{"id":"https://openalex.org/W7225140673","doi":"https://doi.org/10.5281/zenodo.23922726","title":"Design, Synthesis, Evaluation Of Indanone Derivatives For Alzheimer's Disease","display_name":"Design, Synthesis, Evaluation Of Indanone Derivatives For Alzheimer's Disease","publication_year":2026,"publication_date":"2026-11-03","ids":{"openalex":"https://openalex.org/W7225140673","doi":"https://doi.org/10.5281/zenodo.23922726"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.23922726","doi":"https://doi.org/10.5281/zenodo.23922726","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23922726","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.23922726","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160333105","display_name":"S. Vishvaja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116967","display_name":"Sri Manakula Vinayagar Educational Trust","ror":"https://ror.org/02fxe3b78","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210116967"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S. Vishvaja","raw_affiliation_strings":["SMVEC School of Pharmacy, Puducherry, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SMVEC School of Pharmacy, Puducherry, India","institution_ids":["https://openalex.org/I4210116967"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160527691","display_name":"P. Sathya Narayanan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116967","display_name":"Sri Manakula Vinayagar Educational Trust","ror":"https://ror.org/02fxe3b78","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210116967"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"P. Sathya Narayanan","raw_affiliation_strings":["SMVEC School of Pharmacy, Puducherry, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SMVEC School of Pharmacy, Puducherry, India","institution_ids":["https://openalex.org/I4210116967"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160466911","display_name":"R. Yakesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116967","display_name":"Sri Manakula Vinayagar Educational Trust","ror":"https://ror.org/02fxe3b78","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210116967"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"R. Yakesh","raw_affiliation_strings":["SMVEC School of Pharmacy, Puducherry, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SMVEC School of Pharmacy, Puducherry, India","institution_ids":["https://openalex.org/I4210116967"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160414123","display_name":"R. Keerthiga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116967","display_name":"Sri Manakula Vinayagar Educational Trust","ror":"https://ror.org/02fxe3b78","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210116967"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"R. Keerthiga","raw_affiliation_strings":["SMVEC School of Pharmacy, Puducherry, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SMVEC School of Pharmacy, Puducherry, India","institution_ids":["https://openalex.org/I4210116967"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159516125","display_name":"M. Dhanalakshmi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116967","display_name":"Sri Manakula Vinayagar Educational Trust","ror":"https://ror.org/02fxe3b78","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210116967"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M. Dhanalakshmi","raw_affiliation_strings":["SMVEC School of Pharmacy, Puducherry, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SMVEC School of Pharmacy, Puducherry, India","institution_ids":["https://openalex.org/I4210116967"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210116967"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.8475402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/indanone-derivatives","display_name":"indanone derivatives","score":0.9020000100135803},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cholinesterase-inhibitors","display_name":"cholinesterase inhibitors","score":0.8669999837875366},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibition","display_name":"acetylcholinesterase inhibition","score":0.9779999852180481},{"id":"https://openalex.org/keywords/mao-b-inhibition","display_name":"MAO-B inhibition","score":0.8500000238418579},{"id":"https://openalex.org/keywords/amyloid-beta-aggregation","display_name":"amyloid-beta aggregation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.843999981880188},{"id":"https://openalex.org/keywords/donepezil","display_name":"donepezil","score":0.871999979019165},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6352999806404114},{"id":"https://openalex.org/C2776024655","wikidata":"https://www.wikidata.org/wiki/Q410867","display_name":"Monoamine