{"id":"https://openalex.org/W7225200567","doi":"https://doi.org/10.3390/microorganisms14112497","title":"Inactivated Lactiplantibacillus plantarum SCS2 Attenuates STZ-Induced Oxidative Stress via the lncRNA MEG3/STIM1 Axis","display_name":"Inactivated Lactiplantibacillus plantarum SCS2 Attenuates STZ-Induced Oxidative Stress via the lncRNA MEG3/STIM1 Axis","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225200567","doi":"https://doi.org/10.3390/microorganisms14112497"},"language":"en","primary_location":{"id":"doi:10.3390/microorganisms14112497","doi":"https://doi.org/10.3390/microorganisms14112497","is_oa":true,"landing_page_url":"https://doi.org/10.3390/microorganisms14112497","pdf_url":null,"source":{"id":"https://openalex.org/S4210222090","display_name":"Microorganisms","issn_l":"2076-2607","issn":["2076-2607"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microorganisms","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/microorganisms14112497","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078302515","display_name":"Pu Wei","orcid":"https://orcid.org/0009-0001-1512-8627","observed_orcids":["https://orcid.org/0009-0001-1512-8627"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Pu","raw_affiliation_strings":["School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101735271","display_name":"Ting Yuan","orcid":"https://orcid.org/0000-0003-2137-336X","observed_orcids":["https://orcid.org/0000-0003-2137-336X"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Yuan","raw_affiliation_strings":["School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160559549","display_name":"Ziying Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziying Zheng","raw_affiliation_strings":["School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160400897","display_name":"Ying Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zhang","raw_affiliation_strings":["School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076264146","display_name":"Xiao Meng","orcid":"https://orcid.org/0000-0003-2101-9483","observed_orcids":["https://orcid.org/0000-0003-2101-9483"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao Meng","raw_affiliation_strings":["School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"],"raw_orcid":"https://orcid.org/0000-0003-2101-9483","affiliations":[{"raw_affiliation_string":"School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004473957","display_name":"Lishi Jiang","orcid":"https://orcid.org/0000-0002-2223-7979","observed_orcids":["https://orcid.org/0000-0002-2223-7979"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lishi Jiang","raw_affiliation_strings":["School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China","institution_ids":["https://openalex.org/I53411278"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004473957","https://openalex.org/A5076264146"],"corresponding_institution_ids":["https://openalex.org/I53411278"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82197699,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"11","first_page":"2497","last_page":"2497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.5454000234603882,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.5454000234603882,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.23880000412464142,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.057100001722574234,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9890000224113464},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.925000011920929},{"id":"https://openalex.org/keywords/meg3","display_name":"MEG3","score":0.878000020980835},{"id":"https://openalex.org/keywords/stromal-interaction-molecule-1","display_name":"STIM1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.7820000052452087},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9350000023841858},{"id":"https://openalex.org/keywords/store-operated-calcium-entry","display_name":"store-operated calcium entry","score":0.925000011920929},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/chop","display_name":"CHOP","score":0.8600000143051147},{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":0.9990000128746033},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9160000085830688},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8669999837875366},{"id":"https://openalex.org/keywords/ins-1-cells","display_name":"INS-1 cells","score":0.8259999752044678},{"id":"https://openalex.org/keywords/pancreatic-injury","display_name":"pancreatic injury","score":0.6190000176429749},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.972000002861023}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7633000016212463},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.565500020980835},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5576000213623047},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5202000141143799},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4625000059604645},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4489000141620636},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.4447000026702881},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.4198000133037567},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.40290001034736633},{"id":"https://openalex.org/C162740809","wikidata":"https://www.wikidata.org/wiki/Q15334560","display_name":"STIM1","level":3,"score":0.37560001015663147},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.3698999881744385},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.3619000017642975},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.35659998655319214},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3474000096321106},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.33489999175071716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.311599999666214},{"id":"https://openalex.org/C2780967304","wikidata":"https://www.wikidata.org/wiki/Q246156","display_name":"Cytoprotection","level":3,"score":0.2944999933242798},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.2897999882698059},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28610000014305115},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.2838999927043915},{"id":"https://openalex.org/C2779701627","wikidata":"https://www.wikidata.org/wiki/Q207051","display_name":"Taurine","level":3,"score":0.27129998803138733},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.2705000042915344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2703999876976013},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.2671999931335449},{"id":"https://openalex.org/C87975464","wikidata":"https://www.wikidata.org/wiki/Q910704","display_name":"Calcium