{"id":"https://openalex.org/W7225112817","doi":"https://doi.org/10.5281/zenodo.23874411","title":"The Scoville Splice Capsaicin Design Platform: A Computational Framework for Receptor-Normalized Cross-Modal Flavor Engineering Using the Iyengar Flavor Index","display_name":"The Scoville Splice Capsaicin Design Platform: A Computational Framework for Receptor-Normalized Cross-Modal Flavor Engineering Using the Iyengar Flavor Index","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225112817","doi":"https://doi.org/10.5281/zenodo.23874411"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.23874411","doi":"https://doi.org/10.5281/zenodo.23874411","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23874411","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"volume":null,"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.23874411","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5144300586","display_name":"Priyanca Ford","orcid":"https://orcid.org/0000-0003-0395-1752","observed_orcids":["https://orcid.org/0000-0003-0395-1752"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Iyengar Ford, Priyanca","raw_affiliation_strings":["Scoville Splice LLC"],"raw_orcid":"https://orcid.org/0000-0003-0395-1752","affiliations":[{"raw_affiliation_string":"Scoville Splice LLC","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5144300586"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.8461999893188477,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.8461999893188477,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12114","display_name":"Sensory Analysis and Statistical Methods","score":0.07729999721050262,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.05180000141263008,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ec50","display_name":"EC50","score":0.6930000185966492},{"id":"https://openalex.org/keywords/trpv1","display_name":"TRPV1","score":0.8690000176429749},{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.8529999852180481},{"id":"https://openalex.org/keywords/sweet-taste","display_name":"sweet taste","score":0.5099999904632568},{"id":"https://openalex.org/keywords/bitter-taste","display_name":"bitter taste","score":0.6430000066757202},{"id":"https://openalex.org/keywords/umami-taste","display_name":"umami taste","score":0.7229999899864197},{"id":"https://openalex.org/keywords/sour-taste","display_name":"sour taste","score":0.5600000023841858},{"id":"https://openalex.org/keywords/flavor-perception","display_name":"flavor perception","score":0.4429999887943268},{"id":"https://openalex.org/keywords/food-crops","display_name":"food crops","score":0.6159999966621399},{"id":"https://openalex.org/keywords/thermal-sensation","display_name":"thermal sensation","score":0.32199999690055847}],"concepts":[{"id":"https://openalex.org/C2780719635","wikidata":"https://www.wikidata.org/wiki/Q4173974","display_name":"Flavor","level":2,"score":0.6553999781608582},{"id":"https://openalex.org/C2780989783","wikidata":"https://www.wikidata.org/wiki/Q7578557","display_name":"splice","level":3,"score":0.5242000222206116},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.504800021648407},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47440001368522644},{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.42969998717308044},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.37369999289512634},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3379000127315521},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2833000123500824},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27300000190734863},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.26750001311302185},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