{"id":"https://openalex.org/W7225159494","doi":"https://doi.org/10.3390/microorganisms14112496","title":"Comparative Analysis of Innate Immune Modulation Between BeAn19991 and ISCDC-2024 Oropouche Virus Strains","display_name":"Comparative Analysis of Innate Immune Modulation Between BeAn19991 and ISCDC-2024 Oropouche Virus Strains","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225159494","doi":"https://doi.org/10.3390/microorganisms14112496"},"language":"en","primary_location":{"id":"doi:10.3390/microorganisms14112496","doi":"https://doi.org/10.3390/microorganisms14112496","is_oa":true,"landing_page_url":"https://doi.org/10.3390/microorganisms14112496","pdf_url":null,"source":{"id":"https://openalex.org/S4210222090","display_name":"Microorganisms","issn_l":"2076-2607","issn":["2076-2607"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microorganisms","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/microorganisms14112496","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076666185","display_name":"Silvia Accordini","orcid":"https://orcid.org/0000-0003-1857-1429","observed_orcids":["https://orcid.org/0000-0003-1857-1429"]},"institutions":[{"id":"https://openalex.org/I4210101944","display_name":"Ospedale Sacro Cuore Don Calabria","ror":"https://ror.org/010hq5p48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210101944"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Accordini","raw_affiliation_strings":["Department of Infectious\u2014Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Via Don A. Sempreboni, 5, Negrar di Valpolicella, 37024 Verona, Italy"],"raw_orcid":"https://orcid.org/0000-0003-1857-1429","affiliations":[{"raw_affiliation_string":"Department of Infectious\u2014Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Via Don A. Sempreboni, 5, Negrar di Valpolicella, 37024 Verona, Italy","institution_ids":["https://openalex.org/I4210101944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104679866","display_name":"Natasha Gianesini","orcid":"https://orcid.org/0009-0008-4330-1758","observed_orcids":["https://orcid.org/0009-0008-4330-1758"]},"institutions":[{"id":"https://openalex.org/I4210101944","display_name":"Ospedale Sacro Cuore Don Calabria","ror":"https://ror.org/010hq5p48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210101944"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Natasha Gianesini","raw_affiliation_strings":["Department of Infectious\u2014Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Via Don A. Sempreboni, 5, Negrar di Valpolicella, 37024 Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious\u2014Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Via Don A. Sempreboni, 5, Negrar di Valpolicella, 37024 Verona, Italy","institution_ids":["https://openalex.org/I4210101944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121075264","display_name":"Lorena Maria Chesini","orcid":"https://orcid.org/0009-0005-7439-5628","observed_orcids":["https://orcid.org/0009-0005-7439-5628"]},"institutions":[{"id":"https://openalex.org/I4210101944","display_name":"Ospedale Sacro Cuore Don Calabria","ror":"https://ror.org/010hq5p48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210101944"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorena Maria Chesini","raw_affiliation_strings":["Department of Infectious\u2014Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Via Don A. Sempreboni, 5, Negrar di Valpolicella, 37024 Verona, Italy"],"raw_orcid":"https://orcid.org/0009-0005-7439-5628","affiliations":[{"raw_affiliation_string":"Department of Infectious\u2014Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Via Don A. Sempreboni, 5, Negrar di Valpolicella, 37024 Verona, Italy","institution_ids":["https://openalex.org/I4210101944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120628520","display_name":"Elisabetta Vezzelli","orcid":"https://orcid.org/0009-0003-8395-1601","observed_orcids":["https://orcid.org/0009-0003-8395-1601"]},"institutions":[{"id":"https://openalex.org/I4210101944","display_name":"Ospedale Sacro Cuore Don Calabria","ror":"https://ror.org/010hq5p48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210101944"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisabetta Vezzelli","raw_affiliation_strings":["Department of Infectious\u2014Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Via Don A. Sempreboni, 5, Negrar di Valpolicella, 37024 Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious\u2014Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Via Don A. Sempreboni, 5, Negrar di Valpolicella, 37024 Verona, Italy","institution_ids":["https://openalex.org/I4210101944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107089440","display_name":"Rebeca Passarelli Mantovani","orcid":"https://orcid.org/0009-0001-8725-8404","observed_orcids":["https://orcid.org/0009-0001-8725-8404"]},"institutions":[{"id":"https://openalex.org/I4210101944","display_name":"Ospedale Sacro Cuore Don Calabria","ror":"https://ror.org/010hq5p48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210101944"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rebeca Passarelli Mantovani","raw_affiliation_strings":["Department of