{"id":"https://openalex.org/W7225165352","doi":"https://doi.org/10.64898/2026.11.02.762883","title":"Cryo-EM structures of Cereibacter sphaeroides ferrochelatase reveal an oligomeric state that occludes the substrate-binding site","display_name":"Cryo-EM structures of Cereibacter sphaeroides ferrochelatase reveal an oligomeric state that occludes the substrate-binding site","publication_year":2026,"publication_date":"2026-11-03","ids":{"openalex":"https://openalex.org/W7225165352","doi":"https://doi.org/10.64898/2026.11.02.762883"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.02.762883","doi":"https://doi.org/10.64898/2026.11.02.762883","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.02.762883","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/03/2026.11.02.762883.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/03/2026.11.02.762883.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033723352","display_name":"Jack H. Salisbury","orcid":"https://orcid.org/0000-0002-9527-0593","observed_orcids":["https://orcid.org/0000-0002-9527-0593"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I79266365","display_name":"MRC Mitochondrial Biology Unit","ror":"https://ror.org/01vdt8f48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I79266365","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jack H Salisbury","raw_affiliation_strings":["Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK;"],"raw_orcid":"https://orcid.org/0000-0002-9527-0593","affiliations":[{"raw_affiliation_string":"Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK;","institution_ids":["https://openalex.org/I241749","https://openalex.org/I79266365","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006395727","display_name":"Qian Pu","orcid":"https://orcid.org/0000-0002-5888-8546","observed_orcids":["https://orcid.org/0000-0002-5888-8546"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pu Qian","raw_affiliation_strings":["School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK;"],"raw_orcid":"https://orcid.org/0000-0002-5888-8546","affiliations":[{"raw_affiliation_string":"School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK;","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023434580","display_name":"Yibo Jin","orcid":"https://orcid.org/0000-0001-5386-840X","observed_orcids":["https://orcid.org/0000-0001-5386-840X"]},"institutions":[{"id":"https://openalex.org/I4210102558","display_name":"Thermo Fisher Scientific (Netherlands)","ror":"https://ror.org/01139ec29","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102558","https://openalex.org/I4210142480"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Yibo Jin","raw_affiliation_strings":["Materials and Structural Analysis, Thermo Fisher Scientific, 5651 GG Eindhoven, Netherlands;"],"raw_orcid":"https://orcid.org/0000-0001-5386-840X","affiliations":[{"raw_affiliation_string":"Materials and Structural Analysis, Thermo Fisher Scientific, 5651 GG Eindhoven, Netherlands;","institution_ids":["https://openalex.org/I4210102558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025746420","display_name":"Amanda A. Brindley","orcid":"https://orcid.org/0000-0002-2528-8093","observed_orcids":["https://orcid.org/0000-0002-2528-8093"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Amanda A Brindley","raw_affiliation_strings":["School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK;"],"raw_orcid":"https://orcid.org/0000-0002-2528-8093","affiliations":[{"raw_affiliation_string":"School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK;","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141265154","display_name":"Joshua R Barrett","orcid":"https://orcid.org/0009-0000-5497-2647","observed_orcids":["https://orcid.org/0009-0000-5497-2647"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joshua R Barrett","raw_affiliation_strings":["School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK;"],"raw_orcid":"https://orcid.org/0009-0000-5497-2647","affiliations":[{"raw_affiliation_string":"School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK;","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032232299","display_name":"Nathan B. P. Adams","orcid":"https://orcid.org/0000-0003-3080-3448","observed_orcids":["https://orcid.org/0000-0003-3080-3448"]},"institutions":[{"id":"https://openalex.org/I4210112031","display_name":"NanoTemper