{"id":"https://openalex.org/W7225189367","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0951","title":"951 Engineered tumor-homing bacteria enable systemic combination immune checkpoint blockade and cytokine immunotherapy","display_name":"951 Engineered tumor-homing bacteria enable systemic combination immune checkpoint blockade and cytokine immunotherapy","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225189367","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0951"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2026-sitc2026.0951","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0951","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0951","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A1080.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/14/Suppl_2/A1080.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160422619","display_name":"Zongqi Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zongqi Wang","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089734920","display_name":"Jiahe Li","orcid":"https://orcid.org/0000-0002-9889-8546","observed_orcids":["https://orcid.org/0000-0002-9889-8546","https://orcid.org/0009-0007-1812-1328"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiahe Li","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.91847826,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A1080","last_page":"A1082"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetically-modified-bacteria","display_name":"engineered bacteria","score":0.6499999761581421},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.8510000109672546},{"id":"https://openalex.org/keywords/bacterial-surface-display","display_name":"bacterial surface display","score":0.6620000004768372},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.746999979019165},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nanobodies","display_name":"nanobodies","score":0.753000020980835},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.8730000257492065},{"id":"https://openalex.org/keywords/ompa","display_name":"OmpA","score":0.9470000267028809},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8960000276565552},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.6740000247955322},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cd8-t-cell-infiltration","display_name":"CD8+ T cell infiltration","score":0.8100000023841858},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.6240000128746033},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.730400025844574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7293000221252441},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6680999994277954},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.6140999794006348},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5202000141143799},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4860999882221222},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.46549999713897705},{"id":"https://openalex.org/C21705690","wikidata":"https://www.wikidata.org/wiki/Q2907609","display_name":"CTLA-4","level":4,"score":0.45210000872612},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4431999921798706},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.43639999628067017},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.3310999870300293},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.27630001306533813},{"id":"https://openalex.org/C2780850621","wikidata":"https://www.wikidata.org/wiki/Q3961647","display_name":"Cytokine release syndrome","level":5,"score":0.2696000039577484},{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.26030001044273376},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.25999999046325684}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jitc-2026-sitc2026.0951","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0951","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0951","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A1080.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2026-sitc2026.0951","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0951","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0951","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A1080.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225189367.pdf","grobid_xml":"https://content.openalex.org/works/W7225189367.