{"id":"https://openalex.org/W7225149073","doi":"https://doi.org/10.12982/cmjs.2026.103","title":"Neuroprotective Effects of Ganoderma: Mechanisms and Therapeutic Potential","display_name":"Neuroprotective Effects of Ganoderma: Mechanisms and Therapeutic Potential","publication_year":2026,"publication_date":"2026-11-03","ids":{"openalex":"https://openalex.org/W7225149073","doi":"https://doi.org/10.12982/cmjs.2026.103"},"language":"en","primary_location":{"id":"doi:10.12982/cmjs.2026.103","doi":"https://doi.org/10.12982/cmjs.2026.103","is_oa":false,"landing_page_url":"https://doi.org/10.12982/cmjs.2026.103","pdf_url":null,"source":{"id":"https://openalex.org/S4220650895","display_name":"Chiang Mai Journal of Science","issn_l":"0125-2526","issn":["0125-2526","2465-3845"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319374","host_organization_name":"Chiang Mai University","host_organization_lineage":["https://openalex.org/P4310319374"],"host_organization_lineage_names":["Chiang Mai University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chiang Mai Journal of Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160565810","display_name":"Wenhua Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105365","display_name":"Qujing Normal University","ror":"https://ror.org/02ad7ap24","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210105365"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenhua Lu","raw_affiliation_strings":["Center for Yunnan Plateau Biological Resources Protection and Utilization & Yunnan International Joint Laboratory of Fungal Sustainable Utilization in South and Southeast Asia, College of Biology and Food Engineering, Qujing Normal University, Qujing 655099, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Yunnan Plateau Biological Resources Protection and Utilization & Yunnan International Joint Laboratory of Fungal Sustainable Utilization in South and Southeast Asia, College of Biology and Food Engineering, Qujing Normal University, Qujing 655099, China","institution_ids":["https://openalex.org/I4210105365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012751618","display_name":"Saowaluck Tibpromma","orcid":"https://orcid.org/0000-0002-4706-6547","observed_orcids":["https://orcid.org/0000-0002-4706-6547"]},"institutions":[{"id":"https://openalex.org/I4210105365","display_name":"Qujing Normal University","ror":"https://ror.org/02ad7ap24","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210105365"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Saowaluck Tibpromma","raw_affiliation_strings":["Center for Yunnan Plateau Biological Resources Protection and Utilization & Yunnan International Joint Laboratory of Fungal Sustainable Utilization in South and Southeast Asia, College of Biology and Food Engineering, Qujing Normal University, Qujing 655099, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Yunnan Plateau Biological Resources Protection and Utilization & Yunnan International Joint Laboratory of Fungal Sustainable Utilization in South and Southeast Asia, College of Biology and Food Engineering, Qujing Normal University, Qujing 655099, China","institution_ids":["https://openalex.org/I4210105365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129734851","display_name":"Kelum Gayan Saumyasiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11923345","display_name":"Wroc\u0142aw University of Science and Technology","ror":"https://ror.org/008fyn775","country_code":"PL","type":"education","lineage":["https://openalex.org/I11923345"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Kelum Gayan Saumyasiri","raw_affiliation_strings":["Wroclaw University of Science and Technology, 27 Wybrze\u017ce Stanis\u0142awa Wyspia\u0144skiego st. 50-370 Wroc\u0142aw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wroclaw University of Science and Technology, 27 Wybrze\u017ce Stanis\u0142awa Wyspia\u0144skiego st. 50-370 Wroc\u0142aw, Poland","institution_ids":["https://openalex.org/I11923345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128696965","display_name":"Dong\u2010Qin Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105365","display_name":"Qujing Normal University","ror":"https://ror.org/02ad7ap24","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210105365"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong-Qin Dai","raw_affiliation_strings":["Center for Yunnan Plateau Biological Resources Protection and Utilization & Yunnan International Joint Laboratory of Fungal Sustainable Utilization in South and Southeast Asia, College of Biology and Food Engineering, Qujing Normal University, Qujing 655099, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Yunnan Plateau Biological Resources Protection and Utilization & Yunnan International Joint Laboratory of Fungal