Technologies (Germany)","ror":"https://ror.org/01c3zvj45","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210112031"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nathan B P Adams","raw_affiliation_strings":["NanoTemper Technologies, 81369 Munich, Germany;"],"raw_orcid":"https://orcid.org/0000-0003-3080-3448","affiliations":[{"raw_affiliation_string":"NanoTemper Technologies, 81369 Munich, Germany;","institution_ids":["https://openalex.org/I4210112031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160504124","display_name":"Ruby R E Harvey","orcid":"https://orcid.org/0009-0006-2697-0541","observed_orcids":["https://orcid.org/0009-0006-2697-0541"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ruby R E Harvey","raw_affiliation_strings":["School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK;"],"raw_orcid":"https://orcid.org/0009-0006-2697-0541","affiliations":[{"raw_affiliation_string":"School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK;","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072055219","display_name":"Frederick R. Hawkings","orcid":"https://orcid.org/0000-0001-6741-920X","observed_orcids":["https://orcid.org/0000-0001-6741-920X"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Frederick R Hawkings","raw_affiliation_strings":["Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK;"],"raw_orcid":"https://orcid.org/0000-0001-6741-920X","affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK;","institution_ids":["https://openalex.org/I170203145","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160403089","display_name":"Harold A Cannon","orcid":"https://orcid.org/0009-0002-2129-1663","observed_orcids":["https://orcid.org/0009-0002-2129-1663"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Harold A Cannon","raw_affiliation_strings":["Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK;"],"raw_orcid":"https://orcid.org/0009-0002-2129-1663","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK;","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020269992","display_name":"George A. Sutherland","orcid":"https://orcid.org/0000-0002-6319-4637","observed_orcids":["https://orcid.org/0000-0002-6319-4637"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George A Sutherland","raw_affiliation_strings":["Baseimmune, London BioScience Innovation Centre (LBIC), London NW1 0NH, UK;"],"raw_orcid":"https://orcid.org/0000-0002-6319-4637","affiliations":[{"raw_affiliation_string":"Baseimmune, London BioScience Innovation Centre (LBIC), London NW1 0NH, UK;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055889668","display_name":"Matthew P. Johnson","orcid":"https://orcid.org/0000-0002-1663-0205","observed_orcids":["https://orcid.org/0000-0002-1663-0205"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthew P Johnson","raw_affiliation_strings":["School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK;"],"raw_orcid":"https://orcid.org/0000-0002-1663-0205","affiliations":[{"raw_affiliation_string":"School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK;","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077704447","display_name":"J. David Reid","orcid":"https://orcid.org/0000-0003-4921-1047","observed_orcids":["https://orcid.org/0000-0003-4921-1047"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James D Reid","raw_affiliation_strings":["School of Mathematical and Physical Sciences, University of Sheffield, Sheffield S3 7HF, UK;"],"raw_orcid":"https://orcid.org/0000-0003-4921-1047","affiliations":[{"raw_affiliation_string":"School of Mathematical and Physical Sciences, University of Sheffield, Sheffield S3 7HF, UK;","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040129856","display_name":"David J. K. Swainsbury","orcid":"https://orcid.org/0000-0002-0754-0363","observed_orcids":["https://orcid.org/0000-0002-0754-0363"]},"institutions":[{"id":"https://openalex.org/I1118541","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93","country_code":"GB","type":"education","lineage":["https://openalex.org/I1118541"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J K Swainsbury","raw_affiliation_strings":["School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK"],"raw_orcid":"https://orcid.org/0000-0002-0754-0363","affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK","institution_ids":["https://openalex.org/I1118541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035062175","display_name":"Pablo