{"id":"https://openalex.org/W7225117986","doi":"https://doi.org/10.1002/cbf.70334","title":"Resveratrol Modulates Bone Metabolism Through SIRT1\u2010Mediated NF\u2010\u03baB Inhibition: Molecular Mechanisms and Therapeutic Implications","display_name":"Resveratrol Modulates Bone Metabolism Through SIRT1\u2010Mediated NF\u2010\u03baB Inhibition: Molecular Mechanisms and Therapeutic Implications","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225117986","doi":"https://doi.org/10.1002/cbf.70334","pmid":"https://pubmed.ncbi.nlm.nih.gov/42968626","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13725261"},"language":"en","primary_location":{"id":"doi:10.1002/cbf.70334","doi":"https://doi.org/10.1002/cbf.70334","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cbf.70334","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbf.70334","source":{"id":"https://openalex.org/S960618578","display_name":"Cell Biochemistry and Function","issn_l":"0263-6484","issn":["0263-6484","1099-0844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biochemistry and Function","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbf.70334","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000817551","display_name":"Seyyed Hossein Khatami","orcid":"https://orcid.org/0000-0002-8579-5097","observed_orcids":["https://orcid.org/0000-0002-8579-5097"]},"institutions":[{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Seyyed Hossein Khatami","raw_affiliation_strings":["Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"],"raw_orcid":"https://orcid.org/0000-0002-8579-5097","affiliations":[{"raw_affiliation_string":"Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran","institution_ids":["https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093387717","display_name":"Faezeh Gouhari","orcid":"https://orcid.org/0000-0003-2045-3480","observed_orcids":["https://orcid.org/0000-0003-2045-3480"]},"institutions":[{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Faezeh Gouhari","raw_affiliation_strings":["Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran","institution_ids":["https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083788252","display_name":"Alireza Manafi Rasi","orcid":"https://orcid.org/0000-0001-6355-704X","observed_orcids":["https://orcid.org/0000-0001-6355-704X"]},"institutions":[{"id":"https://openalex.org/I4210159370","display_name":"Imam Hossein Hospital","ror":"https://ror.org/053qhtw56","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4210159370"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Alireza Manafi\u2010Rasi","raw_affiliation_strings":["Department of Orthopedics, Imam Hossein Educational Hospital Shahid Beheshti University of Medical Sciences Tehran Iran","Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"],"raw_orcid":"https://orcid.org/0000-0001-6355-704X","affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Imam Hossein Educational Hospital Shahid Beheshti University of Medical Sciences Tehran Iran","institution_ids":["https://openalex.org/I4210159370","https://openalex.org/I58048189"]},{"raw_affiliation_string":"Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran","institution_ids":["https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000271003","display_name":"Maryam Fallah","orcid":"https://orcid.org/0000-0002-2618-806X","observed_orcids":["https://orcid.org/0000-0002-2618-806X"]},"institutions":[{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Maryam Fallah","raw_affiliation_strings":["Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"],"raw_orcid":"https://orcid.org/0000-0002-2618-806X","affiliations":[{"raw_affiliation_string":"Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran","institution_ids":["https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079605527","display_name":"Sajad Ehtiati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Sajad Ehtiati","raw_affiliation_strings":["Department of Clinical Biochemistry, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093996561","display_name":"Ahmadreza Ahmadi Abdashti","orcid":"https://orcid.org/0000-0003-3311-893X","observed_orcids":["https://orcid.org/0000-0003-3311-893X"]},"institutions":[{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ahmad Reza Ahmadi Abdashti","raw_affiliation_strings":["Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"],"raw_orcid":"https://orcid.org/0000-0003-3311-893X","affiliations":[{"raw_affiliation_string":"Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran","institution_ids":["https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015843596","display_name":"Mohsen Ariannik","orcid":"https://orcid.org/0000-0002-9520-9928","observed_orcids":["https://orcid.org/0000-0002-9520-9928"]},"institutions":[{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohsen Ariannik","raw_affiliation_strings":["Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran","institution_ids":["https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047093854","display_name":"Shahin