{"id":"https://openalex.org/W7225120281","doi":"https://doi.org/10.1007/s13659-026-00648-6","title":"A drug\u2013drug cocrystal of breviscapine and borneol: harnessing natural product synergy for synchronized release and improved pharmacokinetics","display_name":"A drug\u2013drug cocrystal of breviscapine and borneol: harnessing natural product synergy for synchronized release and improved pharmacokinetics","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225120281","doi":"https://doi.org/10.1007/s13659-026-00648-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/42970205","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13728050"},"language":"en","primary_location":{"id":"doi:10.1007/s13659-026-00648-6","doi":"https://doi.org/10.1007/s13659-026-00648-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13659-026-00648-6","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13659-026-00648-6.pdf","source":{"id":"https://openalex.org/S2764440545","display_name":"Natural Products and Bioprospecting","issn_l":"2192-2195","issn":["2192-2195","2192-2209"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Products and Bioprospecting","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://link.springer.com/content/pdf/10.1007/s13659-026-00648-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160336402","display_name":"Jiao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46975222","display_name":"Yunnan University of Traditional Chinese Medicine","ror":"https://ror.org/04zap7912","country_code":"CN","type":"education","lineage":["https://openalex.org/I46975222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiao Wang","raw_affiliation_strings":["Yunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China","institution_ids":["https://openalex.org/I46975222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160384597","display_name":"Caixian Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46975222","display_name":"Yunnan University of Traditional Chinese Medicine","ror":"https://ror.org/04zap7912","country_code":"CN","type":"education","lineage":["https://openalex.org/I46975222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Caixian Wang","raw_affiliation_strings":["Yunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China","institution_ids":["https://openalex.org/I46975222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160387038","display_name":"Yan Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]},{"id":"https://openalex.org/I46975222","display_name":"Yunnan University of Traditional Chinese Medicine","ror":"https://ror.org/04zap7912","country_code":"CN","type":"education","lineage":["https://openalex.org/I46975222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Ma","raw_affiliation_strings":["General Hospital of Ningxia Medical University, Yinchuan, 750004, China. mayanni2005@163.com","Yunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Hospital of Ningxia Medical University, Yinchuan, 750004, China. mayanni2005@163.com","institution_ids":["https://openalex.org/I4210139449"]},{"raw_affiliation_string":"Yunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China","institution_ids":["https://openalex.org/I46975222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124894228","display_name":"Tong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46975222","display_name":"Yunnan University of Traditional Chinese Medicine","ror":"https://ror.org/04zap7912","country_code":"CN","type":"education","lineage":["https://openalex.org/I46975222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tong Zhang","raw_affiliation_strings":["Yunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China","institution_ids":["https://openalex.org/I46975222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113956861","display_name":"Anguo Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46975222","display_name":"Yunnan University of Traditional Chinese Medicine","ror":"https://ror.org/04zap7912","country_code":"CN","type":"education","lineage":["https://openalex.org/I46975222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anguo Hou","raw_affiliation_strings":["Yunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China","institution_ids":["https://openalex.org/I46975222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046596595","display_name":"Wenbin Jin","orcid":"https://orcid.org/0009-0005-1485-4191","observed_orcids":["https://orcid.org/0009-0005-1485-4191"]},"institutions":[{"id":"https://openalex.org/I46975222","display_name":"Yunnan University of Traditional Chinese Medicine","ror":"https://ror.org/04zap7912","country_code":"CN","type":"education","lineage":["https://openalex.org/I46975222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenbin Jin","raw_affiliation_strings":["Yunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China","institution_ids":["https://openalex.org/I46975222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160336726","display_name":"Yanni Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]},{"id":"https://openalex.org/I46975222","display_name":"Yunnan University of Traditional Chinese Medicine","ror":"https://ror.org/04zap7912","country_code":"CN","type":"education","lineage":["https://openalex.org/I46975222"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanni Ma","raw_affiliation_strings":["General Hospital of Ningxia Medical University, Yinchuan, 750004, China. mayanni2005@163.com","Yunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Hospital of Ningxia