{"id":"https://openalex.org/W7225171966","doi":"https://doi.org/10.1128/msystems.00535-26","title":"Host genotype-microbiota-metabolome interactions modulate semen quality in Holstein bulls","display_name":"Host genotype-microbiota-metabolome interactions modulate semen quality in Holstein bulls","publication_year":2026,"publication_date":"2026-11-03","ids":{"openalex":"https://openalex.org/W7225171966","doi":"https://doi.org/10.1128/msystems.00535-26","pmid":"https://pubmed.ncbi.nlm.nih.gov/42975129"},"language":"en","primary_location":{"id":"doi:10.1128/msystems.00535-26","doi":"https://doi.org/10.1128/msystems.00535-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/msystems.00535-26","pdf_url":null,"source":{"id":"https://openalex.org/S4210181942","display_name":"mSystems","issn_l":"2379-5077","issn":["2379-5077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1128/msystems.00535-26","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063783095","display_name":"Zhihua Ju","orcid":"https://orcid.org/0000-0003-1703-3215","observed_orcids":["https://orcid.org/0000-0003-1703-3215"]},"institutions":[{"id":"https://openalex.org/I28006308","display_name":"Shandong Normal University","ror":"https://ror.org/01wy3h363","country_code":"CN","type":"education","lineage":["https://openalex.org/I28006308"]},{"id":"https://openalex.org/I4210106325","display_name":"Shandong Academy of Agricultural Sciences","ror":"https://ror.org/01fbgjv04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210106325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihua Ju","raw_affiliation_strings":["College of Life Sciences, Shandong Normal University","Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences"],"raw_orcid":"https://orcid.org/0000-0003-1703-3215","affiliations":[{"raw_affiliation_string":"College of Life Sciences, Shandong Normal University","institution_ids":["https://openalex.org/I28006308"]},{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210106325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160561708","display_name":"Qiang Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106325","display_name":"Shandong Academy of Agricultural Sciences","ror":"https://ror.org/01fbgjv04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210106325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Jiang","raw_affiliation_strings":["Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210106325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124701204","display_name":"Yanqin Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106325","display_name":"Shandong Academy of Agricultural Sciences","ror":"https://ror.org/01fbgjv04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210106325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanqin Li","raw_affiliation_strings":["Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210106325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154234685","display_name":"Yuanpei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106325","display_name":"Shandong Academy of Agricultural Sciences","ror":"https://ror.org/01fbgjv04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210106325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanpei Zhang","raw_affiliation_strings":["Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210106325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160562468","display_name":"Yao Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106325","display_name":"Shandong Academy of Agricultural Sciences","ror":"https://ror.org/01fbgjv04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210106325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Xiao","raw_affiliation_strings":["Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210106325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063474490","display_name":"Yaran Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106325","display_name":"Shandong Academy of Agricultural Sciences","ror":"https://ror.org/01fbgjv04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210106325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaran Zhang","raw_affiliation_strings":["Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210106325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160549386","display_name":"Xiuge Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106325","display_name":"Shandong Academy of Agricultural Sciences","ror":"https://ror.org/01fbgjv04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210106325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiuge Wang","raw_affiliation_strings":["Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210106325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160568897","display_name":"Xiaochao Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106325","display_name":"Shandong