Talebi","orcid":"https://orcid.org/0000-0002-2290-4575","observed_orcids":["https://orcid.org/0000-0002-2290-4575","https://orcid.org/0000-0001-5957-9166"]},"institutions":[{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Shahin Talebi","raw_affiliation_strings":["Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran","institution_ids":["https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134175634","display_name":"Diba Rafienejad","orcid":"https://orcid.org/0009-0004-1136-2530","observed_orcids":["https://orcid.org/0009-0004-1136-2530"]},"institutions":[{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Diba Rafienejad","raw_affiliation_strings":["Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"],"raw_orcid":"https://orcid.org/0009-0004-1136-2530","affiliations":[{"raw_affiliation_string":"Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran","institution_ids":["https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094122746","display_name":"Mina Fakhrzadegan","orcid":"https://orcid.org/0000-0003-2015-3701","observed_orcids":["https://orcid.org/0000-0003-2015-3701"]},"institutions":[{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mina Fakhrzadegan","raw_affiliation_strings":["Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran","institution_ids":["https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051832798","display_name":"Parasta Heidari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]},{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Parasta Heidari","raw_affiliation_strings":["Center for Genomics and Personalized Health Queensland University Brisbane Australia","School of Biomedical Sciences, Faculty of Health Queensland University of Technology Brisbane Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomics and Personalized Health Queensland University Brisbane Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"School of Biomedical Sciences, Faculty of Health Queensland University of Technology Brisbane Australia","institution_ids":["https://openalex.org/I160993911"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004024681","display_name":"Reza Zandi","orcid":"https://orcid.org/0000-0002-0095-6745","observed_orcids":["https://orcid.org/0000-0002-0095-6745"]},"institutions":[{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Reza Zandi","raw_affiliation_strings":["Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"],"raw_orcid":"https://orcid.org/0000-0002-0095-6745","affiliations":[{"raw_affiliation_string":"Musculoskeletal Injuries Research Center Shahid Beheshti University of Medical Sciences Tehran Iran","institution_ids":["https://openalex.org/I58048189"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5004024681"],"corresponding_institution_ids":["https://openalex.org/I58048189"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":{"value":4220,"currency":"USD","value_usd":4220},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62378168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.257099986076355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":1.0},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.8259999752044678},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9769999980926514},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.8019999861717224},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.9139999747276306},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nrf2-are-signaling-pathway","display_name":"Nrf2/ARE pathway","score":0.8299999833106995},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9800000190734863},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/rankl","display_name":"RANKL","score":0.847000002861023},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.7350000143051147},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.9390000104904175},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.8363999724388123},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.579800009727478},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.559499979019165},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5543000102043152},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.5102999806404114},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.507099986076355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4903999865055084},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.44609999656677246},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.3905999958515167},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.367900013923645},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.34689998626708984},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.3465000092983246},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34299999475479126},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3276999890804291},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.3237999975681305},{"id":"https://openalex.org/C2779240191","wikidata":"https://www.wikidata.org/wiki/Q6822340","display_name":"Metabolic bone disease","level":3,"score":0.31779998540878296},{"id":"https://openalex.org/C2776169692","wikidata":"https://www.wikidata.org/wiki/Q4941552","display_name":"Bone