{"id":"https://openalex.org/W7225143103","doi":"https://doi.org/10.1097/dss.0000000000005442","title":"Platelet-Rich Plasma and Platelet-Based Products in Facial Rejuvenation: State of the Evidence in Skin Quality, Periorbital Aesthetics, and Soft Tissue Augmentation","display_name":"Platelet-Rich Plasma and Platelet-Based Products in Facial Rejuvenation: State of the Evidence in Skin Quality, Periorbital Aesthetics, and Soft Tissue Augmentation","publication_year":2026,"publication_date":"2026-11-03","ids":{"openalex":"https://openalex.org/W7225143103","doi":"https://doi.org/10.1097/dss.0000000000005442","pmid":"https://pubmed.ncbi.nlm.nih.gov/42975415"},"language":"en","primary_location":{"id":"doi:10.1097/dss.0000000000005442","doi":"https://doi.org/10.1097/dss.0000000000005442","is_oa":false,"landing_page_url":"https://doi.org/10.1097/dss.0000000000005442","pdf_url":null,"source":{"id":"https://openalex.org/S153994436","display_name":"Dermatologic Surgery","issn_l":"1076-0512","issn":["1076-0512","1524-4725"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatologic Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092070092","display_name":"Iesha L Ticknor","orcid":"https://orcid.org/0000-0001-6938-7731","observed_orcids":["https://orcid.org/0000-0001-6938-7731"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iesha Ticknor","raw_affiliation_strings":["University of California, San Francisco, San Francisco, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, California;","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111045177","display_name":"Katherine ML. Given","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine M. Given","raw_affiliation_strings":["Given Dermatology Institute, Menlo Park, California;","University of California, San Francisco, San Francisco, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Given Dermatology Institute, Menlo Park, California;","institution_ids":[]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, California;","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045300208","display_name":"Amelia K. Hausauer","orcid":"https://orcid.org/0000-0003-1767-4434","observed_orcids":["https://orcid.org/0000-0003-1767-4434"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amelia Hausauer","raw_affiliation_strings":["Aesthetx Plastic Surgery, Cosmetic Dermatology and Aesthetic Medicine, Menlo Park, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aesthetx Plastic Surgery, Cosmetic Dermatology and Aesthetic Medicine, Menlo Park, California","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.88323103,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11322","display_name":"Facial Rejuvenation and Surgery Techniques","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11322","display_name":"Facial Rejuvenation and Surgery Techniques","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.08250000327825546,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-rich-plasma","display_name":"platelet-rich plasma","score":1.0},{"id":"https://openalex.org/keywords/platelet-rich-fibrin","display_name":"platelet-rich fibrin","score":1.0},{"id":"https://openalex.org/keywords/facial-rejuvenation","display_name":"facial rejuvenation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/skin-quality","display_name":"skin quality","score":0.8600000143051147},{"id":"https://openalex.org/keywords/soft-tissue-augmentation","display_name":"soft tissue augmentation","score":0.996999979019165},{"id":"https://openalex.org/keywords/volume-restoration","display_name":"volume restoration","score":0.8119999766349792},{"id":"https://openalex.org/keywords/autologous-fat","display_name":"autologous fat","score":0.8830000162124634},{"id":"https://openalex.org/keywords/microneedling","display_name":"microneedling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/energy-based-devices","display_name":"energy-based devices","score":0.9850000143051147}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8575000166893005},{"id":"https://openalex.org/C2779758324","wikidata":"https://www.wikidata.org/wiki/Q5428567","display_name":"Facial rejuvenation","level":2,"score":0.8291000127792358},{"id":"https://openalex.org/C136948725","wikidata":"https://www.wikidata.org/wiki/Q1458306","display_name":"Soft tissue","level":2,"score":0.6104999780654907},{"id":"https://openalex.org/C112224295","wikidata":"https://www.wikidata.org/wiki/Q2297001","display_name":"Rejuvenation","level":2,"score":0.5274999737739563},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5199000239372253},{"id":"https://openalex.org/C2780076745","wikidata":"https://www.wikidata.org/wiki/Q613879","display_name":"Platelet-rich plasma","level":3,"score":0.4627000093460083},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.4431000053882599},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.44290000200271606},{"id":"https://openalex.org/C2909121775","wikidata":"https://www.wikidata.org/wiki/Q5174008","display_name":"Cosmetic Techniques","level":2,"score":0.3578000068664551},{"id":"https://openalex.org/C19648533","wikidata":"https://www.wikidata.org/wiki/Q691640","display_name":"Evidence-based