{"id":"https://openalex.org/W7225119010","doi":"https://doi.org/10.1093/bib/bbag613","title":"MAGE: an efficient algorithm for identifying Maximal Age-indexed GEne sets","display_name":"MAGE: an efficient algorithm for identifying Maximal Age-indexed GEne sets","publication_year":2026,"publication_date":"2026-10-19","ids":{"openalex":"https://openalex.org/W7225119010","doi":"https://doi.org/10.1093/bib/bbag613","pmid":"https://pubmed.ncbi.nlm.nih.gov/42969857","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13725925"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbag613","doi":"https://doi.org/10.1093/bib/bbag613","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag613","pdf_url":"https://academic.oup.com/bib/article-pdf/27/6/bbag613/72750149/bbag613.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/27/6/bbag613/72750149/bbag613.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5140641648","display_name":"Murat Calis","orcid":"https://orcid.org/0009-0002-2652-223X","observed_orcids":["https://orcid.org/0009-0002-2652-223X"]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Murat \u00c7al\u0131\u015f","raw_affiliation_strings":["Electronics Technology Programme, Electronics and Automation Department, Technical Sciences Vocational School, Bursa Uluda\u011f University, G\u00f6r\u00fckle Campus , G\u00f6r\u00fckle Mahallesi, \u00dcniversite 1. Cadde, No. 711G, Nil\u00fcfer, Bursa 16059, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0009-0002-2652-223X","affiliations":[{"raw_affiliation_string":"Electronics Technology Programme, Electronics and Automation Department, Technical Sciences Vocational School, Bursa Uluda\u011f University, G\u00f6r\u00fckle Campus , G\u00f6r\u00fckle Mahallesi, \u00dcniversite 1. Cadde, No. 711G, Nil\u00fcfer, Bursa 16059, T\u00fcrkiye","institution_ids":["https://openalex.org/I131835042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022580650","display_name":"Volkan Altunta\u015f","orcid":"https://orcid.org/0000-0003-3144-8724","observed_orcids":["https://orcid.org/0000-0003-3144-8724"]},"institutions":[{"id":"https://openalex.org/I192257213","display_name":"Bursa Technical University","ror":"https://ror.org/03rdpn141","country_code":"TR","type":"education","lineage":["https://openalex.org/I192257213"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Volkan Altuntas","raw_affiliation_strings":["Department of Computer Engineering , Bursa Technical University, Bursa 16310, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0003-3144-8724","affiliations":[{"raw_affiliation_string":"Department of Computer Engineering , Bursa Technical University, Bursa 16310, T\u00fcrkiye","institution_ids":["https://openalex.org/I192257213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115859856","display_name":"Omer Kahveci","orcid":"https://orcid.org/0009-0007-4375-9825","observed_orcids":["https://orcid.org/0009-0007-4375-9825"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omer Kahveci","raw_affiliation_strings":["Department of Computer Science, University of Florida , Gainesville, FL 32611 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Florida , Gainesville, FL 32611 ,","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037399554","display_name":"Pietro Hiram Guzzi","orcid":"https://orcid.org/0000-0001-5542-2997","observed_orcids":["https://orcid.org/0000-0001-5542-2997","https://orcid.org/0000-0001-7631-5453"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pietro Hiram Guzzi","raw_affiliation_strings":["Department of Medical and Surgical Sciences, University of Catanzaro , Viale Europa, I-88100 Catanzaro ,"],"raw_orcid":"https://orcid.org/0000-0001-5542-2997","affiliations":[{"raw_affiliation_string":"Department of Medical and Surgical Sciences, University of Catanzaro , Viale Europa, I-88100 Catanzaro ,","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027369094","display_name":"Pierangelo Veltri","orcid":"https://orcid.org/0000-0003-2494-0294","observed_orcids":["https://orcid.org/0000-0003-2494-0294"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pierangelo Veltri","raw_affiliation_strings":["Department of Computer Engineering, Modelling, Electronic and Systems, University of Calabria , Via P Bucci, I-87036 Rende (CS) ,"],"raw_orcid":"https://orcid.org/0000-0003-2494-0294","affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Modelling, Electronic and Systems, University of Calabria , Via P Bucci, I-87036 Rende (CS) ,","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091769289","display_name":"Tamer Kahveci","orcid":"https://orcid.org/0000-0002-4403-8612","observed_orcids":["https://orcid.org/0000-0002-4403-8612"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamer Kahveci","raw_affiliation_strings":["Department of Computer