Infectious\u2014Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Via Don A. Sempreboni, 5, Negrar di Valpolicella, 37024 Verona, Italy"],"raw_orcid":"https://orcid.org/0009-0001-8725-8404","affiliations":[{"raw_affiliation_string":"Department of Infectious\u2014Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Via Don A. Sempreboni, 5, Negrar di Valpolicella, 37024 Verona, Italy","institution_ids":["https://openalex.org/I4210101944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020925104","display_name":"Lorenza Sanfilippo","orcid":"https://orcid.org/0009-0004-5676-5181","observed_orcids":["https://orcid.org/0009-0004-5676-5181"]},"institutions":[{"id":"https://openalex.org/I4210101944","display_name":"Ospedale Sacro Cuore Don Calabria","ror":"https://ror.org/010hq5p48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210101944"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenza Sanfilippo","raw_affiliation_strings":["Section of Biostatistics, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, 37024 Verona, Italy"],"raw_orcid":"https://orcid.org/0009-0004-5676-5181","affiliations":[{"raw_affiliation_string":"Section of Biostatistics, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, 37024 Verona, Italy","institution_ids":["https://openalex.org/I4210101944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018317652","display_name":"Gianni Gori Savellini","orcid":"https://orcid.org/0000-0003-2287-9258","observed_orcids":["https://orcid.org/0000-0003-2287-9258"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianni Gori Savellini","raw_affiliation_strings":["Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy"],"raw_orcid":"https://orcid.org/0000-0003-2287-9258","affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038022203","display_name":"Maria Grazia Cusi","orcid":"https://orcid.org/0000-0001-8869-8164","observed_orcids":["https://orcid.org/0000-0001-8869-8164"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Grazia Cusi","raw_affiliation_strings":["Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8869-8164","affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078608594","display_name":"Maria Rosaria Capobianchi","orcid":"https://orcid.org/0000-0003-3465-0071","observed_orcids":["https://orcid.org/0000-0003-3465-0071"]},"institutions":[{"id":"https://openalex.org/I4210095444","display_name":"Saint Camillus International University of Health and Medical Sciences","ror":"https://ror.org/00qvkm315","country_code":"IT","type":"education","lineage":["https://openalex.org/I4210095444"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Rosaria Capobianchi","raw_affiliation_strings":["Medicine and Surgery Faculty, Saint Camillus International University of Health Sciences, 00131 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine and Surgery Faculty, Saint Camillus International University of Health Sciences, 00131 Rome, Italy","institution_ids":["https://openalex.org/I4210095444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021844447","display_name":"Concetta Castilletti","orcid":"https://orcid.org/0000-0001-9819-236X","observed_orcids":["https://orcid.org/0000-0001-9819-236X"]},"institutions":[{"id":"https://openalex.org/I4210101944","display_name":"Ospedale Sacro Cuore Don Calabria","ror":"https://ror.org/010hq5p48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210101944"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Concetta Castilletti","raw_affiliation_strings":["Department of Infectious\u2014Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Via Don A. Sempreboni, 5, Negrar di Valpolicella, 37024 Verona, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9819-236X","affiliations":[{"raw_affiliation_string":"Department of Infectious\u2014Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Via Don A. Sempreboni, 5, Negrar di Valpolicella, 37024 Verona, Italy","institution_ids":["https://openalex.org/I4210101944"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005273337","display_name":"Sara Caldrer","orcid":"https://orcid.org/0000-0002-2379-1082","observed_orcids":["https://orcid.org/0000-0002-2379-1082"]},"institutions":[{"id":"https://openalex.org/I4210101944","display_name":"Ospedale Sacro Cuore Don Calabria","ror":"https://ror.org/010hq5p48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210101944"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Sara Caldrer","raw_affiliation_strings":["Department of Infectious\u2014Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Via Don A. Sempreboni, 5, Negrar di Valpolicella, 37024 Verona, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2379-1082","affiliations":[{"raw_affiliation_string":"Department of Infectious\u2014Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Via Don A. Sempreboni, 5, Negrar di Valpolicella, 37024 Verona, Italy","institution_ids":["https://openalex.org/I4210101944"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005273337"],"corresponding_institution_ids":["https://openalex.org/I4210101944"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85992995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"11","first_page":"2496","last_page":"2496"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.5228999853134155,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.5228999853134155,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.37299999594688416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0340999998152256,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oropouche-virus","display_name":"Oropouche