Academy of Agricultural Sciences","ror":"https://ror.org/01fbgjv04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210106325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaochao Wei","raw_affiliation_strings":["Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210106325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160399236","display_name":"Yaping Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106325","display_name":"Shandong Academy of Agricultural Sciences","ror":"https://ror.org/01fbgjv04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210106325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaping Gao","raw_affiliation_strings":["Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210106325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160482521","display_name":"Chunhong Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106325","display_name":"Shandong Academy of Agricultural Sciences","ror":"https://ror.org/01fbgjv04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210106325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunhong Yang","raw_affiliation_strings":["Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210106325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160554708","display_name":"Wenhao Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106325","display_name":"Shandong Academy of Agricultural Sciences","ror":"https://ror.org/01fbgjv04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210106325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenhao Liu","raw_affiliation_strings":["Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210106325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100376322","display_name":"Jinpeng Wang","orcid":"https://orcid.org/0000-0003-1892-0246","observed_orcids":["https://orcid.org/0000-0003-1892-0246","https://orcid.org/0009-0007-3964-6553"]},"institutions":[{"id":"https://openalex.org/I4210106325","display_name":"Shandong Academy of Agricultural Sciences","ror":"https://ror.org/01fbgjv04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210106325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinpeng Wang","raw_affiliation_strings":["Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences"],"raw_orcid":"https://orcid.org/0000-0003-1892-0246","affiliations":[{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210106325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089351877","display_name":"Jinming Huang","orcid":"https://orcid.org/0000-0001-9621-5652","observed_orcids":["https://orcid.org/0000-0001-9621-5652"]},"institutions":[{"id":"https://openalex.org/I28006308","display_name":"Shandong Normal University","ror":"https://ror.org/01wy3h363","country_code":"CN","type":"education","lineage":["https://openalex.org/I28006308"]},{"id":"https://openalex.org/I4210106325","display_name":"Shandong Academy of Agricultural Sciences","ror":"https://ror.org/01fbgjv04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210106325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinming Huang","raw_affiliation_strings":["College of Life Sciences, Shandong Normal University","Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences"],"raw_orcid":"https://orcid.org/0000-0001-9621-5652","affiliations":[{"raw_affiliation_string":"College of Life Sciences, Shandong Normal University","institution_ids":["https://openalex.org/I28006308"]},{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210106325"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84698941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"e0053526","last_page":"e0053526"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.6650000214576721,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.6650000214576721,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.28200000524520874,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.034699998795986176,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sperm-quality","display_name":"semen quality","score":0.9959999918937683},{"id":"https://openalex.org/keywords/holstein-bulls","display_name":"Holstein bulls","score":0.949999988079071},{"id":"https://openalex.org/keywords/bull-fertility","display_name":"bull fertility","score":0.8299999833106995},{"id":"https://openalex.org/keywords/rumen-microbiota","display_name":"rumen microbiota","score":0.9700000286102295},{"id":"https://openalex.org/keywords/fibrobacter","display_name":"Fibrobacter","score":0.9380000233650208},{"id":"https://openalex.org/keywords/thromboxane-b2","display_name":"thromboxane B2","score":0.9359999895095825},{"id":"https://openalex.org/keywords/sperm-motility","display_name":"sperm