{"id":"https://openalex.org/W7225190979","doi":"https://doi.org/10.26599/joto.2026.9540083","title":"Systematic Proteome-wide Mendelian Randomization to Identify Novel Therapeutic Targets for Age-related Hearing Loss","display_name":"Systematic Proteome-wide Mendelian Randomization to Identify Novel Therapeutic Targets for Age-related Hearing Loss","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7225190979","doi":"https://doi.org/10.26599/joto.2026.9540083","pmid":"https://pubmed.ncbi.nlm.nih.gov/42996923","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13740632"},"language":"en","primary_location":{"id":"doi:10.26599/joto.2026.9540083","doi":"https://doi.org/10.26599/joto.2026.9540083","is_oa":true,"landing_page_url":"https://doi.org/10.26599/joto.2026.9540083","pdf_url":"https://www.sciopen.com/local/article_pdf/10.26599/JOTO.2026.9540083.pdf","source":{"id":"https://openalex.org/S2765004167","display_name":"Journal of Otology","issn_l":"1672-2930","issn":["1672-2930","2524-1753"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Otology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciopen.com/local/article_pdf/10.26599/JOTO.2026.9540083.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160553907","display_name":"Kun Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Zhang","raw_affiliation_strings":["Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan, Shandong, China","NHC Key Laboratory of Otorhinolaryngology, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"NHC Key Laboratory of Otorhinolaryngology, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160550743","display_name":"Zhuoyan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuoyan Li","raw_affiliation_strings":["Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan, Shandong, China","NHC Key Laboratory of Otorhinolaryngology, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"NHC Key Laboratory of Otorhinolaryngology, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160560328","display_name":"Luyao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Luyao Wang","raw_affiliation_strings":["Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan, Shandong, China","NHC Key Laboratory of Otorhinolaryngology, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"NHC Key Laboratory of Otorhinolaryngology, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135038143","display_name":"Xijian Xin","orcid":"https://orcid.org/0000-0002-2055-0021","observed_orcids":["https://orcid.org/0000-0002-2055-0021"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xijian Xin","raw_affiliation_strings":["Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan, Shandong, China","NHC Key Laboratory of Otorhinolaryngology, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"NHC Key Laboratory of Otorhinolaryngology, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160484586","display_name":"Xiaodong Qiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodong Qiu","raw_affiliation_strings":["Department of Operating Room, Qilu Hospital of Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Operating Room, Qilu Hospital of Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160552124","display_name":"Peng Qu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089721","display_name":"Shandong Provincial Institute of Dermatology and Venereology","ror":"https://ror.org/0169ka518","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089721"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peng Qu","raw_affiliation_strings":["Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China","Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China","institution_ids":["https://openalex.org/I4210089721","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103049484","display_name":"Dingding Dong","orcid":"https://orcid.org/0000-0003-1306-6589","observed_orcids":["https://orcid.org/0000-0003-1306-6589"]},"institutions":[{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dingding Dong","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Qilu Hospital of Shandong University (Qingdao), Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Qilu Hospital of Shandong University (Qingdao), Qingdao, Shandong, China","institution_ids":["https://openalex.org/I4210161528"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160437616","display_name":"Hanbing Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hanbing Zhang","raw_affiliation_strings":["Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan, Shandong, China","NHC Key Laboratory of Otorhinolaryngology, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"NHC Key Laboratory of Otorhinolaryngology, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5103049484","https://openalex.org/A5160437616","https://openalex.org/A5160552124"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210089721","https://openalex.org/I4210161528","https://openalex.org/I4210163399"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"4","first_page":"272","last_page":"279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.03869999945163727,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-hearing-loss","display_name":"age-related