{"id":"https://openalex.org/W7225158277","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0745","title":"745 Spatial enrichment of tumor-associated macrophage subsets near cancer-associated fibroblasts identifies distinct stromal niches in PDAC","display_name":"745 Spatial enrichment of tumor-associated macrophage subsets near cancer-associated fibroblasts identifies distinct stromal niches in PDAC","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225158277","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0745"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2026-sitc2026.0745","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0745","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0745","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A842.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/14/Suppl_2/A842.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041888697","display_name":"Natalie K. Horvat","orcid":"https://orcid.org/0000-0003-2789-8132","observed_orcids":["https://orcid.org/0000-0003-2789-8132"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie K Horvat","raw_affiliation_strings":["Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152872855","display_name":"Alexis F. Dixon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexis F Dixon","raw_affiliation_strings":["Emory University School of Medicine, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003764413","display_name":"Erin E. Grundy","orcid":"https://orcid.org/0000-0001-7094-1461","observed_orcids":["https://orcid.org/0000-0001-7094-1461"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin E Grundy","raw_affiliation_strings":["Emory University School of Medicine, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090028003","display_name":"Brian Scott Robinson","orcid":"https://orcid.org/0000-0002-4344-9575","observed_orcids":["https://orcid.org/0000-0002-4344-9575"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Robinson","raw_affiliation_strings":["Emory University School of Medicine, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032094154","display_name":"Gregory B. Lesinski","orcid":"https://orcid.org/0000-0002-8787-7678","observed_orcids":["https://orcid.org/0000-0002-8787-7678"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory B Lesinski","raw_affiliation_strings":["Emory University School of Medicine, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A842","last_page":"A842"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.30399999022483826,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.9869999885559082},{"id":"https://openalex.org/keywords/stromal-niche","display_name":"stromal niche","score":0.8130000233650208},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9120000004768372},{"id":"https://openalex.org/keywords/folfirinox","display_name":"FOLFIRINOX","score":0.7549999952316284},{"id":"https://openalex.org/keywords/proximity-analysis","display_name":"proximity analysis","score":0.6230000257492065},{"id":"https://openalex.org/keywords/spatial-organization","display_name":"spatial organization","score":0.4129999876022339},{"id":"https://openalex.org/keywords/tam-heterogeneity","display_name":"TAM heterogeneity","score":0.5870000123977661},{"id":"https://openalex.org/keywords/tam-depletion","display_name":"TAM depletion","score":0.3109999895095825},{"id":"https://openalex.org/keywords/tam-reprogramming","display_name":"TAM reprogramming","score":0.33799999952316284},{"id":"https://openalex.org/keywords/tam-polarization","display_name":"TAM polarization","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6747000217437744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5390999913215637},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5005000233650208},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46140000224113464},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.40149998664855957},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36000001430511475},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3458999991416931},{"id":"https://openalex.org/C102715595","wikidata":"https://www.wikidata.org/wiki/Q172861","display_name":"Ecological niche","level":3,"score":0.2996000051498413},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28929999470710754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26440000534057617}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/jitc-2026-sitc2026.0745","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0745","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0745","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A842.