{"id":"https://openalex.org/W7225183530","doi":"https://doi.org/10.3389/fnagi.2026.2003656","title":"Disulfidptosis in neurological disorders: from disulfide stress to actin cytoskeletal collapse","display_name":"Disulfidptosis in neurological disorders: from disulfide stress to actin cytoskeletal collapse","publication_year":2026,"publication_date":"2026-11-03","ids":{"openalex":"https://openalex.org/W7225183530","doi":"https://doi.org/10.3389/fnagi.2026.2003656"},"language":"en","primary_location":{"id":"doi:10.3389/fnagi.2026.2003656","doi":"https://doi.org/10.3389/fnagi.2026.2003656","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2026.2003656","pdf_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.2003656/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.2003656/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5139245461","display_name":"Changbo Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changbo Qi","raw_affiliation_strings":["School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine","institution_ids":["https://openalex.org/I192327786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160567071","display_name":"Yaodong Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaodong Gu","raw_affiliation_strings":["School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine","institution_ids":["https://openalex.org/I192327786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100771444","display_name":"Jun Lei","orcid":"https://orcid.org/0000-0001-5104-3738","observed_orcids":["https://orcid.org/0000-0001-5104-3738"]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Lei","raw_affiliation_strings":["School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine","institution_ids":["https://openalex.org/I192327786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113299987","display_name":"Lifang Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lifang Jiang","raw_affiliation_strings":["School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine","institution_ids":["https://openalex.org/I192327786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160503662","display_name":"Jiawei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiawei Li","raw_affiliation_strings":["School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine","institution_ids":["https://openalex.org/I192327786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139236448","display_name":"Bokai Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bokai Bai","raw_affiliation_strings":["School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine","institution_ids":["https://openalex.org/I192327786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044613788","display_name":"Xicheng Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xicheng Jiang","raw_affiliation_strings":["School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine","institution_ids":["https://openalex.org/I192327786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044613788"],"corresponding_institution_ids":["https://openalex.org/I192327786"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73033897,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5976999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5976999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.20649999380111694,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.11810000240802765,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disulfidptosis","display_name":"disulfidptosis","score":1.0},{"id":"https://openalex.org/keywords/disulfide-stress","display_name":"disulfide stress","score":0.9599999785423279},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7080000042915344},{"id":"https://openalex.org/keywords/sulfur-metabolism","display_name":"sulfur metabolism","score":0.6190000176429749},{"id":"https://openalex.org/keywords/nadph-depletion","display_name":"NADPH