virus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/orthobunyaviruses","display_name":"orthobunyaviruses","score":0.8339999914169312},{"id":"https://openalex.org/keywords/reassortant-viruses","display_name":"reassortant viruses","score":0.6869999766349792},{"id":"https://openalex.org/keywords/innate-immune-evasion","display_name":"innate immune evasion","score":0.8140000104904175},{"id":"https://openalex.org/keywords/type-i-interferon-induction","display_name":"type I interferon induction","score":0.9890000224113464},{"id":"https://openalex.org/keywords/interferon-stimulated-genes","display_name":"interferon-stimulated genes","score":0.7910000085830688},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7760000228881836},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8209999799728394},{"id":"https://openalex.org/keywords/viral-outbreak","display_name":"viral outbreak","score":0.38600000739097595},{"id":"https://openalex.org/keywords/emerging-arboviruses","display_name":"emerging arboviruses","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.8651999831199646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8032000064849854},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7494999766349792},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6815000176429749},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.6313999891281128},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6068999767303467},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5056999921798706},{"id":"https://openalex.org/C191942190","wikidata":"https://www.wikidata.org/wiki/Q4774739","display_name":"Antigenic variation","level":3,"score":0.4253999888896942},{"id":"https://openalex.org/C2909928835","wikidata":"https://www.wikidata.org/wiki/Q70684351","display_name":"Viral Interference","level":4,"score":0.3792000114917755},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.37770000100135803},{"id":"https://openalex.org/C2779174946","wikidata":"https://www.wikidata.org/wiki/Q751911","display_name":"RNA virus","level":4,"score":0.3772999942302704},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3736000061035156},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.36640000343322754},{"id":"https://openalex.org/C2781251061","wikidata":"https://www.wikidata.org/wiki/Q5416089","display_name":"Evasion (ethics)","level":3,"score":0.35519999265670776},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.35100001096725464},{"id":"https://openalex.org/C2778278966","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Interferon type I","level":3,"score":0.3452000021934509},{"id":"https://openalex.org/C134474686","wikidata":"https://www.wikidata.org/wiki/Q21111069","display_name":"MDA5","level":5,"score":0.3059000074863434},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.30320000648498535},{"id":"https://openalex.org/C8769409","wikidata":"https://www.wikidata.org/wiki/Q2066554","display_name":"Viral evolution","level":4,"score":0.29190000891685486},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.2809999883174896},{"id":"https://openalex.org/C2778420691","wikidata":"https://www.wikidata.org/wiki/Q14866230","display_name":"TLR3","level":5,"score":0.26339998841285706},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.2587999999523163},{"id":"https://openalex.org/C196594336","wikidata":"https://www.wikidata.org/wiki/Q1662341","display_name":"Antibody-dependent enhancement","level":4,"score":0.25429999828338623}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/microorganisms14112496","doi":"https://doi.org/10.3390/microorganisms14112496","is_oa":true,"landing_page_url":"https://doi.org/10.3390/microorganisms14112496","pdf_url":null,"source":{"id":"https://openalex.org/S4210222090","display_name":"Microorganisms","issn_l":"2076-2607","issn":["2076-2607"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microorganisms","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/microorganisms14112496","doi":"https://doi.org/10.3390/microorganisms14112496","is_oa":true,"landing_page_url":"https://doi.org/10.3390/microorganisms14112496","pdf_url":null,"source":{"id":"https://openalex.org/S4210222090","display_name":"Microorganisms","issn_l":"2076-2607","issn":["2076-2607"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microorganisms","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W15675854","https://openalex.org/W1978148605","https://openalex.org/W1998624755","https://openalex.org/W2000177767","https://openalex.org/W2001985808","https://openalex.org/W2005481667","https://openalex.org/W2016908681","https://openalex.org/W2042751933","https://openalex.org/W2050963689","https://openalex.org/W2051636160","https://openalex.org/W2055894204","https://openalex.org/W2063919588","https://openalex.org/W2065511410","https://openalex.org/W2071467437","https://openalex.org/W2075125713","https://openalex.org/