{"id":"https://openalex.org/W7225124347","doi":"https://doi.org/10.3389/fendo.2026.1959981","title":"Cell-free DNA in human ovarian follicular fluid as a potential biomarker of embryo quality in IVF cycles: a pilot study","display_name":"Cell-free DNA in human ovarian follicular fluid as a potential biomarker of embryo quality in IVF cycles: a pilot study","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225124347","doi":"https://doi.org/10.3389/fendo.2026.1959981"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2026.1959981","doi":"https://doi.org/10.3389/fendo.2026.1959981","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2026.1959981","pdf_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1959981/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1959981/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160333436","display_name":"Eun-Hye Jo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4405258721","display_name":"CHA University Fertility Center","ror":"https://ror.org/013x1r993","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258721","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun-Hye Jo","raw_affiliation_strings":["CHA Fertility Center Seoul Station, CHA University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHA Fertility Center Seoul Station, CHA University School of Medicine","institution_ids":["https://openalex.org/I4210148737","https://openalex.org/I4405258721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100388897","display_name":"Tae Hyung Kim","orcid":"https://orcid.org/0000-0002-2874-8884","observed_orcids":["https://orcid.org/0000-0002-2874-8884"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210165484","display_name":"CHA University Gangnam Medical Center","ror":"https://ror.org/05rtdxx03","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4210165484","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4405258490","display_name":"CHA University Gangnam Women's Medical Center","ror":"https://ror.org/00rg6e542","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4210165484","https://openalex.org/I4405258490","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4405258721","display_name":"CHA University Fertility Center","ror":"https://ror.org/013x1r993","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258721","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae Hyung Kim","raw_affiliation_strings":["CHA Fertility Center Gangnam, Fertility Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHA Fertility Center Gangnam, Fertility Laboratory","institution_ids":["https://openalex.org/I4210148737","https://openalex.org/I4210165484","https://openalex.org/I4405258490","https://openalex.org/I4405258721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003817471","display_name":"Jin Hee Eum","orcid":"https://orcid.org/0000-0002-7875-1870","observed_orcids":["https://orcid.org/0000-0002-7875-1870"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210165484","display_name":"CHA University Gangnam Medical Center","ror":"https://ror.org/05rtdxx03","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4210165484","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4405258490","display_name":"CHA University Gangnam Women's Medical Center","ror":"https://ror.org/00rg6e542","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4210165484","https://openalex.org/I4405258490","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4405258721","display_name":"CHA University Fertility Center","ror":"https://ror.org/013x1r993","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258721","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Hee EUM","raw_affiliation_strings":["CHA Fertility Center Gangnam, Fertility Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHA Fertility Center Gangnam, Fertility Laboratory","institution_ids":["https://openalex.org/I4210148737","https://openalex.org/I4210165484","https://openalex.org/I4405258490","https://openalex.org/I4405258721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039060790","display_name":"Jihye Jeong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210165484","display_name":"CHA University Gangnam Medical Center","ror":"https://ror.org/05rtdxx03","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4210165484","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4405258490","display_name":"CHA University Gangnam Women's Medical Center","ror":"https://ror.org/00rg6e542","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4210165484","https://openalex.org/I4405258490","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4405258721","display_name":"CHA University Fertility Center","ror":"https://ror.org/013x1r993","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258721","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jihye Jeong","raw_affiliation_strings":["CHA Fertility Center Gangnam, Fertility Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHA Fertility Center Gangnam, Fertility Laboratory","institution_ids":["https://openalex.org/I4210148737","https://openalex.org/I4210165484","https://openalex.org/I4405258490","https://openalex.org/I4405258721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126936688","display_name":"Sol A Yoon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210165484","display_name":"CHA University Gangnam Medical Center","ror":"https://ror.org/05rtdxx03","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4210165484","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4405258490","display_name":"CHA University Gangnam Women's Medical Center","ror":"https://ror.org/00rg6e542","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4210165484","https://openalex.org/I4405258490","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4405258721","display_name":"CHA University Fertility Center","ror":"https://ror.org/013x1r993","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258721","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sol A YOON","raw_affiliation_strings":["CHA Fertility Center Gangnam, Fertility Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHA Fertility Center Gangnam, Fertility