{"id":"https://openalex.org/W7225181756","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0837","title":"837 Targeting a CD36-dependent macrophage immunometabolic program enhances PARP inhibitor response in BRCA-associated TNBC","display_name":"837 Targeting a CD36-dependent macrophage immunometabolic program enhances PARP inhibitor response in BRCA-associated TNBC","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225181756","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0837"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2026-sitc2026.0837","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0837","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0837","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A949.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/14/Suppl_2/A949.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086104883","display_name":"Carlos Wagner S Wanderley","orcid":"https://orcid.org/0000-0003-2100-9963","observed_orcids":["https://orcid.org/0000-0003-2100-9963"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Wagner S Wanderley","raw_affiliation_strings":["Brigham and Women\u2019s Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019470861","display_name":"Daniel E. Michaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel E Michaud","raw_affiliation_strings":["Brigham and Women\u2019s Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000736411","display_name":"Kiran Kurmi","orcid":"https://orcid.org/0000-0002-1345-0196","observed_orcids":["https://orcid.org/0000-0002-1345-0196"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kiran Kurmi","raw_affiliation_strings":["University of Miami Miller School of Medicine, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami Miller School of Medicine, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040696238","display_name":"Adam Nelson","orcid":"https://orcid.org/0000-0002-3074-2713","observed_orcids":["https://orcid.org/0000-0002-3074-2713"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Nelson","raw_affiliation_strings":["Brigham and Women\u2019s Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071162602","display_name":"Kenichi Shimada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenichi Shimada","raw_affiliation_strings":["Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067201940","display_name":"Alexander P. Gottlieb","orcid":"https://orcid.org/0000-0003-2691-927X","observed_orcids":["https://orcid.org/0000-0003-2691-927X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander P Gottlieb","raw_affiliation_strings":["Harvard University/Brigham and Women\u2019s Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University/Brigham and Women\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092248486","display_name":"Gabriella Antonellis","orcid":"https://orcid.org/0009-0006-4495-4772","observed_orcids":["https://orcid.org/0009-0006-4495-4772"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriella Antonellis","raw_affiliation_strings":["Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069984211","display_name":"Kelly F Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly F Zheng","raw_affiliation_strings":["Brigham and Women\u2019s Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160459469","display_name":"Anita Mehta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anita Mehta","raw_affiliation_strings":["Dana Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041420541","display_name":"Madeline G Townsend","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madeline G Townsend","raw_affiliation_strings":["Brigham and Women\u2019s Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004603786","display_name":"Xue Geng","orcid":"https://orcid.org/0000-0003-4100-9899","observed_orcids":["https://orcid.org/0000-0003-4100-9899"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xue Geng","raw_affiliation_strings":["Georgetown University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC, USA","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015642575","display_name":"Candace Bavette Mainor","orcid":"https://orcid.org/0000-0002-4431-7101","observed_orcids":["https://orcid.org/0000-0002-4431-7101"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Candace Mainor","raw_affiliation_strings":["MedStar Georgetown University Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Georgetown University Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090545501","display_name":"Mei Wei","orcid":"https://orcid.org/0000-0003-4411-1178","observed_orcids":["https://orcid.org/0000-0003-4411-1178"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mei Wei","raw_affiliation_strings":["University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030945846","display_name":"Julie Collins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Collins","raw_affiliation_strings":["AstraZeneca, Gaithersburg, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Gaithersburg, MD, USA","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022876688","display_name":"Paula Raffin Pohlmann","orcid":"https://orcid.org/0000-0001-7914-5162","observed_orcids":["https://orcid.org/0000-0001-7914-5162"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula R Pohlmann","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160534075","display_name":"Arielle L Keeke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arielle L Keeke","raw_affiliation_strings":["Atrium Health, Charlotte, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atrium