{"id":"https://openalex.org/W7225165252","doi":"https://doi.org/10.48550/arxiv.2611.02931","title":"Training-Time Domain Transfer for Generator-Free Diagnostics on Novel Modalities in Computational Pathology","display_name":"Training-Time Domain Transfer for Generator-Free Diagnostics on Novel Modalities in Computational Pathology","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225165252","doi":"https://doi.org/10.48550/arxiv.2611.02931"},"language":"en","primary_location":{"id":"pmh:oai:arXiv.org:2611.02931","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2611.02931","pdf_url":"https://arxiv.org/pdf/2611.02931","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"preprint","indexed_in":["arxiv","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2611.02931","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116679627","display_name":"Julia Anna Mielcarz","orcid":"https://orcid.org/0009-0005-3992-4774","observed_orcids":["https://orcid.org/0009-0005-3992-4774"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mielcarz, Julia A.","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117144079","display_name":"Andrea Camilloni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Camilloni, Andrea","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030758146","display_name":"Nita Mulliqi","orcid":"https://orcid.org/0009-0002-7448-4960","observed_orcids":["https://orcid.org/0009-0002-7448-4960"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mulliqi, Nita","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005417593","display_name":"Jessica A. Frank","orcid":"https://orcid.org/0000-0001-5334-3240","observed_orcids":["https://orcid.org/0000-0001-5334-3240"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Frank, Jessica A.","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Sweden","Harvard Medical School , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Harvard Medical School , USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090691354","display_name":"Anders Blilie","orcid":"https://orcid.org/0009-0002-9546-5443","observed_orcids":["https://orcid.org/0009-0002-9546-5443"]},"institutions":[{"id":"https://openalex.org/I2800132241","display_name":"Stavanger University Hospital","ror":"https://ror.org/04zn72g03","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800132241"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Blilie, Anders","raw_affiliation_strings":["Department of Pathology , Stavanger University Hospital , Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology , Stavanger University Hospital , Norway","institution_ids":["https://openalex.org/I2800132241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003110329","display_name":"Emiel A. M. Janssen","orcid":"https://orcid.org/0000-0002-7760-5396","observed_orcids":["https://orcid.org/0000-0002-7760-5396"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janssen, Emilius A. M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135348791","display_name":"Martin Eklund","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Eklund, Martin","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069504905","display_name":"Kimmo Kartasalo","orcid":"https://orcid.org/0000-0002-9470-4783","observed_orcids":["https://orcid.org/0000-0002-9470-4783"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kartasalo, Kimmo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11307","display_name":"Domain Adaptation and Few-Shot Learning","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer-detection","display_name":"prostate cancer detection","score":0.5759999752044678},{"id":"https://openalex.org/keywords/synthetic-training-data-generation","display_name":"synthetic training data generation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/virtual-staining","display_name":"virtual staining","score":0.7509999871253967},{"id":"https://openalex.org/keywords/computational-pathology","display_name":"computational pathology","score":0.5709999799728394},{"id":"https://openalex.org/keywords/histopathology-image-classification","display_name":"histopathological image classification","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C2779903281","wikidata":"https://www.wikidata.org/wiki/Q6888026","display_name":"Modalities","level":2,"score":0.6941999793052673},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6747999787330627},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.6158000230789185},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5680000185966492},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.5454999804496765},{"id":"https://openalex.org/C534262118","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Medical