4210123840","display_name":"Copenhagen Prospective Studies on Asthma in Childhood","ror":"https://ror.org/034zy7551","country_code":"DK","type":"facility","lineage":["https://openalex.org/I4210123840"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Julie Nyholm Kyvsgaard","raw_affiliation_strings":["Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-8089-861X","affiliations":[{"raw_affiliation_string":"Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802567020","https://openalex.org/I2802582725","https://openalex.org/I4210123840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030595289","display_name":"Mona Aarenstrup Karlsen","orcid":"https://orcid.org/0000-0002-2631-5516","observed_orcids":["https://orcid.org/0000-0002-2631-5516"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Mona Aarenstrup Karlsen","raw_affiliation_strings":["Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","Department of Gynecology, Fertility and Obstetrics, Juliane Marie Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Gynecology, Fertility and Obstetrics, Juliane Marie Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056445939","display_name":"Hanne Kristine Hegaard","orcid":"https://orcid.org/0000-0002-7093-0719","observed_orcids":["https://orcid.org/0000-0002-7093-0719"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Hanne Kristine Hegaard","raw_affiliation_strings":["Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","Department of Gynecology, Fertility and Obstetrics, Juliane Marie Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Gynecology, Fertility and Obstetrics, Juliane Marie Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034490180","display_name":"Hengameh Chlo\u00e9 Mirsepasi\u2010Lauridsen","orcid":"https://orcid.org/0000-0002-5883-3262","observed_orcids":["https://orcid.org/0000-0002-5883-3262","https://orcid.org/0000-0002-3351-7407"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801942218","display_name":"Hvidovre Hospital","ror":"https://ror.org/00edrn755","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801942218","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Hengameh Chlo\u00e9 Mirsepasi-Lauridsen","raw_affiliation_strings":["Department of Gastroenterology, Copenhagen University Hospital, Hvidovre, Denmark","Department of Infectious Diseases, Copenhagen University Hospital Hvidovre, Hvidovre, Capital Region of Denmark, Denmark","Department of Public Health, Research Unit for General Practice, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Copenhagen University Hospital, Hvidovre, Denmark","institution_ids":["https://openalex.org/I2801942218","https://openalex.org/I2802567020"]},{"raw_affiliation_string":"Department of Infectious Diseases, Copenhagen University Hospital Hvidovre, Hvidovre, Capital Region of Denmark, Denmark","institution_ids":["https://openalex.org/I2801942218","https://openalex.org/I2802567020"]},{"raw_affiliation_string":"Department of Public Health, Research Unit for General Practice, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036519887","display_name":"Andreas Munk Petersen","orcid":"https://orcid.org/0000-0003-0531-0553","observed_orcids":["https://orcid.org/0000-0003-0531-0553"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2800929696","display_name":"Amager Hospital","ror":"https://ror.org/02g2pz956","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2800929696","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2801942218","display_name":"Hvidovre Hospital","ror":"https://ror.org/00edrn755","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801942218","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Andreas Munk Petersen","raw_affiliation_strings":["Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","Department of Clinical Microbiology, Copenhagen University Hospital \u2013 Amager and Hvidovre, Hvidovre, Denmark","Gastrounit, Medical Section, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Clinical Microbiology, Copenhagen University Hospital \u2013 Amager and Hvidovre, Hvidovre, Denmark","institution_ids":["https://openalex.org/I2800929696","https://openalex.org/I2801942218","https://openalex.org/I2802567020"]},{"raw_affiliation_string":"Gastrounit, Medical Section, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark","institution_ids":["https://openalex.org/I2800929696","https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040342379","display_name":"Lise Aunsholt","orcid":"https://orcid.org/0000-0003-0965-429X","observed_orcids":["https://orcid.org/0000-0003-0965-429X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lise Aunsholt","raw_affiliation_strings":["Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","Department of Neonatal and Paediatric Intensive Care, Copenhagen University Hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Neonatal and Paediatric Intensive Care, Copenhagen University Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050231550","display_name":"Gorm