{"id":"https://openalex.org/W7225137458","doi":"https://doi.org/10.21203/rs.3.rs-11374607/v1","title":"Deceleration Capacity of the Heart Rate: Measurement Characteristics and Biological Determinants","display_name":"Deceleration Capacity of the Heart Rate: Measurement Characteristics and Biological Determinants","publication_year":2026,"publication_date":"2026-11-03","ids":{"openalex":"https://openalex.org/W7225137458","doi":"https://doi.org/10.21203/rs.3.rs-11374607/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11374607/v1","doi":"https://doi.org/10.21203/rs.3.rs-11374607/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11374607/v1","pdf_url":"https://www.researchsquare.com/article/rs-11374607/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11374607/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034277990","display_name":"Sjors R. B. van de Ven","orcid":"https://orcid.org/0000-0003-0910-7704","observed_orcids":["https://orcid.org/0000-0003-0910-7704"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sjors van de Ven","raw_affiliation_strings":["Vrije Universiteit Amsterdam"],"raw_orcid":"https://orcid.org/0000-0003-0910-7704","affiliations":[{"raw_affiliation_string":"Vrije Universiteit Amsterdam","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000049016","display_name":"Martin J. Gevonden","orcid":"https://orcid.org/0000-0001-7867-1443","observed_orcids":["https://orcid.org/0000-0001-7867-1443"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martin J. Gevonden","raw_affiliation_strings":["Vrije Universiteit Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vrije Universiteit Amsterdam","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006210657","display_name":"Matthijs Leendert Noordzij","orcid":"https://orcid.org/0000-0002-5013-9225","observed_orcids":["https://orcid.org/0000-0002-5013-9225"]},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Matthijs L. Noordzij","raw_affiliation_strings":["UT: Universiteit Twente"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT: Universiteit Twente","institution_ids":["https://openalex.org/I94624287"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100285513","display_name":"Eco J.C. de Geus","orcid":"https://orcid.org/0000-0001-6022-2666","observed_orcids":["https://orcid.org/0000-0001-6022-2666"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Eco J.C. de Geus","raw_affiliation_strings":["Vrije Universiteit Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vrije Universiteit Amsterdam","institution_ids":["https://openalex.org/I865915315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11021","display_name":"ECG Monitoring and Analysis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-autonomic-function","display_name":"cardiac autonomic function","score":0.902999997138977},{"id":"https://openalex.org/keywords/phase-rectified-signal-averaging","display_name":"phase-rectified signal averaging","score":0.8240000009536743},{"id":"https://openalex.org/keywords/temporal-stability","display_name":"temporal stability","score":0.9599999785423279},{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.984000027179718},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7059999704360962},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8820000290870667},{"id":"https://openalex.org/keywords/age-effects","display_name":"age effects","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.5971999764442444},{"id":"https://openalex.org/C196083921","wikidata":"https://www.wikidata.org/wiki/Q7915758","display_name":"Variance (accounting)","level":2,"score":0.45419999957084656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44449999928474426},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.43230000138282776},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.42419999837875366},{"id":"https://openalex.org/C35785553","wikidata":"https://www.wikidata.org/wiki/Q756720","display_name":"Ambulatory","level":2,"score":0.3978999853134155},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.34700000286102295},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.299699991941452},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.2818000018596649},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.275299996137619},{"id":"https://openalex.org/C138528620","wikidata":"https://www.wikidata.org/wiki/Q2510752","display_name":"Explained variation","level":2,"score":0.26910001039505005},{"id":"https://openalex.org/C3020318244","wikidata":"https://www.wikidata.org/wiki/Q4812187","display_name":"Large sample","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C19619285","wikidata":"https://www.wikidata.org/wiki/Q196372","display_name":"Observational error","level":2,"score":0.26019999384880066},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.25920000672340393}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11374607/v1","doi":"https://doi.org/10.21203/rs.3.rs-11374607/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11374607/v1","pdf_url":"https://www.researchsquare.com/article/rs-11374607/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11374607/v1","doi":"https://doi.org/10.21203/rs.3.rs-11374607/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11374607/v1","pdf_url":"https://www.researchsquare.com/article/rs-11374607/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225137458.pdf","grobid_xml":"https://content.openalex.org/works/W7225137458.