{"id":"https://openalex.org/W7225146608","doi":"https://doi.org/10.3389/fphar.2026.1960543","title":"Inter-organ interaction axes in systemic inflammation: network pathological mechanisms, pharmacological targets, and precision treatment strategies","display_name":"Inter-organ interaction axes in systemic inflammation: network pathological mechanisms, pharmacological targets, and precision treatment strategies","publication_year":2026,"publication_date":"2026-11-03","ids":{"openalex":"https://openalex.org/W7225146608","doi":"https://doi.org/10.3389/fphar.2026.1960543"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2026.1960543","doi":"https://doi.org/10.3389/fphar.2026.1960543","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1960543","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1960543/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1960543/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160546827","display_name":"Shuangbin Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuangbin Xie","raw_affiliation_strings":["College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine","Research Laboratory, Hubei Shizhen Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine","institution_ids":["https://openalex.org/I205016115"]},{"raw_affiliation_string":"Research Laboratory, Hubei Shizhen Laboratory","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100527846","display_name":"Haoran Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoran Tian","raw_affiliation_strings":["College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine","Research Laboratory, Hubei Shizhen Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine","institution_ids":["https://openalex.org/I205016115"]},{"raw_affiliation_string":"Research Laboratory, Hubei Shizhen Laboratory","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160561322","display_name":"Yanjuan Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanjuan Song","raw_affiliation_strings":["College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine","Research Laboratory, Hubei Shizhen Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine","institution_ids":["https://openalex.org/I205016115"]},{"raw_affiliation_string":"Research Laboratory, Hubei Shizhen Laboratory","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101711891","display_name":"Feng-Xia Liang","orcid":"https://orcid.org/0000-0002-9161-3472","observed_orcids":["https://orcid.org/0000-0002-9161-3472"]},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fengxia Liang","raw_affiliation_strings":["College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine","Research Laboratory, Hubei Shizhen Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine","institution_ids":["https://openalex.org/I205016115"]},{"raw_affiliation_string":"Research Laboratory, Hubei Shizhen Laboratory","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101711891","https://openalex.org/A5160561322"],"corresponding_institution_ids":["https://openalex.org/I205016115"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.86555925,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.40720000863075256,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.40720000863075256,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.10740000009536743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0608999989926815,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inter-organ-communication","display_name":"inter-organ communication","score":0.953000009059906},{"id":"https://openalex.org/keywords/gut-liver-brain-axis","display_name":"gut-liver-brain axis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/microbiota","display_name":"microbiota","score":0.5820000171661377},{"id":"https://openalex.org/keywords/tissue-remodeling","display_name":"tissue remodeling","score":0.8669999837875366},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.8180000185966492},{"id":"https://openalex.org/keywords/microcirculation","display_name":"microcirculation","score":0.902999997138977},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.9829999804496765},{"id":"https://openalex.org/keywords/single-cell-multi-omics","display_name":"single-cell multi-omics","score":0.7879999876022339},{"id":"https://openalex.org/keywords/spatial-omics","display_name":"spatial omics","score":0.9229999780654907},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"artificial intelligence","score":0.8050000071525574},{"id":"https://openalex.org/keywords/organ-on-a-chip","display_name":"organ-on-a-chip","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7483000159263611},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6597999930381775},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6428999900817871},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5548999905586243},{"id":"https://openalex.org/C134448949","wikidata":"https://www.wikidata.org/wiki/Q1384274","display_name":"Expediting","level":2,"score":0.536300003528595},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5083000063896179},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5009999871253967},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.45500001311302185},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.4284999966621399},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.3894999921321869},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3889999985