{"id":"https://openalex.org/W7225141044","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0321","title":"321 Genome-scale CRISPR KO screen identifies PCBP2 as a tumor-intrinsic regulator of cancer cell sensitivity to human CD4 + T cell killing","display_name":"321 Genome-scale CRISPR KO screen identifies PCBP2 as a tumor-intrinsic regulator of cancer cell sensitivity to human CD4 + T cell killing","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225141044","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0321"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2026-sitc2026.0321","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0321","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0321","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A363.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/14/Suppl_2/A363.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027161758","display_name":"Korbinian Nepomuk Kropp","orcid":"https://orcid.org/0000-0001-8104-7166","observed_orcids":["https://orcid.org/0000-0001-8104-7166"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Korbinian Kropp","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060127443","display_name":"Jeetayu Biswas","orcid":"https://orcid.org/0000-0002-1163-539X","observed_orcids":["https://orcid.org/0000-0002-1163-539X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeetayu Biswas","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072852574","display_name":"I\u00f1aki Etxeberr\u00eda","orcid":"https://orcid.org/0000-0003-2713-0836","observed_orcids":["https://orcid.org/0000-0003-2713-0836"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Inaki Etxeberria","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160389664","display_name":"Paul Chapman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Chapman","raw_affiliation_strings":["Weill Cornell Medical College, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020305680","display_name":"Smita S. Chandran","orcid":"https://orcid.org/0000-0001-9266-6878","observed_orcids":["https://orcid.org/0000-0001-9266-6878"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Smita S Chandran","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036191920","display_name":"Rebecca B. Nadler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Nadler","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008868120","display_name":"Michael V. Gormally","orcid":"https://orcid.org/0000-0002-0414-4234","observed_orcids":["https://orcid.org/0000-0002-0414-4234"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Gormally","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160517906","display_name":"John Klement","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Klement","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074959042","display_name":"Jahan A. Rahman","orcid":"https://orcid.org/0000-0001-8755-5890","observed_orcids":["https://orcid.org/0000-0001-8755-5890"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jahan A Rahman","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070466950","display_name":"Michael Mu","orcid":"https://orcid.org/0000-0003-4035-5298","observed_orcids":["https://orcid.org/0000-0003-4035-5298"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Mu","raw_affiliation_strings":["Columbia University Irving Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University Irving Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045195370","display_name":"Salima Benbarche","orcid":"https://orcid.org/0000-0001-5314-0435","observed_orcids":["https://orcid.org/0000-0001-5314-0435"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salima Benbarche","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009458275","display_name":"Fei Yi","orcid":"https://orcid.org/0009-0005-9031-2116","observed_orcids":["https://orcid.org/0009-0005-9031-2116"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fei Yi","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038261275","display_name":"Ruzzo Marco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marco Ruzzo","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024939030","display_name":"Lauren Baker Banks","orcid":"https://orcid.org/0000-0002-3443-6414","observed_orcids":["https://orcid.org/0000-0002-3443-6414"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren B Banks","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086601654","display_name":"Ralph J. Garippa","orcid":"https://orcid.org/0000-0003-3917-0739","observed_orcids":["https://orcid.org/0000-0003-3917-0739"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph Garippa","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022609223","display_name":"Clemens Hinterleitner","orcid":"https://orcid.org/0000-0003-2416-9399","observed_orcids":["https://orcid.org/0000-0003-2416-9399","https://orcid.org/0009-0007-5805-6153"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clemens