O. Greisen","orcid":"https://orcid.org/0000-0001-8042-3262","observed_orcids":["https://orcid.org/0000-0001-8042-3262"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Gorm Greisen","raw_affiliation_strings":["Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","Department of Neonatal and Paediatric Intensive Care, Copenhagen University Hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Neonatal and Paediatric Intensive Care, Copenhagen University Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089838103","display_name":"Dennis Sandris Nielsen","orcid":"https://orcid.org/0000-0001-8121-1114","observed_orcids":["https://orcid.org/0000-0001-8121-1114"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Dennis Sandris Nielsen","raw_affiliation_strings":["Department of Food Science, University of Copenhagen, Frederiksberg C, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science, University of Copenhagen, Frederiksberg C, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028072132","display_name":"S\u00f8ren Johannes S\u00f8rensen","orcid":"https://orcid.org/0000-0001-6227-9906","observed_orcids":["https://orcid.org/0000-0001-6227-9906"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S\u00f8ren J. S\u00f8rensen","raw_affiliation_strings":["Department of Biology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-6227-9906","affiliations":[{"raw_affiliation_string":"Department of Biology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016173323","display_name":"Urvish Trivedi","orcid":"https://orcid.org/0000-0003-1541-6212","observed_orcids":["https://orcid.org/0000-0003-1541-6212"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Urvish Trivedi","raw_affiliation_strings":["Department of Biology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013346955","display_name":"Bo Chawes","orcid":"https://orcid.org/0000-0001-6846-6243","observed_orcids":["https://orcid.org/0000-0001-6846-6243"]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]},{"id":"https://openalex.org/I4210123840","display_name":"Copenhagen Prospective Studies on Asthma in Childhood","ror":"https://ror.org/034zy7551","country_code":"DK","type":"facility","lineage":["https://openalex.org/I4210123840"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Bo Chawes","raw_affiliation_strings":["Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-6846-6243","affiliations":[{"raw_affiliation_string":"Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802567020","https://openalex.org/I2802582725","https://openalex.org/I4210123840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005675278","display_name":"Klaus B\u00f8nnelykke","orcid":"https://orcid.org/0000-0003-2003-1018","observed_orcids":["https://orcid.org/0000-0003-2003-1018"]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]},{"id":"https://openalex.org/I4210123840","display_name":"Copenhagen Prospective Studies on Asthma in Childhood","ror":"https://ror.org/034zy7551","country_code":"DK","type":"facility","lineage":["https://openalex.org/I4210123840"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Klaus B\u00f8nnelykke","raw_affiliation_strings":["Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802567020","https://openalex.org/I2802582725","https://openalex.org/I4210123840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093318592","display_name":"Nilo Vahman","orcid":"https://orcid.org/0009-0005-3604-2602","observed_orcids":["https://orcid.org/0009-0005-3604-2602"]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]},{"id":"https://openalex.org/I4210123840","display_name":"Copenhagen Prospective Studies on Asthma in Childhood","ror":"https://ror.org/034zy7551","country_code":"DK","type":"facility","lineage":["https://openalex.org/I4210123840"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Nilo Vahman","raw_affiliation_strings":["Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802567020","https://openalex.org/I2802582725","https://openalex.org/I4210123840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050384418","display_name":"Morten Arendt Rasmussen","orcid":"https://orcid.org/0000-0001-7431-5206","observed_orcids":["https://orcid.org/0000-0001-7431-5206"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]},{"id":"https://openalex.org/I4210123840","display_name":"Copenhagen Prospective Studies on Asthma in Childhood","ror":"https://ror.org/034zy7551","country_code":"DK","type":"facility","lineage":["https://openalex.org/I4210123840"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Morten Arendt Rasmussen","raw_affiliation_strings":["Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark","Department of Food Science, University of Copenhagen, Frederiksberg C, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802567020","https://openalex.org/I2802582725","https://openalex.org/I4210123840"]},{"raw_affiliation_string":"Department of Food Science, University of Copenhagen, Frederiksberg C, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003075535","display_name":"Jonathan