{"id":"https://openalex.org/W7225198012","doi":"https://doi.org/10.3389/fneur.2026.1987008","title":"Hippocampal circuit remodeling in post-traumatic epileptogenesis: inhibitory dysfunction, glial homeostatic failure, and therapeutic opportunities","display_name":"Hippocampal circuit remodeling in post-traumatic epileptogenesis: inhibitory dysfunction, glial homeostatic failure, and therapeutic opportunities","publication_year":2026,"publication_date":"2026-11-03","ids":{"openalex":"https://openalex.org/W7225198012","doi":"https://doi.org/10.3389/fneur.2026.1987008"},"language":"en","primary_location":{"id":"doi:10.3389/fneur.2026.1987008","doi":"https://doi.org/10.3389/fneur.2026.1987008","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1987008","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1987008/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1987008/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108329373","display_name":"Alex Delgado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123534392","display_name":"University of North Texas","ror":"https://ror.org/00v97ad02","country_code":"US","type":"education","lineage":["https://openalex.org/I123534392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Delgado","raw_affiliation_strings":["Department of Biological Sciences, University of North Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of North Texas","institution_ids":["https://openalex.org/I123534392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160419170","display_name":"Suraya Yasmine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123534392","display_name":"University of North Texas","ror":"https://ror.org/00v97ad02","country_code":"US","type":"education","lineage":["https://openalex.org/I123534392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suraya Yasmine","raw_affiliation_strings":["Department of Biological Sciences, University of North Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of North Texas","institution_ids":["https://openalex.org/I123534392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160409428","display_name":"Sarah Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123534392","display_name":"University of North Texas","ror":"https://ror.org/00v97ad02","country_code":"US","type":"education","lineage":["https://openalex.org/I123534392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Tang","raw_affiliation_strings":["Department of Biological Sciences, University of North Texas","Texas Academy of Mathematics and Science, University of North Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of North Texas","institution_ids":["https://openalex.org/I123534392"]},{"raw_affiliation_string":"Texas Academy of Mathematics and Science, University of North Texas","institution_ids":["https://openalex.org/I123534392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114117859","display_name":"Grace Madden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123534392","display_name":"University of North Texas","ror":"https://ror.org/00v97ad02","country_code":"US","type":"education","lineage":["https://openalex.org/I123534392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace Madden","raw_affiliation_strings":["Department of Biological Sciences, University of North Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of North Texas","institution_ids":["https://openalex.org/I123534392"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078296198","display_name":"Feng Gu","orcid":"https://orcid.org/0000-0001-7302-7333","observed_orcids":["https://orcid.org/0000-0001-7302-7333"]},"institutions":[{"id":"https://openalex.org/I123534392","display_name":"University of North Texas","ror":"https://ror.org/00v97ad02","country_code":"US","type":"education","lineage":["https://openalex.org/I123534392"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Feng Gu","raw_affiliation_strings":["Department of Biological Sciences, University of North Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of North Texas","institution_ids":["https://openalex.org/I123534392"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078296198"],"corresponding_institution_ids":["https://openalex.org/I123534392"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.8475633,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/post-traumatic-epilepsy","display_name":"post-traumatic epilepsy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/epileptogenesis","display_name":"epileptogenesis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9409999847412109},{"id":"https://openalex.org/keywords/dentate-gyrus","display_name":"dentate gyrus","score":0.9649999737739563},{"id":"https://openalex.org/keywords/interneurons","display_name":"interneurons","score":0.6589999794960022},{"id":"https://openalex.org/keywords/gabaergic-transmission","display_name":"GABAergic neurotransmission","score":0.9200000166893005},{"id":"https://openalex.org/keywords/mossy-fiber-sprouting","display_name":"mossy fiber