.2662999927997589}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.5281/zenodo.23874411","doi":"https://doi.org/10.5281/zenodo.23874411","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23874411","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"doi:10.5281/zenodo.23874412","doi":"https://doi.org/10.5281/zenodo.23874412","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23874412","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"doi:10.5281/zenodo.23896518","doi":"https://doi.org/10.5281/zenodo.23896518","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23896518","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.5281/zenodo.23874411","doi":"https://doi.org/10.5281/zenodo.23874411","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23874411","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7225097862","https://openalex.org/W7204459141","https://openalex.org/W1983315215","https://openalex.org/W7225078581","https://openalex.org/W2376925100","https://openalex.org/W4237544266","https://openalex.org/W4316035714","https://openalex.org/W1976912021","https://openalex.org/W7045266048","https://openalex.org/W7225040025"],"abstract_inverted_index":{"Version":[0],"1.0":[1],"\u2014":[2,316],"November":[3],"2026.":[4],"This":[5,742],"preprint":[6],"introduces":[7,761],"the":[8,15,35,54,84,92,98,103,114,118,128,131,143,150,161,603,724,745,748,756,762,770],"Scoville":[9,37,144,165,749],"Splice":[10,750],"Capsaicin":[11],"Design":[12],"Platform":[13],"and":[14,110,140,170,364,553,628,689,727,738,753],"Iyengar":[16,794],"Flavor":[17,795],"Index":[18],"(IFI),":[19],"a":[20,42,177,183,187],"receptor-normalized":[21],"cross-modal":[22,821],"potency":[23],"metric":[24,180],"for":[25,107,527,541],"computational":[26,545,676,816],"flavor":[27,60,365,798],"engineering":[28],"in":[29,245,293,339,424,497,506,710,723,747],"food":[30],"crops.":[31],"The":[32,66,135,156,561],"IFI":[33,67,157,538,638,673,763,790],"extends":[34],"century-old":[36],"Heat":[38],"Unit":[39],"framework":[40,764],"from":[41,345,493,502,549,619,709],"single-axis":[43],"proxy":[44],"(TRPV1":[45],"capsaicin":[46,153],"activation)":[47],"to":[48,182,347,495,504,591,599],"an":[49],"eight-dimensional":[50],"receptor":[51,93,532,554,600,680,704,800],"space":[52],"spanning":[53],"full":[55],"chemosensory":[56,823],"repertoire":[57],"of":[58,102,117,125,519,769],"human":[59],"perception.":[61,201],"THE":[62,190],"IYENGAR":[63],"FLAVOR":[64],"INDEX":[65],"is":[68,83,91,97,113,137,152,158,744],"defined":[69],"as:":[70],"IFI(c,":[71],"m)":[72,77,96,112],"=":[73,214,589,607],"1,000":[74,126],"\u00d7":[75,419,609],"EC\u2085\u2080(ref,":[76,95],"/":[78,611],"EC\u2085\u2080(c,":[79,111],"m),":[80],"where":[81],"c":[82],"candidate":[85,119,129],"compound":[86,185],"or":[87,699],"engineered":[88,542],"construct,":[89],"m":[90],"modality,":[94],"half-maximal":[99],"effective":[100],"concentration":[101],"canonical":[104],"reference":[105,132,151,184],"agonist":[106,133],"modality":[108],"m,":[109],"predicted":[115],"EC\u2085\u2080":[116,204,232,253,271,326,369,408,450,484,705],"at":[120,154,429,467],"that":[121,765],"receptor.":[122,623],"A":[123],"score":[124],"indicates":[127,320],"matches":[130],"exactly.":[134],"formula":[136],"dimensionless,":[138],"receptor-normalized,":[139],"backward-compatible":[141],"with":[142,567,615],"scale:":[145],"IFI-H":[146,213],"equals":[147],"SHU":[148,215],"when":[149],"TRPV1.":[155],"named":[159],"by":[160,164,349],"convention":[162],"established":[163],"(1912),":[166],"S\u00f8rensen":[167],"(1909,":[168],"pH),":[169],"Jenkins":[171],"&":[172],"Wolever":[173],"(1981,":[174],"Glycemic":[175],"Index):":[176],"receptor-physiological