{"id":"https://openalex.org/W7225122004","doi":"https://doi.org/10.1002/advs.78530","title":"Reln mRNA Delivery Drives Neurogenic Bone Regeneration by Orchestrating Schwann Cell\u2010Mediated Exosomal Trafficking","display_name":"Reln mRNA Delivery Drives Neurogenic Bone Regeneration by Orchestrating Schwann Cell\u2010Mediated Exosomal Trafficking","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225122004","doi":"https://doi.org/10.1002/advs.78530","pmid":"https://pubmed.ncbi.nlm.nih.gov/42969166"},"language":"en","primary_location":{"id":"doi:10.1002/advs.78530","doi":"https://doi.org/10.1002/advs.78530","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.78530","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/advs.78530","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160365750","display_name":"Shuai Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Lin","raw_affiliation_strings":["Department of Orthodontics Peking University School and Hospital of Stomatology National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology NHC Key Laboratory of Digital Stomatology NMPA Key Laboratory for Dental Materials  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthodontics Peking University School and Hospital of Stomatology National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology NHC Key Laboratory of Digital Stomatology NMPA Key Laboratory for Dental Materials  Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160366673","display_name":"Qianwen Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianwen Li","raw_affiliation_strings":["Department of Orthodontics Peking University School and Hospital of Stomatology National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology NHC Key Laboratory of Digital Stomatology NMPA Key Laboratory for Dental Materials  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthodontics Peking University School and Hospital of Stomatology National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology NHC Key Laboratory of Digital Stomatology NMPA Key Laboratory for Dental Materials  Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160362586","display_name":"Duo Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Duo Liu","raw_affiliation_strings":["Department of Orthodontics Peking University School and Hospital of Stomatology National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology NHC Key Laboratory of Digital Stomatology NMPA Key Laboratory for Dental Materials  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthodontics Peking University School and Hospital of Stomatology National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology NHC Key Laboratory of Digital Stomatology NMPA Key Laboratory for Dental Materials  Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121354137","display_name":"Mingzhao Li","orcid":"https://orcid.org/0009-0006-7212-0820","observed_orcids":["https://orcid.org/0009-0006-7212-0820"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingzhao Li","raw_affiliation_strings":["Department of Orthodontics Peking University School and Hospital of Stomatology National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology NHC Key Laboratory of Digital Stomatology NMPA Key Laboratory for Dental Materials  Beijing China"],"raw_orcid":"https://orcid.org/0009-0006-7212-0820","affiliations":[{"raw_affiliation_string":"Department of Orthodontics Peking University School and Hospital of Stomatology National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology NHC Key Laboratory of Digital Stomatology NMPA Key Laboratory for Dental Materials  Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160379923","display_name":"Han Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Zhang","raw_affiliation_strings":["Department of Orthodontics Peking University School and Hospital of Stomatology National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology NHC Key Laboratory of Digital Stomatology NMPA Key Laboratory for Dental Materials  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthodontics Peking University School and Hospital of Stomatology National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology NHC Key Laboratory of Digital Stomatology NMPA Key Laboratory for Dental Materials  Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002109008","display_name":"Liujing Chen","orcid":"https://orcid.org/0000-0003-0474-4114","observed_orcids":["https://orcid.org/0000-0003-0474-4114"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liujing Chen","raw_affiliation_strings":["Department of Orthodontics Peking University School and Hospital of Stomatology National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology NHC Key Laboratory of Digital Stomatology NMPA Key Laboratory for Dental Materials  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthodontics Peking University School and Hospital of Stomatology National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology NHC Key Laboratory of Digital Stomatology NMPA Key Laboratory for