depletion","score":0.9309999942779541},{"id":"https://openalex.org/keywords/slc7a11","display_name":"SLC7A11","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cuproptosis","display_name":"cuproptosis","score":1.0},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9549999833106995},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9269999861717224},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.7820000052452087},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.7720999717712402},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.7451000213623047},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6694999933242798},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6035000085830688},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5525000095367432},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5325999855995178},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.48989999294281006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4325000047683716},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4004000127315521},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3815999925136566},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.3765999972820282},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3458999991416931},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3384000062942505},{"id":"https://openalex.org/C2780096491","wikidata":"https://www.wikidata.org/wiki/Q60574533","display_name":"Cellular stress response","level":4,"score":0.33219999074935913},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.3296999931335449},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.3165000081062317},{"id":"https://openalex.org/C2780369685","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell damage","level":2,"score":0.28439998626708984},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.27799999713897705},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.2596000134944916},{"id":"https://openalex.org/C3620293","wikidata":"https://www.wikidata.org/wiki/Q14908027","display_name":"Actin remodeling","level":5,"score":0.2565000057220459},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2540999948978424}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fnagi.2026.2003656","doi":"https://doi.org/10.3389/fnagi.2026.2003656","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2026.2003656","pdf_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.2003656/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:68d125495b41437794ca16df97e0afa6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/68d125495b41437794ca16df97e0afa6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Aging Neuroscience, Vol 18 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnagi.2026.2003656","doi":"https://doi.org/10.3389/fnagi.2026.2003656","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2026.2003656","pdf_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.2003656/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3010994575","display_name":null,"funder_award_id":"81673865","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5614007966","display_name":null,"funder_award_id":"82174261","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8709491364","display_name":null,"funder_award_id":"LH2021H084","funder_id":"https://openalex.org/F4320323085","funder_display_name":"Natural Science Foundation of Heilongjiang Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323085","display_name":"Natural Science Foundation of Heilongjiang Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225183530.pdf","grobid_xml":"https://content.openalex.org/works/W7225183530.grobid-xml"},"referenced_works_count":190,"referenced_works":["https://openalex.org/W1967248496","https://openalex.org/W1972933543","https://openalex.org/W1985124617","https://openalex.org/W1997183854","https://openalex.org/W2000087607","https://openalex.org/W2002269806","https://openalex.org/W2002490399","https://openalex.org/W2012930481","https://openalex.org/W2016980705","https://openalex.org/W2030967651","https://openalex.org/W2041629346","https://openalex.org/W2076176438","https://openalex.org/W2098685543","https://openalex.org/W2125461230","https://openalex.org/W2134936321","https://openalex.org/W2185034389","https://openalex.org/W2292613448","https://openalex.org/W2565099436","https://openalex.org/W2572710398","https://openalex.org/W2587021771","https://openalex.org/W2606700051","https://openalex.org/W2608388268","https://openalex.org/W2640064441","https://openalex.org/W2734441646","https://openalex.org/W2739182934","https://openalex.org/W2762703026","https://openalex.org/W2789253060","https://openalex.org/W2792020073","https://openalex.org/W2793610547","https://openalex.org/W2795039709","https://openalex.org/W2797303549","https://openalex.org/W2882341351","https://openalex.org/W2899600217","https://openalex.org/W2911493122","https://openalex.org/W2946400547","https://openalex.org/W2950913401","https://openalex.org/W2951019346","https://openalex.org/W2964373834","https://openalex.org/W2969573657","https://openalex.org/W3008580132","https://openalex.org/W3010188616","https://