Castro\u2010Hartmann","orcid":"https://orcid.org/0000-0002-8991-9560","observed_orcids":["https://orcid.org/0000-0002-8991-9560"]},"institutions":[{"id":"https://openalex.org/I4210102558","display_name":"Thermo Fisher Scientific (Netherlands)","ror":"https://ror.org/01139ec29","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102558","https://openalex.org/I4210142480"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Pablo Castro-Hartmann","raw_affiliation_strings":["Materials and Structural Analysis, Thermo Fisher Scientific, 5651 GG Eindhoven, Netherlands;"],"raw_orcid":"https://orcid.org/0000-0002-8991-9560","affiliations":[{"raw_affiliation_string":"Materials and Structural Analysis, Thermo Fisher Scientific, 5651 GG Eindhoven, Netherlands;","institution_ids":["https://openalex.org/I4210102558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015977235","display_name":"Per A. Bullough","orcid":"https://orcid.org/0000-0001-8147-1127","observed_orcids":["https://orcid.org/0000-0001-8147-1127"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Per A Bullough","raw_affiliation_strings":["School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK;"],"raw_orcid":"https://orcid.org/0000-0001-8147-1127","affiliations":[{"raw_affiliation_string":"School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK;","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011434749","display_name":"Christopher Neil Hunter","orcid":"https://orcid.org/0000-0003-2533-9783","observed_orcids":["https://orcid.org/0000-0003-2533-9783","https://orcid.org/0000-0003-1498-2327"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C Neil Hunter","raw_affiliation_strings":["School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK;"],"raw_orcid":"https://orcid.org/0000-0003-2533-9783","affiliations":[{"raw_affiliation_string":"School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK;","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047571061","display_name":"Andrew Hitchcock","orcid":"https://orcid.org/0000-0001-6572-434X","observed_orcids":["https://orcid.org/0000-0001-6572-434X"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew Hitchcock","raw_affiliation_strings":["School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK;"],"raw_orcid":"https://orcid.org/0000-0001-6572-434X","affiliations":[{"raw_affiliation_string":"School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK;","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5033723352"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I79266365","https://openalex.org/I90344618"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.7109000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.7109000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10903","display_name":"Porphyrin and Phthalocyanine Chemistry","score":0.12160000205039978,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.04170000180602074,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferrochelatase","display_name":"ferrochelatase","score":0.8820000290870667},{"id":"https://openalex.org/keywords/rhodobacter-sphaeroides","display_name":"Rhodobacter sphaeroides","score":0.9959999918937683},{"id":"https://openalex.org/keywords/protoporphyrin-ix","display_name":"protoporphyrin IX","score":0.8970000147819519},{"id":"https://openalex.org/keywords/heme-biosynthesis","display_name":"heme biosynthesis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/bacteriochlorophyll-biosynthesis","display_name":"bacteriochlorophyll biosynthesis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/enzyme-oligomerization","display_name":"enzyme oligomerization","score":0.8190000057220459},{"id":"https://openalex.org/keywords/homotetramer","display_name":"homotetramer","score":0.7950000166893005},{"id":"https://openalex.org/keywords/active-site-occlusion","display_name":"active site occlusion","score":0.824999988079071},{"id":"https://openalex.org/keywords/heme-coordination","display_name":"heme coordination","score":0.4399999976158142},{"id":"https://openalex.org/keywords/membrane-docking","display_name":"membrane docking","score":0.4020000100135803},{"id":"https://openalex.org/keywords/purple-bacteria","display_name":"purple