Hinterleitner","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080410786","display_name":"Cecilia M. Lezcano","orcid":"https://orcid.org/0000-0001-9436-9623","observed_orcids":["https://orcid.org/0000-0001-9436-9623"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cecilia Lezcano","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040291209","display_name":"Alexander Noor Shoushtari","orcid":"https://orcid.org/0000-0002-8065-4412","observed_orcids":["https://orcid.org/0000-0002-8065-4412"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander N Shoushtari","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052100404","display_name":"Benjamin Izar","orcid":"https://orcid.org/0000-0003-2379-6702","observed_orcids":["https://orcid.org/0000-0003-2379-6702"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Izar","raw_affiliation_strings":["Columbia University Irving Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University Irving Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108249525","display_name":"Michael A. Postow","orcid":"https://orcid.org/0000-0002-3367-7961","observed_orcids":["https://orcid.org/0000-0002-3367-7961"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A Postow","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025595346","display_name":"Omar Ibrahim Abdel-Wahab","orcid":"https://orcid.org/0000-0002-3907-6171","observed_orcids":["https://orcid.org/0000-0002-3907-6171"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omar Abdel-Wahab","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074579867","display_name":"Christopher Austin Klebanoff","orcid":"https://orcid.org/0000-0001-9645-3896","observed_orcids":["https://orcid.org/0000-0001-9645-3896"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher A Klebanoff","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A363","last_page":"A363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.16830000281333923,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pcbp2","display_name":"PCBP2","score":0.8529999852180481},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8489999771118164},{"id":"https://openalex.org/keywords/tumor-intrinsic-resistance","display_name":"tumor-intrinsic resistance","score":0.48399999737739563},{"id":"https://openalex.org/keywords/crispr-knockout-screen","display_name":"CRISPR knockout screen","score":0.7329999804496765},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.6349999904632568},{"id":"https://openalex.org/keywords/isoform-specific-regulation","display_name":"isoform-specific regulation","score":0.5239999890327454},{"id":"https://openalex.org/keywords/u2af2","display_name":"U2AF2","score":0.8980000019073486},{"id":"https://openalex.org/keywords/spliceosome","display_name":"spliceosome","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.8080000281333923},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.7865999937057495},{"id":"https://openalex.org/C2993178667","wikidata":"https://www.wikidata.org/wiki/Q632518","display_name":"Cd4 t cell","level":4,"score":0.6862999796867371},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.6003000140190125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5435000061988831},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49549999833106995},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.4147999882698059},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3837999999523163},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36419999599456787},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.3555000126361847},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3294000029563904},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30720001459121704},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29789999127388},{"id":"https://openalex.org/C3017607883","wikidata":"https://www.wikidata.org/wiki/Q25325354","display_name":"Master regulator","level":4,"score":0.28439998626708984},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2784999907016754},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.266400009393692},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25540000200271606}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/jitc-2026-sitc2026.0321","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0321","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0321","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A363.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},{"id":"pmh:oai:doaj.org/article:019a77ed2e384c7cb7a7125962b17776","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/019a77ed2e384c7cb7a7125962b17776","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 14, Iss Suppl 2 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2026-sitc2026.0321","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0321","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0321","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A363.