{"id":"https://openalex.org/W7225200231","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0811","title":"811 AR166, a novel tri-specific immunocytokine, overcomes anti-PD-1 resistance by delivering cis-acting IL-2v via dual PD-1 and LAG-3 targeting","display_name":"811 AR166, a novel tri-specific immunocytokine, overcomes anti-PD-1 resistance by delivering cis-acting IL-2v via dual PD-1 and LAG-3 targeting","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225200231","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0811"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2026-sitc2026.0811","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0811","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0811","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A918.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/14/Suppl_2/A918.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077404672","display_name":"Jaeho Song","orcid":"https://orcid.org/0000-0002-8376-2072","observed_orcids":["https://orcid.org/0000-0002-8376-2072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaeho Song","raw_affiliation_strings":["Y-Biologics Inc., Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Y-Biologics Inc., Daejeon, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132910863","display_name":"Seon-Mi Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seon-mi Yu","raw_affiliation_strings":["Y-Biologics Inc., Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Y-Biologics Inc., Daejeon, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132920329","display_name":"Jae-Seok Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jae-seok Lee","raw_affiliation_strings":["Y-Biologics Inc., Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Y-Biologics Inc., Daejeon, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132861712","display_name":"Jihye Yoon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jihye Yoon","raw_affiliation_strings":["Y-Biologics Inc., Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Y-Biologics Inc., Daejeon, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052053939","display_name":"Seo-Young Koo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seo-Young Koo","raw_affiliation_strings":["Y-Biologics Inc., Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Y-Biologics Inc., Daejeon, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132872026","display_name":"Min-Young Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min-Young Park","raw_affiliation_strings":["Y-Biologics Inc., Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Y-Biologics Inc., Daejeon, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017650085","display_name":"Seoyun Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seoyun Yang","raw_affiliation_strings":["Y-Biologics Inc., Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Y-Biologics Inc., Daejeon, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160446619","display_name":"Jung Ho Yoon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jung Ho Yoon","raw_affiliation_strings":["Y-Biologics Inc., Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Y-Biologics Inc., Daejeon, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132863427","display_name":"Wanki Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wanki Park","raw_affiliation_strings":["Y-Biologics Inc., Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Y-Biologics Inc., Daejeon, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160417030","display_name":"Jinkeol Mok","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinkeol Mok","raw_affiliation_strings":["Y-Biologics Inc., Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Y-Biologics Inc., Daejeon, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054907411","display_name":"Saehyung Lee","orcid":"https://orcid.org/0000-0002-2728-7801","observed_orcids":["https://orcid.org/0000-0002-2728-7801"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saehyung Lee","raw_affiliation_strings":["Y-Biologics Inc., Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Y-Biologics Inc., Daejeon, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160522879","display_name":"Jaehyeon Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaehyeon Kim","raw_affiliation_strings":["Y-Biologics Inc., Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Y-Biologics Inc., Daejeon, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102969646","display_name":"Hye Kyung Hong","orcid":"https://orcid.org/0000-0002-4604-3765","observed_orcids":["https://orcid.org/0000-0002-4604-3765"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye Kyung Hong","raw_affiliation_strings":["Samsung Medical Center, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samsung Medical Center, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157859392","display_name":"Su-Hyung Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Su-Hyung Park","raw_affiliation_strings":["Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083559838","display_name":"Yong Beom Cho","orcid":"https://orcid.org/0000-0002-9944-4706","observed_orcids":["https://orcid.org/0000-0002-9944-4706"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong Beom Cho","raw_affiliation_strings":["Samsung Medical Center, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samsung Medical Center, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160500268","display_name":"Young Woo Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Young Woo Park","raw_affiliation_strings":["Y-Biologics Inc., Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Y-Biologics Inc., Daejeon, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041485789","display_name":"Wooick Jang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wooick Jang","raw_affiliation_strings":["Y-Biologics Inc., Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Y-Biologics Inc., Daejeon, Republic of Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160407752","display_name":"Juhan Yoon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juhan Yoon","raw_affiliation_strings":["Y-Biologics Inc., Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Y-Biologics Inc., Daejeon, Republic of Korea","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A918","last_page":"A918"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunocytokines","display_name":"immunocytokines","score":0.8659999966621399},{"id":"https://openalex.org/keywords/anti-pd-1-resistance","display_name":"anti-PD-1 