bacteria","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C2781149050","wikidata":"https://www.wikidata.org/wiki/Q408712","display_name":"Ferrochelatase","level":4,"score":0.8712000250816345},{"id":"https://openalex.org/C2777897970","wikidata":"https://www.wikidata.org/wiki/Q4186823","display_name":"Rhodobacter sphaeroides","level":3,"score":0.8385000228881836},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8015999794006348},{"id":"https://openalex.org/C2777710969","wikidata":"https://www.wikidata.org/wiki/Q422399","display_name":"Tetrapyrrole","level":3,"score":0.7868000268936157},{"id":"https://openalex.org/C2778886173","wikidata":"https://www.wikidata.org/wiki/Q53832","display_name":"Tetramer","level":3,"score":0.695900022983551},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.5306000113487244},{"id":"https://openalex.org/C2780784151","wikidata":"https://www.wikidata.org/wiki/Q1992180","display_name":"Bacteriochlorophyll","level":3,"score":0.515999972820282},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.5117999911308289},{"id":"https://openalex.org/C2779671804","wikidata":"https://www.wikidata.org/wiki/Q619815","display_name":"Protoporphyrin IX","level":3,"score":0.5005000233650208},{"id":"https://openalex.org/C2776253728","wikidata":"https://www.wikidata.org/wiki/Q422964","display_name":"Biliverdin","level":5,"score":0.4921000003814697},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.4902999997138977},{"id":"https://openalex.org/C2778417259","wikidata":"https://www.wikidata.org/wiki/Q619815","display_name":"Protoporphyrin","level":3,"score":0.4702000021934509},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.45840001106262207},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4465000033378601},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4447000026702881},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39660000801086426},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.39089998602867126},{"id":"https://openalex.org/C2779480358","wikidata":"https://www.wikidata.org/wiki/Q422926","display_name":"Porphyrin","level":2,"score":0.3772999942302704},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.36629998683929443},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.35519999265670776},{"id":"https://openalex.org/C2776403692","wikidata":"https://www.wikidata.org/wiki/Q898416","display_name":"Trimer","level":3,"score":0.32839998602867126},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.31200000643730164},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.29170000553131104},{"id":"https://openalex.org/C2777002184","wikidata":"https://www.wikidata.org/wiki/Q63370","display_name":"Pheophorbide A","level":3,"score":0.2872999906539917},{"id":"https://openalex.org/C20705724","wikidata":"https://www.wikidata.org/wiki/Q902628","display_name":"Hemeprotein","level":4,"score":0.2816999852657318},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.27619999647140503},{"id":"https://openalex.org/C147604119","wikidata":"https://www.wikidata.org/wiki/Q890481","display_name":"Chlorosome","level":4,"score":0.2711000144481659},{"id":"https://openalex.org/C2780866276","wikidata":"https://www.wikidata.org/wiki/Q7761386","display_name":"DHPS","level":4,"score":0.26969999074935913},{"id":"https://openalex.org/C201663137","wikidata":"https://www.wikidata.org/wiki/Q21198990","display_name":"Periplasmic space","level":4,"score":0.2628999948501587},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2619999945163727},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.2572999894618988},{"id":"https://openalex.org/C2781116636","wikidata":"https://www.wikidata.org/wiki/Q426228","display_name":"Vanadate","level":2,"score":0.2551000118255615},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.2547999918460846}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.02.762883","doi":"https://doi.org/10.64898/2026.11.02.762883","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.02.762883","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/03/2026.11.02.762883.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.02.762883","doi":"https://doi.org/10.64898/2026.11.02.762883","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.02.762883","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/03/2026.11.02.762883.