medicine","level":3,"score":0.35600000619888306},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.32899999618530273},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.30880001187324524},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.29260000586509705},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.2680000066757202},{"id":"https://openalex.org/C2777872592","wikidata":"https://www.wikidata.org/wiki/Q349185","display_name":"Wrinkle","level":2,"score":0.25679999589920044}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/dss.0000000000005442","doi":"https://doi.org/10.1097/dss.0000000000005442","is_oa":false,"landing_page_url":"https://doi.org/10.1097/dss.0000000000005442","pdf_url":null,"source":{"id":"https://openalex.org/S153994436","display_name":"Dermatologic Surgery","issn_l":"1076-0512","issn":["1076-0512","1524-4725"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatologic Surgery","raw_type":"journal-article"},{"id":"pmid:42975415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42975415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1508203333","https://openalex.org/W1987537856","https://openalex.org/W2011995826","https://openalex.org/W2063570212","https://openalex.org/W2105740912","https://openalex.org/W2109932374","https://openalex.org/W2114783134","https://openalex.org/W2120462435","https://openalex.org/W2150073043","https://openalex.org/W2179125235","https://openalex.org/W2309202352","https://openalex.org/W2489155225","https://openalex.org/W2490222838","https://openalex.org/W2492188440","https://openalex.org/W2517167064","https://openalex.org/W2557719001","https://openalex.org/W2584707707","https://openalex.org/W2604294391","https://openalex.org/W2605090611","https://openalex.org/W2740050324","https://openalex.org/W2744757970","https://openalex.org/W2750741006","https://openalex.org/W2764149342","https://openalex.org/W2799707167","https://openalex.org/W2885231782","https://openalex.org/W2915434831","https://openalex.org/W3003176384","https://openalex.org/W3011429862","https://openalex.org/W3013415293","https://openalex.org/W3080503489","https://openalex.org/W3082405945","https://openalex.org/W3177675112","https://openalex.org/W3217061846","https://openalex.org/W4294992182","https://openalex.org/W4318831057","https://openalex.org/W4321224261","https://openalex.org/W4407254778","https://openalex.org/W4409619831","https://openalex.org/W4412722002","https://openalex.org/W4413889902","https://openalex.org/W4415535229","https://openalex.org/W4415958655","https://openalex.org/W4415968193","https://openalex.org/W4416230898","https://openalex.org/W6945185279","https://openalex.org/W7118806676","https://openalex.org/W7121447644","https://openalex.org/W7124886052","https://openalex.org/W7125191913","https://openalex.org/W7125252571","https://openalex.org/W7125416982","https://openalex.org/W7125523869","https://openalex.org/W7144053921","https://openalex.org/W7163814454"],"related_works":["https://openalex.org/W4394740744","https://openalex.org/W4286685225","https://openalex.org/W7221627767","https://openalex.org/W3214689802","https://openalex.org/W7213245778","https://openalex.org/W4236619849","https://openalex.org/W4408647584","https://openalex.org/W4390440239","https://openalex.org/W2898061400","https://openalex.org/W2395311676"],"abstract_inverted_index":{"BACKGROUND:":[0],"As":[1],"interest":[2],"in":[3,43,55,84,102,110,161,172,190],"innovative":[4],"facial":[5,44,85,115,162],"rejuvenation":[6,116,163],"therapies":[7,100,128],"continues":[8],"to":[9,36],"grow,":[10],"platelet-rich":[11,15],"plasma":[12],"(PRP)":[13],"and":[14,33,39,50,54,62,67,151,164,177],"fibrin":[16],"(PRF)":[17],"have":[18,129],"emerged":[19],"as":[20,52],"promising":[21],"treatment":[22],"options.":[23],"OBJECTIVE:":[24],"To":[25],"review":[26],"the":[27,68,96,135],"current":[28],"medical":[29],"literature,":[30],"including":[31],"efficacy":[32,142],"safety,":[34],"pertaining":[35],"PRP,":[37],"PRF,":[38],"platelet-based":[40,82,99],"products":[41,83,189],"use":[42,97,157],"rejuvenation,":[45],"both":[46],"for":[47,76,95,119,143],"skin":[48,105],"quality":[49,148],"augmentation":[51,167],"monotherapy":[53],"combination":[56,111],"with":[57,112],"fillers,":[58],"autologous":[59],"fat,":[60],"microneedling,":[61],"energy-based":[63],"devices.":[64],"METHODS:":[65],"PubMed/MEDLINE":[66],"Cochrane":[69],"Library":[70],"were":[71,89],"searched":[72],"through":[73],"June":[74],"2026":[75],"English-language":[77],"peer-reviewed":[78],"human":[79],"studies":[80],"of":[81,98,158,187],"rejuvenation;":[86],"reference":[87],"lists":[88],"hand-searched.":[90],"RESULTS:":[91],"The":[92],"strongest":[93],"evidence":[94,137,147],"exists":[101],"improving":[103],"overall":[104,146],"quality,":[106],"whether":[107],"alone":[108],"or":[109],"more":[113,124],"traditional":[114],"methods.":[117],"Data":[118],"true":[120],"volume":[121],"restoration":[122],"remain":[123],"preliminary.":[125],"Overall,":[126],"platelet":[127,140,159],"a":[130],"satisfactory":[131],"safety":[132],"profile.":[133],"Despite":[134],"growing":[136],"base":[138],"supporting":[139],"concentrate":[141,160],"various":[144],"indications,":[145],"remains":[149],"poor":[150],"unstandardized.":[152],"CONCLUSION:":[153],"Current":[154],"literature":[155],"describing":[156],"soft":[165],"tissue":[166],"is":[168],"promising.":[169],"Substantial":[170],"variation":[171],"product":[173],"preparation,":[174],"study":[175],"design,":[176],"reporting":[178],"measures":[179],"limits":[180],"general":[181],"conclusions":[182],"and,":[183],"therefore,":[184],"widespread":[185],"adoption":[186],"these":[188],"dermatology":[191],"clinics.":[192]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-04T00:00:00"}