Health, Charlotte, NC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160489463","display_name":"Hongkun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongkun Wang","raw_affiliation_strings":["Georgetown University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC, USA","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071176191","display_name":"Claudine J. Isaacs","orcid":"https://orcid.org/0000-0002-9646-1260","observed_orcids":["https://orcid.org/0000-0002-9646-1260"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudine Isaacs","raw_affiliation_strings":["Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003348942","display_name":"Filipa C. Lynce","orcid":"https://orcid.org/0000-0001-6615-7076","observed_orcids":["https://orcid.org/0000-0001-6615-7076"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Filipa Lynce","raw_affiliation_strings":["Breast Oncology Program, Dana-Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Oncology Program, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045419282","display_name":"Geoffrey Ira Shapiro","orcid":"https://orcid.org/0000-0002-3331-4095","observed_orcids":["https://orcid.org/0000-0002-3331-4095"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey I Shapiro","raw_affiliation_strings":["Dana Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091728889","display_name":"Jessica E. Thaxton","orcid":"https://orcid.org/0000-0003-1759-5576","observed_orcids":["https://orcid.org/0000-0003-1759-5576"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica E Thaxton","raw_affiliation_strings":["University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054904433","display_name":"Marcia C. Haigis","orcid":"https://orcid.org/0000-0003-2530-2681","observed_orcids":["https://orcid.org/0000-0003-2530-2681"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcia C Haigis","raw_affiliation_strings":["Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108281148","display_name":"Jennifer L. Guerriero","orcid":"https://orcid.org/0000-0002-2104-5457","observed_orcids":["https://orcid.org/0000-0002-2104-5457"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L Guerriero","raw_affiliation_strings":["Brigham and Women\u2019s Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A949","last_page":"A949"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.26980000734329224,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8029999732971191},{"id":"https://openalex.org/keywords/parp-inhibitor-resistance","display_name":"PARP inhibitor resistance","score":0.8339999914169312},{"id":"https://openalex.org/keywords/talazoparib","display_name":"talazoparib","score":0.9079999923706055},{"id":"https://openalex.org/keywords/olaparib","display_name":"olaparib","score":0.875},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9620000123977661},{"id":"https://openalex.org/keywords/immunometabolism","display_name":"immunometabolism","score":0.8650000095367432},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.8320000171661377},{"id":"https://openalex.org/keywords/csf1r","display_name":"CSF1R","score":0.6809999942779541},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.5529999732971191},{"id":"https://openalex.org/keywords/cgas-sting-pathway","display_name":"cGAS-STING pathway","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cd8-t-cell-exhaustion","display_name":"CD8+ T cell exhaustion","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.652400016784668},{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.6481999754905701},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6254000067710876},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.4860000014305115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42570000886917114},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3628000020980835},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.23109999299049377},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2240999937057495},{"id":"https://openalex.org/C71472368","wikidata":"https://www.wikidata.org/wiki/Q676880","display_name":"Text mining","level":2,"score":0.210999995470047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2037000060081482}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/jitc-2026-sitc2026.0837","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0837","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0837","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A949.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},{"id":"pmh:oai:doaj.org/article:19e690e098164b1aa8dec0caf6b1d3c1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/19e690e098164b1aa8dec0caf6b1d3c1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 14, Iss Suppl 2 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2026-sitc2026.0837","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0837","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0837","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A949.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225181756.pdf","grobid_xml":"https://content.openalex.org/works/W7225181756.