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4845543370","display_name":null,"funder_award_id":"854126","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5199099248","display_name":null,"funder_award_id":"854126","funder_id":"https://openalex.org/F4320320342","funder_display_name":"University of Sheffield"},{"id":"https://openalex.org/G5373728667","display_name":null,"funder_award_id":"URF\\R1\\191548","funder_id":"https://openalex.org/F4320320342","funder_display_name":"University of Sheffield"},{"id":"https://openalex.org/G8125674145","display_name":"Synthesising the pigments of life: Structure, function and regulation of metal chelatases in phototrophic bacteria","funder_award_id":"2881069","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320313096","display_name":"Diamond Light Source","ror":"https://ror.org/05etxs293"},{"id":"https://openalex.org/F4320320274","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93"},{"id":"https://openalex.org/F4320320342","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225165352.pdf","grobid_xml":"https://content.openalex.org/works/W7225165352.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2071531919","https://openalex.org/W2170728112","https://openalex.org/W2992830388","https://openalex.org/W2948640544","https://openalex.org/W809103659","https://openalex.org/W2768339465","https://openalex.org/W4310954197","https://openalex.org/W2046899794","https://openalex.org/W1978027005","https://openalex.org/W2049208624"],"abstract_inverted_index":{"Protoporphyrin":[0],"IX":[1],"(PPIX)":[2],"is":[3],"the":[4,20,46,64,86,90,114,126,159,176,185,192,200,204,212,232,237],"last":[5],"shared":[6],"intermediate":[7],"of":[8,15,49,53,95,130,135,158,179,225,234],"heme":[9],"and":[10,79,92,215],"(bacterio)chlorophyll":[11],"((B)Chl)":[12],"biosynthesis.":[13],"Insertion":[14],"iron":[16],"into":[17],"PPIX":[18,21,50,173],"by":[19,30],"ferrochelatase":[22],"(FeCh)":[23],"PpfC":[24,136,186],"produces":[25],"heme,":[26],"whereas":[27,203],"magnesium":[28,31],"insertion":[29],"chelatase":[32],"(MgCh)":[33],"initiates":[34],"(B)Chl":[35],"synthesis.":[36],"Chlorophototrophic":[37],"organisms":[38],"must":[39],"regulate":[40],"this":[41],"biosynthetic":[42],"node":[43],"to":[44,51,107,111,199,230],"ensure":[45],"correct":[47],"flux":[48,233],"each":[52,180],"these":[54],"crucial":[55],"tetrapyrrole":[56],"products,":[57],"presenting":[58],"a":[59,119,141,144,154,168,196,207],"particularly":[60],"acute":[61],"problem":[62],"for":[63,89,118],"facultative":[65],"bacterium":[66],"Cereibacter":[67],"(previously":[68],"Rhodobacter":[69],")":[70],"sphaeroides":[71,97],",":[72,138],"which":[73,139,163],"can":[74],"switch":[75],"between":[76],"chemotrophic":[77],"(respiratory)":[78],"phototrophic":[80,122],"(photosynthetic)":[81],"growth":[82],"modes.":[83],"To":[84],"elucidate":[85],"structural":[87],"basis":[88],"catalytic":[91],"regulatory":[93],"functions":[94],"C.":[96],"FeCh":[98,226],"(PpfC":[99],"Cs":[100,137,187],"),":[101],"we":[102],"used":[103],"cryogenic":[104],"electron":[105],"microscopy":[106],"determine":[108],"its":[109],"structure,":[110],"our":[112],"knowledge":[113],"first":[115],"such":[116],"information":[117],"Gram-negative":[120],"or":[121],"organism.":[123],"We":[124,151,182],"determined":[125,153],"2.6":[127],"\u00c5":[128,156],"structure":[129,157],"an":[131],"active":[132,177,216],"site":[133,178,217],"mutant":[134],"forms":[140],"dimer":[142,188],"with":[143],"monomer-to-monomer":[145],"interface":[146],"that":[147,171,184],"coordinates":[148],"two":[149,164],"hemes.":[150],"also":[152],"2.5":[155],"wild-type":[160],"enzyme,":[161,202],"in":[162,167,195,240],"dimers":[165],"interact":[166],"homotetrameric":[169],"arrangement":[170],"occludes":[172],"binding":[174],"at":[175],"monomer.":[181],"propose":[183],"likely":[189],"docks":[190],"onto":[191],"inner":[193],"membrane":[194],"manner":[197],"analogous":[198],"human":[201],"tetramer":[205],"represents":[206],"transiently":[208],"inactive":[209],"state":[210],"whereby":[211],"hydrophobic":[213],"lips":[214],"are":[218],"both":[219],"occluded.":[220],"These":[221],"novel":[222],"oligomerization":[223],"states":[224],"may":[227],"have":[228],"evolved":[229],"influence":[231],"tetrapyrroles":[235],"through":[236],"heme/BChl":[238],"branchpoint":[239],"purple":[241],"bacteria.":[242]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-04T00:00:00"}