Dental Materials  Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160362791","display_name":"Yan Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yan Yu","raw_affiliation_strings":["Charles Perkins Centre The University of Sydney  Camperdown Australia","Sydney Dental School Faculty of Medicine and Health The University of Sydney  Camperdown Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles Perkins Centre The University of Sydney  Camperdown Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Sydney Dental School Faculty of Medicine and Health The University of Sydney  Camperdown Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103207063","display_name":"Jiuhui Jiang","orcid":"https://orcid.org/0000-0003-4881-5949","observed_orcids":["https://orcid.org/0000-0003-4881-5949"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiuhui Jiang","raw_affiliation_strings":["Department of Orthodontics Peking University School and Hospital of Stomatology National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology NHC Key Laboratory of Digital Stomatology NMPA Key Laboratory for Dental Materials  Beijing China"],"raw_orcid":"https://orcid.org/0000-0003-4881-5949","affiliations":[{"raw_affiliation_string":"Department of Orthodontics Peking University School and Hospital of Stomatology National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology NHC Key Laboratory of Digital Stomatology NMPA Key Laboratory for Dental Materials  Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125940052","display_name":"Chun Xu","orcid":"https://orcid.org/0000-0001-8831-3607","observed_orcids":["https://orcid.org/0000-0001-8831-3607"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Chun Xu","raw_affiliation_strings":["Charles Perkins Centre The University of Sydney  Camperdown Australia","Sydney Dental School Faculty of Medicine and Health The University of Sydney  Camperdown Australia"],"raw_orcid":"https://orcid.org/0000-0001-8831-3607","affiliations":[{"raw_affiliation_string":"Charles Perkins Centre The University of Sydney  Camperdown Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Sydney Dental School Faculty of Medicine and Health The University of Sydney  Camperdown Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070846875","display_name":"Ruili Yang","orcid":"https://orcid.org/0000-0002-3283-9893","observed_orcids":["https://orcid.org/0000-0002-3283-9893"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ruili Yang","raw_affiliation_strings":["Department of Orthodontics Peking University School and Hospital of Stomatology National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology NHC Key Laboratory of Digital Stomatology NMPA Key Laboratory for Dental Materials  Beijing China","School of Stomatology Sanya Division (Sanya Stomatology Center) Peking University  Sanya Hainan China"],"raw_orcid":"https://orcid.org/0000-0002-3283-9893","affiliations":[{"raw_affiliation_string":"Department of Orthodontics Peking University School and Hospital of Stomatology National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology NHC Key Laboratory of Digital Stomatology NMPA Key Laboratory for Dental Materials  Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]},{"raw_affiliation_string":"School of Stomatology Sanya Division (Sanya Stomatology Center) Peking University  Sanya Hainan China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5070846875","https://openalex.org/A5125940052"],"corresponding_institution_ids":["https://openalex.org/I129604602","https://openalex.org/I20231570","https://openalex.org/I4210095659"],"apc_list":{"value":6730,"currency":"USD","value_usd":6730},"apc_paid":{"value":6730,"currency":"USD","value_usd":6730},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.78042854,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.24779999256134033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.07750000059604645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7495999932289124},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6255999803543091},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.6212999820709229},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.6021000146865845},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.5371000170707703},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.5116000175476074},{"id":"https://openalex.org/C2777004073","wikidata":"https://www.wikidata.org/wiki/Q465621","display_name":"Schwann