{"id":"https://openalex.org/W7225195141","doi":"https://doi.org/10.1038/s42003-026-11276-8","title":"Melatonin regulates LIN-42/PERIOD through its receptor PCDR-1 to promote dark adaptation in Caenorhabditis elegans","display_name":"Melatonin regulates LIN-42/PERIOD through its receptor PCDR-1 to promote dark adaptation in Caenorhabditis elegans","publication_year":2026,"publication_date":"2026-11-03","ids":{"openalex":"https://openalex.org/W7225195141","doi":"https://doi.org/10.1038/s42003-026-11276-8"},"language":"en","primary_location":{"id":"doi:10.1038/s42003-026-11276-8","doi":"https://doi.org/10.1038/s42003-026-11276-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-026-11276-8","pdf_url":"https://www.nature.com/articles/s42003-026-11276-8_reference.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s42003-026-11276-8_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061755097","display_name":"Jia-Hong Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia-Hong Duan","raw_affiliation_strings":["State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Key Laboratory for Southwest Microbial Diversity of the Ministry of Education, Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, Southwest United Graduate School, Yunnan University, Kunming, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Key Laboratory for Southwest Microbial Diversity of the Ministry of Education, Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, Southwest United Graduate School, Yunnan University, Kunming, Yunnan, China","institution_ids":["https://openalex.org/I189210763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160534675","display_name":"Xin-Yue Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin-Yue Tang","raw_affiliation_strings":["Institute of International Rivers and Eco-Security, Yunnan University, Kunming, Yunnan, China","State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Key Laboratory for Southwest Microbial Diversity of the Ministry of Education, Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, Southwest United Graduate School, Yunnan University, Kunming, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of International Rivers and Eco-Security, Yunnan University, Kunming, Yunnan, China","institution_ids":["https://openalex.org/I189210763"]},{"raw_affiliation_string":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Key Laboratory for Southwest Microbial Diversity of the Ministry of Education, Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, Southwest United Graduate School, Yunnan University, Kunming, Yunnan, China","institution_ids":["https://openalex.org/I189210763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110377665","display_name":"Yan Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Du","raw_affiliation_strings":["State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Key Laboratory for Southwest Microbial Diversity of the Ministry of Education, Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, Southwest United Graduate School, Yunnan University, Kunming, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Key Laboratory for Southwest Microbial Diversity of the Ministry of Education, Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, Southwest United Graduate School, Yunnan University, Kunming, Yunnan, China","institution_ids":["https://openalex.org/I189210763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073098783","display_name":"Qiu-Yu Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiu-Yu Luo","raw_affiliation_strings":["State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Key Laboratory for Southwest Microbial Diversity of the Ministry of Education, Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, Southwest United Graduate School, Yunnan University, Kunming, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Key Laboratory for Southwest Microbial Diversity of the Ministry of Education, Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, Southwest United Graduate School, Yunnan University, Kunming, Yunnan, China","institution_ids":["https://openalex.org/I189210763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103011307","display_name":"Qian Zhu","orcid":"https://orcid.org/0009-0001-2932-6202","observed_orcids":["https://orcid.org/0009-0001-2932-6202"]},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Zhu","raw_affiliation_strings":["State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Key Laboratory for Southwest Microbial Diversity of the Ministry of Education, Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, Southwest United Graduate School, Yunnan University, Kunming, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Key Laboratory for Southwest Microbial Diversity of the Ministry of Education, Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, Southwest United Graduate School, Yunnan University, Kunming, Yunnan, China","institution_ids":["https://openalex.org/I189210763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160454563","display_name":"Yu-Chan Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Chan Zou","raw_affiliation_strings":["State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Key Laboratory for Southwest Microbial Diversity of the Ministry of Education, Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, Southwest United Graduate School, Yunnan University, Kunming, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Key Laboratory for Southwest Microbial Diversity of the Ministry of Education, Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, Southwest United Graduate School, Yunnan University, Kunming, Yunnan, China","institution_ids":["https://openalex.org/I189210763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160522903","display_name":"Yi-Cheng Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yi-Cheng Ma","raw_affiliation_strings":["State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Key Laboratory for Southwest Microbial Diversity of the Ministry of Education, Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, Southwest United Graduate School, Yunnan University, Kunming, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Key Laboratory for Southwest Microbial Diversity of the Ministry of Education, Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, Southwest United Graduate School, Yunnan University, Kunming, Yunnan, China","institution_ids":["https://openalex.org/I189210763"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160527009","display_name":"Cheng-Gang Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cheng-Gang Zou","raw_affiliation_strings":["State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Key Laboratory for Southwest Microbial Diversity of the Ministry of