694885},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.32429999113082886},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3091000020503998},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.28859999775886536},{"id":"https://openalex.org/C149588370","wikidata":"https://www.wikidata.org/wiki/Q424673","display_name":"Autacoid","level":3,"score":0.26089999079704285}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fphar.2026.1960543","doi":"https://doi.org/10.3389/fphar.2026.1960543","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1960543","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1960543/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:fab6e664986f4b318ce85d92b76cd56c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/fab6e664986f4b318ce85d92b76cd56c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2026.1960543","doi":"https://doi.org/10.3389/fphar.2026.1960543","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1960543","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1960543/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225146608.pdf","grobid_xml":"https://content.openalex.org/works/W7225146608.grobid-xml"},"referenced_works_count":203,"referenced_works":["https://openalex.org/W2007252822","https://openalex.org/W2031084334","https://openalex.org/W2083513831","https://openalex.org/W2092509739","https://openalex.org/W2104010066","https://openalex.org/W2177407033","https://openalex.org/W2593515375","https://openalex.org/W2748400555","https://openalex.org/W2769000982","https://openalex.org/W2785567214","https://openalex.org/W2794125559","https://openalex.org/W2794396024","https://openalex.org/W2884081989","https://openalex.org/W2888384778","https://openalex.org/W2974260792","https://openalex.org/W2986700515","https://openalex.org/W2993908729","https://openalex.org/W3024249113","https://openalex.org/W3041701418","https://openalex.org/W3081830235","https://openalex.org/W3088173406","https://openalex.org/W3094534128","https://openalex.org/W3103813916","https://openalex.org/W3124669815","https://openalex.org/W3130126061","https://openalex.org/W3130165094","https://openalex.org/W3156860494","https://openalex.org/W3164411648","https://openalex.org/W3185330383","https://openalex.org/W3194763937","https://openalex.org/W3196675326","https://openalex.org/W3202964273","https://openalex.org/W3204693953","https://openalex.org/W3206170768","https://openalex.org/W3207897009","https://openalex.org/W3209187104","https://openalex.org/W3215732862","https://openalex.org/W3216126620","https://openalex.org/W3216374510","https://openalex.org/W4200296515","https://openalex.org/W4213079338","https://openalex.org/W4214539912","https://openalex.org/W4220652963","https://openalex.org/W4220772699","https://openalex.org/W4220932014","https://openalex.org/W4224121299","https://openalex.org/W4225004714","https://openalex.org/W4225747892","https://openalex.org/W4226140551","https://openalex.org/W4281647171","https://openalex.org/W4281998025","https://openalex.org/W4282965795","https://openalex.org/W4286588842","https://openalex.org/W4290693737","https://openalex.org/W4290964021","https://openalex.org/W4292116822","https://openalex.org/W4293525118","https://openalex.org/W4295290019","https://openalex.org/W4295434145","https://openalex.org/W4297235870","https://openalex.org/W4297244226","https://openalex.org/W4303024505","https://openalex.org/W4304191831","https://openalex.org/W4308183941","https://openalex.org/W4308558768","https://openalex.org/W4312085090","https://openalex.org/W4313515836","https://openalex.org/W4316927575","https://openalex.org/W4318946156","https://openalex.org/W4319316276","https://openalex.org/W4327923084","https://openalex.org/W4362639994","https://openalex.org/W4365513067","https://openalex.org/W4366393083","https://openalex.org/W4366692019","https://openalex.org/W4377011194","https://openalex.org/W4380363720","https://openalex.org/W4382938040","https://openalex.org/W4385185884","https://openalex.org/W4385698328","https://openalex.org/W4385994929","https://openalex.org/W4386036702","https://openalex.org/W4386090432","https://openalex.org/W4386421901","https://openalex.org/W4386439778","https://openalex.org/W4388013971","https://openalex.org/W4388160987","https://openalex.org/W4388830275","https://openalex.org/W4388913695","https://openalex.org/W4389224442","https://openalex.org/W4389327220","https://openalex.org/W4389525869","https://openalex.org/W4390547937","https://openalex.org/W4390585667","https://openalex.org/W4390669227","https://openalex.org/W4390875177","https://openalex.org/W4391240207","https://openalex.org/W4391328351","https://openalex.org/W4391807089","https://openalex.org/W4392563033","https://openalex.org/W4394690900","https://openalex.org/W4394847290","https://openalex.org/W4395111952","https://openalex.org/W4395957187","https://openalex.org/W4400087846","https://openalex.org/W4400094289","https://openalex.org/W4400105718","https://openalex.org/W4400572425","https://openalex.org/W4401711214","https://openalex.org/W4401894635","https://openalex.org/W4402388942","https://openalex.org/W4402496608","https://openalex.org/W4402938722","https://openalex.org/W4403371901","https://openalex.org/W4403377191","https://openalex.org/W4403683563","https://openalex.org/W4403728293","https://openalex.org/W4403830658","https://openalex.org/W4404170422","https://openalex.org/W4404566873