W2077266113","https://openalex.org/W2086882285","https://openalex.org/W2087976276","https://openalex.org/W2089704925","https://openalex.org/W2091129202","https://openalex.org/W2092035695","https://openalex.org/W2096372976","https://openalex.org/W2105777629","https://openalex.org/W2138546984","https://openalex.org/W2141137217","https://openalex.org/W2148658155","https://openalex.org/W2149891361","https://openalex.org/W2157356459","https://openalex.org/W2217370036","https://openalex.org/W2256756668","https://openalex.org/W2314483165","https://openalex.org/W2424076606","https://openalex.org/W2473467134","https://openalex.org/W2565031955","https://openalex.org/W2587460062","https://openalex.org/W2623642206","https://openalex.org/W2743104675","https://openalex.org/W2800469545","https://openalex.org/W2991287997","https://openalex.org/W3042099287","https://openalex.org/W3043990091","https://openalex.org/W4308332179","https://openalex.org/W4400125855","https://openalex.org/W4402549120","https://openalex.org/W4403240367","https://openalex.org/W4403252809","https://openalex.org/W4403412091","https://openalex.org/W4403412105","https://openalex.org/W4404404308","https://openalex.org/W4405094225","https://openalex.org/W4405618480","https://openalex.org/W4410622632","https://openalex.org/W4411339171","https://openalex.org/W7128033930","https://openalex.org/W7135214803","https://openalex.org/W7171494792"],"related_works":["https://openalex.org/W7161633292","https://openalex.org/W7155599097","https://openalex.org/W7171494792","https://openalex.org/W7163740158","https://openalex.org/W3043990091","https://openalex.org/W2788329326","https://openalex.org/W4403252809","https://openalex.org/W4404711236","https://openalex.org/W2902583883","https://openalex.org/W2037005765"],"abstract_inverted_index":{"Oropouche":[0],"virus":[1,25,110],"(OROV)":[2],"has":[3,26],"re-emerged":[4],"as":[5,35,37],"a":[6,59,104,166,209],"significant":[7,258],"public":[8,283],"health":[9,284],"threat":[10],"during":[11],"the":[12,33,41,56,81,95,99,108,113,124,127,147,161,179,196,232,241,269],"2023\u20132025":[13,114],"outbreak,":[14],"characterized":[15,146],"by":[16,85,152,190,193],"an":[17,220],"unprecedented":[18],"geographic":[19],"expansion":[20,57],"beyond":[21],"endemic":[22],"regions.":[23],"The":[24],"been":[27],"detected":[28],"in":[29,38,142,169,182,204,240],"various":[30],"regions,":[31],"including":[32],"Caribbean,":[34],"well":[36],"Europe":[39],"and":[40,48,69,103,134,173,236,265,274,286],"United":[42],"States,":[43],"among":[44],"travelers":[45],"from":[46,157],"Central":[47],"South":[49],"America.":[50],"This":[51],"epidemic":[52,115],"was":[53,184,217],"associated":[54,218],"with":[55,186,219],"of":[58,98,126,155,231,243,277],"novel":[60],"reassortant":[61,109,234],"strain,":[62],"which":[63],"may":[64],"exhibit":[65],"enhanced":[66],"viral":[67,163,170,263],"fitness":[68],"immune":[70,120,149,202,249],"evasion":[71,250],"properties.":[72],"Although":[73,160],"orthobunyaviruses":[74],"are":[75],"known":[76],"to":[77,130,137,176,281],"counteract":[78],"interferon":[79],"responses,":[80],"specific":[82],"strategy":[83],"adopted":[84],"OROV":[86,279],"remains":[87],"incompletely":[88],"understood.":[89],"In":[90],"this":[91,254],"study,":[92],"we":[93,145],"compared":[94],"in-vitro":[96,153],"behavior":[97],"prototype":[100],"strain":[101],"BeAn19991":[102,206],"2024":[105],"isolate":[106,235],"representing":[107],"responsible":[111],"for":[112,260,271],"(ISCDC-2024),":[116],"focusing":[117],"on":[118],"innate":[119,148,201,244],"response.":[121],"We":[122],"examined":[123],"sensitivity":[125,175],"two":[128,162,197],"strains":[129,164,198,280],"IFN-\u03b2":[131,180],"antiviral":[132,211,287],"activity":[133],"their":[135],"ability":[136],"induce":[138],"type":[139],"I":[140],"IFN":[141],"fibroblast.":[143],"Furthermore,":[144],"response":[150],"triggered":[151],"infection":[154,216,261],"PBMCs":[156],"healthy":[158],"donors.":[159],"exhibited":[165],"similar":[167],"plateau":[168],"RNA":[171],"accumulation":[172],"comparable":[174],"exogenous":[177],"IFN-\u03b2,":[178],"induction":[181],"fibroblasts":[183],"delayed,":[185],"higher":[187],"levels":[188],"induced":[189,208],"ISCDC-2024":[191,215],"than":[192],"BeAn19991.":[194],"Moreover,":[195],"displayed":[199],"distinct":[200,228,248],"profiles":[203],"PBMCs:":[205],"predominantly":[207],"robust":[210],"IFN-driven":[212],"response,":[213],"whereas":[214],"IL-6-dominated":[221],"inflammatory":[222],"pattern.":[223],"Overall,":[224],"these":[225],"findings":[226],"highlight":[227],"phenotypic":[229],"features":[230],"contemporary":[233],"suggest":[237],"strain-specific":[238],"differences":[239],"modulation":[242],"immunity,":[245],"potentially":[246],"reflecting":[247],"strategies.":[251],"If":[252],"confirmed,":[253],"hypothesis":[255],"could":[256],"have":[257],"implications":[259],"transmission,":[262],"persistence":[264],"disease":[266],"severity,":[267],"highlighting":[268],"need":[270],"continuous":[272],"surveillance":[273],"functional":[275],"characterization":[276],"emerging":[278],"drive":[282],"interventions":[285],"countermeasures.":[288]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-04T00:00:00"}