motility","score":0.8980000019073486},{"id":"https://openalex.org/keywords/sperm-concentration","display_name":"sperm concentration","score":0.7630000114440918},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8880000114440918},{"id":"https://openalex.org/keywords/candidate-biomarkers","display_name":"candidate biomarkers","score":0.6850000023841858},{"id":"https://openalex.org/keywords/dairy-cattle-reproduction","display_name":"dairy cattle reproduction","score":0.7350000143051147},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C2778093475","wikidata":"https://www.wikidata.org/wiki/Q9715","display_name":"Semen","level":2,"score":0.8105000257492065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7940999865531921},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.7369999885559082},{"id":"https://openalex.org/C2778080409","wikidata":"https://www.wikidata.org/wiki/Q2916689","display_name":"Semen quality","level":3,"score":0.7228999733924866},{"id":"https://openalex.org/C2776549489","wikidata":"https://www.wikidata.org/wiki/Q5446451","display_name":"Fibrobacter succinogenes","level":4,"score":0.49300000071525574},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.4745999872684479},{"id":"https://openalex.org/C2777632594","wikidata":"https://www.wikidata.org/wiki/Q27116486","display_name":"Sperm motility","level":3,"score":0.4388999938964844},{"id":"https://openalex.org/C2778499950","wikidata":"https://www.wikidata.org/wiki/Q7449214","display_name":"Semen collection","level":4,"score":0.3928000032901764},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.36250001192092896},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.33660000562667847},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3271999955177307},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.3244999945163727},{"id":"https://openalex.org/C2780625307","wikidata":"https://www.wikidata.org/wiki/Q264976","display_name":"Periplaneta","level":3,"score":0.31859999895095825},{"id":"https://openalex.org/C2777589648","wikidata":"https://www.wikidata.org/wiki/Q1501844","display_name":"Semen analysis","level":4,"score":0.31679999828338623},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.27399998903274536},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.2671999931335449},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2653000056743622},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.2506999969482422}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1128/msystems.00535-26","doi":"https://doi.org/10.1128/msystems.00535-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/msystems.00535-26","pdf_url":null,"source":{"id":"https://openalex.org/S4210181942","display_name":"mSystems","issn_l":"2379-5077","issn":["2379-5077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"journal-article"},{"id":"pmid:42975129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42975129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/msystems.00535-26","doi":"https://doi.org/10.1128/msystems.00535-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/msystems.00535-26","pdf_url":null,"source":{"id":"https://openalex.org/S4210181942","display_name":"mSystems","issn_l":"2379-5077","issn":["2379-5077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9208999872207642,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1842963151","https://openalex.org/W1913957972","https://openalex.org/W1966119405","https://openalex.org/W1985627474","https://openalex.org/W1991833621","https://openalex.org/W2006223487","https://openalex.org/W2015303573","https://openalex.org/W2020402057","https://openalex.org/W2026006003","https://openalex.org/W2033151532","https://openalex.org/W2036897871","https://openalex.org/W2042473229","https://openalex.org/W2069049474","https://openalex.org/W2110035718","https://openalex.org/W2121612337","https://openalex.org/W2125784987","https://openalex.org/W2131271579","https://openalex.org/W2136879569","https://openalex.org/W2157068460","https://openalex.org/W2161633633","https://openalex.org/W2164229548","https://openalex.org/W2295598076","https://openalex.org/W2625207619","https://openalex.org/W2741777229","https://openalex.org/W2807391293","https://openalex.org/W2810133450","https://openalex.org/W2895695101","https://openalex.org/W2897766421","https://openalex.org/W2953135971","https://openalex.org/W2999204373","https://openalex.org/W3117591089","https://openalex.org/W3122643716","https://openalex.org/W3134360847","https://openalex.org/W3160238730","https://openalex.org/W3160905321","https://openalex.org/W3175752499","https://openalex.org/W4206757948","https://openalex.org/W4210741978","https://openalex.org/W4243150065","https