openalex.org/W3012638502","https://openalex.org/W3013936205","https://openalex.org/W3016811071","https://openalex.org/W3034017823","https://openalex.org/W3044114834","https://openalex.org/W3044760548","https://openalex.org/W3083506679","https://openalex.org/W3090693089","https://openalex.org/W3097987047","https://openalex.org/W3112208644","https://openalex.org/W3120036520","https://openalex.org/W3123922203","https://openalex.org/W3127839532","https://openalex.org/W3133020172","https://openalex.org/W3134873082","https://openalex.org/W3139337054","https://openalex.org/W3140645667","https://openalex.org/W3144674846","https://openalex.org/W3157643617","https://openalex.org/W3170690192","https://openalex.org/W3174731555","https://openalex.org/W3177471967","https://openalex.org/W3181850837","https://openalex.org/W3188164985","https://openalex.org/W3198504181","https://openalex.org/W3205584884","https://openalex.org/W3215743505","https://openalex.org/W3217520255","https://openalex.org/W4206046172","https://openalex.org/W4210401390","https://openalex.org/W4221115671","https://openalex.org/W4224924595","https://openalex.org/W4281250943","https://openalex.org/W4292440746","https://openalex.org/W4309657549","https://openalex.org/W4309673498","https://openalex.org/W4312126174","https://openalex.org/W4313280131","https://openalex.org/W4317379852","https://openalex.org/W4319310752","https://openalex.org/W4323035899","https://openalex.org/W4324309710","https://openalex.org/W4366976470","https://openalex.org/W4367626626","https://openalex.org/W4377289384","https://openalex.org/W4378176669","https://openalex.org/W4381469200","https://openalex.org/W4382343889","https://openalex.org/W4382796397","https://openalex.org/W4383302240","https://openalex.org/W4383873038","https://openalex.org/W4384401187","https://openalex.org/W4384522700","https://openalex.org/W4385580962","https://openalex.org/W4385621831","https://openalex.org/W4385782388","https://openalex.org/W4385971954","https://openalex.org/W4386019651","https://openalex.org/W4386995672","https://openalex.org/W4387507655","https://openalex.org/W4387575633","https://openalex.org/W4387640884","https://openalex.org/W4390964116","https://openalex.org/W4391487252","https://openalex.org/W4391982483","https://openalex.org/W4392238345","https://openalex.org/W4392757206","https://openalex.org/W4392791500","https://openalex.org/W4393238211","https://openalex.org/W4394844535","https://openalex.org/W4394894573","https://openalex.org/W4394926073","https://openalex.org/W4396217049","https://openalex.org/W4399728546","https://openalex.org/W4400430462","https://openalex.org/W4401281121","https://openalex.org/W4401360165","https://openalex.org/W4401534199","https://openalex.org/W4401731976","https://openalex.org/W4402055360","https://openalex.org/W4402550118","https://openalex.org/W4402614942","https://openalex.org/W4402630518","https://openalex.org/W4403190231","https://openalex.org/W4403336104","https://openalex.org/W4403366530","https://openalex.org/W4403474164","https://openalex.org/W4403787064","https://openalex.org/W4403939029","https://openalex.org/W4404533035","https://openalex.org/W4405676000","https://openalex.org/W4405720312","https://openalex.org/W4406155237","https://openalex.org/W4406278311","https://openalex.org/W4406379505","https://openalex.org/W4406527410","https://openalex.org/W4406826144","https://openalex.org/W4408158737","https://openalex.org/W4408208852","https://openalex.org/W4408235302","https://openalex.org/W4409141337","https://openalex.org/W4409157675","https://openalex.org/W4409710864","https://openalex.org/W4409870500","https://openalex.org/W4410031117","https://openalex.org/W4410122440","https://openalex.org/W4410481920","https://openalex.org/W4410842865","https://openalex.org/W4410965641","https://openalex.org/W4411089643","https://openalex.org/W4411297611","https://openalex.org/W4412602698","https://openalex.org/W4412708443","https://openalex.org/W4412943798","https://openalex.org/W4413141508","https://openalex.org/W4413177386","https://openalex.org/W4413402294","https://openalex.org/W4413434431","https://openalex.org/W4413790479","https://openalex.org/W4414001724","https://openalex.org/W4414518314","https://openalex.org/W4414782750","https://openalex.org/W4415092555","https://openalex.org/W4415190965","https://openalex.org/W4415225549","https://openalex.org/W4415571873","https://openalex.org/W4415583298","https://openalex.org/W4415605409","https://openalex.org/W4415727674","https://openalex.org/W4415728933","https