diagnosis","level":2,"score":0.42660000920295715},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.39320001006126404},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3856000006198883},{"id":"https://openalex.org/C2780226545","wikidata":"https://www.wikidata.org/wiki/Q6888030","display_name":"Modality (human\u2013computer interaction)","level":2,"score":0.3840999901294708},{"id":"https://openalex.org/C150899416","wikidata":"https://www.wikidata.org/wiki/Q1820378","display_name":"Transfer of learning","level":2,"score":0.37059998512268066},{"id":"https://openalex.org/C51632099","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Training set","level":2,"score":0.35830000042915344},{"id":"https://openalex.org/C2780029942","wikidata":"https://www.wikidata.org/wiki/Q7935138","display_name":"Virtual microscopy","level":2,"score":0.35569998621940613},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.3305000066757202},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3292999863624573},{"id":"https://openalex.org/C132964779","wikidata":"https://www.wikidata.org/wiki/Q2110223","display_name":"Raw data","level":2,"score":0.3269999921321869},{"id":"https://openalex.org/C206588197","wikidata":"https://www.wikidata.org/wiki/Q846574","display_name":"Reuse","level":2,"score":0.3269999921321869},{"id":"https://openalex.org/C3020606620","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Treatment modality","level":2,"score":0.3197999894618988},{"id":"https://openalex.org/C2777522853","wikidata":"https://www.wikidata.org/wiki/Q5276128","display_name":"Digital pathology","level":2,"score":0.3122999966144562},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.274399995803833},{"id":"https://openalex.org/C20136886","wikidata":"https://www.wikidata.org/wiki/Q749647","display_name":"Interoperability","level":2,"score":0.2535000145435333},{"id":"https://openalex.org/C2776175482","wikidata":"https://www.wikidata.org/wiki/Q1195816","display_name":"Transfer (computing)","level":2,"score":0.25119999051094055}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:arXiv.org:2611.02931","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2611.02931","pdf_url":"https://arxiv.org/pdf/2611.02931","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.2611.02931","doi":"https://doi.org/10.48550/arxiv.2611.02931","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2611.02931","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2611.02931","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2611.02931","pdf_url":"https://arxiv.org/pdf/2611.02931","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225165252.pdf","grobid_xml":"https://content.openalex.org/works/W7225165252.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3092224781","https://openalex.org/W4385211891","https://openalex.org/W4302774391","https://openalex.org/W4212790653","https://openalex.org/W4383498354","https://openalex.org/W7118067964","https://openalex.org/W7160955418","https://openalex.org/W7204083648","https://openalex.org/W4412852478","https://openalex.org/W4295936076"],"abstract_inverted_index":{"Novel":[0],"imaging":[1],"modalities":[2,24],"promise":[3],"improved":[4],"diagnostics,":[5],"but":[6],"AI":[7],"development":[8],"is":[9],"constrained":[10],"by":[11,21,45],"scarce":[12],"training":[13,56],"data.":[14],"Inference-time":[15],"domain":[16,51],"transfer":[17,93],"can":[18],"address":[19],"this":[20,35,81],"mapping":[22],"novel":[23],"to":[25,62],"established":[26],"ones,":[27],"enabling":[28],"reuse":[29],"of":[30],"existing":[31],"diagnostic":[32,129],"models.":[33],"However,":[34],"introduces":[36],"hallucination":[37],"risks,":[38],"computational":[39],"overhead,":[40],"and":[41,87,115],"regulatory":[42],"complexity.":[43],"Inspired":[44],"sim-to-real":[46],"transfer,":[47,52],"we":[48,79],"propose":[49],"training-time":[50],"generating":[53],"synthetic":[54],"target-domain":[55],"data":[57],"from":[58],"archived":[59],"routine":[60],"samples":[61],"enable":[63],"direct":[64],"diagnosis":[65],"on":[66],"real":[67],"inputs":[68],"without":[69],"inference-time":[70,84],"generation.":[71],"Using":[72],"unstained":[73],"prostate":[74],"histopathology":[75],"as":[76],"a":[77],"proof-of-concept,":[78],"compare":[80],"approach":[82],"with":[83,97],"virtual":[85,102],"staining":[86,103],"conventional":[88,99],"H&E-based":[89],"cancer":[90],"detection.":[91],"Training-time":[92],"achieved":[94],"higher":[95],"concordance":[96],"the":[98],"benchmark":[100],"than":[101],"for":[104,127],"both":[105],"raw":[106],"(Cohen's":[107],"$\u03ba$=0.59":[108],"vs.":[109,113,119,122],"0.37;":[110],"Gwet's":[111],"AC1=0.73":[112,121],"0.29)":[114],"deparaffinized":[116],"tissue":[117],"($\u03ba$=0.66":[118],"0.61;":[120],"0.64),":[123],"supporting":[124],"its":[125],"potential":[126],"emerging":[128],"modalities.":[130]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-04T00:00:00"}