disease","level":3,"score":0.3093999922275543},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2996000051498413},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.298799991607666},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2980000078678131},{"id":"https://openalex.org/C13721689","wikidata":"https://www.wikidata.org/wiki/Q18033475","display_name":"HDAC3","level":5,"score":0.29420000314712524},{"id":"https://openalex.org/C17857428","wikidata":"https://www.wikidata.org/wiki/Q533025","display_name":"Nutraceutical","level":2,"score":0.29159998893737793},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.288100004196167},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.28220000863075256},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2816999852657318},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2809999883174896},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.27959999442100525},{"id":"https://openalex.org/C2777083390","wikidata":"https://www.wikidata.org/wiki/Q1367706","display_name":"Osteopenia","level":4,"score":0.2757999897003174},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.27149999141693115},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.26589998602867126},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.2637999951839447},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.25679999589920044},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.2565000057220459}],"mesh":[{"descriptor_ui":"D000077185","descriptor_name":"Resveratrol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/cbf.70334","doi":"https://doi.org/10.1002/cbf.70334","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cbf.70334","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbf.70334","source":{"id":"https://openalex.org/S960618578","display_name":"Cell Biochemistry and Function","issn_l":"0263-6484","issn":["0263-6484","1099-0844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biochemistry and Function","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13725261","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13725261/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13725261/pdf/CBF-44-e70334.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biochem Funct","raw_type":"Text"},{"id":"pmid:42968626","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42968626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell biochemistry and function","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/cbf.70334","doi":"https://doi.org/10.1002/cbf.70334","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cbf.70334","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbf.70334","source":{"id":"https://openalex.org/S960618578","display_name":"Cell Biochemistry and Function","issn_l":"0263-6484","issn":["0263-6484","1099-0844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biochemistry and Function","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225117986.pdf","grobid_xml":"https://content.openalex.org/works/W7225117986.grobid-xml"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W1548494899","https://openalex.org/W1550871940","https://openalex.org/W1862685904","https://openalex.org/W1989456020","https://openalex.org/W2007842741","https://openalex.org/W2010992748","https://openalex.org/W2012077091","https://openalex.org/W2013184426","https://openalex.org/W2013724724","https://openalex.org/W2015792196","https://openalex.org/W2020671379","https://openalex.org/W2038317187","https://openalex.org/W2040435660","https://openalex.org/W2041295404","https://openalex.org/W2042898475","https://openalex.org/W2050625990","https://openalex.org/W2050652835","https://openalex.org/W2060826509","https://openalex.org/W2062269191","https://openalex.org/W2075877600","https://openalex.org/W2078985284","https://openalex.org/W2082410007","https://openalex.org/W2085536927","https://openalex.org/W2088381487","https://openalex.org/W2093252878","https://openalex.org/W2099386481","https://openalex.org/W2121356463","https://openalex.org/W2126873568","https://openalex.org/W2136830554","https://openalex.org/W2139240811","https://openalex.org/W2151089147","https://openalex.org/W2151440119","https://openalex.org/W2155590575","https://openalex.org/W2157445945","https://openalex.org/W2158747282","https://openalex.org/W2166566484","https://openalex.org/W2291522985","https://openalex.org/W2550400579","https://openalex.org/W2559809466","https://openalex.org/W2559916560","https://openalex.org/W2606113946","https://openalex.org/W2607522385","https://openalex.org/W2768440361","https://openalex.org/W2772396790","https://openalex.org/W2888551967","https://openalex.org/W2889763520","https://openalex.org/W2900794505","https://openalex.org/W2911117569","https://openalex.org/W2928939598","https://openalex.org/W2965128704","https://openalex.org/W2966380363","https://openalex.org/W2993309042","https://openalex.org/W2995735301","https://openalex.org/W3006510130","https://openalex.org/W3009723147","https://openalex.org/W3017602451","https://openalex.org/W3029913921","https://openalex.org/W3036296615","https://openalex.org/W3048428