{"id":"https://openalex.org/W7225119987","doi":"https://doi.org/10.1007/s44368-026-00038-7","title":"Molecular mechanisms and clinical tapering strategies for Janus kinase inhibitor relapse in inflammatory dermatoses","display_name":"Molecular mechanisms and clinical tapering strategies for Janus kinase inhibitor relapse in inflammatory dermatoses","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225119987","doi":"https://doi.org/10.1007/s44368-026-00038-7"},"language":"en","primary_location":{"id":"doi:10.1007/s44368-026-00038-7","doi":"https://doi.org/10.1007/s44368-026-00038-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s44368-026-00038-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s44368-026-00038-7.pdf","source":{"id":"https://openalex.org/S4404676864","display_name":"Discover Immunity.","issn_l":"3005-1185","issn":["3005-1185"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4404664013","host_organization_name":"Springer, Singapore","host_organization_lineage":["https://openalex.org/P4404664013","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer, Singapore","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s44368-026-00038-7.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079986193","display_name":"Soroush Moradi","orcid":"https://orcid.org/0000-0001-5164-5317","observed_orcids":["https://orcid.org/0000-0001-5164-5317"]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Soroush Moradi","raw_affiliation_strings":["Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115756636","display_name":"AmirHosein Rostami","orcid":"https://orcid.org/0009-0000-0638-2263","observed_orcids":["https://orcid.org/0009-0000-0638-2263"]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Amirhosein Rostami","raw_affiliation_strings":["Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055665875","display_name":"Vesal Hasani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3122832768","display_name":"Kurdistan University of Medical Sciences","ror":"https://ror.org/01ntx4j68","country_code":"IR","type":"education","lineage":["https://openalex.org/I3122832768"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Vesal Hasani","raw_affiliation_strings":["Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran","institution_ids":["https://openalex.org/I3122832768"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159583077","display_name":"Parand Shariat Rad","orcid":"https://orcid.org/0009-0002-3353-348X","observed_orcids":["https://orcid.org/0009-0002-3353-348X"]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Parand Shariat Rad","raw_affiliation_strings":["Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran","USERN Office, Kermanshah University of Medical Sciences, Kermanshah, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]},{"raw_affiliation_string":"USERN Office, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5159583077"],"corresponding_institution_ids":["https://openalex.org/I39642139"],"apc_list":{"value":1240,"currency":"USD","value_usd":1240},"apc_paid":{"value":1240,"currency":"USD","value_usd":1240},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.88576324,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.2808000147342682,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.06830000132322311,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jak-inhibitors","display_name":"JAK inhibitors","score":0.7680000066757202},{"id":"https://openalex.org/keywords/inflammatory-skin-diseases","display_name":"inflammatory skin diseases","score":0.8569999933242798},{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/alopecia-areata","display_name":"alopecia areata","score":0.9950000047683716},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":1.0},{"id":"https://openalex.org/keywords/dose-de-escalation","display_name":"dose de-escalation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/deprescribing","display_name":"deprescribing","score":0.8939999938011169},{"id":"https://openalex.org/keywords/disease-reactivation","display_name":"disease reactivation","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C112392421","wikidata":"https://www.wikidata.org/wiki/Q903451","display_name":"Janus kinase","level":3,"score":0.7810999751091003},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7473000288009644},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.4894999861717224},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4625000059604645},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.45509999990463257},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.454800009727478},{"id":"https://openalex.org/C2776112149","wikidata":"https://www.wikidata.org/wiki/Q7383611","display_name":"Ruxolitinib","level":4,"score":0.44859999418258667},{"id":"https://openalex.org/C2778886723","wikidata":"https://www.wikidata.org/wiki/Q3530324","display_name":"Tofacitinib","level":3,"score":0.428600013256073},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41040000319480896},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.400299996137619},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.39070001244544983},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3698999881744385},{"id":"https://openalex.org/C130523297","wikidata":"https://www.wikidata.org/wiki/Q14914487","display_name":"Tyrosine