Education, Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, Southwest United Graduate School, Yunnan University, Kunming, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Key Laboratory for Southwest Microbial Diversity of the Ministry of Education, Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, Southwest United Graduate School, Yunnan University, Kunming, Yunnan, China","institution_ids":["https://openalex.org/I189210763"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5160522903","https://openalex.org/A5160527009"],"corresponding_institution_ids":["https://openalex.org/I189210763"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.79905188,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dark-adaptation","display_name":"dark adaptation","score":0.6830000281333923},{"id":"https://openalex.org/keywords/circadian-clock","display_name":"circadian clock","score":0.9459999799728394},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9359999895095825},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9139999747276306},{"id":"https://openalex.org/keywords/melatonin-synthesis","display_name":"melatonin synthesis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/daf-16-foxo","display_name":"DAF-16/FOXO","score":0.9800000190734863},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8259999752044678},{"id":"https://openalex.org/keywords/light-dark-cycle","display_name":"light-dark cycle","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.9447000026702881},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.7839000225067139},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6273999810218811},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6179999709129333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5942000150680542},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.5803999900817871},{"id":"https://openalex.org/C2779027399","wikidata":"https://www.wikidata.org/wiki/Q204170","display_name":"Darkness","level":2,"score":0.5605000257492065},{"id":"https://openalex.org/C2781269140","wikidata":"https://www.wikidata.org/wiki/Q24784310","display_name":"Melatonin receptor","level":3,"score":0.5248000025749207},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.5231000185012817},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5146999955177307},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4487000107765198},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4291999936103821},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.4230000078678131},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41260001063346863},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.3377000093460083},{"id":"https://openalex.org/C2776496032","wikidata":"https://www.wikidata.org/wiki/Q1904768","display_name":"Caenorhabditis","level":4,"score":0.32679998874664307},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.31349998712539673},{"id":"https://openalex.org/C149277555","wikidata":"https://www.wikidata.org/wiki/Q16491","display_name":"Daylight","level":2,"score":0.29319998621940613},{"id":"https://openalex.org/C184738001","wikidata":"https://www.wikidata.org/wiki/Q14908739","display_name":"CLOCK","level":4,"score":0.2928999960422516},{"id":"https://openalex.org/C2780059843","wikidata":"https://www.wikidata.org/wiki/Q198654","display_name":"Pineal gland","level":3,"score":0.2854999899864197},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.26969999074935913},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26440000534057617},{"id":"https://openalex.org/C2778880379","wikidata":"https://www.wikidata.org/wiki/Q7805543","display_name":"Timeless","level":3,"score":0.2581000030040741}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s42003-026-11276-8","doi":"https://doi.org/10.1038/s42003-026-11276-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-026-11276-8","pdf_url":"https://www.nature.com/articles/s42003-026-11276-8_reference.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s42003-026-11276-8","doi":"https://doi.org/10.1038/s42003-026-11276-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-026-11276-8","pdf_url":"https://www.nature.com/articles/s42003-026-11276-8_reference.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4262151657","display_name":null,"funder_award_id":"32470128","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324731","display_name":"Yunnan University","ror":"https://ror.org/0040axw97"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225195141.pdf","grobid_xml":"https://content.openalex.org/works/W7225195141.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4399362995","https://openalex.org/W2075197660","https://openalex.org/W1965438071","https://openalex.org/W2031847182","https://openalex.org/W2166223308","https://openalex.org/W2104918016","https://openalex.org/W2135631496","https://openalex.org/W4200074990","https://openalex.org/W1573583229","https://openalex.org/W4225414452"],"abstract_inverted_index":{"Organisms":[0],"that":[1,53,112,134],"live":[2],"in":[3,59,62,72,93,128],"lightless":[4],"spatial":[5],"niches":[6],"(e.g.,":[7],"caves":[8],"or":[9,23,116],"soil)":[10],"develop":[11],"a":[12,38,67],"daily":[13,34],"clock":[14,40],"using":[15],"other":[16],"senses,":[17],"such":[18],"as":[19],"taste,":[20],"smell,":[21],"temperature,":[22],"mechanical":[24],"senses.":[25],"However,":[26],"how":[27],"these":[28],"organisms,":[29],"which":[30,124],"experience":[31],"only":[32],"muted":[33],"environmental":[35],"cycles,":[36],"use":[37],"circadian":[39],"to":[41,43,104,147,149],"adapt":[42,148],"darkness":[44],"is":[45],"worth":[46],"exploring.":[47],"In":[48],"this":[49],"study,":[50],"we":[51,110],"found":[52,111],"lin-42":[54,64,91,98,117],"/PERIOD":[55],"was":[56],"highly":[57],"expressed":[58],"worms":[60,73],"grown":[61],"darkness.":[63,94,150],"knockdown":[65],"induced":[66,125],"phenotype":[68],"of":[69,81,106,139],"accelerated":[70],"aging":[71],"under":[74],"dark":[75],"conditions.":[76],"Melatonin":[77],"inhibited":[78,97],"the":[79,120,129,135,142],"production":[80,102],"reactive":[82],"oxygen":[83],"species":[84],"through":[85],"its":[86],"receptor,":[87],"PCDR-1,":[88],"thus":[89],"maintaining":[90],"expression":[92,99],"Conversely,":[95],"daylight":[96],"by":[100],"ROS":[101],"due":[103],"suppression":[105],"melatonin":[107,114,140],"synthesis.":[108],"Moreover,":[109],"insufficient":[113],"synthesis":[115],"deficiency":[118],"activated":[119],"transcription":[121],"factor":[122],"DAF-16/FOXO,":[123],"lipid":[126],"accumulation":[127],"worms.":[130],"Our":[131],"results":[132],"suggest":[133],"molecular":[136],"network":[137],"composed":[138],"and":[141],"LIN-42/PERIOD":[143],"enables":[144],"C.":[145],"elegans":[146]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-04T00:00:00"}