oxidase","level":3,"score":0.5723999738693237},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5432999730110168},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5307000279426575},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5058000087738037},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4977000057697296},{"id":"https://openalex.org/C31896038","wikidata":"https://www.wikidata.org/wiki/Q415635","display_name":"Cholinesterase","level":2,"score":0.4722999930381775},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.44369998574256897},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4426000118255615},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4171999990940094},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.39910000562667847},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.3634999990463257},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.3569999933242798},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.35100001096725464},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.3434999883174896},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.3391999900341034},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3264999985694885},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.3061000108718872},{"id":"https://openalex.org/C2777752112","wikidata":"https://www.wikidata.org/wiki/Q903238","display_name":"Lead compound","level":3,"score":0.2865999937057495},{"id":"https://openalex.org/C39398028","wikidata":"https://www.wikidata.org/wiki/Q18028862","display_name":"Monoamine oxidase B","level":4,"score":0.28119999170303345},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.275299996137619},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.26820001006126404},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26190000772476196},{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.25609999895095825},{"id":"https://openalex.org/C2779059548","wikidata":"https://www.wikidata.org/wiki/Q383701","display_name":"Ach\u00e9","level":4,"score":0.2524000108242035}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.23922726","doi":"https://doi.org/10.5281/zenodo.23922726","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23922726","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.23922727","doi":"https://doi.org/10.5281/zenodo.23922727","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23922727","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5281/zenodo.23922726","doi":"https://doi.org/10.5281/zenodo.23922726","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23922726","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4312082415","https://openalex.org/W4384484712","https://openalex.org/W1972072620","https://openalex.org/W2092632097","https://openalex.org/W2327504290","https://openalex.org/W4226515462","https://openalex.org/W4388014297","https://openalex.org/W3044028026","https://openalex.org/W2149637115","https://openalex.org/W1921187308"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,65],"(AD)":[2],"is":[3,19,100,193],"a":[4,173],"progressive":[5],"neurodegenerative":[6],"syndrome":[7],"that":[8],"leads":[9],"to":[10,57],"memory":[11],"loss":[12],"and":[13,27,45,66,84,135,139,160,183,190],"decline":[14],"in":[15,47,60,90,93,133,136,161,181],"cognitive":[16],"function.":[17],"This":[18,112,127],"one":[20,81],"of":[21,25,35,39,50,63,76,105,118,124,143,146,175],"the":[22,48,61,64,68,101,106,116,122,130,184],"leading":[23],"causes":[24],"dementia":[26],"currently":[28],"has":[29,114],"no":[30],"single":[31,82],"known":[32],"cause.":[33],"Loss":[34],"cholinergic":[36],"neurons,":[37],"formation":[38],"amyloid-\u03b2":[40],"(A\u03b2)":[41],"aggregates,":[42],"oxidative":[43],"stress":[44],"changes":[46],"activity":[49,141,155],"monoamine":[51],"oxidase":[52],"(MAO)":[53],"are":[54,67],"all":[55],"thought":[56],"be":[58],"involved":[59],"development":[62,123],"targets":[69],"for":[70,121],"most":[71,107],"current":[72],"therapeutic":[73],"approaches.":[74],"Most":[75],"this":[77],"only":[78,87,172],"aim":[79],"at":[80],"target":[83],"thus":[85],"have":[86,151,178],"limited":[88],"success":[89],"relieving":[91],"symptoms":[92],"patients":[94],"with":[95],"AD.":[96],"The":[97],"indanone":[98,147],"ring":[99,113],"active":[102],"pharmaceutical":[103],"ingredient":[104],"prescribed":[108],"cholinesterase":[109],"inhibitor":[110],"donepezil.":[111],"formed":[115],"basis":[117],"many":[119],"strategies":[120],"anti-AD":[125],"drugs.":[126],"review":[128],"follows":[129],"design,":[131],"synthesis,":[132],"vitro":[134],"vivo":[137,182],"testing":[138],"structure":[140],"relationships":[142],"numerous":[144],"series":[145,150],"derivatives.":[148],"Published":[149],"shown":[152],"sub-nanomolar":[153],"inhibitory":[154],"against":[156,164],"AChE":[157],"or":[158],"MAO-B":[159],"some":[162],"cases":[163],"A\u03b2":[165],"aggregation":[166],"as":[167],"well.":[168],"However,":[169],"so":[170],"far":[171],"few":[174],"these":[176],"compounds":[177],"been":[179],"tested":[180],"available":[185],"data":[186],"regarding":[187],"their":[188],"pharmacokinetic":[189],"pharmacological":[191],"profile":[192],"very":[194],"limited.":[195]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-04T00:00:00"}