":[178],"response":[179,606],"normalized":[181],"on":[186],"dimensionless":[188],"scale.":[189],"EIGHT":[191],"RECEPTOR":[192],"AXES":[193],"IFI-H:":[194,219],"TRPV1":[195],"(NCBI":[196],"Gene":[197],"ID":[198,311,360,441],"7442).":[199,401],"Heat/burn":[200],"Reference:":[202,230,268,323,367,405,446,481],"capsaicin,":[203],"3.16":[205],"nM":[206,255,371],"(Caterina":[207],"et":[208,236,275,281,330,373,412,454],"al.":[209,237,276,282,331,374,413,455],"1997,":[210],"Nature":[211,415,457],"389:816).":[212],"(backward-compatible).":[216],"D.N.R.":[217,635],"(SS-CV-010)":[218],"2,956,310.":[220],"IFI-S:":[221,648],"TAS1R2/TAS1R3":[222,252],"heterodimer":[223],"(Gene":[224,262,310,359,398,440],"IDs":[225,263,399],"80834,":[226],"83756).":[227],"Sweet":[228],"taste.":[229],"sucrose,":[231],"34.2":[233],"mM":[234],"(Nelson":[235],"2002,":[238,277,414],"Cell":[239],"106:381).":[240],"Brazzein":[241],"(PbBRZ,":[242],"54":[243],"aa)":[244],"Capsicum":[246,294,425,778,810],"background":[247],"achieves":[248],"IFI-S":[249],"~2,200,000":[250,649],"via":[251,299,387,602],"~5":[254],"(Paper":[256,304,353,391,434,472,509,775,782,788],"3,":[257],"this":[258,306,355,393,436,474,511],"series).":[259,307,356,394,437,475,512],"IFI-U:":[260,651],"TAS1R1/mGluR1":[261],"80835,":[264],"2911).":[265],"Umami/savory":[266],"depth.":[267],"L-glutamate":[269],"(MSG),":[270],"820":[272],"\u00b5M":[273,328,410,452],"(Li":[274],"PNAS":[278],"99:4692;":[279],"Chaudhari":[280],"2000,":[283],"Nat":[284],"Neurosci":[285],"3:113).":[286],"GAD1/GAD4":[287],"double":[288,337],"KO":[289,338],"plus":[290],"AtGDH1":[291],"overexpression":[292,382],"projects":[295,383,426,464],"IFI-U":[296],"\u2265":[297,385],"800":[298],"8.3\u00d7":[300],"free":[301],"glutamate":[302],"accumulation":[303,390],"5,":[305],"IFI-B:":[308,654],"TAS2R38":[309],"5726).":[312],"Bitterness":[313],"suppression":[314],"axis":[315],"IFI-B":[317,344],"toward":[318],"0":[319],"bitterness":[321],"elimination.":[322],"PTC":[324],"(phenylthiocarbamide),":[325],"1.2":[327],"(Behrens":[329],"2004,":[332,456],"BBRC":[333],"319:479).":[334],"TGG1/TGG2":[335],"myrosinase":[336],"allotetraploid":[340],"Brassica":[341],"oleracea":[342],"reduces":[343,491],"~770":[346],"<40":[348],"eliminating":[350],"isothiocyanate":[351,448],"production":[352],"6,":[354],"IFI-K:":[357,657],"CaSR":[358],"846).":[361],"Kokumi":[362],"mouthfeel":[363],"continuity.":[366],"\u03b3-Glu-Val-Gly,":[368],"48":[370],"(Ohsu":[372],"2010,":[375],"J":[376],"Biol":[377],"Chem":[378],"285:1016).":[379],"GCS1":[380],"(AtGSH1)":[381],"IFI-K":[384],"2,400":[386],"\u03b3-glutamyl":[388],"peptide":[389],"7,":[392],"IFI-C:":[395,660],"TRPM8/TRPV1":[396],"biphasic":[397],"79054,":[400],"Cool-burn":[402],"temperature":[403],"duality.":[404],"menthol:capsaicin":[406],"composite,":[407],"78":[409],"(McKemy":[411],"416:52).":[416],"Five-gene":[417],"Mentha":[418],"piperita":[420],"menthol":[421,433],"pathway":[422,478,550],"reconstitution":[423],"IFI-C":[427],"~85,000":[428,661],"~85":[430],"\u00b5g/g":[431,469],"FW":[432,470],"9,":[435],"IFI-P:":[438,663],"TRPA1":[439],"8989).":[442],"Pungency":[443],"(wasabi/cinnamon":[444],"axis).":[445],"allyl":[447],"(AITC),":[449],"56":[451],"(Jordt":[453],"427:260).":[458],"CrCCR1":[459],"insertion":[460],"under":[461],"E8":[462],"promoter":[463],"IFI-P":[465],"~170,000":[466,664],"~500":[468],"cinnamaldehyde":[471],"10,":[473],"IFI-A:":[476,666],"Proanthocyanidin":[477],"(VvLAR1/VvANR/VvDFR).":[479],"Astringency.":[480],"tannic":[482],"acid,":[483],"1,100":[485],"\u00b5g/mL":[486],"(Bate-Smith":[487],"1954).":[488],"ANR":[489],"knockout":[490,501],"IFI-A":[492],"~600":[494],"<100":[496],"Vitis":[498],"vinifera;":[499],"TAN1":[500],"~1,200":[503],"<80":[505],"Sorghum":[507],"bicolor":[508],"8,":[510],"IFI-F":[513],"(Full":[514],"Spectrum":[515],"Composite):":[516],"geometric":[517],"mean":[518],"all":[520,642],"8":[521,643],"subscale":[522],"scores,":[523],"(\u220f":[524],"IFI_i)^(1/8).":[525],"Used":[526],"polypharmacology":[528],"products":[529],"targeting":[530],"multiple":[531],"axes":[533],"simultaneously.":[534],"COMPUTATIONAL":[535],"METHODOLOGY":[536],"All":[537,672],"scores":[539,674],"reported":[540],"constructs":[543],"are":[544,597,675],"design":[546,562],"targets":[547],"derived":[548],"flux":[551,575,586,688,813],"modeling":[552],"binding":[555],"estimation,":[556],"NOT":[557],"experimentally":[558],"measured":[559,679],"values.":[560,682],"pipeline":[563],"uses":[564],"COBRApy":[565],"v0.29":[566],"PlantCoreMetabolism":[568],"v2.0.":[569],"Objective":[570],"functions":[571],"maximize":[572],"target":[573,725],"metabolite":[574,595],"(capsaicin,":[576],"glutamate,":[577],"menthol,":[578],"cinnamaldehyde,":[579],"etc.).":[580],"Ten":[581],"stochastic":[582],"replicates":[583],"apply":[584],"Gaussian":[585],"perturbation":[587],"(\u03c3":[588],"0.1)":[590],"non-target":[592],"fluxes.":[593],"Predicted":[594],"concentrations":[596],"mapped":[598],"activation":[601,681],"Hill":[604,616],"equation:":[605],"E_max":[608],"[A]^n":[610],"(EC\u2085\u2080^n":[612],"+":[613,641],"[A]^n),":[614],"coefficients":[617],"estimated":[618],"primary":[620],"literature":[621],"per":[622],"Physical":[624],"transformation,":[625],"transgene":[626],"expression,":[627],"sensory":[629],"validation":[630,722],"require":[631,719,735],"independent":[632],"experimental":[633,720],"verification.":[634],"FULL":[636],"SPECTRUM":[637],"PROFILE":[639],"(SS-CV-010":[640],"series":[644],"interventions):IFI-H:":[645],"2,956,310":[646],"|":[647,650,653,656,659,662,665],"~820":[652],"~30":[655],"~2,400":[658],"~42":[667],"LIMITATIONS":[668],"Stated":[669],"explicitly:":[670],"(1)":[671],"predictions,":[677],"not":[678,691],"(2)":[683],"FBA":[684],"models":[685],"assume":[686],"steady-state":[687],"do":[690],"capture":[692],"post-translational":[693],"regulation,":[694],"epigenetic":[695],"silencing,":[696],"insertion-site":[697],"effects,":[698],"developmental":[700],"dynamics.":[701],"(3)":[702],"Heterologous":[703],"values":[706],"may":[707],"differ":[708],"vivo":[711],"oral":[712],"exposure":[713],"kinetics.":[714],"(4)":[715],"CRISPR":[716],"guide":[717],"sequences":[718],"off-target":[721],"organism":[726],"BSL-appropriate":[728],"facility.":[729],"(5)":[730],"Constructs":[731],"involving":[732],"transgenic":[733],"organisms":[734],"IBC":[736],"review":[737],"jurisdiction-specific":[739],"regulatory":[740],"approval.":[741],"paper":[743],"eleventh":[746],"Research":[751],"Series":[752],"serves":[754],"as":[755],"platform":[757],"methodology":[758],"overview.":[759],"It":[760],"underpins":[766],"Papers":[767],"3\u201310":[768],"series.":[771],"Related":[772],"records:":[773],"10.5281/zenodo.23743695":[774],"1,":[776],"main":[777],"cultivars":[779],"paper),":[780],"10.5281/zenodo.23749878":[781],"2,":[783],"Beyond":[784],"Peppers":[785],"cross-species),":[786],"10.5281/zenodo.23873914":[787],"4,":[789],"sub-scale":[791],"calibration).":[792],"Keywords:":[793],"Index,":[796],"IFI,":[797],"engineering,":[799],"normalization,":[801],"TRPV1,":[802],"TAS1R2/TAS1R3,":[803],"mGluR1,":[804],"TAS2R38,":[805],"CaSR,":[806],"TRPM8,":[807],"TRPA1,":[808],"proanthocyanidin,":[809],"annuum,":[811],"CRISPR,":[812],"balance":[814],"analysis,":[815],"plant":[817],"biology,":[818,820],"synthetic":[819],"flavor,":[822],"receptors":[824]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-03T00:00:00"}