metabolism","level":3,"score":0.2506999969482422}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/microorganisms14112497","doi":"https://doi.org/10.3390/microorganisms14112497","is_oa":true,"landing_page_url":"https://doi.org/10.3390/microorganisms14112497","pdf_url":null,"source":{"id":"https://openalex.org/S4210222090","display_name":"Microorganisms","issn_l":"2076-2607","issn":["2076-2607"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microorganisms","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/microorganisms14112497","doi":"https://doi.org/10.3390/microorganisms14112497","is_oa":true,"landing_page_url":"https://doi.org/10.3390/microorganisms14112497","pdf_url":null,"source":{"id":"https://openalex.org/S4210222090","display_name":"Microorganisms","issn_l":"2076-2607","issn":["2076-2607"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microorganisms","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329861","display_name":"Natural Science Foundation of Sichuan Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W315390173","https://openalex.org/W1518120013","https://openalex.org/W1743153984","https://openalex.org/W1890772623","https://openalex.org/W1905283186","https://openalex.org/W1979959179","https://openalex.org/W1998666012","https://openalex.org/W2010290591","https://openalex.org/W2020708758","https://openalex.org/W2025891649","https://openalex.org/W2029191844","https://openalex.org/W2088012387","https://openalex.org/W2096012966","https://openalex.org/W2101586949","https://openalex.org/W2108250096","https://openalex.org/W2121605483","https://openalex.org/W2125871871","https://openalex.org/W2136575869","https://openalex.org/W2145869245","https://openalex.org/W2490120783","https://openalex.org/W2508596879","https://openalex.org/W2509539134","https://openalex.org/W2518040164","https://openalex.org/W2567115140","https://openalex.org/W2584561009","https://openalex.org/W2791041977","https://openalex.org/W2809830861","https://openalex.org/W2885527294","https://openalex.org/W2888394101","https://openalex.org/W2895438388","https://openalex.org/W2955926019","https://openalex.org/W2968358279","https://openalex.org/W2993695315","https://openalex.org/W3020528808","https://openalex.org/W3026813733","https://openalex.org/W3084049261","https://openalex.org/W3111703679","https://openalex.org/W3185671904","https://openalex.org/W3194189363","https://openalex.org/W4200017567","https://openalex.org/W4224987851","https://openalex.org/W4306911633","https://openalex.org/W4307229478","https://openalex.org/W4308867375","https://openalex.org/W4311509260","https://openalex.org/W4315647211","https://openalex.org/W4317568321","https://openalex.org/W4319159321","https://openalex.org/W4327811419","https://openalex.org/W4367834920","https://openalex.org/W4379798282","https://openalex.org/W4381570218","https://openalex.org/W4387058300","https://openalex.org/W4388836785","https://openalex.org/W4396952094","https://openalex.org/W4399055462","https://openalex.org/W4400246198","https://openalex.org/W4402976760","https://openalex.org/W4404740892","https://openalex.org/W4405691833","https://openalex.org/W4405814643","https://openalex.org/W4408808887","https://openalex.org/W4414923241","https://openalex.org/W7128535430"],"related_works":["https://openalex.org/W4307643076","https://openalex.org/W4386889741","https://openalex.org/W4281886338","https://openalex.org/W4296327610","https://openalex.org/W3161204753","https://openalex.org/W4407867969","https://openalex.org/W3185573489","https://openalex.org/W2964771954","https://openalex.org/W4402034920","https://openalex.org/W2087982280"],"abstract_inverted_index":{"Type":[0],"2":[1],"diabetes":[2],"(T2D)":[3],"is":[4],"a":[5,14],"major":[6],"public":[7],"health":[8],"concern,":[9],"and":[10,26,44,62,76,91,101,108,114,147,151,158,161,164,193,199],"oxidative":[11,37,57,152,184],"stress":[12,38],"plays":[13],"critical":[15],"role":[16],"in":[17,39,49,59,66,167,209],"its":[18],"pathogenesis.":[19],"This":[20],"study":[21],"investigated":[22],"the":[23,207,213],"protective":[24,187],"effects":[25,188],"underlying":[27,214],"mechanisms":[28],"of":[29],"pretreatment":[30],"with":[31,140,186],"inactivated":[32,134,177],"Lactiplantibacillus":[33],"plantarum":[34,54,136,179],"SCS2":[35,55,137,180],"against":[36,182],"streptozotocin":[40],"(STZ)-treated":[41],"INS-1":[42,60],"cells":[43,61],"STZ/high-fat":[45],"diet":[46],"(HFD)\u2013induced":[47],"T2D":[48,64],"C57BL/6J":[50],"mice.":[51,67],"Inactivated":[52],"L.":[53,135,178],"alleviated":[56],"damage":[58],"delayed":[63],"development":[65],"In":[68,132],"vitro,":[69],"treatment":[70],"reduced":[71,123,200],"intracellular":[72],"reactive":[73],"oxygen":[74],"species":[75],"malondialdehyde":[77],"levels,":[78],"enhanced":[79],"antioxidant":[80],"enzyme":[81],"activities,":[82],"attenuated":[83,148],"endoplasmic":[84],"reticulum":[85],"(ER)":[86],"swelling,":[87],"restored":[88],"calcium":[89,93,197],"homeostasis":[90],"store-operated":[92],"entry,":[94],"increased":[95,156,191],"maternally":[96],"expressed":[97],"gene":[98],"3":[99],"(MEG3)":[100],"stromal":[102],"interaction":[103],"molecule":[104],"1":[105],"(STIM1)":[106],"expression,":[107,125,195,211],"decreased":[109],"C/EBP":[110],"homologous":[111],"protein":[112,116],"(CHOP)":[113],"glucose-regulated":[115],"78":[117],"(GRP78)":[118],"expression.":[119],"MEG3":[120,128,157,192,203],"knockdown":[121],"significantly":[122],"STIM1":[124,159,194,210],"suggesting":[126],"that":[127,176],"may":[129,204],"regulate":[130],"STIM1.":[131],"vivo,":[133],"was":[138],"associated":[139],"lower":[141],"body":[142],"weight,":[143],"improved":[144,196],"glucose":[145],"homeostasis,":[146,198],"pancreatic":[149,168],"injury":[150],"stress.":[153,202],"It":[154],"also":[155],"expression":[160,166],"suppressed":[162],"CHOP":[163],"GRP78":[165],"tissue":[169],"(p":[170],"<":[171],"0.05).":[172],"These":[173],"findings":[174],"suggest":[175],"protects":[181],"STZ-induced":[183],"stress,":[185],"accompanied":[189],"by":[190],"ER":[201],"contribute":[205],"to":[206],"changes":[208],"although":[212],"molecular":[215],"mechanism":[216],"remains":[217],"unresolved.":[218]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-04T00:00:00"}