Medical University, Yinchuan, 750004, China. mayanni2005@163.com","institution_ids":["https://openalex.org/I4210139449"]},{"raw_affiliation_string":"Yunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China","institution_ids":["https://openalex.org/I46975222"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100668415","display_name":"Wenping Wang","orcid":"https://orcid.org/0000-0002-1355-5115","observed_orcids":["https://orcid.org/0000-0002-1355-5115","https://orcid.org/0009-0009-6115-3880"]},"institutions":[{"id":"https://openalex.org/I46975222","display_name":"Yunnan University of Traditional Chinese Medicine","ror":"https://ror.org/04zap7912","country_code":"CN","type":"education","lineage":["https://openalex.org/I46975222"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenping Wang","raw_affiliation_strings":["Yunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China. wangwenping@ynucm.edu.cn"],"raw_orcid":"https://orcid.org/0009-0009-6115-3880","affiliations":[{"raw_affiliation_string":"Yunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China. wangwenping@ynucm.edu.cn","institution_ids":["https://openalex.org/I46975222"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100668415","https://openalex.org/A5160336726"],"corresponding_institution_ids":["https://openalex.org/I4210139449","https://openalex.org/I46975222"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82818581,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10798","display_name":"Crystallography and molecular interactions","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breviscapine","display_name":"breviscapine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/borneol","display_name":"borneol","score":1.0},{"id":"https://openalex.org/keywords/drug-drug-cocrystals","display_name":"drug-drug cocrystals","score":0.8709999918937683},{"id":"https://openalex.org/keywords/solvent-evaporation","display_name":"solvent evaporation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.8429999947547913},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.7409999966621399},{"id":"https://openalex.org/keywords/first-pass-metabolism","display_name":"first-pass metabolism","score":0.7269999980926514},{"id":"https://openalex.org/keywords/poorly-water-soluble-drugs","display_name":"poorly water-soluble drugs","score":0.8180000185966492},{"id":"https://openalex.org/keywords/natural-flavonoids","display_name":"natural flavonoids","score":0.6790000200271606},{"id":"https://openalex.org/keywords/dissolution-kinetics","display_name":"dissolution kinetics","score":0.5870000123977661},{"id":"https://openalex.org/keywords/fickian-diffusion","display_name":"Fickian diffusion","score":0.7950000166893005},{"id":"https://openalex.org/keywords/solid-state-characterization","display_name":"solid-state characterization","score":0.5699999928474426},{"id":"https://openalex.org/keywords/density-functional-theory","display_name":"density functional theory","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C100687433","wikidata":"https://www.wikidata.org/wiki/Q5139913","display_name":"Cocrystal","level":4,"score":0.972000002861023},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7838000059127808},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.6858999729156494},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6712999939918518},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.5813000202178955},{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.5720000267028809},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.47530001401901245},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.4724000096321106},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.45410001277923584},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.4174000024795532},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3614000082015991},{"id":"https://openalex.org/C14029885","wikidata":"https://www.wikidata.org/wiki/Q5282807","display_name":"Dissolution testing","level":4,"score":0.34769999980926514},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.3458999991416931},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.29179999232292175},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.29170000553131104},{"id":"https://openalex.org/C185867374","wikidata":"https://www.wikidata.org/wiki/Q2562769","display_name":"Physiologically based pharmacokinetic modelling","level":3,"score":0.28679999709129333},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2863999903202057},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.27889999747276306},{"id":"https://openalex.org/C118419359","wikidata":"https://www.wikidata.org/wiki/Q682585","display_name":"Supercritical fluid","level":2,"score":0.26179999113082886},{"id":"https://openalex.org/C64452783","wikidata":"https://www.wikidata.org/wiki/Q1524945","display_name":"Ternary operation","level":2,"score":0.2563000023365021},{"id":"https://openalex.org/C178855305","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmaceutical sciences","level":2,"score":0.2515000104904175}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/s13659-026-00648-6","doi":"https://doi.org/10.1007/s13659-026-00648-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13659-026-00648-6","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13659-026-00648-6.pdf","source":{"id":"https://openalex.org/S2764440545","display_name":"Natural Products and Bioprospecting","issn_l":"2192-2195","issn":["2192-2195","2192-2209"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Products