resistance","score":0.8320000171661377},{"id":"https://openalex.org/keywords/lag-3","display_name":"LAG-3","score":0.8050000071525574},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.6209999918937683},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8289999961853027},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.8970000147819519},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8149999976158142},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.49399998784065247},{"id":"https://openalex.org/keywords/immunological-memory","display_name":"immunological memory","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.7394000291824341},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37770000100135803},{"id":"https://openalex.org/C3019440502","wikidata":"https://www.wikidata.org/wiki/Q500430","display_name":"Dual role","level":2,"score":0.3614000082015991},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.357699990272522},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3546999990940094},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2971000075340271},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2906000018119812},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2851000130176544},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2531000077724457},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.24400000274181366}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jitc-2026-sitc2026.0811","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0811","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0811","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A918.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2026-sitc2026.0811","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0811","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0811","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A918.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225200231.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7149004921","https://openalex.org/W7225176959","https://openalex.org/W7148840905","https://openalex.org/W4404625243","https://openalex.org/W4282983920","https://openalex.org/W7225203751","https://openalex.org/W2529896352","https://openalex.org/W7114798132","https://openalex.org/W7225151155","https://openalex.org/W4225312716"],"abstract_inverted_index":{"Background":[0],"Immunocytokines":[1],"fusing":[2],"anti-PD-1":[3,179,299],"antibody":[4],"with":[5,30,49,78,148,195,244,275,315,359],"interleukin-2":[6],"(IL-2)":[7],"show":[8],"clinical":[9],"potential":[10,368],"in":[11,28,156,178,219,226,232,269,271,279,291,325],"overcoming":[12],"resistance":[13,34,297],"to":[14,35,51,65,112,151,169,198,266,298,347,369],"PD-(L)1":[15],"inhibitors.":[16],"However,":[17],"varied":[18],"response":[19],"rates":[20],"highlight":[21],"the":[22,157,209,280,349],"need":[23],"for":[24],"improved":[25],"efficacy,":[26],"particularly":[27],"tumors":[29],"primary":[31],"and":[32,110,115,120,127,137,190,214,223,240,303,322,342,364],"acquired":[33,296],"PD-1":[36,50,114,222,341,371],"blockade":[37,58,83,126],"expressing":[38],"high":[39],"levels":[40],"of":[41,159,252,352],"LAG-3.":[42],"Emerging":[43],"evidence":[44],"indicates":[45],"LAG-3":[46,116,224,343],"acts":[47],"synergistically":[48],"promote":[52],"T":[53,63,88,140,153,228,262,305],"cell":[54,89,154,263],"exhaustion,":[55],"while":[56,84],"dual":[57,81,340],"can":[59],"reprogram":[60],"CD8":[61,227],"+":[62],"cells":[64,141,150,197,229],"enhance":[66],"antitumor":[67],"immunity.":[68],"Here,":[69],"we":[70],"present":[71],"AR166,":[72],"a":[73,360],"novel":[74],"tri-specific":[75,336],"immunocytokine":[76],"engineered":[77],"Fc-silencing,":[79],"delivering":[80],"PD-1/LAG-3":[82],"inducing":[85],"targeted":[86],"CD8+":[87],"activation":[90,129],"via":[91,125,134],"an":[92,270,334],"optimized":[93,335],"cis-acting":[94,121,353],"IL-2":[95],"variant":[96],"(IL-2v).Methods":[97],"Patient-derived":[98],"tumor":[99,149,164,181,196,233,283,288,316],"samples,":[100],"including":[101],"colorectal":[102],"cancer":[103],"(CRC),":[104],"were":[105,123,146,167,193,206,217],"profiled":[106,207],"by":[107,143],"flow":[108],"cytometry":[109],"IHC":[111],"confirm":[113],"expression.":[117],"PD-1\u00d7LAG-3":[118],"activity":[119],"IL-2v":[122,245],"assessed":[124],"pSTAT5":[128],"assays.":[130],"Fc-silencing":[131,253],"was":[132,176,230,311],"evaluated":[133,168,177],"ADCC,":[135],"ADCP,":[136],"CDC.":[138],"Exhausted":[139],"induced":[142],"repeated":[144],"stimulation":[145],"co-cultured":[147],"determine":[152],"cytotoxicity":[155],"presence":[158],"AR166.":[160],"The":[161],"ex":[162,281],"vivo":[163,282],"patient-derived":[165,234,284],"TILs":[166],"characterize":[170],"AR166-mediated":[171],"immune":[172,200,309],"activation.":[173],"Antitumor":[174],"efficacy":[175,351],"drug-resistant":[180],"models":[182,294],"using":[183,208],"humanized":[184],"PD-1/LAG-3/PD-L1":[185],"triple":[186,292],"knock-in":[187],"(KI)":[188],"mice,":[189],"complete":[191],"responders":[192],"rechallenged":[194],"assess":[199],"memory.":[201],"Tumor":[202],"infiltrating":[203],"lymphocytes":[204],"(TILs)":[205],"same":[210],"mouse":[211],"model.":[212],"Safety":[213],"PK":[215,323],"profiles":[216,324],"analyzed":[218],"cynomolgus":[220,326],"monkeys.Results":[221],"expression":[225],"confirmed":[231,312],"samples.":[235],"AR166":[236,259,318,332],"effectively":[237],"inhibited":[238],"PD-1/PD-L1":[239],"LAG-3/MHC":[241],"II":[242],"pathways,":[243],"showing":[246],"strictly":[247],"cis-activity":[248],"upon":[249,313],"anchoring.":[250],"Assessment":[251],"showed":[254,286],"no":[255],"detectable":[256],"effector":[257,304],"functions.":[258],"elicited":[260],"robust":[261],"responses":[264],"compared":[265],"bi-specific":[267],"counterpart":[268],"vitro":[272],"exhaustion":[273],"model,":[274],"similar":[276],"results":[277],"observed":[278],"TILs.AR166":[285],"remarkable":[287],"growth":[289],"inhibition":[290],"KI":[293],"recapitulating":[295],"therapy,":[300],"expanding":[301],"stem-like":[302],"cells.":[306,317],"Furthermore,":[307],"tumor-specific":[308],"memory":[310],"rechallenge":[314],"achieved":[319],"favorable":[320,361],"safety":[321,362],"monkeys.Conclusions":[327],"Our":[328],"findings":[329],"demonstrate":[330],"that":[331,339],"represents":[333],"immunocytokine,":[337],"establishing":[338],"targeting":[344],"is":[345],"essential":[346],"maximize":[348],"therapeutic":[350,367],"IL-2v,":[354],"thereby":[355],"outperforming":[356],"individual":[357],"controls":[358],"profile":[363],"highlighting":[365],"its":[366],"overcome":[370],"resistance.":[372]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-04T00:00:00"}