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},{"id":"pmh:oai:doaj.org/article:1fb74f4cb66d45b886a36357a5854a4c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1fb74f4cb66d45b886a36357a5854a4c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 14, Iss Suppl 2 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2026-sitc2026.0745","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0745","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0745","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A842.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225158277.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387566619","https://openalex.org/W4404053025","https://openalex.org/W4390914981","https://openalex.org/W4409682522","https://openalex.org/W4401081619","https://openalex.org/W4285267925","https://openalex.org/W4390915749","https://openalex.org/W4415743097","https://openalex.org/W4409625860","https://openalex.org/W4404159505"],"abstract_inverted_index":{"Background":[0],"Pancreatic":[1],"ductal":[2],"adenocarcinoma":[3],"(PDAC)":[4],"is":[5,34],"characterized":[6],"by":[7,207],"a":[8],"dense":[9],"stromal":[10,105,120,340,355],"barrier":[11,33],"that":[12,57,107,114],"impedes":[13],"therapeutic":[14,351],"efficacy":[15],"and":[16,28,49,71,100,142,167,173,190,195,204,269,308,331],"restricts":[17],"immune":[18],"cell":[19,196],"infiltration":[20],"into":[21,66],"tumors.":[22],"Composed":[23],"of":[24,54,94,305,339,349],"cancer-associated":[25],"fibroblasts":[26],"(CAFs)":[27],"tumor-associated":[29],"macrophages":[30],"(TAMs),":[31],"the":[32,42,81,91,127,135,201],"thought":[35],"to":[36,79,98,179,253,283,353],"arise":[37],"from":[38,155],"their":[39],"interactions,":[40],"yet":[41],"mechanisms":[43],"remain":[44],"poorly":[45],"understood.":[46],"Both":[47],"CAFs":[48,99,125,192,285,310,330],"TAMs":[50,61,69,73,78],"are":[51],"heterogeneous":[52],"populations":[53],"diverse":[55],"phenotypes":[56],"promote":[58],"tumor":[59,82,101,143,187,255,313,332],"progression.":[60],"can":[62,108],"be":[63,109],"broadly":[64],"divided":[65],"pancreatic":[67],"resident":[68],"(PR-TAMs)":[70],"monocytic-derived":[72],"(Mo-TAMs).":[74],"Prior":[75],"efforts":[76],"targeting":[77],"impact":[80],"microenvironment":[83],"(TME)":[84],"have":[85],"largely":[86],"failed":[87],"in":[88,122,126,145,210,259,286,342,357],"PDAC.":[89,343,358],"Deciphering":[90],"spatial":[92,136,208,327],"organization":[93,341],"TAM":[95,116,140],"subsets":[96,117],"relative":[97],"cells":[102,144,188,256],"may":[103],"identify":[104],"niches":[106,121,356],"therapeutically":[110],"targeted.":[111],"We":[112],"hypothesized":[113],"distinct":[115,326],"occupy":[118],"specialized":[119],"association":[123],"with":[124,157,175,222,290,321],"PDAC":[128,147,159,214],"TME.":[129],"To":[130],"test":[131],"this,":[132],"we":[133],"examined":[134],"relationships":[137],"between":[138],"CAFs,":[139],"subsets,":[141],"human":[146],"tissue":[148],"sections.Methods":[149],"Resected":[150],"archival":[151],"tissues":[152],"were":[153,161,198,317],"obtained":[154],"patients":[156],"primary":[158],"who":[160],"treatment":[162],"na\u00efve":[163],"(n":[164,170],"=":[165,171,232,244,267,277],"12)":[166,172],"FOLFIRINOX":[168],"treated":[169,270,287],"stained":[174],"multiplex":[176],"immunofluorescence":[177],"panels":[178],"detect":[180],"PR-TAMs":[181,249,280,307,324],"(CD68":[182],"+),":[183],"Mo-TAMs":[184,235,258,291,316],"(CD68+":[185],"CCR2+),":[186],"(CK19+),":[189],"activated":[191],"(\u03b1SMA+).":[193],"Imaging":[194],"detection":[197],"performed":[199],"using":[200],"Zeiss":[202],"Axioscan":[203],"QuPath,":[205],"followed":[206],"analysis":[209,247],"R.Results":[211],"In":[212],"FOLFIRINOX-treated":[213],"tumors,":[215],"PR-TAM":[216],"density":[217],"was":[218],"significantly":[219,251],"increased":[220],"compared":[221,289],"treatment-na\u00efve":[223,261],"tumors":[224,271,288],"(median":[225,238],"348":[226],"vs.":[227,240,263,273,293],"73":[228],"cells/mm":[229],"2,":[230],"p":[231,243,266,276,296],"0.041),":[233],"whereas":[234,315],"remained":[236],"unchanged":[237],"113":[239],"78":[241],"cells/mm2,":[242],"0.216).":[245],"Proximity":[246],"revealed":[248,303],"localized":[250,281],"closer":[252,282],"CK19+":[254],"than":[257],"both":[260,306],"(35.6":[262],"90.2":[264],"\u00b5m,":[265,275,295],"0.009)":[268],"(44.8":[272],"115.7":[274],"0.03).":[278],"Similarly,":[279],"\u03b1SMA+":[284,309],"(98.55":[292],"319.2":[294],"<":[297],"0.0005).":[298],"Tumor":[299],"nest":[300],"analyses":[301],"further":[302,347],"enrichment":[304,328],"around":[311],"smaller":[312],"nests,":[314],"more":[318],"frequently":[319],"associated":[320],"larger":[322],"nests.Conclusions":[323],"exhibit":[325],"near":[329],"cells,":[333],"identifying":[334],"them":[335],"as":[336],"candidate":[337],"mediators":[338],"These":[344],"findings":[345],"support":[346],"investigation":[348],"PR-TAM-directed":[350],"strategies":[352],"disrupt":[354]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-04T00:00:00"}