and Bioprospecting","raw_type":"journal-article"},{"id":"pmid:42970205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42970205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural products and bioprospecting","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13728050","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13728050/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Prod Bioprospect","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s13659-026-00648-6","doi":"https://doi.org/10.1007/s13659-026-00648-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13659-026-00648-6","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13659-026-00648-6.pdf","source":{"id":"https://openalex.org/S2764440545","display_name":"Natural Products and Bioprospecting","issn_l":"2192-2195","issn":["2192-2195","2192-2209"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Products and Bioprospecting","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322877","display_name":"Natural Science Foundation of Ningxia Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225120281.pdf","grobid_xml":"https://content.openalex.org/works/W7225120281.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W2005913052","https://openalex.org/W2029667189","https://openalex.org/W2132525235","https://openalex.org/W2896070889","https://openalex.org/W3026222144","https://openalex.org/W3041579170","https://openalex.org/W3047708549","https://openalex.org/W3095359694","https://openalex.org/W3125719612","https://openalex.org/W3127589332","https://openalex.org/W3136546815","https://openalex.org/W3159268917","https://openalex.org/W3168251971","https://openalex.org/W3169596185","https://openalex.org/W3177942183","https://openalex.org/W3215583501","https://openalex.org/W4200392912","https://openalex.org/W4212811057","https://openalex.org/W4220694746","https://openalex.org/W4220802877","https://openalex.org/W4220918605","https://openalex.org/W4224324081","https://openalex.org/W4282940769","https://openalex.org/W4293036402","https://openalex.org/W4294904338","https://openalex.org/W4323306114","https://openalex.org/W4376620136","https://openalex.org/W4384155475","https://openalex.org/W4385829662","https://openalex.org/W4386760240","https://openalex.org/W4388214647","https://openalex.org/W4388450008","https://openalex.org/W4390665627","https://openalex.org/W4390985532","https://openalex.org/W4392373759","https://openalex.org/W4396668593","https://openalex.org/W4399730433","https://openalex.org/W4400411650","https://openalex.org/W4401916766","https://openalex.org/W4407712107","https://openalex.org/W4409236644","https://openalex.org/W4409729740"],"related_works":["https://openalex.org/W7168492223","https://openalex.org/W2804498191","https://openalex.org/W2950366188","https://openalex.org/W2942213745","https://openalex.org/W4403064326","https://openalex.org/W3125719612","https://openalex.org/W2006957749","https://openalex.org/W2809258311","https://openalex.org/W3162863616","https://openalex.org/W2910609009"],"abstract_inverted_index":{"A":[0],"drug\u2013drug":[1,165],"cocrystal":[2,59,76],"strategy":[3,178],"harnessing":[4],"natural":[5,20,83,185],"product":[6],"synergy":[7,122],"was":[8,30],"developed":[9],"to":[10,42,92,145,158],"address":[11],"the":[12,33,58,68,93,97,103,121,180,188],"oral":[13,133],"delivery":[14],"barriers":[15],"of":[16,81,96,110,182,190],"breviscapine":[17],"(BRE),":[18],"a":[19,44,129,139,176],"flavonoid":[21,69],"with":[22,32,100],"poor":[23],"solubility":[24],"and":[25,51,70,148,172],"extensive":[26],"first-pass":[27],"metabolism.":[28],"BRE":[29],"integrated":[31],"monoterpenoid":[34],"permeation":[35],"enhancer":[36],"borneol":[37],"(BO)":[38],"via":[39],"solvent":[40],"evaporation":[41],"form":[43],"stable":[45],"supramolecular":[46],"assembly.":[47],"Comprehensive":[48],"solid-state":[49],"characterization":[50],"density":[52],"functional":[53],"theory":[54],"calculations":[55],"confirmed":[56],"that":[57,120,164],"lattice":[60],"is":[61],"stabilized":[62],"by":[63,124],"specific":[64],"hydrogen":[65],"bonding":[66],"between":[67],"terpenoid":[71],"scaffolds.":[72],"The":[73],"optimized":[74],"BRE-BO":[75],"exhibited":[77],"highly":[78],"synchronized":[79],"release":[80],"both":[82],"products":[84],"(":[85,135],"R":[86],"2":[87],"=":[88,107],"0.86),":[89],"in":[90,117,128,132],"contrast":[91],"discordant":[94],"dissolution":[95,170],"physical":[98],"mixture,":[99],"kinetics":[101],"following":[102],"Korsmeyer\u2013Peppas":[104],"model":[105],"(n":[106],"0.45)":[108],"indicative":[109],"Fickian":[111],"diffusion.":[112],"In":[113],"vivo":[114],"pharmacokinetic":[115,173],"evaluation":[116],"rats":[118],"demonstrated":[119],"conferred":[123],"co-delivered":[125],"BO":[126],"resulted":[127],"1.6-fold":[130],"enhancement":[131],"bioavailability":[134],"AUC":[136],"0-24":[137],"),":[138],"prolonged":[140],"T":[141],"max":[142,152],"(from":[143],"2.3":[144],"3.3":[146],"h),":[147],"an":[149],"elevated":[150],"C":[151],"(1.2":[153],"vs.":[154],"0.8":[155],"mg/L)":[156],"compared":[157],"bulk":[159],"BRE.":[160],"These":[161],"findings":[162],"demonstrate":[163],"cocrystallization":[166],"can":[167],"simultaneously":[168],"achieve":[169],"synchronization":[171],"optimization,":[174],"providing":[175],"viable":[177],"for":[179],"formulation":[181],"poorly":[183],"bioavailable":[184],"flavonoids":[186],"without":[187],"use":[189],"polymeric":[191],"excipients.":[192]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-03T00:00:00"}
