{"id":"https://openalex.org/W7225112106","doi":"https://doi.org/10.3390/biology15211967","title":"Intracellular Responses to Ionizing Radiation: From Initial Damage to Cell Fate and Intercellular Communication","display_name":"Intracellular Responses to Ionizing Radiation: From Initial Damage to Cell Fate and Intercellular Communication","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225112106","doi":"https://doi.org/10.3390/biology15211967"},"language":"en","primary_location":{"id":"doi:10.3390/biology15211967","doi":"https://doi.org/10.3390/biology15211967","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology15211967","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biology15211967","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081961746","display_name":"Song Mi Lee","orcid":"https://orcid.org/0000-0001-5553-3232","observed_orcids":["https://orcid.org/0000-0001-5553-3232"]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Song Mi Lee","raw_affiliation_strings":["Laboratory of Biochemistry & Cancer Immunology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-5553-3232","affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry & Cancer Immunology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070573588","display_name":"Moon\u2010Taek Park","orcid":"https://orcid.org/0000-0001-7665-2265","observed_orcids":["https://orcid.org/0000-0001-7665-2265"]},"institutions":[{"id":"https://openalex.org/I4210148139","display_name":"Dongnam Institute of Radiological & Medical Sciences","ror":"https://ror.org/055fmxa32","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210148139"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Moon-Taek Park","raw_affiliation_strings":["Research Center, Dongnam Institute of Radiological & Medical Sciences, Busan 46033, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center, Dongnam Institute of Radiological & Medical Sciences, Busan 46033, Republic of Korea","institution_ids":["https://openalex.org/I4210148139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5158987626","display_name":"Sung Dae Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sung Dae Kim","raw_affiliation_strings":["Laboratory of Biochemistry & Cancer Immunology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry & Cancer Immunology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea","institution_ids":["https://openalex.org/I31419693"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070573588","https://openalex.org/A5158987626"],"corresponding_institution_ids":["https://openalex.org/I31419693","https://openalex.org/I4210148139"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82851921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"21","first_page":"1967","last_page":"1967"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.7360000014305115},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.6510000228881836},{"id":"https://openalex.org/keywords/cell-cycle-checkpoint-control","display_name":"cell cycle checkpoint control","score":0.6589999794960022},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.777999997138977},{"id":"https://openalex.org/keywords/inflammatory-signaling-pathways","display_name":"inflammatory signaling","score":0.6790000200271606},{"id":"https://openalex.org/keywords/cell-fate","display_name":"cell fate","score":0.5019999742507935},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8059999942779541},{"id":"https://openalex.org/keywords/mitotic-catastrophe","display_name":"mitotic catastrophe","score":0.9890000224113464},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/regulated-necrosis","display_name":"regulated necrosis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.9760000109672546},{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.9039999842643738},{"id":"https://openalex.org/keywords/damage-associated-molecular-patterns","display_name":"damage-associated molecular patterns","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cgas-sting-pathway","display_name":"cGAS-STING pathway","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cytokines-and-chemokines","display_name":"cytokines and chemokines","score":0.8050000071525574},{"id":"https://openalex.org/keywords/normal-tissue-damage","display_name":"normal tissue damage","score":0.8159999847412109},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.9117000102996826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7585999965667725},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7452999949455261},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7172999978065491},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.6337000131607056},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5048999786376953},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4936999976634979},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.39340001344680786},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.3894999921321869},{"id":"https://openalex.org/C2780369685","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell damage","level":2,"score":0.38940000534057617},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3693000078201294},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.36410000920295715},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.3434000015258789},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.32120001316070557},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.319599986076355},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.31029999256134033},{"id":"https://openalex.org/C66887884","wikidata":"https://www.wikidata.org/wiki/Q2126498","display_name":"Radiolysis","level":3,"score":0.30660000443458557},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.2962000072002411},{"id":"https://openalex.org/C125118446","wikidata":"https://www.wikidata.org/wiki/Q690200","display_name":"Radiobiology","level":3,"score":0.25110000371932983},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.25}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/biology15211967","doi":"https://doi.org/10.3390/biology15211967","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology15211967","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/biology15211967","doi":"https://doi.org/10.3390/biology15211967","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology15211967","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W1506174877","https://openalex.org/W1968469516","https://openalex.org/W1976711675","https://openalex.org/W1977082403","https://openalex.org/W1977145510","https://openalex.org/W1979385111","https://openalex.org/W1985775217","https://openalex.org/W1988227131","https://openalex.org/W1988876917","https://openalex.org/W1994826332","https://openalex.org/W1998129814","https://openalex.org/W1998526204","https://openalex.org/W2007263630","https://openalex.org/W2007369689","https://openalex.org/W2009779043","https://openalex.org/W2013276113","https://openalex.org/W2013580891","https://openalex.org/W2016612145","https://openalex.org/W2019531395","https://openalex.org/W2022811243","https://openalex.org/W2025850775","https://openalex.org/W2028361915","https://openalex.org/W2032361307","https://openalex.org/W2041186477","https://openalex.org/W2043895957","https://openalex.org/W2044323425","https://openalex.org/W2053703796","https://openalex.org/W2060451852","https://openalex.org/W2070023258","https://openalex.org/W2078581194","https://openalex.org/W2084745121","https://openalex.org/W2090750060","https://openalex.org/W2093424661","https://openalex.org/W2099610218","https://openalex.org/W2099627146","https://openalex.org/W2103596198","https://openalex.org/W2109126550","https://openalex.org/W2111313313","https://openalex.org/W2111774458","https://openalex.org/W2115338196","https://openalex.org/W2116054786","https://openalex.org/W2119847832","https://openalex.org/W2120600243","https://openalex.org/W2125667702","https://openalex.org/W2126425813","https://openalex.org/W2127099673","https://openalex.org/W2130351327","https://openalex.org/W2134807701","https://openalex.org/W2136176800","https://openalex.org/W2136917684","https://openalex.org/W2151469020","https://openalex.org/W2154210648","https://openalex.org/W2155784435","https://openalex.org/W2158380484","https://openalex.org/W2166284889","https://openalex.org/W2166624257","https://openalex.org/W2168395641","https://openalex.org/W2317949769","https://openalex.org/W2326176611","https://openalex.org/W2331130318","https://openalex.org/W2513422974","https://openalex.org/W2581712788","https://openalex.org/W2586867260","https://openalex.org/W2624275086","https://openalex.org/W2625452721","https://openalex.org/W2733154631","https://openalex.org/W2738136165","https://openalex.org/W2889786008","https://openalex.org/W2890229842","https://openalex.org/W2988270385","https://openalex.org/W2988572118","https://openalex.org/W2993386018","https://openalex.org/W3000233190","https://openalex.org/W3082811350","https://openalex.org/W3195685486","https://openalex.org/W4288885985","https://openalex.org/W4293538574","https://openalex.org/W4308721068","https://openalex.org/W4323317409","https://openalex.org/W4366463631","https://openalex.org/W4400512808","https://openalex.org/W4402693902"],"related_works":["https://openalex.org/W2084497339","https://openalex.org/W4403567260","https://openalex.org/W7220722209","https://openalex.org/W2177380697","https://openalex.org/W178871068","https://openalex.org/W2909486662","https://openalex.org/W1553763991","https://openalex.org/W2155784435","https://openalex.org/W2154248376","https://openalex.org/W1986566995"],"abstract_inverted_index":{"Ionizing":[0],"radiation":[1],"induces":[2],"biological":[3],"effects":[4,133],"through":[5,110],"direct":[6],"energy":[7],"deposition":[8],"in":[9],"biomolecules":[10],"and":[11,18,27,47,52,66,82,99,119,134,143],"indirect":[12],"damage":[13,43,62,74],"mediated":[14],"by":[15],"water":[16],"radiolysis":[17],"reactive":[19],"oxygen":[20],"species.":[21],"This":[22],"review":[23],"synthesizes":[24],"the":[25,59,64],"intracellular":[26,65],"intercellular":[28,67],"events":[29,68],"that":[30,69],"connect":[31,58],"these":[32,56],"initial":[33,60],"reactions":[34],"to":[35],"cell-fate":[36],"determination.":[37],"Following":[38],"irradiation,":[39],"cells":[40,105],"coordinate":[41],"DNA":[42],"recognition,":[44],"checkpoint":[45],"control,":[46],"repair":[48,76],"with":[49,63],"oxidative":[50],"stress":[51],"inflammatory":[53],"signaling.":[54,126],"Together,":[55],"responses":[57,129],"molecular":[61,117],"follow.":[70],"The":[71],"balance":[72],"among":[73],"severity,":[75],"capacity,":[77],"cell-cycle":[78],"stage,":[79],"genetic":[80],"background,":[81],"microenvironmental":[83],"signals":[84],"shapes":[85],"outcomes":[86],"including":[87],"recovery,":[88],"transient":[89],"or":[90,102],"permanent":[91],"arrest,":[92],"senescence,":[93],"mitotic":[94],"catastrophe,":[95],"apoptosis,":[96],"regulated":[97],"necrosis,":[98],"autophagy-associated":[100],"survival":[101],"death.":[103],"Irradiated":[104],"further":[106],"influence":[107],"surrounding":[108],"tissues":[109],"cytokines,":[111],"chemokines,":[112],"senescence-associated":[113],"secretory":[114],"factors,":[115],"damage-associated":[116],"patterns,":[118],"cyclic":[120],"GMP\u2013AMP":[121],"synthase\u2013stimulator":[122],"of":[123],"interferon":[124],"genes":[125],"These":[127],"integrated":[128],"determine":[130],"both":[131],"therapeutic":[132],"normal-tissue":[135],"injury,":[136],"supporting":[137],"investigation":[138],"across":[139],"molecular,":[140],"cellular,":[141],"immune,":[142],"tissue":[144],"levels.":[145]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-03T00:00:00"}