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7225138669","https://openalex.org/W2575882253","https://openalex.org/W7163896558","https://openalex.org/W2005721505","https://openalex.org/W7117306734","https://openalex.org/W4399608120","https://openalex.org/W7225147797","https://openalex.org/W6982813856","https://openalex.org/W2510013297","https://openalex.org/W2905679618"],"abstract_inverted_index":{"Background":[0],"Immune":[1,252],"checkpoint":[2,69,111,201,309,323,399],"blockade":[3,310,400],"(ICB)":[4],"has":[5],"transformed":[6],"cancer":[7,76,341],"treatment":[8,455],"but":[9],"remains":[10],"ineffective":[11],"for":[12,63,337],"many":[13],"patients":[14],"because":[15],"of":[16,38,67,199,236,266,304],"limited":[17],"intratumoral":[18,131,256],"drug":[19],"delivery,":[20],"systemic":[21,43,65,147,285,384],"toxicity,":[22],"and":[23,45,71,85,98,132,150,158,177,203,211,264,311,331,362,383,401,414,434,448],"an":[24],"immunosuppressive":[25],"tumor":[26,139,186,209,230,242,268,281,329,381,410,437],"microenvironment.":[27,439],"Engineered":[28],"bacteria":[29,378,429,443],"have":[30],"recently":[31],"emerged":[32],"as":[33,297],"programmable":[34],"therapeutic":[35],"platforms":[36],"capable":[37,303],"selectively":[39],"colonizing":[40],"tumors":[41,433,447],"following":[42,130,287,453],"administration":[44,134,182],"delivering":[46,306],"immunomodulatory":[47],"payloads":[48],"to":[49,74,82,103],"enhance":[50],"antitumor":[51,99,179,246,319,385,417,450],"immunity.":[52,386],"1":[53],"2":[54],"Here,":[55],"we":[56],"developed":[57],"a":[58,117,234,272,298,333],"modular":[59,315],"bacterial":[60,90,165,294,394,406],"surface-display":[61,107,166],"platform":[62,302,316,336],"the":[64,105,163,171,225,267,421,436],"delivery":[66],"immune":[68,144,151,247,269,308,398,418,438,451],"nanobodies":[70,87,202],"cytokine":[72,148,160,312],"stimulation":[73],"improve":[75],"immunotherapy.Methods":[77],"We":[78],"engineered":[79,119,293,339,393,405,428,442],"Escherichia":[80,354],"coli":[81,355],"display":[83,191,296],"anti-CTLA-4":[84,219],"anti-PD-L1":[86,221],"using":[88,155],"five":[89,164],"outer":[91],"membrane":[92],"protein":[93],"scaffolds.":[94,192],"Functional":[95],"target":[96],"binding":[97],"efficacy":[100,127],"were":[101,153],"compared":[102,188],"identify":[104],"optimal":[106],"platform.":[108],"The":[109],"optimized":[110],"nanobody-displaying":[112],"strain":[113,120],"was":[114,128],"combined":[115],"with":[116,189,283],"second":[118],"displaying":[121,356],"membrane-anchored":[122],"decoy-resistant":[123,357],"IL-18":[124],"(mDR18).":[125],"Therapeutic":[126],"evaluated":[129],"intravenous":[133,194,288,454],"in":[135,224,233,326,420,432,446],"multiple":[136,327],"syngeneic":[137],"murine":[138],"models.":[140],"Tumor":[141],"growth,":[142,411],"survival,":[143,413],"memory,":[145],"biodistribution,":[146],"responses,":[149],"remodeling":[152,265,452],"assessed":[154],"flow":[156],"cytometry":[157],"multiplex":[159],"profiling.Results":[161],"Among":[162],"scaffolds":[167],"evaluated,":[168],"YiaT181":[169],"mediated":[170],"most":[172],"efficient":[173],"functional":[174],"nanobody":[175],"presentation":[176],"superior":[178],"activity.":[180],"Intratumoral":[181],"significantly":[183,207],"suppressed":[184],"MC38":[185],"growth":[187],"alternative":[190],"Following":[193],"administration,":[195],"combination":[196,307,407],"therapy":[197,223,325,408],"consisting":[198],"YiaT181-displayed":[200],"OmpA-displayed":[204],"mDR18":[205],"achieved":[206],"greater":[208],"control":[210],"prolonged":[212],"survival":[213],"than":[214],"either":[215],"monotherapy":[216],"or":[217],"conventional":[218,322,397],"plus":[220],"antibody":[222,324],"Yummer1.7":[226,422],"melanoma":[227,423],"model.":[228],"Complete":[229],"regression":[231,382],"occurred":[232],"subset":[235],"treated":[237],"mice,":[238],"which":[239],"rejected":[240],"subsequent":[241],"rechallenge,":[243],"demonstrating":[244],"durable":[245,380,416],"memory":[248,419],"(":[249],"figure":[250],"1).":[251],"profiling":[253],"revealed":[254],"enhanced":[255],"CD8+":[257],"T-cell":[258,262],"infiltration,":[259],"reduced":[260],"regulatory":[261],"abundance,":[263],"microenvironment":[270],"toward":[271],"pro-inflammatory":[273],"state":[274],"(figure":[275],"2).":[276],"Biodistribution":[277],"studies":[278],"demonstrated":[279],"preferential":[280],"accumulation":[282],"minimal":[284],"toxicity":[286],"administration.Conclusions":[289],"This":[290,314],"study":[291],"establishes":[292],"surface":[295],"versatile":[299],"off-the-shelf":[300],"immunotherapy":[301,395],"systemically":[305],"stimulation.":[313],"substantially":[317],"enhances":[318],"immunity,":[320],"outperforms":[321,396],"preclinical":[328],"models,":[330],"provides":[332],"broadly":[334],"applicable":[335],"next-generation":[338],"microbial":[340],"immunotherapies.References":[342],"Yang":[343],"S,":[344,370,372],"Sheffer":[345],"M,":[346],"Kaplan":[347],"I,":[348],"Wang":[349],"Z,":[350],"et":[351,375],"al.":[352,376],"Non-pathogenic":[353],"IL18":[358],"mutein":[359],"boosts":[360],"anti-tumor":[361],"CAR":[363],"NK":[364],"cell":[365],"responses.":[366],"Nat":[367,387],"Biotechnol.":[368],"2024.Chowdhury":[369],"Castro":[371],"Coker":[373],"C,":[374],"Programmable":[377],"induce":[379],"Med.":[388],"2019;25:1057-1063.Abstract":[389],"951":[390,425],"Figure":[391,426],"1Intravenous":[392],"prolongs":[402,412],"survival.":[403],"Systemic":[404],"suppresses":[409],"induces":[415],"modelAbstract":[424],"2Systemic":[427],"preferentially":[430,444],"accumulate":[431,445],"remodel":[435],"Systemically":[440],"administered":[441],"promote":[449]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-04T00:00:00"}