Thorsen","orcid":"https://orcid.org/0000-0003-0200-0461","observed_orcids":["https://orcid.org/0000-0003-0200-0461"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]},{"id":"https://openalex.org/I4210123840","display_name":"Copenhagen Prospective Studies on Asthma in Childhood","ror":"https://ror.org/034zy7551","country_code":"DK","type":"facility","lineage":["https://openalex.org/I4210123840"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jonathan Thorsen","raw_affiliation_strings":["Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark","Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802567020","https://openalex.org/I2802582725","https://openalex.org/I4210123840"]},{"raw_affiliation_string":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031414961","display_name":"Jakob Stokholm","orcid":"https://orcid.org/0000-0003-4989-9769","observed_orcids":["https://orcid.org/0000-0003-4989-9769"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]},{"id":"https://openalex.org/I4210123840","display_name":"Copenhagen Prospective Studies on Asthma in Childhood","ror":"https://ror.org/034zy7551","country_code":"DK","type":"facility","lineage":["https://openalex.org/I4210123840"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Jakob Stokholm","raw_affiliation_strings":["Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark","Department of Food Science, University of Copenhagen, Frederiksberg C, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802567020","https://openalex.org/I2802582725","https://openalex.org/I4210123840"]},{"raw_affiliation_string":"Department of Food Science, University of Copenhagen, Frederiksberg C, Denmark","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5031414961"],"corresponding_institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801827564","https://openalex.org/I2802567020","https://openalex.org/I2802582725","https://openalex.org/I4210123840"],"apc_list":{"value":1500,"currency":"GBP","value_usd":1839},"apc_paid":{"value":1500,"currency":"GBP","value_usd":1839},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72243537,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"11","first_page":"e126018","last_page":"e126018"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cesarean-section","display_name":"cesarean section","score":0.9710000157356262},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9039999842643738},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/infant-microbiota","display_name":"infant microbiome","score":0.6510000228881836},{"id":"https://openalex.org/keywords/childhood-asthma","display_name":"childhood asthma","score":0.6480000019073486},{"id":"https://openalex.org/keywords/immune-imprinting","display_name":"immune imprinting","score":0.9480000138282776},{"id":"https://openalex.org/keywords/infection-incidence","display_name":"infection incidence","score":0.640999972820282},{"id":"https://openalex.org/keywords/fecal-metabolomics","display_name":"fecal metabolomics","score":0.9350000023841858},{"id":"https://openalex.org/keywords/vaginal-delivery","display_name":"vaginal delivery","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7239999771118164},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5171999931335449},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.49410000443458557},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.4417000114917755},{"id":"https://openalex.org/C2908597655","wikidata":"https://www.wikidata.org/wiki/Q228036","display_name":"Caesarean delivery","level":4,"score":0.426800012588501},{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.4205000102519989},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4117000102996826},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.31869998574256897},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.28540000319480896},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.2754000127315521},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.275299996137619},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.2563999891281128},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2540999948978424},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.25119999051094055}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1136/bmjopen-2026-126018","doi":"https://doi.org/10.1136/bmjopen-2026-126018","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2026-126018","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/16/11/e126018.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13735317","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13735317/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13735317/pdf/bmjopen-16-11.