sprouting","score":0.8140000104904175},{"id":"https://openalex.org/keywords/adult-neurogenesis","display_name":"adult neurogenesis","score":0.843999981880188},{"id":"https://openalex.org/keywords/granule-cells","display_name":"granule cells","score":0.7540000081062317},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.8500000238418579},{"id":"https://openalex.org/keywords/medial-ganglionic-eminence","display_name":"medial ganglionic eminence","score":0.8510000109672546},{"id":"https://openalex.org/keywords/aquaporin-4","display_name":"aquaporin-4","score":0.8849999904632568},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9860000014305115},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8849999904632568},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5070000290870667},{"id":"https://openalex.org/keywords/glutamate-uptake","display_name":"glutamate uptake","score":0.7979999780654907},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8420000076293945},{"id":"https://openalex.org/keywords/seizure-biomarkers","display_name":"seizure biomarkers","score":0.6700000166893005},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8313000202178955},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.8044000267982483},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.6790000200271606},{"id":"https://openalex.org/C2779296341","wikidata":"https://www.wikidata.org/wiki/Q1500732","display_name":"Interneuron","level":3,"score":0.6722999811172485},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.586899995803833},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.48019999265670776},{"id":"https://openalex.org/C57236427","wikidata":"https://www.wikidata.org/wiki/Q5382987","display_name":"Epileptogenesis","level":3,"score":0.4799000024795532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44929999113082886},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4138999879360199},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.40549999475479126},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.35929998755455017},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.3370000123977661},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.3174000084400177},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.31290000677108765},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30799999833106995},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.30640000104904175},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.299699991941452},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.28859999775886536},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.2854999899864197},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.2757999897003174},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.26969999074935913},{"id":"https://openalex.org/C2777771985","wikidata":"https://www.wikidata.org/wiki/Q210021","display_name":"gamma-Aminobutyric acid","level":3,"score":0.26930001378059387},{"id":"https://openalex.org/C2778437258","wikidata":"https://www.wikidata.org/wiki/Q2116409","display_name":"Pyramidal cell","level":3,"score":0.259799987077713}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fneur.2026.1987008","doi":"https://doi.org/10.3389/fneur.2026.1987008","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1987008","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1987008/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:ae202487850140aa94150713a5533837","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ae202487850140aa94150713a5533837","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neurology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fneur.2026.1987008","doi":"https://doi.org/10.3389/fneur.2026.1987008","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1987008","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1987008/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225198012.pdf","grobid_xml":"https://content.openalex.org/works/W7225198012.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1504817278","https://openalex.org/W1557124033","https://openalex.org/W1746603715","https://openalex.org/W1983635597","https://openalex.org/W1983665651","https://openalex.org/W1995716693","https://openalex.org/W2006841345","https://openalex.org/W2025910619","https://openalex.org/W2029038733","https://openalex.org/W2048916015","https://openalex.org/W2065662771","https://openalex.org/W2078412655","https://openalex.org/W2086267716","https://openalex.org/W2115303625","https://openalex.org/W2116883357","https://openalex.org/W2118783961","https://openalex.org/W2123977622","https://openalex.org/W2124077349","https://openalex.org/W2125898821","https://openalex.org/W2129151648","https://openalex.org/W2136052079","https://openalex.org/W2294937041","https://openalex.org/W2325851205","https://openalex.org/W2355034969","https://openalex.org/W2570560022","https://openalex.org/W2695717798","https://openalex.org/W2747436811","https://openalex.org/W2750127374","https://openalex.org/W2789329186","https