cell","level":2,"score":0.46320000290870667},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.392300009727478},{"id":"https://openalex.org/C2779918246","wikidata":"https://www.wikidata.org/wiki/Q613203","display_name":"Calvaria","level":3,"score":0.38029998540878296},{"id":"https://openalex.org/C2778063154","wikidata":"https://www.wikidata.org/wiki/Q13561329","display_name":"Reelin","level":3,"score":0.367000013589859},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.3384999930858612},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.33309999108314514},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.32690000534057617},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32679998874664307},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31940001249313354},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.31790000200271606},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.31709998846054077},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.31360000371932983},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.290800005197525},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.2847000062465668},{"id":"https://openalex.org/C2780973866","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Osteocyte","level":4,"score":0.26840001344680786},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2623000144958496},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.25220000743865967}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/advs.78530","doi":"https://doi.org/10.1002/advs.78530","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.78530","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},{"id":"pmid:42969166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42969166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/advs.78530","doi":"https://doi.org/10.1002/advs.78530","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.78530","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1938236935","https://openalex.org/W1979890518","https://openalex.org/W1994339099","https://openalex.org/W1995220749","https://openalex.org/W2009630995","https://openalex.org/W2021026189","https://openalex.org/W2054077259","https://openalex.org/W2070828333","https://openalex.org/W2075230442","https://openalex.org/W2098095516","https://openalex.org/W2120989136","https://openalex.org/W2146120203","https://openalex.org/W2156036794","https://openalex.org/W2357241585","https://openalex.org/W2464410938","https://openalex.org/W2548949426","https://openalex.org/W2753608792","https://openalex.org/W2768241957","https://openalex.org/W2775034467","https://openalex.org/W2794238057","https://openalex.org/W2806854794","https://openalex.org/W2972505478","https://openalex.org/W3035951711","https://openalex.org/W3049483573","https://openalex.org/W3086329702","https://openalex.org/W3095605465","https://openalex.org/W3157211637","https://openalex.org/W3194528980","https://openalex.org/W3213438222","https://openalex.org/W3215717850","https://openalex.org/W3215989640","https://openalex.org/W4226352594","https://openalex.org/W4308184518","https://openalex.org/W4308952057","https://openalex.org/W4362676554","https://openalex.org/W4366714099","https://openalex.org/W4378651694","https://openalex.org/W4387779498","https://openalex.org/W4412384449","https://openalex.org/W4413203133","https://openalex.org/W4414920664","https://openalex.org/W4416447498","https://openalex.org/W7171323077"],"related_works":[],"abstract_inverted_index":{"Neurogenic":[0],"bone":[1,10,21,38,49,93,121,148,162],"regeneration":[2,22,50,122,149],"is":[3],"essential":[4],"for":[5,48,106],"the":[6,14,83,112,154],"effective":[7,91],"restoration":[8],"of":[9,157],"tissue":[11],"functionality,":[12],"while":[13],"mechanisms":[15],"and":[16,127],"new":[17],"strategies":[18],"underlying":[19],"neurogenic":[20,92,135],"remain":[23],"to":[24],"be":[25],"further":[26],"explored.":[27],"Here,":[28],"single-cell":[29],"transcriptomic":[30],"analysis":[31],"revealed":[32],"enhanced":[33],"mesenchymal-Schwann":[34],"cell":[35,143],"crosstalk":[36,54,160],"during":[37],"regeneration.":[39,163],"Functionally,":[40],"we":[41,95],"verify":[42],"that":[43],"Schwann":[44,65],"cells":[45],"are":[46],"indispensable":[47],"via":[51,71],"paracrine":[52],"exosome-mediated":[53],"with":[55,87,150],"MSCs,":[56],"a":[57,102,133,141],"process":[58],"promoted":[59],"by":[60,69,131],"Reelin.":[61],"Mechanistically,":[62],"Reelin":[63],"enhances":[64],"cell-derived":[66],"exosome":[67],"internalization":[68],"MSCs":[70],"regulating":[72],"exosomal":[73],"proteins,":[74],"especially":[75],"UBE2K,":[76],"which":[77],"promotes":[78],"MSC":[79],"osteogenic":[80],"differentiation":[81],"through":[82],"ERK":[84],"pathway,":[85],"associated":[86],"Lys63-linked":[88],"polyubiquitination.":[89],"For":[90],"regeneration,":[94],"engineered":[96],"mesoporous":[97],"silica":[98],"nanoparticles":[99],"(MSNs)":[100],"as":[101],"CRISPRa":[103],"delivery":[104,117],"system":[105,118],"local":[107],"Reln":[108],"gene":[109],"activation":[110],"at":[111],"defect":[113,126],"area.":[114],"This":[115],"mRNA":[116],"could":[119],"promote":[120],"in":[123,147,161],"both":[124],"calvarial":[125],"tibial":[128],"fracture":[129],"models":[130],"constructing":[132],"pro-osteogenic":[134],"microenvironment.":[136],"Collectively,":[137],"our":[138],"findings":[139],"uncover":[140],"Reelin-Schwann":[142],"exosomes-ERK":[144],"regulatory":[145],"axis":[146],"translational":[151],"potential,":[152],"highlighting":[153],"therapeutic":[155],"value":[156],"targeting":[158],"neural-osteogenic":[159]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2026-11-03T00:00:00"}