Sustainable Utilization in South and Southeast Asia, College of Biology and Food Engineering, Qujing Normal University, Qujing 655099, China","institution_ids":["https://openalex.org/I4210105365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052334240","display_name":"M S Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105365","display_name":"Qujing Normal University","ror":"https://ror.org/02ad7ap24","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210105365"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meimei Wang","raw_affiliation_strings":["Center for Yunnan Plateau Biological Resources Protection and Utilization & Yunnan International Joint Laboratory of Fungal Sustainable Utilization in South and Southeast Asia, College of Biology and Food Engineering, Qujing Normal University, Qujing 655099, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Yunnan Plateau Biological Resources Protection and Utilization & Yunnan International Joint Laboratory of Fungal Sustainable Utilization in South and Southeast Asia, College of Biology and Food Engineering, Qujing Normal University, Qujing 655099, China","institution_ids":["https://openalex.org/I4210105365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012763625","display_name":"Kalani Kanchana Hapuarachchi","orcid":"https://orcid.org/0000-0002-5946-4526","observed_orcids":["https://orcid.org/0000-0002-5946-4526"]},"institutions":[{"id":"https://openalex.org/I25399270","display_name":"Southwest Forestry University","ror":"https://ror.org/03dfa9f06","country_code":"CN","type":"education","lineage":["https://openalex.org/I25399270"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kalani Kanchana Hapuarachchi","raw_affiliation_strings":["College of Biodiversity Conservation, Southwest Forestry University, Kunming, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biodiversity Conservation, Southwest Forestry University, Kunming, China","institution_ids":["https://openalex.org/I25399270"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114203256","display_name":"Samantha C. Karunarathna","orcid":"https://orcid.org/0000-0001-7080-0781","observed_orcids":["https://orcid.org/0000-0001-7080-0781"]},"institutions":[{"id":"https://openalex.org/I4210105365","display_name":"Qujing Normal University","ror":"https://ror.org/02ad7ap24","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210105365"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Samantha C. Karunarathna","raw_affiliation_strings":["Center for Yunnan Plateau Biological Resources Protection and Utilization & Yunnan International Joint Laboratory of Fungal Sustainable Utilization in South and Southeast Asia, College of Biology and Food Engineering, Qujing Normal University, Qujing 655099, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Yunnan Plateau Biological Resources Protection and Utilization & Yunnan International Joint Laboratory of Fungal Sustainable Utilization in South and Southeast Asia, College of Biology and Food Engineering, Qujing Normal University, Qujing 655099, China","institution_ids":["https://openalex.org/I4210105365"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012763625","https://openalex.org/A5114203256"],"corresponding_institution_ids":["https://openalex.org/I25399270","https://openalex.org/I4210105365"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84816294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"53","issue":"6","first_page":"e2026103","last_page":"e2026103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13130","display_name":"Biological and pharmacological studies of plants","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ganoderma-lucidum","display_name":"Ganoderma lucidum","score":1.0},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.972000002861023},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9760000109672546},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/polysaccharides","display_name":"polysaccharides","score":0.9599999785423279},{"id":"https://openalex.org/keywords/triterpenoids","display_name":"triterpenoids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":1.0},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.9430000185966492},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7730000019073486},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.9350000023841858},{"id":"https://openalex.org/keywords/standardization","display_name":"standardization","score":0.6060000061988831},{"id":"https://openalex.org/keywords/cultivation-techniques","display_name":"cultivation