://openalex.org/W2789787241","https://openalex.org/W2792801585","https://openalex.org/W2796418566","https://openalex.org/W2801769333","https://openalex.org/W2805677861","https://openalex.org/W2884809477","https://openalex.org/W2912920302","https://openalex.org/W2984812814","https://openalex.org/W2996279962","https://openalex.org/W3029057765","https://openalex.org/W3121736477","https://openalex.org/W3182499107","https://openalex.org/W3196441931","https://openalex.org/W3200713748","https://openalex.org/W4286247396","https://openalex.org/W4293102825","https://openalex.org/W4306181180","https://openalex.org/W4367054583","https://openalex.org/W4397033828","https://openalex.org/W4399765760","https://openalex.org/W4402017998","https://openalex.org/W4402489848","https://openalex.org/W4402664441","https://openalex.org/W4404430508","https://openalex.org/W4407985976","https://openalex.org/W4410511863","https://openalex.org/W4411983830"],"related_works":["https://openalex.org/W2167054761","https://openalex.org/W4319459255","https://openalex.org/W2173271778","https://openalex.org/W2034827271","https://openalex.org/W1703482695","https://openalex.org/W4367054583","https://openalex.org/W2116883357","https://openalex.org/W3016774843","https://openalex.org/W1968757552","https://openalex.org/W7223367918"],"abstract_inverted_index":{"Traumatic":[0],"brain":[1,19],"injury":[2,20],"(TBI)":[3],"is":[4,43],"a":[5,44,56,184,242],"major":[6,45],"cause":[7],"of":[8,97,112,152,157,163,176,187,249],"acquired":[9],"epilepsy,":[10],"yet":[11],"no":[12],"established":[13],"therapy":[14],"prevents":[15],"the":[16,26,32,93,116,232,263],"transition":[17],"from":[18,127,138,241,246],"to":[21,206],"post-traumatic":[22,180],"epilepsy":[23],"(PTE).":[24],"Although":[25],"primary":[27],"lesion":[28,244],"frequently":[29],"involves":[30],"neocortex,":[31],"hippocampus":[33],"undergoes":[34],"rapid":[35],"and":[36,39,42,72,82,89,95,101,106,137,161,202,221,272],"persistent":[37,103],"cellular":[38],"circuit":[40,70],"remodeling":[41],"candidate":[46,226],"substrate":[47],"for":[48,121,228,274],"epileptogenesis.":[49,122],"This":[50],"review":[51],"evaluates":[52],"hippocampal":[53,79,164],"PTE":[54,136,217,238],"through":[55],"dentate-gate":[57],"framework":[58],"in":[59,130,265],"which":[60],"three":[61],"interacting":[62],"dimensions":[63],"determine":[64],"network":[65],"stability:":[66],"inhibitory":[67,165],"control,":[68],"structural":[69],"topology,":[71],"extracellular/glial":[73],"homeostasis.":[74,189],"TBI":[75],"can":[76],"selectively":[77],"disrupt":[78],"interneuron":[80,171],"populations":[81],"GABAergic":[83],"signaling,":[84,201],"generate":[85],"recurrent":[86],"excitatory":[87],"connectivity":[88],"mossy-fiber":[90],"sprouting,":[91],"alter":[92],"production":[94],"integration":[96],"adult-born":[98],"granule":[99],"cells,":[100],"induce":[102],"astrocytic,":[104],"inflammatory,":[105],"blood\u2013brain":[107,207],"barrier":[108,208],"responses.":[109],"Not":[110],"all":[111],"these":[113],"observations":[114],"carry":[115],"same":[117],"weight":[118],"as":[119],"evidence":[120,149],"We":[123,235],"distinguish":[124],"injury-associated":[125],"changes":[126],"abnormalities":[128,223],"enriched":[129],"animals":[131],"that":[132,237],"later":[133],"develop":[134],"spontaneous":[135,144,181,216],"mechanisms":[139,255],"whose":[140],"targeted":[141],"manipulation":[142],"alters":[143],"seizure":[145],"development.":[146],"Direct":[147],"intervention":[148],"includes":[150],"suppression":[151],"dentate":[153,251],"granule-cell":[154],"mechanistic":[155,270],"target":[156],"rapamycin":[158],"(mTOR)":[159],"signaling":[160],"reconstruction":[162],"circuitry":[166],"with":[167,253],"medial":[168],"ganglionic":[169],"eminence-derived":[170],"precursors,":[172],"whereas":[173],"genetic":[174],"loss":[175],"astrocytic":[177,203],"aquaporin-4":[178],"worsens":[179],"seizures,":[182],"supporting":[183],"causal":[185],"contribution":[186],"extracellular":[188],"By":[190],"contrast,":[191],"several":[192],"compelling":[193],"pathways":[194],"-":[195,210],"including":[196],"altered":[197],"glutamate":[198],"transport,":[199],"connexin":[200],"TGF-\u03b2":[204],"responses":[205],"dysfunction":[209],"still":[211],"require":[212],"direct":[213],"testing":[214],"against":[215],"endpoints.":[218],"Hippocampal":[219],"electrophysiological":[220],"imaging":[222],"also":[224],"offer":[225],"biomarkers":[227],"stratifying":[229],"risk":[230],"during":[231],"latent":[233],"period.":[234],"propose":[236],"emerges":[239],"not":[240],"single":[243],"but":[245],"time-dependent":[247],"failure":[248],"coordinated":[250],"homeostasis,":[252],"different":[254,258],"dominating":[256],"at":[257],"stages":[259],"after":[260],"injury.":[261],"Organizing":[262],"literature":[264],"this":[266],"way":[267],"highlights":[268],"testable":[269],"gaps":[271],"opportunities":[273],"biomarker-guided":[275],"disease-modifying":[276],"therapy.":[277]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-04T00:00:00"}