{"id":"https://openalex.org/W7225159481","doi":"https://doi.org/10.3390/biomedicines14112525","title":"The Role of Carvedilol (CARV) in Improving Metabolic-Associated Fatty Liver Disease","display_name":"The Role of Carvedilol (CARV) in Improving Metabolic-Associated Fatty Liver Disease","publication_year":2026,"publication_date":"2026-11-03","ids":{"openalex":"https://openalex.org/W7225159481","doi":"https://doi.org/10.3390/biomedicines14112525"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines14112525","doi":"https://doi.org/10.3390/biomedicines14112525","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines14112525","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biomedicines14112525","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023632287","display_name":"Zhihui Luan","orcid":"https://orcid.org/0000-0001-9733-0484","observed_orcids":["https://orcid.org/0000-0001-9733-0484"]},"institutions":[{"id":"https://openalex.org/I202028630","display_name":"Changchun Normal University","ror":"https://ror.org/00cbhey71","country_code":"CN","type":"education","lineage":["https://openalex.org/I202028630"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhihui Luan","raw_affiliation_strings":["School of Life Sciences, Changchun Normal University, Changchun 130032, China"],"raw_orcid":"https://orcid.org/0000-0001-9733-0484","affiliations":[{"raw_affiliation_string":"School of Life Sciences, Changchun Normal University, Changchun 130032, China","institution_ids":["https://openalex.org/I202028630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124727037","display_name":"Jiarong Ge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202028630","display_name":"Changchun Normal University","ror":"https://ror.org/00cbhey71","country_code":"CN","type":"education","lineage":["https://openalex.org/I202028630"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiarong Ge","raw_affiliation_strings":["School of Life Sciences, Changchun Normal University, Changchun 130032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Changchun Normal University, Changchun 130032, China","institution_ids":["https://openalex.org/I202028630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100863573","display_name":"Tian Luan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian Luan","raw_affiliation_strings":["School of Public Health, Jilin University, Changchun 130021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Jilin University, Changchun 130021, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139670055","display_name":"Hongyao Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202028630","display_name":"Changchun Normal University","ror":"https://ror.org/00cbhey71","country_code":"CN","type":"education","lineage":["https://openalex.org/I202028630"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyao Yu","raw_affiliation_strings":["School of Life Sciences, Changchun Normal University, Changchun 130032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Changchun Normal University, Changchun 130032, China","institution_ids":["https://openalex.org/I202028630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125159658","display_name":"Yongli Bao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongli Bao","raw_affiliation_strings":["Key Laboratory of Molecular Epigenetics, Institute of Genetics and Cytology, Ministry of Education, Northeast Normal University, Changchun 130024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Molecular Epigenetics, Institute of Genetics and Cytology, Ministry of Education, Northeast Normal University, Changchun 130024, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139642251","display_name":"Qingru Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202028630","display_name":"Changchun Normal University","ror":"https://ror.org/00cbhey71","country_code":"CN","type":"education","lineage":["https://openalex.org/I202028630"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingru Yang","raw_affiliation_strings":["School of Life Sciences, Changchun Normal University, Changchun 130032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Changchun Normal University, Changchun 130032, China","institution_ids":["https://openalex.org/I202028630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129837435","display_name":"Xiaodong Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202028630","display_name":"Changchun Normal University","ror":"https://ror.org/00cbhey71","country_code":"CN","type":"education","lineage":["https://openalex.org/I202028630"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodong Xie","raw_affiliation_strings":["School of Life Sciences, Changchun Normal University, Changchun 130032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Changchun Normal University, Changchun 130032, China","institution_ids":["https://openalex.org/I202028630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160534044","display_name":"Shiyao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202028630","display_name":"Changchun