925","https://openalex.org/W3081914143","https://openalex.org/W3083938621","https://openalex.org/W3106482867","https://openalex.org/W3110905239","https://openalex.org/W3120757286","https://openalex.org/W3122504368","https://openalex.org/W3163809020","https://openalex.org/W3189831004","https://openalex.org/W3193867634","https://openalex.org/W3195573124","https://openalex.org/W3196997543","https://openalex.org/W3197252013","https://openalex.org/W3198290067","https://openalex.org/W4224063610","https://openalex.org/W4281384567","https://openalex.org/W4282924174","https://openalex.org/W4283743781","https://openalex.org/W4286685563","https://openalex.org/W4293769747","https://openalex.org/W4317653903","https://openalex.org/W4318754804","https://openalex.org/W4321793169","https://openalex.org/W4322617466","https://openalex.org/W4362733745","https://openalex.org/W4376644055","https://openalex.org/W4385301677","https://openalex.org/W4387033702","https://openalex.org/W4388111436","https://openalex.org/W4390971902","https://openalex.org/W4392730481","https://openalex.org/W4396497953","https://openalex.org/W4400294787","https://openalex.org/W4401442368","https://openalex.org/W4402603464","https://openalex.org/W4404990437","https://openalex.org/W4406035222","https://openalex.org/W4406561042","https://openalex.org/W4407587402","https://openalex.org/W4408798678","https://openalex.org/W4410792758","https://openalex.org/W4413191844","https://openalex.org/W7116796239","https://openalex.org/W7118078757","https://openalex.org/W7156841189"],"related_works":["https://openalex.org/W4376644055","https://openalex.org/W2755131382","https://openalex.org/W2139240811","https://openalex.org/W4408798678","https://openalex.org/W2078985284","https://openalex.org/W3006510130","https://openalex.org/W2766020381","https://openalex.org/W1911379586","https://openalex.org/W2161292170","https://openalex.org/W3198290067"],"abstract_inverted_index":{"Osteoporosis":[0],"and":[1,15,25,32,45,63,93,116,121,162,198,225],"associated":[2],"skeletal":[3,56,110],"pathologies":[4],"impose":[5],"a":[6,37,51,97,133,140,211,218],"staggering":[7],"global":[8],"health":[9],"burden,":[10],"disproportionately":[11],"impacting":[12],"elderly":[13],"populations":[14],"postmenopausal":[16],"women.":[17],"At":[18],"the":[19,69,129,150,154,171,199,223],"root":[20],"of":[21,83,131,143,149,156,174,201,227],"excessive":[22],"bone":[23,76,122,182,206],"resorption":[24],"stalled":[26],"osteogenesis":[27],"lie":[28],"persistent":[29],"oxidative":[30,185],"stress":[31],"chronic":[33],"inflammation.":[34],"Enter":[35],"resveratrol,":[36],"naturally":[38],"occurring":[39],"polyphenol":[40],"derived":[41],"from":[42,128,184],"red":[43],"wine":[44],"grapes,":[46],"which":[47,73],"has":[48],"surfaced":[49],"as":[50,139,217],"compelling":[52],"therapeutic":[53],"candidate":[54],"for":[55,205,222],"preservation":[57],"owing":[58],"to":[59,214],"its":[60],"robust":[61],"antioxidant":[62,177],"anti-inflammatory":[64],"capacities.":[65],"Herein,":[66],"we":[67],"evaluate":[68,215],"molecular":[70],"pathways":[71],"through":[72,170],"resveratrol":[74,216],"governs":[75],"metabolism,":[77],"focusing":[78],"sharply":[79],"on":[80,100,109],"SIRT1-driven":[81],"suppression":[82],"NF-\u03baB":[84,144,151],"signaling.":[85],"Integrating":[86],"findings":[87],"across":[88],"cell":[89],"cultures,":[90],"animal":[91],"models,":[92],"clinical":[94],"trials":[95],"yields":[96],"unified":[98],"perspective":[99],"these":[101,125],"osteoprotective":[102],"mechanisms.":[103],"Dual":[104],"benefits":[105],"define":[106],"resveratrol's":[107],"impact":[108],"architecture:":[111],"it":[112],"stimulates":[113],"osteoblast":[114],"differentiation":[115],"mineralization":[117],"while":[118],"suppressing":[119],"osteoclastogenesis":[120],"resorption.":[123],"Primarily,":[124],"outcomes":[126],"stem":[127],"activation":[130],"SIRT1,":[132],"NAD":[134],"+":[135],"-dependent":[136],"deacetylase":[137],"acting":[138],"negative":[141],"regulator":[142],"transcription.":[145],"Through":[146],"SIRT1-mediated":[147],"deacetylation":[148],"p65":[152],"subunit,":[153],"transcription":[155],"pro-inflammatory":[157],"cytokines":[158],"including":[159],"IL-1\u03b2,":[160],"TNF-\u03b1,":[161],"IL-6":[163],"diminishes,":[164],"subsequently":[165],"dampening":[166],"RANKL-driven":[167],"osteoclastogenesis.":[168],"Simultaneously,":[169],"SIRT1-dependent":[172],"engagement":[173],"Nrf2/ARE":[175],"pathways,":[176],"defenses":[178],"are":[179],"bolstered,":[180],"sparing":[181],"cells":[183],"stress-induced":[186],"apoptosis.":[187],"Substantial":[188],"preclinical":[189],"promise":[190],"notwithstanding,":[191],"hurdles":[192],"persist":[193],"regarding":[194],"both":[195],"systemic":[196],"bioavailability":[197],"standardization":[200],"ideal":[202],"dosing":[203],"protocols":[204],"preservation.":[207],"This":[208],"review":[209],"provides":[210],"mechanistic":[212],"framework":[213],"viable":[219],"nutraceutical":[220],"modality":[221],"prevention":[224],"management":[226],"osteoporosis.":[228]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-11-03T00:00:00"}