Science, University of Florida , Gainesville, FL 32611 ,"],"raw_orcid":"https://orcid.org/0000-0002-4403-8612","affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Florida , Gainesville, FL 32611 ,","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5140641648"],"corresponding_institution_ids":["https://openalex.org/I131835042"],"apc_list":{"value":3885,"currency":"USD","value_usd":3885},"apc_paid":{"value":3885,"currency":"USD","value_usd":3885},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.71815967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.798799991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.798799991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.18790000677108765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6119999885559082},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.7950000166893005},{"id":"https://openalex.org/keywords/age-index","display_name":"age index","score":0.5839999914169312},{"id":"https://openalex.org/keywords/influence-maximization","display_name":"influence maximization","score":0.7860000133514404},{"id":"https://openalex.org/keywords/np-hardness","display_name":"NP-hardness","score":0.8510000109672546},{"id":"https://openalex.org/keywords/stochastic-algorithms","display_name":"stochastic algorithms","score":0.5450000166893005},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.6740000247955322},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.597100019454956},{"id":"https://openalex.org/C2776330181","wikidata":"https://www.wikidata.org/wiki/Q18358244","display_name":"Maximization","level":2,"score":0.5968999862670898},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5317000150680542},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5224999785423279},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5180000066757202},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4772999882698059},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.39910000562667847},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3955000042915344},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.37139999866485596},{"id":"https://openalex.org/C3018263672","wikidata":"https://www.wikidata.org/wiki/Q1296251","display_name":"Efficient algorithm","level":2,"score":0.3700000047683716},{"id":"https://openalex.org/C2780009758","wikidata":"https://www.wikidata.org/wiki/Q6804172","display_name":"Measure (data warehouse)","level":2,"score":0.30399999022483826},{"id":"https://openalex.org/C182081679","wikidata":"https://www.wikidata.org/wiki/Q1275153","display_name":"Expectation\u2013maximization algorithm","level":3,"score":0.26919999718666077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26840001344680786},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.26829999685287476},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.26759999990463257},{"id":"https://openalex.org/C2780898871","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Performance metric","level":2,"score":0.2639000117778778},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.26339998841285706},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2623000144958496},{"id":"https://openalex.org/C2777382242","wikidata":"https://www.wikidata.org/wiki/Q6017816","display_name":"Index (typography)","level":2,"score":0.26100000739097595},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.26019999384880066},{"id":"https://openalex.org/C127491075","wikidata":"https://www.wikidata.org/wiki/Q7617825","display_name":"Stochastic modelling","level":2,"score":0.25429999828338623},{"id":"https://openalex.org/C105565629","wikidata":"https://www.wikidata.org/wiki/Q1248292","display_name":"Gene prediction","level":4,"score":0.25099998712539673}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbag613","doi":"https://doi.org/10.1093/bib/bbag613","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag613","pdf_url":"https://academic.oup.com/bib/article-pdf/27/6/bbag613/72750149/bbag613.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13725925","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13725925/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13725925/pdf/bbag613.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brief Bioinform","raw_type":"Text"},{"id":"pmid:42969857","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42969857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":"Journal Article"},{"id":"pmh:e728cd72-ff08-492d-bfc7-269b84914c75","doi":null,"is_oa":false,"landing_page_url":"https://avesis.uludag.edu.tr/publication/details/e728cd72-ff08-492d-bfc7-269b84914c75/oai","pdf_url":null,"source":{"id":"https://openalex.org/S7407055210","display_name":"Bursa Uludag University - AVESIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/bib/bbag613","doi":"https://doi.org/10.1093/bib/bbag613","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag613","pdf_url":"https://academic.oup.com/bib/article-pdf/27/6/bbag613/72750149/bbag613.