Normal University","ror":"https://ror.org/00cbhey71","country_code":"CN","type":"education","lineage":["https://openalex.org/I202028630"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiyao Wang","raw_affiliation_strings":["School of Life Sciences, Changchun Normal University, Changchun 130032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Changchun Normal University, Changchun 130032, China","institution_ids":["https://openalex.org/I202028630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160491201","display_name":"Dongwang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202028630","display_name":"Changchun Normal University","ror":"https://ror.org/00cbhey71","country_code":"CN","type":"education","lineage":["https://openalex.org/I202028630"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongwang Zhang","raw_affiliation_strings":["School of Life Sciences, Changchun Normal University, Changchun 130032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Changchun Normal University, Changchun 130032, China","institution_ids":["https://openalex.org/I202028630"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160487590","display_name":"Linlin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202028630","display_name":"Changchun Normal University","ror":"https://ror.org/00cbhey71","country_code":"CN","type":"education","lineage":["https://openalex.org/I202028630"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linlin Zhang","raw_affiliation_strings":["School of Life Sciences, Changchun Normal University, Changchun 130032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Changchun Normal University, Changchun 130032, China","institution_ids":["https://openalex.org/I202028630"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023632287","https://openalex.org/A5125159658"],"corresponding_institution_ids":["https://openalex.org/I184983240","https://openalex.org/I202028630"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"11","first_page":"2525","last_page":"2525"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carvedilol","display_name":"carvedilol","score":1.0},{"id":"https://openalex.org/keywords/metabolic-associated-fatty-liver-disease","display_name":"metabolic-associated fatty liver disease","score":0.9869999885559082},{"id":"https://openalex.org/keywords/apolipoprotein-c-iii","display_name":"apolipoprotein C-III","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/hepatic-lipid-metabolism","display_name":"hepatic lipid metabolism","score":0.7889999747276306},{"id":"https://openalex.org/keywords/de-novo-lipogenesis","display_name":"de novo lipogenesis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/fatty-acid-beta-oxidation","display_name":"fatty acid beta-oxidation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/ampk-signaling","display_name":"AMPK signaling","score":0.8529999852180481},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.652999997138977},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.6570000052452087},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.7009999752044678},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.7694000005722046},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.7369999885559082},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.6018000245094299},{"id":"https://openalex.org/C2780591200","wikidata":"https://www.wikidata.org/wiki/Q412534","display_name":"Carvedilol","level":3,"score":0.5597000122070312},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.5278000235557556},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5151000022888184},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.503600001335144},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.4632999897003174},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.4625000059604645},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4586000144481659},{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.4505999982357025},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42590001225471497},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.41769999265670776},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3894999921321869},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3813999891281128},{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.3594000041484833},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.35899999737739563},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.3240000009536743},{"id":"https://openalex.org/C2908676283","wikidata":"https://www.wikidata.org/wiki/Q2351083","display_name":"Metabolism disorder","level":2,"score":0.32359999418258667},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3206000030040741},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31200000643730164},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.31139999628067017},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.3068999946117401},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.3059000074863434},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.3046000003814697},{"id":"https://openalex.org/C2909799055","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid Metabolism Disorder","level":4,"score":0.28380000591278076},{"id":"https://openalex.org/C2777735490","wikidata":"https://www.wikidata.org/wiki/Q2351083","display_name":"Metabolic disorder","level":2,"score":0.2743000090122223},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.27410000562667847},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.27070000767707825},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.2694999873638153},{"id":"https://openalex.org/C2776780712","wikidata":"https://www.wikidata.org/wiki/Q295240","display_name":"AMP-activated protein kinase","level":5,"score":0.26910001039505005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26510000228881836},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.2603999972343445},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.2524999976158142}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/biomedicines14112525","doi":"https://doi.org/10.3390/biomedicines14112525","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines14112525","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines14112525","doi":"https://doi.org/10.3390/biomedicines14112525","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines14112525","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1504102762","https://openalex.org/W2273379630","https://openalex.org/W2283843704","https://openalex.org/W2738107772","https://openalex.org/W2784619339","https://openalex.org/W2790564280","https://openalex.org/W2944625943","https://openalex.org/W2999907367","https://openalex.org/W3003865038","https://openalex.org/W3016284126","https://openalex.org/W4283804489","https://openalex.org/W4315619045","https://openalex.org/W4361199137","https://openalex.org/W4389220157","https://openalex.org/W4391232753","https://openalex.org/W4400408092","https://openalex.org/W4405672649","https://openalex.org/W4412490442","https://openalex.org/W7129040037","https://openalex.org/W7140169407"],"related_works":["https://openalex.org/W4296803763","https://openalex.org/W7155706671","https://openalex.org/W4376643427","https://openalex.org/W4388141141","https://openalex.org/W7219961952","https://openalex.org/W4213434662","https://openalex.org/W4403173138","https://openalex.org/W4416297218","https://openalex.org/W4402581751","https://openalex.org/W7164928331"],"abstract_inverted_index":{"Background/Objectives:":[0],"Metabolic-associated":[1],"fatty":[2,141],"liver":[3,160],"disease":[4],"(MAFLD)":[5],"has":[6,37,74],"emerged":[7],"as":[8],"a":[9,34,67,108,172,180],"significant":[10],"global":[11],"health":[12],"concern,":[13],"closely":[14],"linked":[15],"to":[16,86],"metabolic":[17,55,174,188],"syndrome":[18],"and":[19,73,96,113,139,164,186],"characterized":[20],"by":[21,126,144],"hepatic":[22,60,81,93,123,158],"fat":[23],"accumulation":[24,125],"in":[25,41,59,77,103,111,114,150],"the":[26,42,78,88,97,146],"absence":[27],"of":[28,44,70,80,90,100,110,177],"excessive":[29],"alcohol":[30],"consumption.":[31],"Carvedilol":[32],"(CARV),":[33],"non-selective":[35],"\u03b2-blocker,":[36],"long":[38],"been":[39,75],"used":[40],"treatment":[43],"cardiovascular":[45],"conditions,":[46],"but":[47],"emerging":[48],"evidence":[49],"suggests":[50],"that":[51,119,133],"it":[52],"also":[53],"exhibits":[54],"regulatory":[56],"properties,":[57],"particularly":[58],"lipid":[61,94,124],"metabolism.":[62],"Apolipoprotein":[63],"C3":[64],"(APOC3)":[65],"is":[66],"key":[68],"regulator":[69],"triglyceride":[71],"metabolism":[72],"implicated":[76],"development":[79],"steatosis.":[82],"This":[83],"research":[84],"aimed":[85],"investigate":[87],"effects":[89],"carvedilol":[91],"on":[92],"synthesis":[95],"potential":[98,181],"role":[99],"APOC3":[101,128],"downregulation":[102],"this":[104],"process.":[105],"Methods:":[106],"Through":[107],"combination":[109],"vivo":[112],"vitro":[115],"models.":[116],"Results:we":[117],"demonstrate":[118],"CARV":[120,134,156],"significantly":[121],"reduces":[122],"downregulating":[127],"expression.":[129],"Mechanistic":[130],"assays":[131],"revealed":[132],"suppresses":[135],"de":[136],"novo":[137],"lipogenesis":[138],"facilitates":[140],"acid":[142],"\u03b2-oxidation":[143],"activating":[145],"AMPK":[147],"signaling":[148],"pathway":[149],"hepatocytes.":[151],"In":[152],"HFF-induced":[153],"MAFLD":[154,185],"mice,":[155],"ameliorated":[157],"steatosis,":[159],"injury,":[161],"lobular":[162],"inflammation":[163],"collagen":[165],"deposition.":[166],"Conclusions:":[167],"Collectively,":[168],"our":[169],"findings":[170],"identify":[171],"novel":[173],"protective":[175],"function":[176],"carvedilol,":[178],"providing":[179],"therapeutic":[182],"strategy":[183],"for":[184],"related":[187],"diseases.":[189]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-11-04T00:00:00"}