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225141044.pdf","grobid_xml":"https://content.openalex.org/works/W7225141044.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3031602396","https://openalex.org/W2914404046","https://openalex.org/W3177826291","https://openalex.org/W4386910605","https://openalex.org/W4220735010","https://openalex.org/W4308378344","https://openalex.org/W3186737070","https://openalex.org/W7148628357","https://openalex.org/W3131593383","https://openalex.org/W6944445385"],"abstract_inverted_index":{"Background":[0],"A":[1],"major":[2],"roadblock":[3],"preventing":[4],"durable":[5],"responses":[6],"to":[7,50,62,86,117,158,175,224,351,355,384],"CD8":[8],"+":[9,94,345],"T":[10,48,95,121,161,180,230,346,357,393],"cell-based":[11],"immunotherapies":[12],"in":[13,74,195,243,316,372],"melanoma":[14,104],"and":[15,60,144,208,234,271,297,329,360],"other":[16],"solid":[17,37],"cancers":[18,38],"is":[19,308,314],"loss":[20],"or":[21,115],"downregulation":[22],"of":[23,36,91,98,134,169,187,219,276,281,288,294,321,326,367,389],"human":[24,119],"leukocyte":[25],"antigen":[26,64,139],"class":[27],"I":[28],"(HLA-I)":[29],"on":[30],"tumor":[31,67,99,222,291,333],"cells.":[32,100,292,319,394],"However,":[33],"a":[34,75,80,209,244,309,362,379],"subset":[35],"aberrantly":[39],"express":[40],"HLA-II,":[41],"potentially":[42],"enabling":[43],"HLA-II":[44,63,125,149,211,390],"restricted":[45,126,150,212,391],"tumor-specific":[46],"CD4+":[47,120,179,229,392],"cells":[49,68,122,223,334,347],"overcome":[51,159,352],"HLA-I":[52,138],"resistance.":[53,163],"Unlike":[54],"HLA-I,":[55],"the":[56,88,102,170,185,228,285,303,368,386],"mechanisms":[57,90],"governing":[58],"response":[59],"resistance":[61,116,354],"presentation":[65],"by":[66,227,266],"have":[69],"previously":[70,363],"not":[71],"been":[72],"studied":[73],"systematic":[76],"fashion.Methods":[77],"We":[78,164,183],"performed":[79],"genome-scale":[81],"CRISPR":[82,192],"knockout":[83],"(KO)":[84],"screen":[85],"interrogate":[87],"molecular":[89],"direct":[92],"CD4":[93,344],"cell":[96,105,162,181,201,337,358],"engagement":[97],"Using":[101],"HLA-II+/HLA-I+":[103],"line":[106],"A375,":[107],"we":[108,215,257,341],"identified":[109],"genes":[110,135],"that":[111,148,167,217,241,259,302,313,343],"either":[112],"confer":[113],"sensitivity":[114],"primary":[118],"expressing":[123],"an":[124,155],"TCR.Results":[127],"Tumor":[128],"killing":[129,359],"was":[130],"preserved":[131],"upon":[132],"KO":[133,168,193,290,318,332],"relevant":[136],"for":[137],"presentation,":[140],"including":[141],"B2M,":[142],"TAP1/2,":[143],"TAPBP.":[145],"This":[146],"highlights":[147],"TCRs":[151],"can":[152,262,348],"function":[153],"as":[154],"orthogonal":[156],"strategy":[157],"CD8+":[160,356],"further":[165],"discovered":[166,258],"RNA-binding":[171,369],"protein":[172,239,370],"PCBP2":[173,220,236,269,274,282,289,310,317,327,331,371],"led":[174],"enhanced":[176],"depletion":[177],"under":[178],"selection.":[182],"established":[184],"generalizability":[186],"this":[188],"finding":[189],"through":[190],"focused":[191],"screens":[194],"n":[196],"=":[197],"3":[198],"unique":[199],"HLA-II+":[200],"lines":[202],"using":[203],"distinct":[204],"guide":[205],"RNA":[206,249],"sequences":[207],"different":[210],"TCR.":[213],"Mechanistically,":[214],"found":[216],"deletion":[218],"sensitized":[221],"apoptosis":[225],"induced":[226],"cell-derived":[231],"cytokines":[232],"TNF":[233],"IFN\u03b3.":[235],"encodes":[237],"multiple":[238],"isoforms":[240,261],"differ":[242],"linker":[245],"region":[246],"separating":[247],"two":[248],"binding":[250],"KH":[251],"domains.":[252],"In":[253,339],"genetic":[254],"complementation":[255,325],"experiments,":[256],"these":[260],"be":[263,349],"functionally":[264],"grouped":[265],"inclusion":[267],"(i.e.":[268,273],"long)":[270],"exclusion":[272],"short)":[275],"exon":[277],"8.":[278],"Only":[279],"re-expression":[280],"short":[283,328],"reverted":[284],"cytokine-sensitized":[286],"phenotype":[287],"Integration":[293],"RNA-seq,":[295],"proteomics,":[296],"isoform-specific":[298,365],"eCLIP":[299],"experiments":[300],"revealed":[301],"core":[304],"spliceosome":[305],"component":[306],"U2AF2":[307,322],"short-selective":[311],"target":[312],"downregulated":[315],"Re-expression":[320],"largely":[323],"phenocopied":[324],"protected":[330],"from":[335],"cytokine-induced":[336],"death.Conclusions":[338],"conclusion,":[340],"establish":[342,378],"employed":[350],"acquired":[353],"describe":[361],"unknown":[364],"role":[366],"regulating":[373],"antitumor":[374,387],"immunity.":[375],"These":[376],"findings":[377],"novel,":[380],"mechanism-based":[381],"immunotherapeutic":[382],"approach":[383],"augment":[385],"efficacy":[388]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-04T00:00:00"}