kinase 2","level":5,"score":0.3686000108718872},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35350000858306885},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.35199999809265137},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.34369999170303345},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.33899998664855957},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.3312000036239624},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3301999866962433},{"id":"https://openalex.org/C2777524370","wikidata":"https://www.wikidata.org/wiki/Q5075435","display_name":"Alopecia areata","level":2,"score":0.329800009727478},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.325300008058548},{"id":"https://openalex.org/C154472170","wikidata":"https://www.wikidata.org/wiki/Q18030556","display_name":"PIN1","level":4,"score":0.31529998779296875},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.3142000138759613},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.3127000033855438},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.2989000082015991},{"id":"https://openalex.org/C157333092","wikidata":"https://www.wikidata.org/wiki/Q902835","display_name":"JAK-STAT signaling pathway","level":4,"score":0.28380000591278076},{"id":"https://openalex.org/C183315844","wikidata":"https://www.wikidata.org/wiki/Q6155969","display_name":"Janus kinase 3","level":5,"score":0.26809999346733093},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.2678999900817871},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.25440001487731934},{"id":"https://openalex.org/C2909310144","wikidata":"https://www.wikidata.org/wiki/Q7553358","display_name":"Phenylbutyrate","level":2,"score":0.25}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s44368-026-00038-7","doi":"https://doi.org/10.1007/s44368-026-00038-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s44368-026-00038-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s44368-026-00038-7.pdf","source":{"id":"https://openalex.org/S4404676864","display_name":"Discover Immunity.","issn_l":"3005-1185","issn":["3005-1185"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4404664013","host_organization_name":"Springer, Singapore","host_organization_lineage":["https://openalex.org/P4404664013","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer, Singapore","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Immunity","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s44368-026-00038-7","doi":"https://doi.org/10.1007/s44368-026-00038-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s44368-026-00038-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s44368-026-00038-7.pdf","source":{"id":"https://openalex.org/S4404676864","display_name":"Discover Immunity.","issn_l":"3005-1185","issn":["3005-1185"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4404664013","host_organization_name":"Springer, Singapore","host_organization_lineage":["https://openalex.org/P4404664013","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer, Singapore","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225119987.pdf","grobid_xml":"https://content.openalex.org/works/W7225119987.grobid-xml"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W1570980823","https://openalex.org/W1671779243","https://openalex.org/W1959947589","https://openalex.org/W1969532899","https://openalex.org/W1971734719","https://openalex.org/W1988224733","https://openalex.org/W2028648418","https://openalex.org/W2040734118","https://openalex.org/W2040848458","https://openalex.org/W2065238506","https://openalex.org/W2131666890","https://openalex.org/W2145557630","https://openalex.org/W2149895449","https://openalex.org/W2163586656","https://openalex.org/W2167617907","https://openalex.org/W2205406616","https://openalex.org/W2402117629","https://openalex.org/W2472242299","https://openalex.org/W2508182513","https://openalex.org/W2528662867","https://openalex.org/W2548181497","https://openalex.org/W2549145921","https://openalex.org/W2580870032","https://openalex.org/W2596223246","https://openalex.org/W2601742683","https://openalex.org/W2613958818","https://openalex.org/W2718751133","https://openalex.org/W2775663182","https://openalex.org/W2901678825","https://openalex.org/W2902846647","https://openalex.org/W2903972816","https://openalex.org/W2914209107","https://openalex.org/W2924895007","https://openalex.org/W2980286352","https://openalex.org/W2987931162","https://openalex.org/W2990076552","https://openalex.org/W3026346347","https://openalex