hearing loss","score":1.0},{"id":"https://openalex.org/keywords/proteome-wide-mendelian-randomization","display_name":"proteome-wide Mendelian randomization","score":0.9200000166893005},{"id":"https://openalex.org/keywords/therapeutic-target-discovery","display_name":"therapeutic target discovery","score":0.6800000071525574},{"id":"https://openalex.org/keywords/plasma-proteins","display_name":"plasma proteins","score":0.890999972820282},{"id":"https://openalex.org/keywords/eef2k","display_name":"eEF2K","score":0.8650000095367432},{"id":"https://openalex.org/keywords/atf6","display_name":"ATF6","score":1.0},{"id":"https://openalex.org/keywords/kir2dl3","display_name":"KIR2DL3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/micb","display_name":"MICB","score":1.0},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.7639999985694885},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cytosolic-calcium-regulation","display_name":"cytosolic calcium regulation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.597000002861023},{"id":"https://openalex.org/keywords/withaferin-a","display_name":"withaferin A","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cianidanol","display_name":"cianidanol","score":0.8899999856948853},{"id":"https://openalex.org/keywords/danthron","display_name":"danthron","score":0.8230000138282776},{"id":"https://openalex.org/keywords/adenosine-triphosphate","display_name":"adenosine triphosphate","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.7567999958992004},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6610999703407288},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.5709999799728394},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5684999823570251},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4912000000476837},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.41260001063346863},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.39739999175071716},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.3779999911785126},{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.3700000047683716},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.3580999970436096},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3287999927997589},{"id":"https://openalex.org/C132455925","wikidata":"https://www.wikidata.org/wiki/Q16965677","display_name":"Cas9","level":4,"score":0.32589998841285706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31619998812675476},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.31380000710487366},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.30230000615119934},{"id":"https://openalex.org/C2776879804","wikidata":"https://www.wikidata.org/wiki/Q7630919","display_name":"Subcellular localization","level":3,"score":0.3003999888896942},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.29510000348091125},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2928999960422516},{"id":"https://openalex.org/C162740809","wikidata":"https://www.wikidata.org/wiki/Q15334560","display_name":"STIM1","level":3,"score":0.28769999742507935},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.28209999203681946},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.27390000224113464},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.2720000147819519},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2687999904155731},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26339998841285706},{"id":"https://openalex.org/C175783326","wikidata":"https://www.wikidata.org/wiki/Q185055","display_name":"Mendelian inheritance","level":3,"score":0.25110000371932983}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.26599/joto.2026.9540083","doi":"https://doi.org/10.26599/joto.2026.9540083","is_oa":true,"landing_page_url":"https://doi.org/10.26599/joto.2026.9540083","pdf_url":"https://www.sciopen.com/local/article_pdf/10.26599/JOTO.2026.9540083.pdf","source":{"id":"https://openalex.org/S2765004167","display_name":"Journal of Otology","issn_l":"1672-2930","issn":["1672-2930","2524-1753"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Otology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13740632","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13740632/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13740632/pdf/jo-21-4-272.