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"Text"},{"id":"pmid:42971625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42971625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ open","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c85138d536fd4373b38551046d602bd4","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c85138d536fd4373b38551046d602bd4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"BMJ Open, Vol 16, Iss 11 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/bmjopen-2026-126018","doi":"https://doi.org/10.1136/bmjopen-2026-126018","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2026-126018","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/16/11/e126018.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Study Protocol","id":"https://openalex.org/study-designs/study-protocol"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225201001.pdf","grobid_xml":"https://content.openalex.org/works/W7225201001.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W2001930923","https://openalex.org/W2077553363","https://openalex.org/W2093274439","https://openalex.org/W2119114528","https://openalex.org/W2148171446","https://openalex.org/W2320903983","https://openalex.org/W2343758687","https://openalex.org/W2550586225","https://openalex.org/W2782017756","https://openalex.org/W2907954911","https://openalex.org/W2965461923","https://openalex.org/W3086214339","https://openalex.org/W3105035345","https://openalex.org/W3155344935","https://openalex.org/W3159504416","https://openalex.org/W3166989839","https://openalex.org/W3179542223","https://openalex.org/W3200865010","https://openalex.org/W3204641172","https://openalex.org/W4297924154","https://openalex.org/W4310663915","https://openalex.org/W4321611856","https://openalex.org/W4375856487","https://openalex.org/W4381804761","https://openalex.org/W4391539951","https://openalex.org/W4399592629","https://openalex.org/W4400181714","https://openalex.org/W4400476999"],"related_works":["https://openalex.org/W2399905487","https://openalex.org/W6939715207","https://openalex.org/W3174257901","https://openalex.org/W4407341299","https://openalex.org/W4295431300","https://openalex.org/W2276953362","https://openalex.org/W7204813004","https://openalex.org/W6893268523","https://openalex.org/W7160082391","https://openalex.org/W3086214339"],"abstract_inverted_index":{"Introduction":[0],"Birth":[1],"by":[2],"caesarean":[3],"section":[4],"(CS)":[5],"is":[6,50,139],"associated":[7],"with":[8],"early":[9],"gut":[10,31,160],"microbiome":[11,129,142,161],"perturbations":[12],"and":[13,41,47,60,83,114,116,121,126,147,162,190,199,211,242,250],"an":[14],"increased":[15],"risk":[16],"of":[17,173,183,192,204,229],"childhood":[18],"asthma,":[19],"likely":[20],"reflecting":[21],"long-term":[22],"immune":[23],"imprinting.":[24],"This":[25,213],"trial":[26,55,214,244],"aims":[27],"to":[28,69,102,202],"restore":[29],"the":[30,77,145,151,170,180,196,219,226,243,251],"microbiota":[32,38],"in":[33,76,141,159,176,186,195,225],"CS-born":[34,59,65],"infants":[35,66],"through":[36,239],"faecal":[37,42,187],"transplantation":[39,44],"(FMT)":[40],"virome":[43,163],"(FVT).":[45],"Methods":[46],"analysis":[48],"RestoreGut":[49],"a":[51,97,205],"double-blinded,":[52],"randomised,":[53],"placebo-controlled":[54],"enrolling":[56],"60":[57],"elective":[58],"20":[61],"vaginally":[62,206],"born":[63,207],"infants.":[64],"are":[67,85,108],"randomised":[68],"receive":[70],"maternal":[71,89],"FMT,":[72,197],"FVT":[73,198],"or":[74],"placebo":[75,148,200],"first":[78,171,181],"hours":[79],"after":[80,124],"birth.":[81],"FMTs":[82],"FVTs":[84],"derived":[86],"from":[87,218],"pathogen-screened":[88],"stool":[90,106],"samples":[91,107],"collected":[92,109],"during":[93,169,179],"late":[94],"pregnancy,":[95],"using":[96,133],"novel":[98],"bacterial":[99],"enumeration":[100],"technique":[101],"standardise":[103],"dosing.":[104],"Infant":[105],"on":[110,221],"days":[111],"1,":[112,118],"3":[113],"7,":[115],"at":[117,150],"3,":[119],"6":[120],"12":[122],"months":[123],"birth":[125],"analysed":[127],"for":[128],"composition":[130,143,164],"over":[131],"time":[132],"metagenomic":[134],"sequencing.":[135],"The":[136,234],"primary":[137],"outcome":[138],"differences":[140,158,175,185],"between":[144],"treatment":[146],"groups":[149,201],"1-week":[152],"timepoint.":[153],"Secondary":[154],"outcomes":[155],"include":[156],"longitudinal":[157],"across":[165],"all":[166],"subsequent":[167],"timepoints":[168],"year":[172,182],"life,":[174,184],"infection":[177],"incidence":[178],"metabolomic":[188],"profiles":[189],"comparisons":[191],"infant":[193],"microbiomes":[194],"those":[203],"reference":[208],"cohort.":[209],"Ethics":[210,224],"dissemination":[212],"has":[215],"received":[216],"approval":[217],"Committees":[220],"Health":[222],"Research":[223],"Capital":[227],"Region":[228],"Denmark":[230],"(Approval":[231],"ID":[232],"H-24002284).":[233],"results":[235],"will":[236],"be":[237],"disseminated":[238],"peer-reviewed":[240],"publications":[241],"website,":[245],"targeting":[246],"both":[247],"scientific":[248],"audiences":[249],"general":[252],"public.":[253],"Trial":[254],"registration":[255],"number":[256],"NCT06264219.":[257]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-04T00:00:00"}