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225119010.pdf","grobid_xml":"https://content.openalex.org/works/W7225119010.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1533942137","https://openalex.org/W1585895556","https://openalex.org/W1824527491","https://openalex.org/W1986348806","https://openalex.org/W1992424099","https://openalex.org/W1994917595","https://openalex.org/W2005989770","https://openalex.org/W2010533371","https://openalex.org/W2022980325","https://openalex.org/W2029784001","https://openalex.org/W2042913529","https://openalex.org/W2090054883","https://openalex.org/W2092334563","https://openalex.org/W2107116656","https://openalex.org/W2108700752","https://openalex.org/W2113296450","https://openalex.org/W2117398145","https://openalex.org/W2126525177","https://openalex.org/W2132083557","https://openalex.org/W2150686846","https://openalex.org/W2152541965","https://openalex.org/W2162809230","https://openalex.org/W2164802216","https://openalex.org/W2403934794","https://openalex.org/W2525975096","https://openalex.org/W2594612497","https://openalex.org/W2744971673","https://openalex.org/W2761275051","https://openalex.org/W2769595242","https://openalex.org/W2777892103","https://openalex.org/W2782454362","https://openalex.org/W2793267387","https://openalex.org/W2804633924","https://openalex.org/W2805850299","https://openalex.org/W2885764193","https://openalex.org/W2900099657","https://openalex.org/W2931120067","https://openalex.org/W2944545583","https://openalex.org/W2949475756","https://openalex.org/W2985398088","https://openalex.org/W3006074294","https://openalex.org/W3037859040","https://openalex.org/W3088977951","https://openalex.org/W3093026272","https://openalex.org/W3096294596","https://openalex.org/W3097127970","https://openalex.org/W3099175442","https://openalex.org/W3111441242","https://openalex.org/W3115247620","https://openalex.org/W3117221748","https://openalex.org/W3179857518","https://openalex.org/W3208629828","https://openalex.org/W3211482167","https://openalex.org/W4210639503","https://openalex.org/W4285728858","https://openalex.org/W4300167390","https://openalex.org/W4308155906","https://openalex.org/W4310810388","https://openalex.org/W4365151452","https://openalex.org/W4381893169","https://openalex.org/W4382138786","https://openalex.org/W4385782562","https://openalex.org/W4386895047","https://openalex.org/W4399886706","https://openalex.org/W4401556795","https://openalex.org/W4403113359","https://openalex.org/W4415146958"],"related_works":["https://openalex.org/W7204168692","https://openalex.org/W3000208207","https://openalex.org/W2883337000","https://openalex.org/W3153861134","https://openalex.org/W2094587261","https://openalex.org/W1992930018","https://openalex.org/W1974651858","https://openalex.org/W2093196581","https://openalex.org/W2985443901","https://openalex.org/W4414168900"],"abstract_inverted_index":{"Aging":[0],"alters":[1],"transcriptional":[2],"regulation":[3],"in":[4,20],"a":[5,49,98],"tissue-":[6],"and":[7,14,32,61,67,79,83],"time-specific":[8],"manner,":[9],"reshaping":[10],"gene":[11,29,55,74,104,119],"regulatory":[12,16,135],"networks":[13],"shifting":[15],"influence":[17,22,37],"dynamics.":[18],"Traditional":[19],"silico":[21],"maximization":[23],"methods":[24],"often":[25],"rely":[26],"on":[27],"static":[28],"expression":[30],"snapshots":[31],"fail":[33],"to":[34,110,132],"capture":[35],"gene-to-gene":[36],"variations":[38],"over":[39],"time.":[40],"To":[41,89],"address":[42],"this,":[43],"we":[44,92],"introduce":[45],"the":[46,59,70,77,112,122],"Age":[47,63,81,113],"Index,":[48,82],"network-based":[50],"metric":[51],"that":[52,101],"quantifies":[53],"time-varying":[54],"influence.":[56],"We":[57],"define":[58],"Maximal":[60],"Minimal":[62],"Index":[64],"Problems":[65],"(MAP$^{+}$":[66],"MAP$^{-}$)":[68],"as":[69],"tasks":[71],"of":[72],"identifying":[73],"sets":[75,105,120],"with":[76,125],"highest":[78],"lowest":[80],"prove":[84],"these":[85],"problems":[86],"are":[87],"NP-hard.":[88],"solve":[90],"them,":[91],"develop":[93],"MAGE":[94,115],"(Maximal":[95],"Age-Index":[96],"Algorithm),":[97],"stochastic":[99],"method":[100],"iteratively":[102],"constructs":[103],"by":[106],"prioritizing":[107],"genes":[108],"likely":[109],"optimize":[111],"Index.":[114],"identifies":[116],"statistically":[117],"significant":[118],"at":[121],"genome":[123],"scale,":[124],"strong":[126],"literature":[127],"support,":[128],"highlighting":[129],"its":[130],"potential":[131],"uncover":[133],"age-sensitive":[134],"mechanisms.":[136]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-03T00:00:00"}