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Otol","raw_type":"Text"},{"id":"pmid:42996923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42996923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of otology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.26599/joto.2026.9540083","doi":"https://doi.org/10.26599/joto.2026.9540083","is_oa":true,"landing_page_url":"https://doi.org/10.26599/joto.2026.9540083","pdf_url":"https://www.sciopen.com/local/article_pdf/10.26599/JOTO.2026.9540083.pdf","source":{"id":"https://openalex.org/S2765004167","display_name":"Journal of Otology","issn_l":"1672-2930","issn":["1672-2930","2524-1753"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Otology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225190979.pdf","grobid_xml":"https://content.openalex.org/works/W7225190979.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W2143685991","https://openalex.org/W2789220650","https://openalex.org/W2810861632","https://openalex.org/W2911277088","https://openalex.org/W2945024695","https://openalex.org/W2950099124","https://openalex.org/W3012370544","https://openalex.org/W3083496521","https://openalex.org/W3087180542","https://openalex.org/W3126225518","https://openalex.org/W3128195746","https://openalex.org/W3134601984","https://openalex.org/W3134799826","https://openalex.org/W3183054208","https://openalex.org/W3213787774","https://openalex.org/W3215894083","https://openalex.org/W4323035146","https://openalex.org/W4390449326","https://openalex.org/W4393938910","https://openalex.org/W4396532135","https://openalex.org/W4399852178","https://openalex.org/W4400698521","https://openalex.org/W4401122697","https://openalex.org/W4402019555","https://openalex.org/W4402450244","https://openalex.org/W4404877685","https://openalex.org/W4406230392","https://openalex.org/W4406727345","https://openalex.org/W4406805910"],"related_works":["https://openalex.org/W4406240065","https://openalex.org/W7139007067","https://openalex.org/W7119158921","https://openalex.org/W4406932343","https://openalex.org/W4387378576","https://openalex.org/W7118821018","https://openalex.org/W4220985260","https://openalex.org/W4385938105","https://openalex.org/W3012370544","https://openalex.org/W4404864273"],"abstract_inverted_index":{"Objectives:":[0],"Age-related":[1],"hearing":[2],"loss":[3],"is":[4],"a":[5,45],"common":[6],"neurodegenerative":[7],"disorder":[8],"worldwide,":[9],"with":[10,99],"significant":[11],"public":[12],"health":[13],"implications,":[14],"emphasizing":[15],"the":[16,118,230],"urgent":[17],"need":[18],"for":[19,33,179,193,212,235],"identifying":[20,86],"novel":[21,30],"therapeutic":[22,31,91,177,195,210],"targets.":[23],"This":[24,42],"study":[25],"seeks":[26],"to":[27],"uncover":[28],"potential":[29],"targets":[32,178,211],"ARHL":[34,105],"by":[35],"employing":[36],"proteome-wide":[37,46],"Mendelian":[38,47],"randomization":[39,48],"analysis.":[40],"Methods:":[41],"investigation":[43],"employed":[44],"approach,":[49],"utilizing":[50],"publicly":[51],"accessible":[52],"data":[53],"from":[54],"GWAS":[55],"and":[56,79,89,131,147,160,173,181,190,206,228],"pQTL":[57],"studies.":[58],"Additionally,":[59,139],"we":[60],"performed":[61],"phenome-wide":[62,151],"association":[63],"studies,":[64],"enrichment":[65],"analysis,":[66,73,75],"protein":[67,137,153],"network":[68],"construction,":[69],"single-cell":[70,155],"RNA":[71],"sequencing":[72],"colocalization":[74],"drug":[76,158,233],"repurposing":[77],"predictions,":[78],"molecular":[80,161],"docking":[81,162],"simulations,":[82],"all":[83],"aimed":[84],"at":[85],"more":[87],"precise":[88],"targeted":[90],"strategies.":[92],"Results:":[93],"We":[94],"identified":[95,182,200],"six":[96],"plasma":[97],"proteins":[98,223],"genetically":[100],"predicted":[101],"causal":[102],"effects":[103],"on":[104,221],"risk.":[106],"GO":[107],"analysis":[108],"highlighted":[109],"their":[110],"predominant":[111],"roles":[112],"in":[113],"key":[114],"biological":[115],"processes,":[116],"including":[117],"regulation":[119,126,132],"of":[120,127,133,232],"cytosolic":[121],"calcium":[122],"ion":[123],"concentration,":[124],"negative":[125],"homotypic":[128],"cell-cell":[129],"adhesion,":[130],"endoplasmic":[134,145],"reticulum":[135],"unfolded":[136],"response.":[138],"important":[140],"cellular":[141],"components":[142],"include":[143],"smooth":[144],"reticulum,":[146],"dendritic":[148],"shaft.":[149],"Follow-up":[150],"association,":[152],"network,":[154],"transcriptomic,":[156],"colocalization,":[157],"repurposing,":[159],"analyses":[163],"provided":[164],"convergent":[165],"evidence":[166],"supporting":[167],"EEF2K,":[168,201],"C1QTNF1,":[169,202],"ATF6,":[170,203],"JPH4,":[171,204],"KIR2DL3,":[172,205],"MICB":[174,207],"as":[175,208],"promising":[176],"ARHL,":[180,213],"four":[183],"candidate":[184,209],"compounds":[185],"(Withaferin":[186],"A,":[187],"Cianidanol,":[188],"Danthron,":[189],"adenosine":[191],"triphosphate)":[192],"further":[194],"investigation.":[196],"Conclusions:":[197],"Proteome-wide":[198],"MR":[199],"offering":[214],"new":[215],"insights":[216],"into":[217],"target":[218,226],"discovery.":[219],"Focusing":[220],"these":[222],"may":[224],"improve":[225],"prioritization":[227],"enhance":[229],"efficiency":[231],"development":[234],"ARHL.":[236]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-04T00:00:00"}