://openalex.org/W4300427303","https://openalex.org/W4308772947","https://openalex.org/W4318206005","https://openalex.org/W4372346305","https://openalex.org/W4376631172","https://openalex.org/W4390788601","https://openalex.org/W4390880895","https://openalex.org/W4390907473","https://openalex.org/W4391324527","https://openalex.org/W4392083840","https://openalex.org/W4398132933","https://openalex.org/W4399857377","https://openalex.org/W4401480476","https://openalex.org/W4402175872","https://openalex.org/W4404234258"],"related_works":["https://openalex.org/W7168412930","https://openalex.org/W4411930134","https://openalex.org/W7124315068","https://openalex.org/W4399047968","https://openalex.org/W7215911626","https://openalex.org/W4210538578","https://openalex.org/W7154977024","https://openalex.org/W4389711879","https://openalex.org/W4282932213","https://openalex.org/W4401148467"],"abstract_inverted_index":{"ABSTRACT":[0],"Semen":[1],"quality":[2,37,43,50,241,272,283],"is":[3,258,287],"critical":[4],"for":[5,249,260,320,335],"reproductive":[6,261,339],"performance":[7],"in":[8,75,102,107,128,199,242,263,281,284,292],"dairy":[9,264],"cattle;":[10],"however,":[11],"its":[12],"microbial,":[13,235],"metabolic,":[14],"and":[15,26,40,67,78,84,99,104,117,135,150,165,193,218,236,245,252,296,306,325,332,338],"genetic":[16,298],"bases":[17],"remain":[18,273],"poorly":[19],"understood.":[20,275],"We":[21],"integrated":[22],"rumen":[23,60,293],"microbiota,":[24,294],"metabolome,":[25],"genome-wide":[27,151],"variation":[28,280],"from":[29],"55":[30],"Holstein":[31,243,285],"bulls":[32,77,244,286],"stratified":[33],"into":[34,183],"relative":[35,41],"semen":[36,42,49,129,142,200,214,240,271,282,313],"high":[38,148],"(RSQH)":[39],"low":[44],"(RSQL)":[45],"groups":[46,91],"based":[47,175],"on":[48,176],"records":[51],"to":[52,114,126,172,239],"investigate":[53],"host-microbiome-metabolome":[54],"interactions":[55],"associated":[56,80,162,212,226,288],"with":[57,81,92,163,187,213,227,289],"fertility.":[58],"The":[59,86],"microbiota":[61],"was":[62,73],"dominated":[63],"by":[64,145],"Bacteroidota,":[65],"Firmicutes,":[66],"Proteobacteria,":[68],"while":[69],"Fibrobacter":[70,131,164,302],"(phylum":[71],"Fibrobacterota)":[72],"enriched":[74],"RSQH":[76,103],"positively":[79,211],"sperm":[82,173],"motility":[83,174],"density.":[85],"metabolome":[87],"distinguished":[88],"the":[89,267,328],"two":[90,184],"64":[93],"discriminatory":[94],"metabolites,":[95,167,295],"including":[96,168],"elevated":[97],"N-acetyl-L-phenylalanine":[98],"prostaglandin":[100],"H2":[101],"sebacic":[105],"acid":[106],"RSQL.":[108],"Machine":[109],"learning":[110],"models":[111],"were":[112,160,181,210,224],"used":[113],"prioritize":[115],"microbial":[116,217],"metabolic":[118,237],"features,":[119],"identifying":[120],"candidate":[121,139,247],"markers":[122],"that":[123,207,279],"may":[124,326],"contribute":[125],"differences":[127,291],"quality.":[130,314],",":[132,303],"thromboxane":[133,304],"B2,":[134,305],"N1-[4-(cyanomethyl)phenyl]-4-chlorobenzamide":[136,307],"emerged":[137,308],"as":[138,309],"indicators":[140,311],"of":[141,312,330],"quality,":[143],"supported":[144],"machine":[146],"learning,":[147],"heritability,":[149],"association":[152],"study":[153,277],"signals.":[154],"Overall,":[155],"511":[156],"single-nucleotide":[157],"polymorphisms":[158],"(SNPs)":[159],"jointly":[161],"these":[166],"six":[169],"significantly":[170],"linked":[171],"GWAS":[177],"analysis.":[178],"These":[179,229,315],"SNPs":[180],"grouped":[182],"contrasting":[185],"types,":[186],"C1-type":[188,222],"variants":[189,195,209,223],"showing":[190,196],"decreasing":[191],"trends":[192,198],"C2-type":[194,208],"increasing":[197],"quality-related":[201],"traits.":[202],"Structural":[203],"equation":[204],"modeling":[205],"revealed":[206],"traits":[215],"through":[216],"metabolite":[219],"enrichment,":[220],"whereas":[221],"negatively":[225],"them.":[228],"findings":[230,316],"highlight":[231],"coordinated":[232,290],"host":[233,297],"genetic,":[234],"contributions":[238],"provide":[246,317],"biomarkers":[248],"fertility-related":[250],"research":[251,324],"breeding.":[253],"IMPORTANCE":[254],"Improving":[255],"bull":[256,336],"fertility":[257,322],"important":[259],"efficiency":[262],"production,":[265],"but":[266],"biological":[268],"factors":[269],"underlying":[270],"incompletely":[274],"This":[276],"shows":[278],"variation.":[299],"In":[300],"particular,":[301],"promising":[310],"a":[318],"basis":[319],"future":[321],"biomarker":[323],"support":[327],"development":[329],"genetics-":[331],"microbiota-informed":[333],"strategies":[334],"selection":[337],"management.":[340]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-04T00:00:00"}