.org/W3035077806","https://openalex.org/W3090120549","https://openalex.org/W3095400296","https://openalex.org/W3122981268","https://openalex.org/W3157423361","https://openalex.org/W3159897478","https://openalex.org/W3184749817","https://openalex.org/W3194436702","https://openalex.org/W3195260976","https://openalex.org/W3196275328","https://openalex.org/W4200621023","https://openalex.org/W4220758863","https://openalex.org/W4225163971","https://openalex.org/W4251944893","https://openalex.org/W4290190465","https://openalex.org/W4292883993","https://openalex.org/W4295807681","https://openalex.org/W4297855220","https://openalex.org/W4306839892","https://openalex.org/W4310034722","https://openalex.org/W4310690298","https://openalex.org/W4318477968","https://openalex.org/W4319978914","https://openalex.org/W4381469630","https://openalex.org/W4382775815","https://openalex.org/W4384201317","https://openalex.org/W4385295173","https://openalex.org/W4385475958","https://openalex.org/W4386156879","https://openalex.org/W4386888562","https://openalex.org/W4388304988","https://openalex.org/W4388863091","https://openalex.org/W4390919561","https://openalex.org/W4391407644","https://openalex.org/W4392653298","https://openalex.org/W4394758325","https://openalex.org/W4399901377","https://openalex.org/W4400056464","https://openalex.org/W4401388310","https://openalex.org/W4401577096","https://openalex.org/W4401728805","https://openalex.org/W4403208637","https://openalex.org/W4404198701","https://openalex.org/W4405656229","https://openalex.org/W4406870811","https://openalex.org/W4407002077","https://openalex.org/W4407348743","https://openalex.org/W4409081978","https://openalex.org/W4409369841","https://openalex.org/W4409568038","https://openalex.org/W4410331493","https://openalex.org/W4411340060","https://openalex.org/W4411921912","https://openalex.org/W4411928345","https://openalex.org/W4413106595","https://openalex.org/W4413451325","https://openalex.org/W4415932871","https://openalex.org/W4416084993","https://openalex.org/W4416238681","https://openalex.org/W4416297181","https://openalex.org/W4417124921","https://openalex.org/W4417246314","https://openalex.org/W7117247860","https://openalex.org/W7117359154","https://openalex.org/W7164017257","https://openalex.org/W7171123885"],"related_works":["https://openalex.org/W7142063854","https://openalex.org/W4410036592","https://openalex.org/W7164663623","https://openalex.org/W7113910419","https://openalex.org/W4297855220","https://openalex.org/W7128161086","https://openalex.org/W4406103952","https://openalex.org/W4320884636","https://openalex.org/W7166532754","https://openalex.org/W4304128272"],"abstract_inverted_index":{"Janus":[0],"kinase":[1,54],"(JAK)":[2],"inhibitors":[3],"have":[4],"revolutionized":[5],"the":[6,25,36,44,53,96,99,103,121],"management":[7,132],"of":[8,39,47,69,98,137],"inflammatory":[9],"dermatoses":[10],"over":[11,144],"recent":[12],"decades;":[13],"however,":[14],"discontinuation":[15],"is":[16,82],"frequently":[17],"associated":[18],"with":[19],"rapid":[20,109],"disease":[21,31],"recurrence,":[22],"known":[23],"as":[24],"\u201crelapse\u201d":[26],"phenomenon,":[27],"which":[28,51],"complicates":[29],"long-term":[30],"control.":[32],"Current":[33],"evidence":[34],"on":[35,95],"molecular":[37],"pathophysiology":[38],"JAK":[40],"inhibitor":[41],"relapse":[42,105,124],"emphasizes":[43],"unique":[45],"pharmacodynamics":[46],"Type":[48],"I":[49],"inhibitors,":[50],"bind":[52],"in":[55,75,114,126,158],"its":[56],"active":[57],"conformation.":[58],"This":[59,88],"binding":[60],"paradoxically":[61],"stabilizes":[62],"primed":[63],"hyperphosphorylated":[64],"JAKs":[65],"and":[66,117],"depletes":[67],"Suppressors":[68],"Cytokine":[70],"Signaling":[71],"(SOCS)":[72],"proteins,":[73],"resulting":[74],"a":[76,152],"\u201cpharmacokinetic":[77],"cliff\u201d":[78],"where":[79],"pathway":[80],"suppression":[81],"abruptly":[83],"lost":[84],"upon":[85],"drug":[86],"clearance.":[87],"review":[89],"further":[90],"categorizes":[91],"clinical":[92,159],"outcomes":[93],"based":[94],"velocity":[97],"underlying":[100],"pathology,":[101],"contrasting":[102],"high":[104],"potential":[106],"driven":[107],"by":[108],"neural":[110],"or":[111],"cytotoxic":[112],"reactivation":[113],"atopic":[115],"dermatitis":[116],"alopecia":[118],"areata":[119],"against":[120],"slower,":[122],"structural":[123],"seen":[125],"psoriasis.":[127],"Finally,":[128],"we":[129],"propose":[130],"evidence-based":[131],"frameworks,":[133],"advocating":[134],"for":[135],"\u201cslope":[136],"reduction\u201d":[138],"strategies":[139],"that":[140],"prioritize":[141],"dose":[142],"de-escalation":[143],"frequency":[145],"extension":[146],"to":[147,155],"maintain":[148],"steady-state":[149],"suppression,":[150],"providing":[151],"rational":[153],"approach":[154],"safer":[156],"deprescribing":[157],"practice.":[160]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-03T00:00:00"}