techniques","score":0.7590000033378601},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.9377999901771545},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.7031000256538391},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5202999711036682},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5157999992370605},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5141000151634216},{"id":"https://openalex.org/C2776618520","wikidata":"https://www.wikidata.org/wiki/Q1799774","display_name":"Ganoderma","level":3,"score":0.489300012588501},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4142000079154968},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4043000042438507},{"id":"https://openalex.org/C2992468417","wikidata":"https://www.wikidata.org/wiki/Q271098","display_name":"Ganoderma lucidum","level":2,"score":0.3977999985218048},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2962999939918518},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2957000136375427},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.27900001406669617},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.26579999923706055}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.12982/cmjs.2026.103","doi":"https://doi.org/10.12982/cmjs.2026.103","is_oa":false,"landing_page_url":"https://doi.org/10.12982/cmjs.2026.103","pdf_url":null,"source":{"id":"https://openalex.org/S4220650895","display_name":"Chiang Mai Journal of Science","issn_l":"0125-2526","issn":["0125-2526","2465-3845"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319374","host_organization_name":"Chiang Mai University","host_organization_lineage":["https://openalex.org/P4310319374"],"host_organization_lineage_names":["Chiang Mai University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chiang Mai Journal of Science","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2383269889","https://openalex.org/W4399044757","https://openalex.org/W2896943815","https://openalex.org/W2989824881","https://openalex.org/W4389352372","https://openalex.org/W4411531535","https://openalex.org/W4313268749","https://openalex.org/W4391517483","https://openalex.org/W7214788059","https://openalex.org/W7160939691"],"abstract_inverted_index":{"Neurodegenerative":[0],"disorders":[1],"(NDs),":[2],"including":[3],"Alzheimer's":[4],"disease":[5,9,25],"(AD)":[6],"and":[7,21,57,67,95,106,114,117,133,173],"Parkinson's":[8],"(PD),":[10],"remain":[11],"challenging":[12],"to":[13,40,99,159],"treat.":[14],"Existing":[15],"therapies":[16],"provide":[17],"only":[18,183],"symptomatic":[19],"relief":[20],"do":[22],"not":[23,156,182],"halt":[24],"progression.":[26],"This":[27,54,163,178],"limitation":[28],"has":[29,155],"driven":[30],"the":[31,61,119,141,170],"search":[32],"for":[33,50,60,194],"multi-target":[34],"neuroprotective":[35,62,123],"agents,":[36],"with":[37,198],"growing":[38],"attention":[39],"natural":[41],"products.":[42],"The":[43,122],"medicinal":[44],"fungus":[45,179],"Ganoderma":[46,69,126],"lucidum":[47,66],"is":[48,128,180],"notable":[49],"its":[51,199],"diverse":[52],"bioactivities.":[53],"review":[55,164],"integrates":[56],"analyzes":[58],"evidence":[59,154],"effects":[63],"of":[64,73,125,176],"G.":[65],"related":[68],"species,":[70],"emphasizing":[71],"mechanisms":[72],"action":[74],"within":[75],"a":[76,136,185,191],"multi-targeted":[77],"framework":[78],"rather":[79],"than":[80],"merely":[81],"cataloging":[82],"reported":[83],"effects.":[84],"Preclinical":[85],"studies":[86],"indicate":[87],"that":[88],"bioactive":[89],"compounds":[90],"from":[91],"Ganoderma,":[92],"particularly":[93],"polysaccharides":[94],"triterpenoids,":[96],"act":[97],"synergistically":[98],"counteract":[100],"neurodegeneration":[101],"by":[102],"reducing":[103],"oxidative":[104],"stress":[105],"neuroinflammation,":[107],"attenuating":[108],"protein":[109],"misfolding":[110],"(A\u03b2,":[111],"Tau,":[112],"\u03b1-synuclein)":[113],"mitochondrial":[115],"dysfunction,":[116],"modulating":[118],"gut-brain":[120],"axis.":[121],"efficacy":[124],"extracts":[127],"highly":[129],"dependent":[130],"on":[131],"extraction":[132],"processing":[134],"methods,":[135],"factor":[137],"often":[138],"underemphasized":[139],"in":[140,147],"literature.":[142],"These":[143],"findings":[144],"require":[145],"validation":[146],"standardized":[148],"clinical":[149,161,207],"trials,":[150],"as":[151,184,190],"robust":[152],"preclinical":[153],"yet":[157],"led":[158],"approved":[160],"therapies.":[162],"also":[165,189],"critically":[166],"examines":[167],"factors":[168],"influencing":[169],"bioavailability,":[171],"standardization,":[172],"cultivation":[174],"practices":[175],"Ganoderma.":[177],"positioned":[181],"traditional":[186],"remedy":[187],"but":[188],"promising":[192],"candidate":[193],"future":[195],"neurotherapeutic":[196],"development,":[197],"full":[200],"therapeutic":[201],"potential":[202],"contingent":[203],"upon":[204],"well-controlled,":[205],"rigorous":[206],"trials.":[208]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-04T00:00:00"}