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3112241528","https://openalex.org/W3098985666","https://openalex.org/W4205964579","https://openalex.org/W4388047803","https://openalex.org/W4322773872","https://openalex.org/W4362592065","https://openalex.org/W4404064559","https://openalex.org/W4233287672","https://openalex.org/W4206823874","https://openalex.org/W3013459929"],"abstract_inverted_index":{"Background":[0],"Although":[1],"Poly":[2],"(ADP-ribose)":[3],"polymerase":[4],"inhibitors":[5],"(PARPi)":[6],"induce":[7],"tumor":[8,16,209,293,314,336],"DNA":[9],"damage,":[10],"activating":[11],"cGAS-STING":[12],"signaling":[13,162],"and":[14,18,45,58,69,77,103,119,126,146,156,201,214,227,252,257,266,287,292,340,367,382,416,438],"enhance":[15],"immunogenicity,":[17],"immune":[19,67,127,380],"infiltration,":[20],"we":[21],"have":[22],"demonstrated":[23,218],"that,":[24],"in":[25,53,56,172,191,237,263,346,370],"BRCA-deficient":[26],"triple-negative":[27],"breast":[28,88],"cancer":[29,89],"(TNBC),":[30],"PARPi":[31,70,142,195,243,270,321,334,384,398],"simultaneously":[32],"promotes":[33],"the":[34,62,141,439],"accumulation":[35,55,171,272],"of":[36,168,199,220,229,260,273,311,338,350,433,442],"immunosuppressive":[37],"tumor-associated":[38],"macrophages":[39,57,175],"(TAMs),":[40],"characterized":[41,248],"by":[42,130,150,249,328,408,417,429],"CSF1R,":[43],"PD-L1":[44],"CD36,":[46],"a":[47,166,238,312,392],"key":[48,309],"lipid":[49,54,170,221,230,264,278,304,317,376,389],"scavenger":[50],"receptor":[51],"involved":[52,262],"therapy":[59,196],"resistance.":[60],"However,":[61],"metabolic":[63,125,210,222],"mechanisms":[64],"driving":[65],"TAM-mediated":[66],"suppression":[68],"resistance":[71],"remain":[72],"poorly":[73],"defined.Methods":[74],"Paired":[75],"baseline":[76],"1-month":[78],"on-treatment":[79],"biopsies":[80],"were":[81,110,138,148,427],"obtained":[82],"from":[83],"12":[84],"patients":[85],"with":[86,98,101,105,140,193,207,276,301,372],"BRCA1/2-mutated":[87],"receiving":[90],"talazoparib":[91],"monotherapy":[92],"(TALAVE":[93],"trial-":[94],"NCT03964532),":[95],"including":[96,224],"5":[97],"gBRCA1,":[99],"6":[100],"gBRCA2,":[102],"1":[104],"sBRCA2":[106],"mutations.":[107],"The":[108,403],"samples":[109],"analyzed":[111,149],"using":[112,180,355],"NanoString":[113],"IO360TM,":[114],"Digital":[115],"Spatial":[116,212],"Profiling":[117],"(DSP),":[118],"multiplexed":[120,215],"immunofluorescence":[121,216],"(CyCIF)":[122],"to":[123,396],"characterize":[124],"changes":[128],"induced":[129,244,335],"PARPi.":[131],"In":[132],"parallel,":[133],"BRCA1-deficient":[134,239],"tumor-bearing":[135],"mice":[136],"(K14-Cre/Brca1f/f/Trp53f/f)":[137],"treated":[139],"Olaparib":[143],"or":[144,186,345,359],"vehicle":[145],"tumors":[147,291],"bulk":[151],"RNA":[152],"sequencing,":[153],"flow":[154],"cytometry,":[155],"metabolomics.":[157],"Mechanistic":[158],"studies":[159],"evaluated":[160],"IL-34/M-CSF":[161],"via":[163],"CSF1R":[164],"as":[165,308,391,431],"driver":[167],"CD36-dependent":[169],"bone":[173],"marrow-derived":[174],"(BMDMs).":[176],"CD36":[177,353],"was":[178,406],"targeted":[179],"Sulfosuccinimidyl":[181],"oleate":[182],"(SSO),":[183],"anti-CD36":[184,357],"antibodies,":[185,358],"myeloid-specific":[187,360],"Cd36":[188,361],"deletion":[189,362],"(LysM-Cre+/-/Cd36fl/fl)":[190],"combination":[192,371],"PARPi.Results":[194],"increased":[197,250,277,285,348],"infiltration":[198,256],"TAMs":[200,275,307],"exhausted":[202],"CD8":[203,253],"T":[204],"cells":[205],"together":[206],"marked":[208],"remodeling.":[211],"transcriptomic":[213],"analyses":[217],"enrichment":[219],"pathways,":[223],"cholesterol":[225],"transport":[226],"regulation":[228],"metabolism,":[231],"particularly":[232],"within":[233,290],"TAM-rich":[234],"regions.":[235],"Similarly,":[236],"TNBC":[240],"mouse":[241],"model,":[242],"broad":[245],"immunometabolic":[246],"remodeling":[247],"myeloid":[251],"+":[254],"T-cell":[255],"enhanced":[258,364,383],"expression":[259,337,349],"genes":[261],"transport,":[265],"fatty":[267],"acid":[268],"metabolism.":[269],"promoted":[271],"CD36+PD-L1+":[274],"uptake":[279,377],"capacity.":[280],"Moreover,":[281],"metabolomic":[282],"profiling":[283],"showed":[284],"phospholipid":[286],"triglyceride":[288],"species":[289,318],"interstitial":[294],"fluid":[295],"following":[296],"PARPi,":[297],"whereas":[298],"TAM":[299,388],"depletion":[300],"anti-CSF1R":[302],"prevented":[303],"accumulation,":[305],"identifying":[306,387],"mediators":[310],"lipid-rich":[313],"microenvironment.":[315],"Importantly,":[316],"enriched":[319],"after":[320],"treatment":[322],"directly":[323],"suppressed":[324],"CD8+T-cell":[325],"effector":[326],"function":[327],"reducing":[329],"granzyme":[330],"B":[331],"expression.":[332],"Mechanistically,":[333],"IL-34":[339],"M-CSF.":[341],"These":[342],"cytokines,":[343],"alone":[344],"combination,":[347],"CD36.":[351],"Therapeutically,":[352],"inhibition":[354],"SSO,":[356],"significantly":[363],"antitumor":[365,379],"responses":[366,381],"prolonged":[368],"survival":[369],"PARPi.Conclusions":[373],"Targeting":[374],"CD36-mediated":[375],"restored":[378],"therapeutic":[385,394],"activity,":[386],"metabolism":[390],"promising":[393],"vulnerability":[395],"overcome":[397],"resistance.Trial":[399],"Registration":[400],"NCT03964532Ethics":[401],"Approval":[402],"present":[404],"study":[405],"approved":[407],"BWH":[409],"CMM":[410],"IACUC,":[411],"protocol":[412,421],"number":[413,422],"is":[414,423],"2020N000142":[415],"Dana-Farber":[418],"Cancer":[419],"Institute,":[420],"20\u2013627.":[424],"Study":[425],"drugs":[426],"provided":[428],"Pfizer,":[430],"part":[432],"an":[434],"alliance":[435],"between":[436],"Pfizer":[437],"healthcare":[440],"business":[441],"Merck":[443],"KGaA,":[444],"Darmstadt,":[445],"Germany":[446],"(CrossRef":[447],"Funder":[448],"ID:":[449],"10.13039/100009945).":[450]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-04T00:00:00"}