","https://openalex.org/W4404657578","https://openalex.org/W4404678094","https://openalex.org/W4405835096","https://openalex.org/W4406083735","https://openalex.org/W4406662562","https://openalex.org/W4407020219","https://openalex.org/W4407056429","https://openalex.org/W4407938670","https://openalex.org/W4407973732","https://openalex.org/W4408148067","https://openalex.org/W4408962001","https://openalex.org/W4409020924","https://openalex.org/W4409033195","https://openalex.org/W4409366659","https://openalex.org/W4409781891","https://openalex.org/W4409974660","https://openalex.org/W4410004858","https://openalex.org/W4410382863","https://openalex.org/W4410411646","https://openalex.org/W4410426514","https://openalex.org/W4410477291","https://openalex.org/W4410606182","https://openalex.org/W4410640931","https://openalex.org/W4410974018","https://openalex.org/W4411208565","https://openalex.org/W4411329518","https://openalex.org/W4411991705","https://openalex.org/W4412042767","https://openalex.org/W4412110634","https://openalex.org/W4412392966","https://openalex.org/W4412513306","https://openalex.org/W4412820237","https://openalex.org/W4413138787","https://openalex.org/W4413229344","https://openalex.org/W4413432132","https://openalex.org/W4413878580","https://openalex.org/W4413905104","https://openalex.org/W4414044764","https://openalex.org/W4414168707","https://openalex.org/W4414670007","https://openalex.org/W4414686120","https://openalex.org/W4415031233","https://openalex.org/W4415700325","https://openalex.org/W4415722804","https://openalex.org/W4415776220","https://openalex.org/W4415786295","https://openalex.org/W4415887627","https://openalex.org/W4415924014","https://openalex.org/W4416068430","https://openalex.org/W4416257190","https://openalex.org/W4416337920","https://openalex.org/W4416602249","https://openalex.org/W4416943560","https://openalex.org/W4416980467","https://openalex.org/W4417141839","https://openalex.org/W4417158917","https://openalex.org/W7117990056","https://openalex.org/W7122811868","https://openalex.org/W7123351031","https://openalex.org/W7124242929","https://openalex.org/W7124307331","https://openalex.org/W7125476051","https://openalex.org/W7127897130","https://openalex.org/W7128020354","https://openalex.org/W7128822312","https://openalex.org/W7131229524","https://openalex.org/W7131291638","https://openalex.org/W7133195341","https://openalex.org/W7140225707","https://openalex.org/W7141084223","https://openalex.org/W7141317426","https://openalex.org/W7141744987","https://openalex.org/W7147592669","https://openalex.org/W7151900244","https://openalex.org/W7154938367","https://openalex.org/W7161345149","https://openalex.org/W7162214381","https://openalex.org/W7162683283","https://openalex.org/W7168388786","https://openalex.org/W7169829860","https://openalex.org/W7171717332","https://openalex.org/W7171803159","https://openalex.org/W7207546568"],"related_works":["https://openalex.org/W4200481272","https://openalex.org/W4411324804","https://openalex.org/W7140279959","https://openalex.org/W4415411986","https://openalex.org/W7221105661","https://openalex.org/W2580098964","https://openalex.org/W3086534650","https://openalex.org/W7213639026","https://openalex.org/W7213357049","https://openalex.org/W4400166275"],"abstract_inverted_index":{"Systemic":[0],"inflammation":[1,14,28],"plays":[2],"a":[3],"central":[4],"role":[5],"in":[6,95],"both":[7],"acute":[8],"and":[9,39,54,77,90,92,106,132],"chronic":[10],"pathological":[11],"states.":[12],"Acute":[13],"is":[15,29],"often":[16],"triggered":[17],"by":[18,23,50],"infections":[19],"or":[20],"trauma,":[21],"characterized":[22],"rapid":[24],"immune":[25,52],"activation":[26],"low-grade":[27],"closely":[30],"associated":[31],"with":[32],"aging-related":[33],"diseases":[34,38],"such":[35,123],"as":[36,124],"cardiovascular":[37],"diabetes.":[40],"During":[41],"disease":[42],"progression,":[43],"inter-organ":[44,68],"communication":[45],"forms":[46],"dynamic":[47],"networks":[48],"mediated":[49],"metabolites,":[51],"factors,":[53],"neural":[55],"signals,":[56],"further":[57],"amplifying":[58],"the":[59,71,74,78,96,140],"inflammatory":[60],"response.":[61],"This":[62],"article":[63],"focuses":[64],"on":[65,102],"three":[66],"key":[67],"interaction":[69],"axes:":[70],"gut-liver-brain":[72],"axis,":[73,76],"adipose-muscle-bone":[75],"heart-kidney-lung":[79],"axis.":[80],"It":[81],"discusses":[82],"microbiota-driven":[83],"metabolic":[84],"neuroinflammation,":[85],"immune-metabolic":[86],"imbalance-induced":[87],"tissue":[88],"remodeling,":[89],"endothelial":[91],"microcirculatory":[93],"damage":[94],"context":[97],"of":[98,143],"multi-organ":[99],"inflammation.":[100,145],"Based":[101],"axis-specific":[103],"molecular":[104],"targets":[105],"spatiotemporal":[107],"precision,":[108],"pharmacological":[109],"strategies":[110],"are":[111,134],"shifting":[112],"from":[113],"single-factor":[114],"interventions":[115],"to":[116],"multitarget":[117],"combination":[118],"therapies.":[119],"Meanwhile,":[120],"innovative":[121],"technologies":[122],"single-cell":[125],"multi-omics,":[126],"spatial":[127],"omics,":[128],"artificial":[129],"intelligence":[130],"(AI),":[131],"organ-on-a-chip":[133],"expediting":[135],"precision":[136],"medicine":[137],"approaches":[138],"for":[139],"individualized":[141],"treatment":[142],"systemic":[144]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-04T00:00:00"}