Laboratory","institution_ids":["https://openalex.org/I4210148737","https://openalex.org/I4210165484","https://openalex.org/I4405258490","https://openalex.org/I4405258721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100776693","display_name":"Min Kyoung Kim","orcid":"https://orcid.org/0000-0003-0477-2588","observed_orcids":["https://orcid.org/0000-0003-0477-2588"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210165484","display_name":"CHA University Gangnam Medical Center","ror":"https://ror.org/05rtdxx03","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4210165484","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4405258721","display_name":"CHA University Fertility Center","ror":"https://ror.org/013x1r993","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258721","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min Kyoung Kim","raw_affiliation_strings":["CHA Fertility Center Gangnam, CHA University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHA Fertility Center Gangnam, CHA University School of Medicine","institution_ids":["https://openalex.org/I4210148737","https://openalex.org/I4210165484","https://openalex.org/I4405258721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101847265","display_name":"Jee Hyun Kim","orcid":"https://orcid.org/0000-0002-2584-108X","observed_orcids":["https://orcid.org/0000-0002-2584-108X","https://orcid.org/0000-0003-1336-3620"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4405258721","display_name":"CHA University Fertility Center","ror":"https://ror.org/013x1r993","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258721","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4405259711","display_name":"CHA University Bundang Women's Medical Center","ror":"https://ror.org/02keexa98","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985","https://openalex.org/I4405259711"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jee Hyun Kim","raw_affiliation_strings":["CHA Fertility Center Bundang, CHA University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHA Fertility Center Bundang, CHA University School of Medicine","institution_ids":["https://openalex.org/I4210148737","https://openalex.org/I4405258721","https://openalex.org/I4405259711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160357538","display_name":"Hee Jun Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210165484","display_name":"CHA University Gangnam Medical Center","ror":"https://ror.org/05rtdxx03","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4210165484","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4405258721","display_name":"CHA University Fertility Center","ror":"https://ror.org/013x1r993","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258721","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hee Jun Lee","raw_affiliation_strings":["CHA Fertility Center Gangnam, CHA University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHA Fertility Center Gangnam, CHA University School of Medicine","institution_ids":["https://openalex.org/I4210148737","https://openalex.org/I4210165484","https://openalex.org/I4405258721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5160357538"],"corresponding_institution_ids":["https://openalex.org/I4210148737","https://openalex.org/I4210165484","https://openalex.org/I4405258721"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.03280000016093254,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.9980000257492065},{"id":"https://openalex.org/keywords/follicular-fluid","display_name":"follicular fluid","score":0.9769999980926514},{"id":"https://openalex.org/keywords/embryo-quality","display_name":"embryo quality","score":0.953000009059906},{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.6660000085830688},{"id":"https://openalex.org/keywords/intracytoplasmic-sperm-injection","display_name":"intracytoplasmic sperm injection","score":0.902999997138977},{"id":"https://openalex.org/keywords/cfdna-fragmentation","display_name":"cfDNA fragmentation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6589999794960022},{"id":"https://openalex.org/keywords/embryo-selection","display_name":"embryo selection","score":0.7110000252723694},{"id":"https://openalex.org/keywords/maternal-age","display_name":"maternal age","score":0.7239999771118164},{"id":"https://openalex.org/keywords/embryo-morphology","display_name":"embryo morphology","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2776188440","wikidata":"https://www.wikidata.org/wiki/Q3746826","display_name":"Follicular fluid","level":4,"score":0.7721999883651733},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.6729999780654907},{"id":"https://openalex.org/C2777542035","wikidata":"https://www.wikidata.org/wiki/Q17001806","display_name":"Embryo quality","level":4,"score":0.6503000259399414},{"id":"https://openalex.org/C2778278907","wikidata":"https://www.wikidata.org/wiki/Q28700","display_name":"Intracytoplasmic sperm injection","level":4,"score":0.6448000073432922},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6401000022888184},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5967000126838684},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5550000071525574},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.41370001435279846},{"id":"https://openalex.org/C160099875","wikidata":"https://www.wikidata.org/wiki/Q237118","display_name":"Embryo transfer","level":3,"score":0.40939998626708984},{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.4074999988079071},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3790999948978424},{"id":"https://openalex.org/C518429986","wikidata":"https://www.wikidata.org/wiki/Q964401","display_name":"Fertility","level":3,"score":0.37130001187324524},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.3555999994277954},{"id":"https://openalex.org/C187785154","wikidata":"https://www.wikidata.org/wiki/Q5464664","display_name":"Follicular phase","level":2,"score":0.3483000099658966},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3377000093460083},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.3287000060081482},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3253999948501587},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3244999945163727},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.3181999921798706},{"id":"https://openalex.org/C2778279030","wikidata":"https://www.wikidata.org/wiki/Q1543380","display_name":"Live