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W171275827","https://openalex.org/W1967105231","https://openalex.org/W1974185429","https://openalex.org/W1998767783","https://openalex.org/W2000926512","https://openalex.org/W2019723087","https://openalex.org/W2027995996","https://openalex.org/W2031597554","https://openalex.org/W2063524446","https://openalex.org/W2064722828","https://openalex.org/W2109349396","https://openalex.org/W2131217017","https://openalex.org/W2135609443","https://openalex.org/W2138570186","https://openalex.org/W2159162038","https://openalex.org/W2166475150","https://openalex.org/W2167441819","https://openalex.org/W2168000166","https://openalex.org/W2168948247","https://openalex.org/W2259128162","https://openalex.org/W2313493433","https://openalex.org/W2328914507","https://openalex.org/W2398204186","https://openalex.org/W2399777618","https://openalex.org/W2437763950","https://openalex.org/W2467154308","https://openalex.org/W2625940930","https://openalex.org/W2749929555","https://openalex.org/W2773478070","https://openalex.org/W2791322619","https://openalex.org/W2800665818","https://openalex.org/W2905374294","https://openalex.org/W2983790886","https://openalex.org/W2990731435","https://openalex.org/W3081082235","https://openalex.org/W3101153286","https://openalex.org/W3181426730","https://openalex.org/W4285741973","https://openalex.org/W4385575842","https://openalex.org/W4393233318","https://openalex.org/W4396777565","https://openalex.org/W4405558744","https://openalex.org/W4405569134"],"related_works":["https://openalex.org/W2004802271","https://openalex.org/W1558514526","https://openalex.org/W2387068437","https://openalex.org/W2159162038","https://openalex.org/W4396777565","https://openalex.org/W2163284287","https://openalex.org/W4393233318","https://openalex.org/W1987118987","https://openalex.org/W2366917142","https://openalex.org/W3181426730"],"abstract_inverted_index":{"Abstract":[0],"Purpose":[1],"Deceleration":[2],"capacity":[3,58,73,131,180,221],"is":[4,240],"becoming":[5],"a":[6,34,94,235],"more":[7],"widely":[8],"used":[9,108],"predictor":[10],"for":[11,53,247],"health":[12,248],"outcomes":[13],"and":[14,22,56,104,121,147,192,200],"cardiac":[15],"autonomic":[16],"dysfunction,":[17],"but":[18],"its":[19,244],"measurement":[20,165],"characteristics":[21],"biological":[23,237],"determinants":[24],"remain":[25],"insufficiently":[26],"understood.":[27],"This":[28],"study":[29],"examined":[30,92],"these":[31,149,228],"factors":[32],"in":[33,93,203,241],"large":[35],"population-based":[36],"sample":[37],"(n":[38],"=":[39,172,175,187,190,195,198,208,212,224],"1291)":[40],"from":[41,76,84,133,139,142],"the":[42,114,143,154],"Netherlands":[43],"Twin":[44],"Register.":[45],"Methods":[46],"Participants":[47],"wore":[48],"an":[49],"physiological":[50],"monitoring":[51],"device":[52],"24":[54],"hours,":[55],"deceleration":[57,72,130,179,220],"was":[59,91,107,117,181,201],"computed":[60],"through":[61],"phase-rectified":[62],"signal":[63],"averaging.":[64],"To":[65],"test":[66],"whether":[67],"short":[68],"recordings":[69],"might":[70],"suffice,":[71],"estimates":[74,82],"derived":[75,132,141],"5-minute":[77,134],"segments":[78,135],"were":[79],"compared":[80],"with":[81,184,243],"obtained":[83],"full":[85,144],"24-hour":[86,145,232],"ambulatory":[87],"recordings.":[88],"Temporal":[89],"stability":[90,162],"subsample":[95],"of":[96,113,219],"participants":[97],"measured":[98],"again":[99],"roughly":[100,167],"three":[101,168],"years":[102,169],"later,":[103],"twin":[105],"modeling":[106],"to":[109,159],"determine":[110],"how":[111],"much":[112],"individual":[115],"variance":[116],"explained":[118],"by":[119],"environmental":[120],"genetic":[122],"factors.":[123],"Results":[124],"The":[125],"results":[126],"indicated":[127],"that":[128,148,231],"short-term":[129],"can":[136],"deviate":[137],"substantially":[138],"those":[140],"recording,":[146],"deviations":[150],"vary":[151],"systematically":[152],"across":[153,163],"day.":[155],"It":[156],"showed":[157],"moderate":[158],"strong":[160],"temporal":[161],"two":[164],"occasions":[166],"apart":[170],"(r":[171],".74,":[173],"ICC(A,1)":[174],".74).":[176],"In":[177],"addition,":[178],"negatively":[182],"associated":[183],"age":[185],"(\u03b2":[186,194],"-0.04,":[188,196],"R\u00b2":[189,197],".14)":[191],"BMI":[193],".03),":[199],"higher":[202],"males":[204],"than":[205],"females":[206],"(M":[207],"4.70":[209],"vs":[210],"M":[211],"4.12).":[213],"We":[214],"further":[215],"found":[216],"substantial":[217],"heritability":[218],"(h":[222],"2":[223],".62).":[225],"Conclusions":[226],"Together,":[227],"findings":[229],"establish":[230],"DC":[233],"reflects":[234],"stable":[236],"trait,":[238],"which":[239],"line":[242],"prognostic":[245],"potential":[246],"outcomes.":[249]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-04T00:00:00"}