://openalex.org/W7117966657","https://openalex.org/W7124285462","https://openalex.org/W7124311247","https://openalex.org/W7125190459","https://openalex.org/W7127067253","https://openalex.org/W7127386270","https://openalex.org/W7131101350","https://openalex.org/W7131297327","https://openalex.org/W7136055184","https://openalex.org/W7136086094","https://openalex.org/W7138348808","https://openalex.org/W7140272979","https://openalex.org/W7155195906","https://openalex.org/W7155203868","https://openalex.org/W7161305486","https://openalex.org/W7162106265","https://openalex.org/W7164990230","https://openalex.org/W7204171226","https://openalex.org/W7214080784"],"related_works":["https://openalex.org/W7155195906","https://openalex.org/W7214080784","https://openalex.org/W7170073844","https://openalex.org/W7224266721","https://openalex.org/W4399728546","https://openalex.org/W4408158737","https://openalex.org/W7131101350","https://openalex.org/W7211938344","https://openalex.org/W4403336104","https://openalex.org/W4385782388"],"abstract_inverted_index":{"The":[0,12],"mechanisms":[1],"driving":[2],"irreversible":[3],"neural":[4,92,218],"cell":[5,26,42,101,219,270],"loss":[6],"in":[7,113,119,272],"neurodegenerative":[8,223,273],"diseases":[9,274],"remain":[10],"elusive.":[11],"collapse":[13],"of":[14,23,40,145,160,175],"cellular":[15,128],"redox":[16],"balance":[17],"has":[18],"unveiled":[19],"a":[20,36,56,157,165,203,249,264,277],"complex":[21],"network":[22],"emerging":[24],"metabolic":[25,69,96,269],"death":[27,43,271],"modalities":[28],"that":[29,88,98,131],"extend":[30,237],"far":[31],"beyond":[32],"classical":[33],"apoptosis.":[34],"Disulfidptosis,":[35],"newly":[37],"identified":[38],"form":[39],"regulated":[41],"driven":[44],"by":[45,51],"disulfide":[46,110,161,284],"stress":[47,111,117,162],"and":[48,115,122,127,185,195,224,231,234,255,275],"uniquely":[49],"marked":[50],"actin":[52],"cytoskeletal":[53,72,187],"collapse,":[54],"adds":[55],"critical":[57,166],"dimension":[58],"to":[59,71,91,215,217,238],"this":[60,75,211,261],"network.":[61],"This":[62],"review":[63,262],"establishes":[64],"an":[65,153],"integrative":[66],"framework\u2014from":[67],"sulfur":[68,146],"imbalance":[70],"collapse\u2014for":[73],"understanding":[74,268],"lethal":[76,158],"pathway":[77],"specifically":[78],"within":[79],"the":[80,94,106,123,138,142,172,181,199],"nervous":[81],"system.":[82],"we":[83,197,247],"focus":[84],"on":[85,178],"three":[86],"features":[87],"are":[89],"distinctive":[90],"tissue:":[93],"neuron\u2013glia":[95],"coupling":[97],"dictates":[99],"which":[100],"type":[102],"is":[103],"most":[104],"vulnerable;":[105],"contrast":[107],"between":[108],"chronic":[109,222],"dynamics":[112,118],"neurodegeneration":[114],"acute":[116,225,239],"ischemic":[120,244],"stroke;":[121],"blood\u2013brain":[124],"barrier":[125],"(BBB)":[126],"heterogeneity":[129],"constraints":[130],"shape":[132],"translational":[133],"strategies.":[134],"We":[135,168,207],"first":[136],"establish":[137],"cystine/cysteine":[139],"cycle":[140],"as":[141,202,243],"central":[143],"hub":[144],"metabolism,":[147],"revealing":[148],"how":[149,210],"it":[150],"transforms":[151],"from":[152],"antioxidant":[154],"defense":[155],"into":[156],"driver":[159],"upon":[163],"crossing":[164],"threshold.":[167],"then":[169],"systematically":[170,190],"dissect":[171],"molecular":[173],"machinery":[174],"disulfidptosis,":[176],"centered":[177],"NADPH":[179],"depletion,":[180],"SLC7A11":[182],"bidirectional":[183],"paradox,":[184],"aberrant":[186],"crosslinking.":[188],"By":[189],"comparing":[191],"disulfidptosis":[192,254],"with":[193],"ferroptosis":[194],"cuproptosis,":[196],"identify":[198],"SLC7A11-cystine-NADPH":[200],"axis":[201],"shared":[204],"regulatory":[205],"node.":[206],"further":[208],"discuss":[209],"mechanism":[212],"may":[213,235],"converge":[214],"contribute":[216],"injury":[220],"across":[221],"neurological":[226,240],"conditions,":[227],"including":[228],"Alzheimer\u2019s":[229],"disease":[230],"Parkinson\u2019s":[232],"disease,":[233],"also":[236],"conditions":[241],"such":[242],"stroke.":[245],"Finally,":[246],"propose":[248],"dual":[250],"neuroprotective":[251,281],"strategy":[252],"targeting":[253,283],"highlight":[256],"its":[257],"biomarker":[258],"potential.":[259],"Collectively,":[260],"offers":[263],"new":[265],"paradigm":[266],"for":[267,280],"lays":[276],"theoretical":[278],"foundation":[279],"strategies":[282],"homeostasis.":[285]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-04T00:00:00"}