birth","level":3,"score":0.31630000472068787},{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.3082999885082245},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.2928999960422516},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.28790000081062317},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2770000100135803},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.275299996137619},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2667999863624573},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.2583000063896179},{"id":"https://openalex.org/C500014431","wikidata":"https://www.wikidata.org/wiki/Q25862","display_name":"Assisted reproductive technology","level":4,"score":0.25209999084472656}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fendo.2026.1959981","doi":"https://doi.org/10.3389/fendo.2026.1959981","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2026.1959981","pdf_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1959981/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:4cd709f7f798445492209a8f09b6941b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4cd709f7f798445492209a8f09b6941b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2026.1959981","doi":"https://doi.org/10.3389/fendo.2026.1959981","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2026.1959981","pdf_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1959981/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225124347.pdf","grobid_xml":"https://content.openalex.org/works/W7225124347.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1865461924","https://openalex.org/W1963823714","https://openalex.org/W1967090815","https://openalex.org/W1975809777","https://openalex.org/W1990915258","https://openalex.org/W1993651044","https://openalex.org/W2031696206","https://openalex.org/W2049922617","https://openalex.org/W2053744674","https://openalex.org/W2072746629","https://openalex.org/W2076201780","https://openalex.org/W2077064497","https://openalex.org/W2077879604","https://openalex.org/W2086190847","https://openalex.org/W2092741900","https://openalex.org/W2096167208","https://openalex.org/W2119475803","https://openalex.org/W2121656197","https://openalex.org/W2127332827","https://openalex.org/W2136625051","https://openalex.org/W2147242642","https://openalex.org/W2148101348","https://openalex.org/W2167902484","https://openalex.org/W2168018194","https://openalex.org/W2519192497","https://openalex.org/W2909976052","https://openalex.org/W2995973730","https://openalex.org/W3091320226","https://openalex.org/W7131690883"],"related_works":["https://openalex.org/W2120769480","https://openalex.org/W1975809777","https://openalex.org/W4313640592","https://openalex.org/W4409035410","https://openalex.org/W1865461924","https://openalex.org/W3216906591","https://openalex.org/W3041865054","https://openalex.org/W2971013297","https://openalex.org/W1988532564","https://openalex.org/W4200112851"],"abstract_inverted_index":{"Introduction":[0],"There":[1],"is":[2],"growing":[3],"interest":[4],"in":[5,10,55,101,144,176,199],"evaluating":[6],"cell-free":[7],"DNA":[8],"(cfDNA)":[9],"follicular":[11,20,64],"fluid":[12,65],"(FF)":[13],"as":[14,242],"a":[15,77,117,243],"molecular":[16],"feature":[17],"of":[18,217],"the":[19,37,45,98,209,215],"microenvironment":[21],"and":[22,51,88,158,214,227,261],"examining":[23],"its":[24],"association":[25,38],"with":[26,71,123,203],"subsequent":[27],"embryo":[28,53,124,206,253,259],"development.":[29],"This":[30,59],"exploratory":[31,235],"pilot":[32],"study":[33,61],"aimed":[34],"to":[35,103],"investigate":[36],"between":[39],"FF":[40,81,200,240],"cfDNA":[41,89,197,241],"integrity,":[42],"measured":[43],"by":[44],"Arthrobacter":[46],"luteus":[47],"(ALU)":[48],"247/115":[49],"ratio,":[50],"morphology-based":[52,205],"quality":[54,125],"IVF":[56,70],"cycles.":[57],"Methods":[58],"observational":[60],"analyzed":[62],"106":[63],"samples":[66,82],"from":[67],"patients":[68,129],"undergoing":[69],"intracytoplasmic":[72],"sperm":[73],"injection":[74],"(ICSI)":[75],"at":[76],"single":[78],"fertility":[79],"center.":[80],"were":[83,91,106,212],"collected":[84],"during":[85],"ovum":[86],"pick-up,":[87],"concentrations":[90],"quantified":[92],"using":[93],"ALU-quantitative":[94],"PCR.":[95],"To":[96],"evaluate":[97],"ALU247/115":[99,114],"ratio":[100,115],"relation":[102],"age,":[104],"participants":[105],"categorized":[107],"into":[108],"three":[109],"age":[110],"groups.":[111],"Results":[112],"The":[113],"showed":[116],"significant":[118,172],"but":[119],"weak":[120],"positive":[121],"correlation":[122,173],"score":[126],"across":[127],"all":[128],"(n":[130,149,163,182],"=":[131,134,137,150,153,156,166,169,183,186,189],"106,":[132],"r":[133,152,165,185],"0.23,":[135],"p":[136,155,168,188],"0.016).":[138],"Subgroup":[139],"analysis":[140],"revealed":[141],"stronger":[142],"correlations":[143,211],"women":[145,177,193],"under":[146,194],"35":[147],"years":[148,162],"31,":[151],"0.38,":[154],"0.035)":[157],"those":[159],"aged":[160,178],"35\u201339":[161],"=40,":[164],"0.32,":[167],"0.044).":[170],"No":[171],"was":[174,201],"observed":[175,210],"40":[179],"or":[180,248],"older":[181],"35,":[184],"0.21,":[187],"0.225).":[190],"Conclusions":[191],"In":[192],"40,":[195],"increased":[196],"fragmentation":[198],"associated":[202],"lower":[204],"quality.":[207],"However,":[208],"modest,":[213],"absence":[216],"preimplantation":[218],"genetic":[219],"testing":[220],"for":[221],"aneuploidy":[222],"(PGT-A),":[223],"implantation,":[224],"clinical":[225,232],"pregnancy,":[226],"live":[228],"birth":[229],"outcomes":[230,265],"limits":[231],"interpretation.":[233],"These":[234],"findings":[236],"do":[237],"not":[238],"establish":[239],"clinically":[244,262],"validated":[245],"predictive":[246],"biomarker":[247],"demonstrate":[249],"that":[250],"it":[251],"improves":[252],"selection.":[254],"Larger":[255],"prospective":[256],"studies":[257],"incorporating":[258],"ploidy":[260],"relevant":[263],"reproductive":[264],"are":[266],"warranted.":[267]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-03T00:00:00"}
